4,635 research outputs found
Expression of the ubiquitin variant ubR48 decreases proteolytic activity in Arabidopsis and induces cell death
Disk stars in the Milky Way detected beyond 25 kpc from its center
CONTEXT. The maximum size of the Galactic stellar disk is not yet known. Some
studies have suggested an abrupt drop-off of the stellar density of the disk at
Galactocentric distances kpc, which means that in practice no
disk stars or only very few of them should be found beyond this limit. However,
stars in the Milky Way plane are detected at larger distances. In addition to
the halo component, star counts have placed the end of the disk beyond 20 kpc,
although this has not been spectroscopically confirmed so far.
AIMS. Here, we aim to spectroscopically confirm the presence of the disk
stars up to much larger distances.
METHODS. With data from the LAMOST and SDSS-APOGEE spectroscopic surveys, we
statistically derived the maximum distance at which the metallicity
distribution of stars in the Galactic plane is distinct from that of the halo
populations.
RESULTS. Our analysis reveals the presence of disk stars at R>26 kpc (99.7%
C.L.) and even at R>31 kpc (95.4% C.L.).Comment: 4 pages, accepted to be published in A&A-Letter
Studying the accretion geometry of EXO 2030+375 at luminosities close to the propeller regime
The Be X-ray binary EXO 2030+375 was in an extended low luminosity state
during most of 2016. We observed this state with NuSTAR and Swift, supported by
INTEGRAL observations as well as optical spectroscopy with the NOT. We present
a comprehensive spectral and timing analysis of these data here to study the
accretion geometry and investigate a possible onset of the propeller effect.
The H-alpha data show that the circumstellar disk of the Be-star is still
present. We measure equivalent widths similar to values found during more
active phases in the past, indicating that the low-luminosity state is not
simply triggered by a smaller Be disk. The NuSTAR data, taken at a 3-78 keV
luminosity of ~6.8e35 erg/s (for a distance of 7.1 kpc), are well described by
standard accreting pulsar models, such as an absorbed power-law with a
high-energy cutoff. We find that pulsations are still clearly visible at these
luminosities, indicating that accretion is continuing despite the very low mass
transfer rate. In phase-resolved spectroscopy we find a peculiar variation of
the photon index from ~1.5 to ~2.5 over only about 3% of the rotational period.
This variation is similar to that observed with XMM-Newton at much higher
luminosities. It may be connected to the accretion column passing through our
line of sight. With Swift/XRT we observe luminosities as low as 1e34 erg/s
during which the data quality did not allow us to search for pulsations, but
the spectrum is much softer and well described by either a blackbody or soft
power-law continuum. This softer spectrum might be due to the fact that
accretion has been stopped by the propeller effect and we only observe the
neutron star surface cooling.Comment: 11 pages, 6 figures, accepted for publication in A&A (v2 including
language edits
Wave Attenuation by Spartina Saltmarshes in the Chesapeake Bay Under Storm Surge Conditions
This material is based upon work supported by the National Fish and Wildlife Foundation and the U.S. Department of the Interior under grant 43932.This material is also based upon work supported by the National Science Foundation under grant SES‐1331399.This research was also supported in part by the Thomas F. and Kate Miller Jeffress Memorial Trust, Bank of America, Trustee. M. Maza, J.L. Lara, and I.J. Losada are indebted to the Spanish Ministry of Economy and Competitiveness for the funding provided in the RETOS INVESTIGACION 2014 (grant BIA2014‐59718‐R) grant program
PRT6/At5g02310 encodes an Arabidopsis ubiquitin ligase of the N-end rule pathway with arginine specificity and is not the CER3 locus
NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival
Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML). Posttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells. In this study, we identified and characterised NRF2-regulated miRNAs in AML. An miRNA array identified miRNA expression level changes in response to NRF2 knockdown in AML cells. Further analysis of miRNAs concomitantly regulated by knockdown of the NRF2 inhibitor KEAP1 revealed the major candidate NRF2-mediated miRNAs in AML. We identified miR-125B to be upregulated and miR-29B to be downregulated by NRF2 in AML. Subsequent bioinformatic analysis identified putative NRF2 binding sites upstream of the miR-125B1 coding region and downstream of the mir-29B1 coding region. Chromatin immunoprecipitation analyses showed that NRF2 binds to these antioxidant response elements (AREs) located in the 5′ untranslated regions of miR-125B and miR-29B. Finally, primary AML samples transfected with anti-miR-125B antagomiR or miR-29B mimic showed increased cell death responsiveness either alone or co-treated with standard AML chemotherapy. In summary, we find that NRF2 regulation of miR-125B and miR-29B acts to promote leukaemic cell survival, and their manipulation enhances AML responsiveness towards cytotoxic chemotherapeutics
The Use of Sunn Hemp as Forage in Florida
Sunn hemp (Crotalaria juncea L.) is a warm-season annual legume that has been widely used as cover crop; however, there is potential to use sunn hemp as forage in subtropical regions. The objective of this study was to evaluate management practices to improve the efficiency of using sunn hemp as a forage crop. The study was conducted in Ona, Florida, USA from 2016 to 2018 and tested the factorial arrangement of five sunn hemp genotypes (Crescent Sunn, Ubon, Blue Leaf, and AU Golden) and two harvest times (60 d after seeding or flowering) with four replicates. There was a cultivar × harvest period effect on HA, crude protein (CP), and in vitro digestible organic matter (IVDOM) concentrations. Herbage accumulation was greater at flowering than 60 d harvest for all cultivars; however, the magnitude of increase was greater for Blue Leaf and Crescent Sun than AU Golden and Ubon. AU Golden and Ubon flowered at 83 and 92 d after seeding, while Blue Leaf and Crescent Sun flowered or were harvested at 166 d after seeding. AU Golden and Crescent Sunn had the greatest CP at 60 d harvest, and Blue Leaf and Ubon had the least CP concentrations. AU Golden and Crescent Sun had the greatest IVDOM at 60-d harvest; however, AU Golden and Ubon had greater IVDOM than Blue Leaf and Crescent Sun at flowering. Sunn hemp may be a feasible warm-season annual legume to be used in forage systems in Florida and harvest 60 d after seeding would results in forage with greater nutritive value
What’s really damaging the Reef?: Tracing the origin and fate of the ecologically detrimental sediment and associated bioavailable nutrients
This report addresses six key systematic questions to help inform the debate on the influence of anthropogenic sediment and associated particulate nutrients delivered to the Great Barrier Reef (GBR) lagoon. They are:
1. What is the influence of the newly-delivered sediment (i.e. from flood plumes) on turbidity regimes at coral reef and seagrass locations of the inshore GBR?
2. What is the contribution of the anthropogenic component of this sediment on turbidity regimes?
3. What are the characteristics of the suspended particulate matter (and associated particulate nutrients) that influence light and turbidity regimes and how do these change over the estuarine mixing gradient of flood plumes?
4. How does the particulate organic component of the suspended particulate matter and associated microbial community composition change from the catchment to reef?
5. How bioavailable is the suspended particulate matter along the estuarine mixing gradient
6. Where does the sediment (and associated particulate nutrients) that influence light and turbidity regimes in the GBR come from in the Burdekin catchment so that management efforts can be prioritised?
This final project report is divided into eight separate stand-alone research chapters which collectively address these six key questions
A major star formation region in the receding tip of the stellar Galactic bar
We present an analysis of the optical spectroscopy of 58 stars in the
Galactic plane at \arcdeg, where a prominent excess in the flux
distribution and star counts have been observed in several spectral regions, in
particular in the Two Micron Galactic Survey (TMGS) catalog. The sources were
selected from the TMGS, to have a magnitude brighter than +5 mag and be
within 2 degrees of the Galactic plane. More than 60% of the spectra correspond
to stars of luminosity class I, and a significant proportion of the remainder
are very late giants which would also be fast evolving. This very high
concentration of young sources points to the existence of a major star
formation region in the Galactic plane, located just inside the assumed origin
of the Scutum spiral arm. Such regions can form due to the concentrations of
shocked gas where a galactic bar meets a spiral arm, as is observed at the ends
of the bars of face-on external galaxies. Thus, the presence of a massive star
formation region is very strong supporting evidence for the presence of a bar
in our Galaxy.Comment: 13 pages (latex) + 4 figures (eps), accepted in ApJ Let
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