Neutrino Large Mixing in Universal Yukawa Coupling Model with Small Violation

We have analyzed the possibility that the universal Yukawa coupling (democratic mass matrix) with small violations of Dirac and Majorana neutrinos can induce the large mixing of neutrinos through the seesaw mechanism. The possibility can be achieved by the condition that the violation parameters of Majorana neutrinos are sufficiently smaller than the violation parameters of Dirac neutrinos. Allowed regions of the violation parameters producing the observed neutrino mass hierarchy and large neutrino mixing are not so restricted at present in contrast to the violation parameters for quark sector.Comment: 14 pages, 4figure

Design and evaluation of an osteogenesis-on-a-chip microfluidic device incorporating 3D cell culture

Microfluidic-based tissue-on-a-chip devices have generated significant research interest for biomedical applications, such as pharmaceutical development, as they can be used for small volume, high throughput studies on the effects of therapeutics on tissue-mimics. Tissue-on-a-chip devices are evolving from basic 2D cell cultures incorporated into microfluidic devices to complex 3D approaches, with modern designs aimed at recapitulating the dynamic and mechanical environment of the native tissue. Thus far, most tissue-on-a-chip research has concentrated on organs involved with drug uptake, metabolism and removal (e.g., lung, skin, liver, and kidney); however, models of the drug metabolite target organs will be essential to provide information on therapeutic efficacy. Here, we develop an osteogenesis-on-a-chip device that comprises a 3D environment and fluid shear stresses, both important features of bone. This inexpensive, easy-to-fabricate system based on a polymerized High Internal Phase Emulsion (polyHIPE) supports proliferation, differentiation and extracellular matrix production of human embryonic stem cell-derived mesenchymal progenitor cells (hES-MPs) over extended time periods (up to 21 days). Cells respond positively to both chemical and mechanical stimulation of osteogenesis, with an intermittent flow profile containing rest periods strongly promoting differentiation and matrix formation in comparison to static and continuous flow. Flow and shear stresses were modeled using computational fluid dynamics. Primary cilia were detectable on cells within the device channels demonstrating that this mechanosensory organelle is present in the complex 3D culture environment. In summary, this device aids the development of ‘next-generation’ tools for investigating novel therapeutics for bone in comparison with standard laboratory and animal testing

The effect of spontaneous collapses on neutrino oscillations

We compute the effect of collapse models on neutrino oscillations. The effect of the collapse is to modify the evolution of the `spatial' part of the wave function, which indirectly amounts to a change on the flavor components. In many respects, this phenomenon is similar to neutrino propagation through matter. For the analysis we use the mass proportional CSL model, and perform the calculation to second order perturbation theory. As we will show, the CSL prediction is very small - mainly due to the very small mass of neutrinos - and practically undetectable.Comment: 24 pages, RevTeX. Updated versio

Removing Ambiguities in the Neutrino Mass Matrix

We suggest that the weak-basis independent condition det(M_nu)=0 for the effective neutrino mass matrix can be used in order to remove the ambiguities in the reconstruction of the neutrino mass matrix from input data available from present and future feasible experiments. In this framework, we study the full reconstruction of M_nu with special emphasis on the correlation between the Majorana CP-violating phase and the various mixing angles. The impact of the recent KamLAND results on the effective neutrino mass parameter is also briefly discussed.Comment: 11 pages, 4 figures. Comments and references added; final version to appear in Phys. Lett.

Genotipagem de Toxoplasma gondii em galinhas domésticas em uma área rural do Rio Grande do Sul, Brasil

Free-range chickens may ingest oocysts of T. gondii present in the environment and consequently harbor virulent strains of this parasite in different tissues, without any clinical signs. Isolation of T. gondii through bioassays on mice and cats from naturally infected chicken tissues has been described in several countries, demonstrating the importance of free-range chickens in the transmission of this parasite. The aim of this study was the genotypic characterization of T. gondii isolates obtained from naturally infected free-range chickens in a rural area of the state of Rio Grande do Sul, Brazil. Brain and heart tissue from 12 chickens seropositive for T. gondii were processed using peptic digestion technique for parasite isolation. From 12 samples subjected to mouse bioassay, nine isolates were obtained. RFLP-PCR genotypic characterization was performed using 11 genetic markers: SAG1, 5'-3'SAG2, alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29- 2, L358, PK1 and Apico. Genetic characterization of the isolates revealed the presence of five atypical genotypes according to ToxoDB (# 11, # 55, # 64, # 140 and # 163). Our results showed a wide genetic diversity of T. gondii in free-range chickens in this region.Galinhas criadas ao ar livre podem ingerir oocistos de T. gondii presentes no ambiente e, com isso, albergar cepas virulentas desse parasita em diferentes tecidos, sem sinais clínicos. O isolamento de T. gondii por meio de bioensaios em camundongos e gatos, a partir de tecidos de galinhas naturalmente infectadas, tem sido descrito em vários países. Isso demonstra a importância das galinhas caipiras na epidemiologia desse parasita. O objetivo deste trabalho foi caracterizar genotipicamente isolados de T. gondii obtidos de galinhas caipiras naturalmente infectadas em uma área rural do município de Santa Maria, estado do Rio Grande do Sul, Brasil. Fragmentos de cérebro e de coração, de 12 galinhas soropositivas para T. gondii, foram processados pela técnica de digestão péptica para isolamento do parasita. Das 12 amostras submetidas a bioensaio com camundongos, nove isolados foram obtidos. A caracterização genotípica por RFLP-PCR foi realizada utilizando-se 11 marcadores genéticos: SAG1, 5'- 3'SAG2, alt.SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1 e Apico e revelou a presença de cinco genótipos atípicos de acordo com o ToxoDB (# 11, # 55, # 64, # 140 e # 163). Os resultados mostraram uma ampla diversidade genética de T. gondii em galinhas caipiras nessa região.Fil: Camillo, G.. Universidade Federal de Santa Maria; BrasilFil: Machado, M. E. A.. Universidade Federal de Santa Maria; BrasilFil: Cadore, G.C.. Universidade Federal de Santa Maria; BrasilFil: Bräunig, P.. Universidade Federal de Santa Maria; BrasilFil: Venturini, María Cecilia. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; ArgentinaFil: Pardini, Lais Luján. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Barros, L.D.. Universidade Estadual de Londrina; BrasilFil: Garcia, J.L.. Universidade Estadual de Londrina; BrasilFil: Sangioni, L.A.. Universidade Federal de Santa Maria; BrasilFil: Vogel, F.S.F.. Universidade Federal de Santa Maria; Brasi

Neutrino Masses and Lepton Flavour Violation in Thick Brane Scenarios

We address the issue of lepton flavour violation and neutrino masses in the ``fat-brane'' paradigm, where flavour changing processes are suppressed by localising different fermion field wave-functions at different positions (in the extra dimensions) in a thick brane. We study the consequences of suppressing lepton number violating charged lepton decays within this scenario for lepton masses and mixing angles. In particular, we find that charged lepton mass matrices are constrained to be quasi-diagonal. We further consider whether the same paradigm can be used to naturally explain small Dirac neutrino masses by considering the existence of three right-handed neutrinos in the brane, and discuss the requirements to obtain phenomenologically viable neutrino masses and mixing angles. Finally, we examine models where neutrinos obtain a small Majorana mass by breaking lepton number in a far away brane and show that, if the fat-brane paradigm is the solution to the absence of lepton number violating charged lepton decays, such models predict, in the absence of flavour symmetries, that charged lepton flavour violation will be observed in the next round of rare muon/tau decay experiments.Comment: 33 pages, 9 eps figure

Neutrino masses and mixing with seesaw mechanism and universal breaking of extended democracy

In the framework of a minimal extension of the SM, where the only additional fields are three right-handed neutrinos, we suggest that the charged lepton, the Dirac neutrino and the right-handed Majorana neutrino mass matrices are all, to leading approximation, proportional to the democratic matrix. With the further assumption that the breaking of this extended democracy is universal for all leptonic mass matrices, a large mixing in the 2-3 sector can be obtained and is linked to the seesaw mechanism, together with the existence of a strong hierarchy in the masses of right-handed neutrinos. The structure of the resulting effective mass matrix of light neutrinos is stable against the RGE evolution, and a good fit to all solar and atmospheric neutrino data is obtained.Comment: LaTeX, 17 pages, 2 eps figures. A section on RGE evolution and a few references added; minor typos correcte

Minimal Scenarios for Leptogenesis and CP Violation

The relation between leptogenesis and CP violation at low energies is analyzed in detail in the framework of the minimal seesaw mechanism. Working, without loss of generality, in a weak basis where both the charged lepton and the right-handed Majorana mass matrices are diagonal and real, we consider a convenient generic parametrization of the Dirac neutrino Yukawa coupling matrix and identify the necessary condition which has to be satisfied in order to establish a direct link between leptogenesis and CP violation at low energies. In the context of the LMA solution of the solar neutrino problem, we present minimal scenarios which allow for the full determination of the cosmological baryon asymmetry and the strength of CP violation in neutrino oscillations. Some specific realizations of these minimal scenarios are considered. The question of the relative sign between the baryon asymmetry and CP violation at low energies is also discussed.Comment: 36 pages, 5 figures; minor corrections and references updated. Final version to appear in Phys. Rev.

Constraints on Large Extra Dimensions with Bulk Neutrinos

We consider right-handed neutrinos propagating in $\delta$ (large) extra dimensions, whose only coupling to Standard Model fields is the Yukawa coupling to the left-handed neutrino and the Higgs boson. These theories are attractive as they can explain the smallness of the neutrino mass, as has already been shown. We show that if $\delta$ is bigger than two, there are strong constraints on the radius of the extra dimensions, resulting from the experimental limit on the probability of an active state to mix into the large number of sterile Kaluza-Klein states of the bulk neutrino. We also calculate the bounds on the radius resulting from requiring that perturbative unitarity be valid in the theory, in an imagined Higgs-Higgs scattering channel.Comment: 24 pages, 4 figures, revtex4. v2: Minor typos corrected, references adde

Bi-large Neutrino Mixing and Mass of the Lightest Neutrino from Third Generation Dominance in a Democratic Approach

We show that both small mixing in the quark sector and large mixing in the lepton sector can be obtained from a simple assumption of universality of Yukawa couplings and the right-handed neutrino Majorana mass matrix in leading order. We discuss conditions under which bi-large mixing in the lepton sector is achieved with a minimal amount of fine-tuning requirements for possible models. From knowledge of the solar and atmospheric mixing angles we determine the allowed values of sin \theta_{13}. If embedded into grand unified theories, the third generation Yukawa coupling unification is a generic feature while masses of the first two generations of charged fermions depend on small perturbations. In the neutrino sector, the heavier two neutrinos are model dependent, while the mass of the lightest neutrino in this approach does not depend on perturbations in the leading order. The right-handed neutrino mass scale can be identified with the GUT scale in which case the mass of the lightest neutrino is given as (m_{top}^2/M_{GUT}) sin^2 \theta_{23} sin^2 \theta_{12} in the limit sin \theta_{13} = 0. Discussing symmetries we make a connection with hierarchical models and show that the basis independent characteristic of this scenario is a strong dominance of the third generation right-handed neutrino, M_1, M_2 < 10^{-4} M_3, M_3 = M_{GUT}.Comment: typos correcte