Identifying lifestyle factors associated to co-morbidity of obesity and psychiatric disorders, a pilot study

Obesity and psychiatric disorders are linked through a bidirectional association. Obesity rates have tripled globally in the past decades, and it is predicted that by 2025, one billion people will be affected by obesity, often with a co-morbidity such as depression. While this co-morbidity seems to be a global health issue, lifestyle factors associated to it differ between countries and are often attributed to more than one factor. Prior obesity studies were performed in Western populations; this is the first study that investigates lifestyle factors relating to obesity and mental health of the diverse population in Qatar, a country that has witnessed tremendous lifestyle change in a short time. In this pilot study, we surveyed 379 respondents to assess and compare the lifestyles of Qatar residents to the global population. However due to the high proportion of responses from the United Kingdom (UK) residents, we have made comparisons between Qatar residents and UK residents. We used chi-square analysis, spearman rank correlation and logistic regression to compare the lifestyle factors of individuals suffering from both increased BMI and mental health conditions. The types of food consumed, stress, exercise frequency and duration, alcohol and tobacco consumption, and sleep duration, were explored and results argue that different lifestyle factors can contribute to the same health condition, suggesting different mechanisms involved. We found that both groups reported similar sleep durations (p = 0.800), but that perception of sleep (p = 0.011), consumption of alcohol (p = 0.001), consumption of takeaway food (p = 0.007), and physical activity significantly varied between the groups (p = 0.0001). The study examined the predictors of comorbidity in Qatar as well as UK populations using multivariate logistic regression analysis. The result of the study showed no statistical association between comorbidity and the predictors drinking habit, smoking, physical activity, vegetable consumption, eat outs, and sleep perception for the Qatar population, and for the combined population. This study, however showed a significant association (p = 0.033) between sleep perception and comorbidity for the UK population. We conclude that further analysis is needed to understand the relationship between specific lifestyle factors and multimorbidity in each country

The Effects of High Liquid Water Content on Thunderstorm Charging

Charge transfer to a riming graupel target during interactions with ice crystals has been investigated in the laboratory. When liquid water contents sufficiently high to cause wet growth are achieved, the charge transfer falls to values which are insignificant to thunderstorm electrification. The implications of this null result to a recent analysis of thunderstorm-charging processes by Wiliams et al. (1991) are discussed

First-principles prediction of a decagonal quasicrystal containing boron

We interpret experimentally known B-Mg-Ru crystals as quasicrystal approximants. These approximant structures imply a deterministic decoration of tiles by atoms that can be extended quasiperiodically. Experimentally observed structural disorder corresponds to phason (tile flip) fluctuations. First-principles total energy calculations reveal that many distinct tilings lie close to stability at low temperatures. Transfer matrix calculations based on these energies suggest a phase transition from a crystalline state at low temperatures to a high temperature state characterized by tile fluctuations. We predict B$_{38}$Mg$_{17}$Ru$_{45}$ forms a decagonal quasicrystal that is metastable at low temperatures and may be thermodynamically stable at high temperatures.Comment: 4 pages, 3 figures, submitted to Phys. Rev. Let

What are the interactions in quantum glasses?

The form of the low-temperature interactions between defects in neutral glasses is reconsidered. We analyse the case where the defects can be modelled either as simple 2-level tunneling systems, or tunneling rotational impurities. The coupling to strain fields is determined up to 2nd order in the displacement field. It is shown that the linear coupling generates not only the usual $1/r^3$ Ising-like interaction between the rotational tunneling defect modes, which cause them to freeze around a temperature $T_G$, but also a random field term. At lower temperatures the inversion symmetric tunneling modes are still active - however the coupling of these to the frozen rotational modes, now via the 2nd-order coupling to phonons, generates another random field term acting on the inversion symmetric modes (as well as shorter-range $1/r^5$ interactions between them). Detailed expressions for all these couplings are given.Comment: 12 pages, 2 figures. Minor modifications, published versio

A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200 mg oral fluconazole in Blantyre, Malawi.

OBJECTIVE: We have previously reported high ten-week mortality from cryptococcal meningitis in Malawian adults following treatment-induction with 800 mg oral fluconazole (57% [33/58]). National guidelines in Malawi and other African countries now advocate an increased induction dose of 1200 mg. We assessed whether this has improved outcomes. DESIGN: This was a prospective observational study of HIV-infected adults with cryptococcal meningitis confirmed by diagnostic lumbar puncture. Treatment was with fluconazole 1200 mg/day for two weeks then 400mg/day for 8 weeks. Mortality within the first 10 weeks was the study end-point, and current results were compared with data from our prior patient cohort who started on fluconazole 800 mg/day. RESULTS: 47 participants received fluconazole monotherapy. Despite a treatment-induction dose of 1200 mg, ten-week mortality remained 55% (26/47). This was no better than our previous study (Hazard Ratio [HR] of death on 1200 mg vs. 800 mg fluconazole: 1.29 (95% CI: 0.77-2.16, p = 0.332)). There was some evidence for improved survival in patients who had repeat lumbar punctures during early therapy to lower intracranial pressure (HR: 0.27 [95% CI: 0.07-1.03, p = 0.055]). CONCLUSION: There remains an urgent need to identify more effective, affordable and deliverable regimens for cryptococcal meningitis

Reverberation measurement of the inner radius of the dust torus in NGC 4151 during 2008-2013

We investigate the correlation between infrared (JHKL) and optical (B) fluxes of the variable nucleus of the Seyfert galaxy NGC 4151 using partially published data for the last 6 years (2008-2013.). Here we are using the same data as in Oknyansky et al. (2014), but include also optical (B) data from Guo et al. We find that the lag of flux in all the infrared bands is the same, 40 +- 6 days, to within the measurement accuracy. Variability in the J and K bands is not quite simultaneous, perhaps due to the differing contributions of the accretion disk in these bands. The lag found for the K band compared with the B band is not significantly different from earlier values obtained for the period 2000-2007. However, finding approximately the same lags in all IR bands for 2008-2013 differs from previous results at earlier epochs when the lag increased with increasing wavelength. Examples of almost the same lag in different IR bands are known for some other active nuclei. In the case of NGC 4151 it appears that the relative lags between the IR bands may be different in different years. The available data, unfortunately, do not allow us to investigate a possible change in the lags during the test interval. We discuss our results in the framework of the standard model where the variable infrared radiation is mainly due to thermal re-emission from the part of the dusty torus closest to the central source. There is also a contribution of some IR emission from the accretion disk, and this contribution increases with decreasing wavelength. Some cosmological applications of obtained results are discussed.Comment: 3 pages, 2 figures, 14-th Odessa International Astronomical Gamow Conference-School Astronomy and beyond: Astrophysics, Cosmology and Gravitation, Cosmomicrophysics, Radio-astronomy and Astrobiolog

Eddy genesis and manipulation in plane laminar shear flow

Eddy formation and presence in a plane laminar shear flow configuration consisting of two infinitely long plates orientated parallel to each other is investigated theoretically. The upper plate, which is planar, drives the flow; the lower one has a sinusoidal profile and is fixed. The governing equations are solved via a full finite element formulation for the general case and semi-analytically at the Stokes flow limit. The effects of varying geometry (involving changes in the mean plate separation or the amplitude and wavelength of the lower plate) and inertia are explored separately. For Stokes flow and varying geometry, excellent agreement between the two methods of solution is found. Of particular interest with regard to the flow structure is the importance of the clearance that exists between the upper plate and the tops of the corrugations forming the lower one. When the clearance is large, an eddy is only present at sufficiently large amplitudes or small wavelengths. However, as the plate clearance is reduced, a critical value is found which triggers the formation of an eddy in an otherwise fully attached flow for any finite amplitude and arbitrarily large wavelength. This is a precursor to the primary eddy to be expected in the lid-driven cavity flow which is formed in the limit of zero clearance between the plates. The influence of the flow driving mechanism is assessed by comparison with corresponding solutions for the case of gravity-driven fluid films flowing over an undulating substrate. When inertia is present, the flow generally becomes asymmetrical. However, it is found that for large mean plate separations the flow local to the lower plate becomes effectively decoupled from the inertia dominated overlying flow if the wavelength of the lower plate is sufficiently small. In such cases the local flow retains its symmetry. A local Reynolds number based on the wavelength is shown to be useful in characterising these large-gap flows. As the mean plate separation is reduced, the form of the asymmetry caused by inertia changes, and becomes strongly dependent on the plate separation. For lower plate wavelengths which do not exhibit a cinematically induced secondary eddy, an inertially induced secondary eddy can be created if the mean plate separation is sufficiently small and the global Reynolds number sufficiently large

The effects of ecolabels on environmentally- and health-friendly cars : an online survey and two experimental studies

Purpose: Given the increasing importance of political decision-making to reduce emission targets, the main purpose of the current paper is to identify and test the considerations that would nudge consumers towards an environmentally and health-friendly motor vehicle. Methods: An online survey was conducted to assess public responses and the role of public authorities to a voluntary emission standard for passenger cars. In addition, two online experiments were conducted to test incentives in the design of ecolabels (e.g. price, safety, performance) for optimization. A random sample of 6400 individuals was drawn from eight countries: Germany, Ireland, Italy, the Netherlands, Spain, UK, Czech Republic and Lithuania. An online survey was conducted among 3200 respondents, 400 in each of the 8 countries, and 2 online experiments with 3200 subjects, 400 in each of the 8 countries, allowing for 200 respondents for each experiment in each country. Results and discussion: The survey shows that Europeans are aware of the health and environmental impact of cars. The findings also confirm the gap between self-reported attitudes/intentions and actual behaviours. In influencing car purchase decisions, health and environmental concerns are less important than other attributes such as price, safety and performance. The experiments show that all these attributes have a significant effect on consumers\u2019 choices. However, message content was found to have the strongest effect. Respondents are more likely to choose European Union Low Emitting carS (EULES)-friendly cars when the label shows information on lower costs or lower taxes and less likely to be influenced by health-related benefits, convenient parking or access fees. Finally, combinations of one message with other elements\u2014EULES logo, CO2 logo or both\u2014within the same label have a small but positive effect on respondents\u2019 choices. Conclusions: The findings of this study assist governmental decision-making processes by identifying those issues that have the greatest impact on consumers\u2019 car purchasing decisions. Furthermore, the results will help to guide environmentally conscious customers towards the purchase of vehicles with clean emission profiles