448 research outputs found

    LICENSE COMPLIANCE ISSUES IN FREE AND OPEN SOURCE SOFTWARE

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    Today, Free and open source software (FOSS) is widely used by organizations and individuals and viewed as a new approach to developing software. New software can be developed by integrating FOSS components or incorporating source code fragments, thus adding value in terms of functionality and quality. The use of FOSS components in developing new software requires developers to comply with the terms of the licenses associated with those components. The issues related to this compliance scenario are of paramount importance, because the license of a FOSS component can impact the whole Information System or computer application being developed. License compliance in FOSS is a significant issue today and organizations using FOSS are predominately focusing on this issue. The non-compliance to licenses in FOSS systems leads to the loss of reputation and the high costs of litigation for organizations. An automated approach is preferred to verifying license compliance of an FOSS being developed. Towards an automated approach, in this paper, we will argue for FOSS licenses in a machine interpretable form and for managing license compliance in a FOSS development process

    Anisotropic scattering and quantum magnetoresistivities of a periodically modulated 2D electron gas

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    We calculate the longitudinal conductivities of a two-dimensional noninteracting electron gas in a uniform magnetic field and a lateral electric or magnetic periodic modulation in one spatial direction, in the quantum regime. We consider the effects of the electron-impurity scattering anisotropy through the vertex corrections on the Kubo formula, which are calculated with the Bethe-Salpeter equation, in the self-consistent Born approximation. We find that due to the scattering anisotropy the band conductivity increases, and the scattering conductivities decrease and become anisotropic. Our results are in qualitative agreement with recent experiments.Comment: 19 pages, 8 figures, Revtex, to appear in Phys. Rev.

    An Essential Physiological Role for MCT8 in Bone in Male Mice

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    T3 is an important regulator of skeletal development and adult bone maintenance. Thyroid hormone action requires efficient transport of T4 and T3 into target cells. We hypothesized that monocarboxylate transporter (MCT) 8, encoded by Mct8 on the X-chromosome, is an essential thyroid hormone transporter in bone. To test this hypothesis, we determined the juvenile and adult skeletal phenotypes of male Mct8 knockout mice (Mct8KO) and Mct8D1D2KO compound mutants, which additionally lack the ability to convert the prohormone T4 to the active hormone T3. Prenatal skeletal development was normal in both Mct8KO and Mct8D1D2KO mice, whereas postnatal endochondral ossification and linear growth were delayed in both Mct8KO and Mct8D1D2KO mice. Furthermore, bone mass and mineralization were decreased in adult Mct8KO and Mct8D1D2KO mice, and compound mutants also had reduced bone strength. Delayed bone development and maturation in Mct8KO and Mct8D1D2KO mice is consistent with decreased thyroid hormone action in growth plate chondrocytes despite elevated serum T3 concentrations, whereas low bone mass and osteoporosis reflects increased thyroid hormone action in adult bone due to elevated systemic T3 levels. These studies identify an essential physiological requirement for MCT8 in chondrocytes, and demonstrate a role for additional transporters in other skeletal cells during adult bone maintenance

    Cyclotron effective masses in layered metals

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    Many layered metals such as quasi-two-dimensional organic molecular crystals show properties consistent with a Fermi liquid description at low temperatures. The effective masses extracted from the temperature dependence of the magnetic oscillations observed in these materials are in the range, m^*_c/m_e \sim 1-7, suggesting that these systems are strongly correlated. However, the ratio m^*_c/m_e contains both the renormalization due to the electron-electron interaction and the periodic potential of the lattice. We show that for any quasi-two-dimensional band structure, the cyclotron mass is proportional to the density of states at the Fermi energy. Due to Luttinger's theorem, this result is also valid in the presence of interactions. We then evaluate m_c for several model band structures for the \beta, \kappa, and \theta families of (BEDT-TTF)_2X, where BEDT-TTF is bis-(ethylenedithia-tetrathiafulvalene) and X is an anion. We find that for \kappa-(BEDT-TTF)_2X, the cyclotron mass of the \beta-orbit, m^{*\beta}_c, is close to 2 m^{*\alpha}_c, where m^{*\alpha}_c is the effective mass of the \alpha- orbit. This result is fairly insensitive to the band structure details. For a wide range of materials we compare values of the cyclotron mass deduced from band structure calculations to values deduced from measurements of magnetic oscillations and the specific heat coefficient.Comment: 12 pages, 3 eps figure

    Transversity distributions in the nucleon in the large-N_c limit

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    We compute the quark and antiquark transversity distributions in the nucleon at a low normalization point of 600 MeV in the large-NcN_c limit, where the nucleon can be described as a soliton of an effective chiral theory (chiral quark-soliton model). The flavor-nonsinglet distributions, δu(x)δd(x)\delta u(x) - \delta d(x) and δuˉ(x)δdˉ(x)\delta\bar u(x) - \delta\bar d(x), appear in leading order of the 1/Nc1/N_c-expansion, while the flavor-singlet distributions, δu(x)+δd(x)\delta u(x) + \delta d(x) and δuˉ(x)+δdˉ(x)\delta\bar u(x) + \delta\bar d(x), are non-zero only in next-to-leading order. The transversity quark and antiquark distributions are found to be significantly different from the longitudinally polarized distributions Δu(x)±Δd(x)\Delta u (x) \pm \Delta d (x) and Δuˉ(x)±Δdˉ(x)\Delta\bar u (x) \pm \Delta\bar d (x), respectively, in contrast to the prediction of the naive non-relativistic quark model. We show that this affects the predictions for the spin asymmetries in Drell-Yan pair production in transversely polarized pp and ppbar collisions.Comment: 45 pages, 16 figure

    Electromagnetic form factors of the nucleon in a covariant diquark model

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    We present a simple covariant constituent diquark-quark model for the nucleon. The nucleon is assumed to be composed of a scalar diquark and a quark which interact via a quark exchange. Starting from the Bethe-Salpeter equation, the instantaneous approximation leads to a diquark-quark Salpeter equation. In the Mandelstam formalism, the electromagnetic form factors of the nucleon are calculated for momentum transfers up to q^2 = - 3 \; (\mbox{GeV/c})^2. A remarkable description of the experimental data is obtained. Especially, the model gives nearly the right values for the proton and (negative) neutron charge radii, and a qualitative description of the magnetic form factors.Comment: 17 pages, revtex, 8 figures in additional fil

    Measurement of the Charged Multiplicities in b, c and Light Quark Events from Z0 Decays

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    Average charged multiplicities have been measured separately in bb, cc and light quark (u,d,su,d,s) events from Z0Z^0 decays measured in the SLD experiment. Impact parameters of charged tracks were used to select enriched samples of bb and light quark events, and reconstructed charmed mesons were used to select cc quark events. We measured the charged multiplicities: nˉuds=20.21±0.10(stat.)±0.22(syst.)\bar{n}_{uds} = 20.21 \pm 0.10 (\rm{stat.})\pm 0.22(\rm{syst.}), nˉc=21.28±0.46(stat.)0.36+0.41(syst.)\bar{n}_{c} = 21.28 \pm 0.46(\rm{stat.}) ^{+0.41}_{-0.36}(\rm{syst.}) nˉb=23.14±0.10(stat.)0.37+0.38(syst.)\bar{n}_{b} = 23.14 \pm 0.10(\rm{stat.}) ^{+0.38}_{-0.37}(\rm{syst.}), from which we derived the differences between the total average charged multiplicities of cc or bb quark events and light quark events: Δnˉc=1.07±0.47(stat.)0.30+0.36(syst.)\Delta \bar{n}_c = 1.07 \pm 0.47(\rm{stat.})^{+0.36}_{-0.30}(\rm{syst.}) and Δnˉb=2.93±0.14(stat.)0.29+0.30(syst.)\Delta \bar{n}_b = 2.93 \pm 0.14(\rm{stat.})^{+0.30}_{-0.29}(\rm{syst.}). We compared these measurements with those at lower center-of-mass energies and with perturbative QCD predictions. These combined results are in agreement with the QCD expectations and disfavor the hypothesis of flavor-independent fragmentation.Comment: 19 pages LaTex, 4 EPS figures, to appear in Physics Letters

    Fitting the integrated Spectral Energy Distributions of Galaxies

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    Fitting the spectral energy distributions (SEDs) of galaxies is an almost universally used technique that has matured significantly in the last decade. Model predictions and fitting procedures have improved significantly over this time, attempting to keep up with the vastly increased volume and quality of available data. We review here the field of SED fitting, describing the modelling of ultraviolet to infrared galaxy SEDs, the creation of multiwavelength data sets, and the methods used to fit model SEDs to observed galaxy data sets. We touch upon the achievements and challenges in the major ingredients of SED fitting, with a special emphasis on describing the interplay between the quality of the available data, the quality of the available models, and the best fitting technique to use in order to obtain a realistic measurement as well as realistic uncertainties. We conclude that SED fitting can be used effectively to derive a range of physical properties of galaxies, such as redshift, stellar masses, star formation rates, dust masses, and metallicities, with care taken not to over-interpret the available data. Yet there still exist many issues such as estimating the age of the oldest stars in a galaxy, finer details ofdust properties and dust-star geometry, and the influences of poorly understood, luminous stellar types and phases. The challenge for the coming years will be to improve both the models and the observational data sets to resolve these uncertainties. The present review will be made available on an interactive, moderated web page (sedfitting.org), where the community can access and change the text. The intention is to expand the text and keep it up to date over the coming years.Comment: 54 pages, 26 figures, Accepted for publication in Astrophysics & Space Scienc

    Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

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    Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants would predict COPD and associated phenotypes. Methods We constructed a polygenic risk score using a genome-wide association study of lung function (FEV1 and FEV1/forced vital capacity [FVC]) from the UK Biobank and SpiroMeta. We tested this polygenic risk score in nine cohorts of multiple ethnicities for an association with moderate-to-severe COPD (defined as FEV1/FVC <0·7 and FEV1 <80% of predicted). Associations were tested using logistic regression models, adjusting for age, sex, height, smoking pack-years, and principal components of genetic ancestry. We assessed predictive performance of models by area under the curve. In a subset of studies, we also studied quantitative and qualitative CT imaging phenotypes that reflect parenchymal and airway pathology, and patterns of reduced lung growth. Findings The polygenic risk score was associated with COPD in European (odds ratio [OR] per SD 1·81 [95% CI 1·74–1·88] and non-European (1·42 [1·34–1·51]) populations. Compared with the first decile, the tenth decile of the polygenic risk score was associated with COPD, with an OR of 7·99 (6·56–9·72) in European ancestry and 4·83 (3·45–6·77) in non-European ancestry cohorts. The polygenic risk score was superior to previously described genetic risk scores and, when combined with clinical risk factors (ie, age, sex, and smoking pack-years), showed improved prediction for COPD compared with a model comprising clinical risk factors alone (AUC 0·80 [0·79–0·81] vs 0·76 [0·75–0·76]). The polygenic risk score was associated with CT imaging phenotypes, including wall area percent, quantitative and qualitative measures of emphysema, local histogram emphysema patterns, and destructive emphysema subtypes. The polygenic risk score was associated with a reduced lung growth pattern. Interpretation A risk score comprised of genetic variants can identify a small subset of individuals at markedly increased risk for moderate-to-severe COPD, emphysema subtyp
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