448 research outputs found
LICENSE COMPLIANCE ISSUES IN FREE AND OPEN SOURCE SOFTWARE
Today, Free and open source software (FOSS) is widely used by organizations and individuals and viewed as a new approach to developing software. New software can be developed by integrating FOSS components or incorporating source code fragments, thus adding value in terms of functionality and quality. The use of FOSS components in developing new software requires developers to comply with the terms of the licenses associated with those components. The issues related to this compliance scenario are of paramount importance, because the license of a FOSS component can impact the whole Information System or computer application being developed. License compliance in FOSS is a significant issue today and organizations using FOSS are predominately focusing on this issue. The non-compliance to licenses in FOSS systems leads to the loss of reputation and the high costs of litigation for organizations. An automated approach is preferred to verifying license compliance of an FOSS being developed. Towards an automated approach, in this paper, we will argue for FOSS licenses in a machine interpretable form and for managing license compliance in a FOSS development process
Anisotropic scattering and quantum magnetoresistivities of a periodically modulated 2D electron gas
We calculate the longitudinal conductivities of a two-dimensional
noninteracting electron gas in a uniform magnetic field and a lateral electric
or magnetic periodic modulation in one spatial direction, in the quantum
regime. We consider the effects of the electron-impurity scattering anisotropy
through the vertex corrections on the Kubo formula, which are calculated with
the Bethe-Salpeter equation, in the self-consistent Born approximation. We find
that due to the scattering anisotropy the band conductivity increases, and the
scattering conductivities decrease and become anisotropic. Our results are in
qualitative agreement with recent experiments.Comment: 19 pages, 8 figures, Revtex, to appear in Phys. Rev.
An Essential Physiological Role for MCT8 in Bone in Male Mice
T3 is an important regulator of skeletal development and adult bone maintenance. Thyroid hormone
action requires efficient transport of T4 and T3 into target cells. We hypothesized that
monocarboxylate transporter (MCT) 8, encoded by Mct8 on the X-chromosome, is an essential
thyroid hormone transporter in bone. To test this hypothesis, we determined the juvenile and adult
skeletal phenotypes of male Mct8 knockout mice (Mct8KO) and Mct8D1D2KO compound mutants,
which additionally lack the ability to convert the prohormone T4 to the active hormone T3. Prenatal
skeletal development was normal in both Mct8KO and Mct8D1D2KO mice, whereas postnatal
endochondral ossification and linear growth were delayed in both Mct8KO and Mct8D1D2KO mice.
Furthermore, bone mass and mineralization were decreased in adult Mct8KO and Mct8D1D2KO
mice, and compound mutants also had reduced bone strength. Delayed bone development and
maturation in Mct8KO and Mct8D1D2KO mice is consistent with decreased thyroid hormone action
in growth plate chondrocytes despite elevated serum T3 concentrations, whereas low bone mass
and osteoporosis reflects increased thyroid hormone action in adult bone due to elevated systemic
T3 levels. These studies identify an essential physiological requirement for MCT8 in chondrocytes,
and demonstrate a role for additional transporters in other skeletal cells during adult bone
maintenance
Cyclotron effective masses in layered metals
Many layered metals such as quasi-two-dimensional organic molecular crystals
show properties consistent with a Fermi liquid description at low temperatures.
The effective masses extracted from the temperature dependence of the magnetic
oscillations observed in these materials are in the range, m^*_c/m_e \sim 1-7,
suggesting that these systems are strongly correlated. However, the ratio
m^*_c/m_e contains both the renormalization due to the electron-electron
interaction and the periodic potential of the lattice. We show that for any
quasi-two-dimensional band structure, the cyclotron mass is proportional to the
density of states at the Fermi energy. Due to Luttinger's theorem, this result
is also valid in the presence of interactions. We then evaluate m_c for several
model band structures for the \beta, \kappa, and \theta families of
(BEDT-TTF)_2X, where BEDT-TTF is bis-(ethylenedithia-tetrathiafulvalene) and X
is an anion. We find that for \kappa-(BEDT-TTF)_2X, the cyclotron mass of the
\beta-orbit, m^{*\beta}_c, is close to 2 m^{*\alpha}_c, where m^{*\alpha}_c is
the effective mass of the \alpha- orbit. This result is fairly insensitive to
the band structure details. For a wide range of materials we compare values of
the cyclotron mass deduced from band structure calculations to values deduced
from measurements of magnetic oscillations and the specific heat coefficient.Comment: 12 pages, 3 eps figure
Transversity distributions in the nucleon in the large-N_c limit
We compute the quark and antiquark transversity distributions in the nucleon
at a low normalization point of 600 MeV in the large- limit, where the
nucleon can be described as a soliton of an effective chiral theory (chiral
quark-soliton model). The flavor-nonsinglet distributions, and , appear in leading order
of the -expansion, while the flavor-singlet distributions, and , are non-zero only in
next-to-leading order. The transversity quark and antiquark distributions are
found to be significantly different from the longitudinally polarized
distributions and , respectively, in contrast to the prediction of the naive
non-relativistic quark model. We show that this affects the predictions for the
spin asymmetries in Drell-Yan pair production in transversely polarized pp and
ppbar collisions.Comment: 45 pages, 16 figure
Electromagnetic form factors of the nucleon in a covariant diquark model
We present a simple covariant constituent diquark-quark model for the
nucleon. The nucleon is assumed to be composed of a scalar diquark and a quark
which interact via a quark exchange. Starting from the Bethe-Salpeter equation,
the instantaneous approximation leads to a diquark-quark Salpeter equation. In
the Mandelstam formalism, the electromagnetic form factors of the nucleon are
calculated for momentum transfers up to q^2 = - 3 \; (\mbox{GeV/c})^2. A
remarkable description of the experimental data is obtained. Especially, the
model gives nearly the right values for the proton and (negative) neutron
charge radii, and a qualitative description of the magnetic form factors.Comment: 17 pages, revtex, 8 figures in additional fil
Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays
Average charged multiplicities have been measured separately in , and
light quark () events from decays measured in the SLD experiment.
Impact parameters of charged tracks were used to select enriched samples of
and light quark events, and reconstructed charmed mesons were used to select
quark events. We measured the charged multiplicities:
,
, from
which we derived the differences between the total average charged
multiplicities of or quark events and light quark events: and . We compared
these measurements with those at lower center-of-mass energies and with
perturbative QCD predictions. These combined results are in agreement with the
QCD expectations and disfavor the hypothesis of flavor-independent
fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters
Fitting the integrated Spectral Energy Distributions of Galaxies
Fitting the spectral energy distributions (SEDs) of galaxies is an almost
universally used technique that has matured significantly in the last decade.
Model predictions and fitting procedures have improved significantly over this
time, attempting to keep up with the vastly increased volume and quality of
available data. We review here the field of SED fitting, describing the
modelling of ultraviolet to infrared galaxy SEDs, the creation of
multiwavelength data sets, and the methods used to fit model SEDs to observed
galaxy data sets. We touch upon the achievements and challenges in the major
ingredients of SED fitting, with a special emphasis on describing the interplay
between the quality of the available data, the quality of the available models,
and the best fitting technique to use in order to obtain a realistic
measurement as well as realistic uncertainties. We conclude that SED fitting
can be used effectively to derive a range of physical properties of galaxies,
such as redshift, stellar masses, star formation rates, dust masses, and
metallicities, with care taken not to over-interpret the available data. Yet
there still exist many issues such as estimating the age of the oldest stars in
a galaxy, finer details ofdust properties and dust-star geometry, and the
influences of poorly understood, luminous stellar types and phases. The
challenge for the coming years will be to improve both the models and the
observational data sets to resolve these uncertainties. The present review will
be made available on an interactive, moderated web page (sedfitting.org), where
the community can access and change the text. The intention is to expand the
text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics &
Space Scienc
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants
that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants
would predict COPD and associated phenotypes.
Methods We constructed a polygenic risk score using a genome-wide association study of lung function (FEV1 and
FEV1/forced vital capacity [FVC]) from the UK Biobank and SpiroMeta. We tested this polygenic risk score in nine
cohorts of multiple ethnicities for an association with moderate-to-severe COPD (defined as FEV1/FVC <0·7 and FEV1
<80% of predicted). Associations were tested using logistic regression models, adjusting for age, sex, height, smoking
pack-years, and principal components of genetic ancestry. We assessed predictive performance of models by area
under the curve. In a subset of studies, we also studied quantitative and qualitative CT imaging phenotypes that
reflect parenchymal and airway pathology, and patterns of reduced lung growth.
Findings The polygenic risk score was associated with COPD in European (odds ratio [OR] per SD 1·81
[95% CI 1·74–1·88] and non-European (1·42 [1·34–1·51]) populations. Compared with the first decile, the tenth decile
of the polygenic risk score was associated with COPD, with an OR of 7·99 (6·56–9·72) in European ancestry and
4·83 (3·45–6·77) in non-European ancestry cohorts. The polygenic risk score was superior to previously described
genetic risk scores and, when combined with clinical risk factors (ie, age, sex, and smoking pack-years), showed
improved prediction for COPD compared with a model comprising clinical risk factors alone (AUC 0·80 [0·79–0·81]
vs 0·76 [0·75–0·76]). The polygenic risk score was associated with CT imaging phenotypes, including wall area
percent, quantitative and qualitative measures of emphysema, local histogram emphysema patterns, and destructive
emphysema subtypes. The polygenic risk score was associated with a reduced lung growth pattern.
Interpretation A risk score comprised of genetic variants can identify a small subset of individuals at markedly
increased risk for moderate-to-severe COPD, emphysema subtyp
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