The PHENIX Experiment at RHIC

The physics emphases of the PHENIX collaboration and the design and current status of the PHENIX detector are discussed. The plan of the collaboration for making the most effective use of the available luminosity in the first years of RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program available at http://www.rhic.bnl.gov/phenix

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have led to the development of mutations that stabilize Betacoronavirus spike proteins in the prefusion state, improving their expression and increasing immunogenicity1. This principle has been applied to design mRNA-1273, an mRNA vaccine that encodes a SARS-CoV-2 spike protein that is stabilized in the prefusion conformation. Here we show that mRNA-1273 induces potent neutralizing antibody responses to both wild-type (D614) and D614G mutant2 SARS-CoV-2 as well as CD8+ T cell responses, and protects against SARS-CoV-2 infection in the lungs and noses of mice without evidence of immunopathology. mRNA-1273 is currently in a phase III trial to evaluate its efficacy

Highly-parallelized simulation of a pixelated LArTPC on a GPU

The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The algorithms have been written in Python and translated into CUDA kernels using Numba, a just-in-time compiler for a subset of Python and NumPy instructions. The GPU implementation achieves a speed up of four orders of magnitude compared with the equivalent CPU version. The simulation of the current induced on 10^3 pixels takes around 1 ms on the GPU, compared with approximately 10 s on the CPU. The results of the simulation are compared against data from a pixel-readout LArTPC prototype

Three-dimensional gravity and magnetic modelling of the Irish sector of the NE Atlantic margin

A new 3D lithospheric model has been constructed using high-resolution gravity data from the Irish National Seabed Survey. The sedimentary component of the model incorporated density variations due to laterally varying overcompaction associated with Cenozoic denudation. After optimisation based on gravity inversion, regional crustal thickness variations were defined which are in reasonable agreement with the results of wide-angle seismic experiments. High crustal extension factors (β>5) characterise the deeper parts of the Rockall and Porcupine basins and in places the model indicates extreme stretching (β>10) beneath these basins. This could be because of instability in the gravity inversion, although other recent investigations have independently suggested similarly high extension factors. In contrast, the Hatton Basin is characterised by an apparent extension factor of about 2. The modelling resolves a pattern of NE- to NNE-trending local Mesozoic basins on the margins of the Rockall Trough, helping to delineate structures that were previously only sparsely sampled by seismic surveys. It appears possible that rifts with similar trends underlie the volcanic rocks which obscure the deeper parts of the Hatton Basin. The linear trends of the basins to the south and east of Ireland are interpreted to have been inherited from a basement fabric that was initially established during the late Precambrian assembly of this basement and subsequently subjected to Caledonian and Variscan reactivation. Magnetic modelling indicates that the variations in the thickness of the crystalline crust predicted by the gravity models can explain the regional magnetic anomaly patterns over the Rockall and Porcupine basins, but that significant additional magnetic material (probably igneous rocks of both Palaeogene and Cretaceous ages) is required to explain the anomalies in the Hatton Basin region. The magnetic signature of the Rockall Basin is distinctly different to that over the basement (of similar apparent thickness) formed during mid Cretaceous (C34N) opening of the ocean basin to the south. This is an impediment to hypotheses that invoke mid Cretaceous sea-floor spreading rather than intracontinental rifting to explain the development of the basin. The exception is in the extreme south of the basin where the volcanism associated with the Barra Volcanic Ridges combined with indications of relatively strong lithosphere could be evidence of incipient ocean opening

Age accuracy and resolution of Quaternary corals used as proxies for sea level

The accuracy of global eustatic sea level curves measured from raised Quaternary reefs, using radiometric ages of corals at known heights, may be limited by time-averaging, which affects the variation in coral age at a given height. Time-averaging was assessed in uplifted Holocene reef sequences from the Huon Peninsula, Papua New Guinea, using radiocarbon dating of coral skeletons in both horizontal transects and vertical sequences. Calibrated 2 sigma age ranges varied from 800 to 1060 years along horizontal transects, but weighted mean ages calculated from 15-18 dates per horizon were accurate to a resolution within 154-214 yr. Approximately 40% of the variability in age estimate resulted from internal variability inherent to C-14 estimates, and 60% was due to time-averaging. The accuracy of age estimates of sea level change in studies using single dated corals as proxies for sea level is probably within 1000 yr of actual age, but can be resolved t