Screening of Synergic Interactions of Anti-Angiogenic and Anti-Tumor Compounds

Solid cancers have several common characteristics that Hanahan & Weinberg named as the hallmarks of cancer. Angiogenesis is an essential hallmark of cancer because tumor cells need oxygen and nutrients delivered by the vascular system. In fact, tumor growth and metastasis are angiogenesis dependent, and microvascular endothelial cells recruited by tumors have become an important target in cancer therapy. Combinations of drugs with different modes of action may lead to enhanced antitumor and antiangiogenic effects without injuring the host. The combined use of two drugs may sometimes produce enhanced, unchanged or diminished effects in comparison with their individual effects. These three different types of behaviour of the interacting drugs are called synergy, additive/indifferent and antagonistic effects. In the present work, we analyze 105 paired combinations of 15 compounds, some described by our research group as potent antiangiogenic compounds, and others currently used in clinical therapy. Our results show synergistic effects of several paired combinations using the MTT assay. [Our experimental work is supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)].This communication has the support of a travel grant "Universidad de Málaga.Campus de Excelencia Internacional Andalucía Tech".Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

General Relativity as an Attractor in Scalar-Tensor Stochastic Inflation

Quantum fluctuations of scalar fields during inflation could determine the very large-scale structure of the universe. In the case of general scalar-tensor gravity theories these fluctuations lead to the diffusion of fundamental constants like the Planck mass and the effective Brans--Dicke parameter, $\omega$. In the particular case of Brans--Dicke gravity, where $\omega$ is constant, this leads to runaway solutions with infinitely large values of the Planck mass. However, in a theory with variable $\omega$ we find stationary probability distributions with a finite value of the Planck mass peaked at exponentially large values of $\omega$ after inflation. We conclude that general relativity is an attractor during the quantum diffusion of the fields.Comment: LaTeX (with RevTex) 11 pages, 2 uuencoded figures appended, also available on WWW via http://star.maps.susx.ac.uk/index.htm

Conditions for Successful Extended Inflation

We investigate, in a model-independent way, the conditions required to obtain a satisfactory model of extended inflation in which inflation is brought to an end by a first-order phase transition. The constraints are that the correct present strength of the gravitational coupling is obtained, that the present theory of gravity is satisfactorily close to general relativity, that the perturbation spectra from inflation are compatible with large scale structure observations and that the bubble spectrum produced at the phase transition doesn't conflict with the observed level of microwave background anisotropies. We demonstrate that these constraints can be summarized in terms of the behaviour in the conformally related Einstein frame, and can be compactly illustrated graphically. We confirm the failure of existing models including the original extended inflation model, and construct models, albeit rather contrived ones, which satisfy all existing constraints.Comment: 8 pages RevTeX file with one figure incorporated (uses RevTeX and epsf). Also available by e-mailing ARL, or by WWW at http://star-www.maps.susx.ac.uk/papers/infcos_papers.html; Revised to include extra references, results unchanged, to appear Phys Rev

ACUMULACIÓN DE FORRAJE, COMPOSICIÓN MORFOLÓGICA E INTERCEPCIÓN LUMINOSA EN TRIGOS (Triticum sp.)

The objectives of the study were to perform the fodder accumulation curves and morphological components and light interception to determine the optimal moment of cutting for green fodder of three lines and one wheat variety (Triticum sp.). Harvests were performed at intervals of 7 d, 43 days after sowing (DAS). In each harvest the average height of 20 plants was recorded, the intercepted radiation (IR), dry matter accumulation, morphological composition, and leaf area index (LAI). The sampling unit was a square of 0.45 m2. The data were analyzed with the GLM procedure of the SAS software, for an experimental design in completely random blocks with arrangement of divided plots and three repetitions. The optimal moment of cutting for fodder was found in the “staking”, since in this state of development is when the highest leaf yields were found, LAI, and the highest light interceptions. The IR, the LAI, and the height can be used to determine the optimal moment of harvesting for wheats used to produce fodder.Los objetivos del estudio fueron realizar las curvas de acumulación de forraje y componentes morfológicos e intercepción luminosa para determinar el momento óptimo de corte para forraje verde de tres líneas y una variedad de trigo (Triticum sp.). Se realizaron cosechas a intervalos de 7 d, después de 43 d de la siembra (DDS). En cada cosecha se registró la altura promedio de 20 plantas, la radiación interceptada (RI), acumulación de materia seca, composición morfológica e índice de área foliar (IAF). La unidad de muestreo fue un cuadro de 0.45 m2. Los datos fueron analizados con el procedimiento GLM de SAS, para un diseño experimental en bloques completamente aleatorizados con arreglo de parcelas divididas y tres repeticiones. El momento óptimo de corte para forraje se encontró en el “encañe”, ya que en este estado de desarrollo es cuando se registraron los más altos rendimientos de hojas, IAF, y las más altas intercepciones luminosas. La RI, el IAF y la altura pueden ser utilizados para determinar el momento óptimo de cosecha para trigos para producir forraje

Reciclado del firme de la N-VI en el tramo Rábade-límite de la provincia de A Coruña

Este congreso tivo lugar na Coruña do 2 ao 4 de xullo de 2008[Resumen:] En esta comunicación se describe el comportamiento mecánico de la capa de base reciclada in situ mediante emulsión asfáltica en la carretera N-VI Madrid a La Coruña p.k. 515,9 al p.k. 546,4 tramo comprendido entre Rábade y el límite de la provincia de A Coruña. Se describe la experiencia técnica de laboratorio y de ejecución de la obra, así como el proceso de control de la obra

Síndrome compartimental en joven con alteración hemática

El síndrome compartimental es una patología bien conocida que se produce por un aumento de la presión dentro de un compartimiento miofascial. Presentamos el caso de un paciente con trombopenia que sufrió un traumatismo banal. Necesitó fasciotomía del compartimiento anteroexterno de la pierna y, más tarde, esplenectomía. El diagnóstico y tratamiento tardíos de esta complicación, así como una descomprensión inadecuada, pueden conducir a la pérdida de función en una extremidad.The compartment syndrome is a well described cli- nical entity that results from increased pressure within a myo- fascial compartment. An unusual case of a patient with thrombopenia and a minimal traumatism, is reported. He required fasciotomy of the anterolateral compartment of the leg and, later, splenectomy. Late recognition and treatment of this complication, as well as inadequate decompression, can lead to loss of limb

The Differentiation and Promotion of Students’ Rights in Portugal

This investigation includes a differential study (Study 1) and a quasi-experimental research (Study 2). In Study 1, the objective was to establish to what extent students’ rights existed and analyse the differentiation between students’ rights with Portuguese and immigrant mothers, throughout school years. The sample consisted of 537 students with Portuguese and immigrant mothers, distributed by different school years (7th, 9th and 11th grades). The Children’s Rights Scale (Hart et al., 1996; Veiga, 2001) was used. In Study 2, the purpose was to analyse the effects on students’ rights of the use by teachers of a communicational intervention program, supervised by school psychologists. The sample involved 7th and 9th grade students, in a total of four classes, two forming the experimental groups (n = 36) and two the control groups (n = 43); as in Study 1, the Children’s Rights Scale was used. The results indicated the effectiveness of the communicational intervention program on students’ rights and are consistent with previous studies. An implication is that psychologists and teachers, working together and taking a human rights perspective, may develop an important role in projects to promote the students’ rights

Noncommutativity in quantum cosmology and the Hierarchy problem

We study the quantum cosmology of an empty (4+1)-dimensional Kaluza-Klein cosmology with a negative cosmological constant and a FRW type metric with two scale factors, one for 4-D universe and the other for one compact extra dimension. By assuming the noncommutativity in the corresponding mini-superspace we suggest a solution for the Hierarchy problem, at the level of Wheeler-DeWitt equation.Comment: 7 pages; Title, abstract and text changed; references added; to appear in PL