139 research outputs found
Ignition of thermally sensitive explosives between a contact surface and a shock
The dynamics of ignition between a contact surface and a shock wave is investigated using a
one-step reaction model with Arrhenius kinetics. Both large activation energy asymptotics and
high-resolution finite activation energy numerical simulations are employed. Emphasis is on comparing
and contrasting the solutions with those of the ignition process between a piston and a shock,
considered previously. The large activation energy asymptotic solutions are found to be qualitatively
different from the piston driven shock case, in that thermal runaway first occurs ahead of
the contact surface, and both forward and backward moving reaction waves emerge. These waves
take the form of quasi-steady weak detonations that may later transition into strong detonation
waves. For the finite activation energies considered in the numerical simulations, the results are
qualitatively different to the asymptotic predictions in that no backward weak detonation wave
forms, and there is only a weak dependence of the evolutionary events on the acoustic impedance
of the contact surface. The above conclusions are relevant to gas phase equation of state models.
However, when a large polytropic index more representative of condensed phase explosives is used,
the large activation energy asymptotic and finite activation energy numerical results are found to
be in quantitative agreement
Mycotoxins that Affect the North American Agri-Food Sector: State of the Art and Directions for the Future
This paper summarises workshop discussions at the 5th international MYCORED meeting in Ottawa, Canada (June 2012) with over 200 participants representing academics, government and industry scientists, government officials and farming organisations (present in roughly equal proportions) from 27 countries. Workshops centred on how mycotoxins in food and feed affect value chains and trade in the region covered by the North American Free Trade Agreement. Crops are contaminated by one or more of five important mycotoxins in parts of Canada and the United States every year, and when contaminated food and feed are consumed in amounts above tolerable limits, human and animal health are at risk. Economic loss from such contamination includes reduced crop yield, grain quality, animal productivity and loss of domestic and export markets. A systematic effort by grain producers, primary, transfer, and terminal elevators, millers and food and feed processers is required to manage these contaminants along the value chain. Workshops discussed lessons learned from investments in plant genetics, fungal genomics, toxicology, analytical and sampling science, management strategies along the food and feed value chains and methods to ameliorate the effects of toxins in grain on animal production and on reducing the impact of mycotoxins on population health in developing countries. These discussions were used to develop a set of priorities and recommendations
Disruption of Transforming Growth Factor ÎČ Signaling by a Novel Ligand-dependent Mechanism
Transforming growth factor (TGF)-ÎČ is the prototype in a family of secreted proteins that act in autocrine and paracrine pathways to regulate cell development and function. Normal cells typically coexpress TGF-ÎČ receptors and one or more isoforms of TGF-ÎČ, thus the synthesis and secretion of TGF-ÎČ as an inactive latent complex is considered an essential step in regula-ting the activity of this pathway. To determine whether intracellular activation of TGF-ÎČ results in TGF-ÎČ ligandâreceptor interactions within the cell, we studied pristane-induced plasma cell tumors (PCTs). We now demonstrate that active TGF-ÎČ1 in the PCT binds to intracellular TGF-ÎČ type II receptor (TÎČRII). Disruption of the expression of TGF-ÎČ1 by antisense TGF-ÎČ1 mRNA restores localization of TÎČRII at the PCT cell surface, indicating a ligand-induced impediment in receptor trafficking. We also show that retroviral expression of a truncated, dominant-negative TÎČRII (dnTÎČRII) effectively competes for intracellular binding of active ligand in the PCT and restores cell surface expression of the endogenous TÎČRII. Analysis of TGF-ÎČ receptorâactivated Smad2 suggests the intracellular ligandâreceptor complex is not capable of signaling. These data are the first to demonstrate the formation of an intracellular TGF-ÎČâreceptor complex, and define a novel mechanism for modulating the TGF-ÎČ signaling pathway
Deformed General Relativity and Torsion
We argue that the natural framework for embedding the ideas of deformed, or
doubly, special relativity (DSR) into a curved spacetime is a generalisation of
Einstein-Cartan theory, considered by Stelle and West. Instead of interpreting
the noncommuting "spacetime coordinates" of the Snyder algebra as endowing
spacetime with a fundamentally noncommutative structure, we are led to consider
a connection with torsion in this framework. This may lead to the usual
ambiguities in minimal coupling. We note that observable violations of charge
conservation induced by torsion should happen on a time scale of 10^3 s, which
seems to rule out these modifications as a serious theory. Our considerations
show, however, that the noncommutativity of translations in the Snyder algebra
need not correspond to noncommutative spacetime in the usual sense.Comment: 20 pages, 1 figure, revtex; expanded sections 3 and 4 for clarity,
moved material to appendix B, corrected a few minor error
Mechanical properties of freely suspended atomically thin dielectric layers of mica
We have studied the elastic deformation of freely suspended atomically thin
sheets of muscovite mica, a widely used electrical insulator in its bulk form.
Using an atomic force microscope, we carried out bending test experiments to
determine the Young's modulus and the initial pre-tension of mica nanosheets
with thicknesses ranging from 14 layers down to just one bilayer. We found that
their Young's modulus is high (190 GPa), in agreement with the bulk value,
which indicates that the exfoliation procedure employed to fabricate these
nanolayers does not introduce a noticeable amount of defects. Additionally,
ultrathin mica shows low pre-strain and can withstand reversible deformations
up to tens of nanometers without breaking. The low pre-tension and high Young's
modulus and breaking force found in these ultrathin mica layers demonstrates
their prospective use as a complement for graphene in applications requiring
flexible insulating materials or as reinforcement in nanocomposites.Comment: 9 pages, 5 figures, selected as cover of Nano Research, Volume 5,
Number 8 (2012
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
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Analysis of the African coelacanth genome sheds light on tetrapod evolution
It was a zoological sensation when a living specimen of the coelacanth was first discovered in 1938, as this lineage of lobe-finned fish was thought to have gone extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the African coelacanth, Latimeria chalumnae. Through a phylogenomic analysis, we conclude that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Coelacanth protein-coding genes are significantly more slowly evolving than those of tetrapods, unlike other genomic features . Analyses of changes in genes and regulatory elements during the vertebrate adaptation to land highlight genes involved in immunity, nitrogen excretion and the development of fins, tail, ear, eye, brain, and olfaction. Functional assays of enhancers involved in the fin-to-limb transition and in the emergence of extra-embryonic tissues demonstrate the importance of the coelacanth genome as a blueprint for understanding tetrapod evolution
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Redirecting research efforts on the diversification-performance linkage: The search for synergy
We review the literature on the diversification-performance (D-P) relationship to a) propose that the time is ripe for a renewed attack on understanding the relationship between diversification and firm performance, and b) outline a new approach to attacking the question. Our paper makes four main contributions. First, through a review of the literature we establish the inherent complexities in the D-P relationship and the methodological challenges confronted by the literature in reaching its current conclusion of a non-linear relationship between diversification and performance. Second, we argue that to better guide managers the literature needs to develop along a complementary path â whereas past research has often focused on answering the big question of does diversification affect firm performance, this second path would focus more on identifying the precise micro-mechanisms through which diversification adds or subtracts value. Third, we outline a new approach to the investigation of this topic, based on (a) identifying the precise underlying mechanisms through which diversification affects performance; (b) identifying performance outcomes that are âproximateâ to the mechanism that the researcher is studying, and (c) identifying an appropriate research design that can enable a causal claim. Finally, we outline a set of directions for future research
A generalized nonlinear tempeature response function for some growth and developmental parameters in kiwifruit (Actinidia deliciosa (A. Chev.) C. F. Liang & A. R. Ferguson)
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