Atividade sexual e doenças sexualmente transmissíveis em escolares do 2º grau de Rio Branco-Acre, Brasil La actividad sexual y las enfermedades sexualmente trasmisibles en estudiantes de segundo grado (estudios secundarios) de Rio Branco-Acre, Brasil Sexual activity and sexually transmissible diseases of high school students in Rio Branco-Acre, Brasil

Este estudo foi realizado junto a 2.684 alunos do Segundo Grau de Rio Branco¾Acre, Brasil, para verificar aspectos da atividade sexual e a ocorrência de DST/AIDS. Dos alunos pesquisados, 48,9% tiveram relações sexuais, sendo que para o sexo masculino o início mais freqüente foi aos 13 anos, representando 34,3% e para o feminino foi aos 16 anos, com 31,6%. Da ocorrência de DST/AIDS mencionadas 58,4% foi para a Hepatite B, 39,4% para a Monilíase e 2,2% para a Gonorréia. Dos que tiveram relações sexuais 47,6% foi com o/a namorado/a, 25,8% com o/a vizinho/a e 10,5% com a empregada doméstica. Como conclusão, 52,3% dos alunos das escolas particulares, 50,0% da federal, 45,7% das estaduais e 41,8% da municipal, tiveram relação sexual.<br>Este estudio se realizó con 2.684 estudiantes de secundaria de Rio Branco-Acre, Brasil, para verificar los aspectos de la actividad sexual y la incidencia de ETS/SIDA. De los estudiantes investigados 48,9% tuvieron relaciones sexuales. De ellos el 34,3% pertenecen al sexo masculino y empezaron a los 13 años de edad. 31,6% son del sexo femenino e iniciaron su vida sexual a los 16 años. De la incidencia referida de ETS/SIDA el 58,4% fue para Hepatitis B, el 39,4% para Candidiasis y el 2,2% para Gonorrea. De los que tuvieron relaciones sexuales, el 47,6% fue con el novio (¾a); el 25,8% con el vecino (-a) y el 10,5% con la empleada domestica de la casa. Por lo tanto, se concluye que el 52,3% de los alunnos de las escuelas privadas, el 50,0% de la federal, el 45,7% de las estatales y el 41,8% de las municipales (provinciales) tuvieron relación sexual.<br>This study was realized with 2.684 students of the high school in Rio Branco¾Acre, Brazil, to verify aspects of the sexual activity and the occurrence of DST/AIDS. From the researched students, 48,9% had sexual intercourses, and the largest frequency was 34,3% for male sex, with the beginning at 13 years old, and for female sex 31,6%, with the beginning at 16 years old. The occurrence of mentioned DST/AIDS was: 58,4% for Hepatite B, 39,4% for Monilíase and 2,2% for Gonorrhea. Among those ones who had their first sexual intercourse, 47,6% were with the boyfriend, 25,8% with the neighbor and 10,5% with the domestic maid. Concluding, the students who had sexual intercourses were 52,3% of private schools, 50,0% of federal ones, 45,7% of state ones and 41,8% of municipal ones

3-[4′-bromo-(1,1′-biphenyl)-4-y1]-n,n-dimethyl-3- (2-thienyl)-2-propen-1-amine: Synthesis, Cytotoxicity, And Leishmanicidal, Trypanocidal And Antimycobacterial Activities

Current therapies for Chagas' disease, leishmaniasis and tuberculosis are unsatisfactory because of the failure rates, significant toxicity and/or drug resistance. In this study, the compound 3-[4′-bromo- (1,1′-biphenyl)- 4-yl] -N,N-dimethyl-3- (2-thienyl) -2-propen-1-amine (IV) was synthesized and its trypanocidal, leishmanicidal and antimycobacterial activities were investigated. The cytotoxicity was determined on V79 cells with three endpoints: nucleic acid content, 3-(4,5-dimethylthiazole- 2-yl)-2,5-diphenyl tetrazolium bromide reduction and Neutral Red uptake. This compound was active against different species of mycobacteria and different life cycle stages of Trypanosoma cruzi. In experiments with trypomastigotes performed at 4° C in the presence of blood, the activity was 8.8-fold more active than the standard drug, Crystal Violet. Higher activity was achieved against Leishmania amazonensis, with an ED50/24 h of 3.0 ± 0.3 μmol/L. The effect against trypanosomatids, which suggests high activity of compound IV against promastigotes of L. amazonensis and amastigotes of T. cruzi, stimulated further studies in vitro with amastigotes interiorized in macrophages and with in vivo models. Our results indicate that mammalian V79 cells are less susceptible to the action of compound IV than promastigotes of L. amazonensis (8.0-13.3-fold) and axenic amastigotes of T. cruzi (3.5-5.9-fold).505629637Bleed, D., Watt, C., Dye, C., (2000) Global Tuberculosis. Control, 275, pp. 1-175. , WHO/CDS/TB/2000 Geneva, SwitzerlandGbayisomore, A., Lardizabal, A.A., Reichman, L.B., Update: Prevention and treatment of tuberculosis (2000) Current Opinion in Infectious Disease, 13, pp. 155-159(1998) Weekly Epidemiology Records, 1-2, p. 1. , World Health Organization. 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