19 research outputs found
Comment on "Long-range electrostatic interactions between like-charged colloids: Steric and confinement effects"
In a recent study [Phys. Rev. E 60, 6530 (1999)], Trizac and Raimbault showed
that the effective pair interaction between like charged colloids immersed in a
cylindrically confined electrolyte remains repulsive even when the size of the
micro-ions or the finite longitudinal extension of the confining cylinder are
taken into account. Contrary to their claim, we argue that the case of finite
longitudinal confinement doesn't always generate repulsive interactions and to
illustrate this point we also provide a simple example.Comment: 3 pages, 1 figure. Accepted for publication in Phys. Rev. E 200
A dynamic model for induced reactivation of latent virus
We develop a deterministic mathematical model to describe reactivation of latent virus by chemical inducers. This model is applied to the reactivation of latent KSHV in BCBL-1 cell cultures with butyrate as the inducing agent. Parameters for the model are first estimated from known properties of the exponentially growing, uninduced cell cultures. Additional parameters that are necessary to describe induction are determined from fits to experimental data from the literature. Our initial model provides good agreement with two independent sets of experimental data, but also points to the need for a new class of experiments which are required for further understanding of the underlying mechanisms
Interaction model for magnetic holes in a ferrofluid layer
Nonmagnetic spheres confined in a ferrofluid layer (magnetic holes) present
dipolar interactions when an external magnetic field is exerted. The
interaction potential of a microsphere pair is derived analytically, with a
precise care for the boundary conditions along the glass plates confining the
system. Considering external fields consisting of a constant normal component
and a high frequency rotating in-plane component, this interaction potential is
averaged over time to exhibit the average interparticular forces acting when
the imposed frequency exceeds the inverse of the viscous relaxation time of the
system. The existence of an equilibrium configuration without contact between
the particles is demonstrated for a whole range of exciting fields, and the
equilibrium separation distance depending on the structure of the external
field is established. The stability of the system under out-of-plane buckling
is also studied. The dynamics of such a particle pair is simulated and
validated by experiments.Comment: 15 pages, 11 figures (18 with subfigures). to appear in Phys. Rev.
Anomalous Effects of "Guest" Charges Immersed in Electrolyte: Exact 2D Results
We study physical situations when one or two "guest" arbitrarily-charged
particles are immersed in the bulk of a classical electrolyte modelled by a
Coulomb gas of positive/negative unit point-like charges, the whole system
being in thermal equilibrium. The models are treated as two-dimensional with
logarithmic pairwise interactions among charged constituents; the
(dimensionless) inverse temperature is considered to be smaller than 2
in order to ensure the stability of the electrolyte against the collapse of
positive-negative pairs of charges. Based on recent progress in the integrable
(1+1)-dimensional sine-Gordon theory, exact formulas are derived for the
chemical potential of one guest charge and for the asymptotic large-distance
behavior of the effective interaction between two guest charges. The exact
results imply, under certain circumstances, anomalous effects such as an
effective attraction (repulsion) between like-charged (oppositely-charged)
guest particles and the charge inversion in the electrolyte vicinity of a
highly-charged guest particle. The adequacy of the concept of renormalized
charge is confirmed in the whole stability region of inverse temperatures and
the related saturation phenomenon is revised.Comment: 21 pages, 1 figur
Non-monotonic variation with salt concentration of the second virial coefficient in protein solutions
The osmotic virial coefficient of globular protein solutions is
calculated as a function of added salt concentration at fixed pH by computer
simulations of the ``primitive model''. The salt and counter-ions as well as a
discrete charge pattern on the protein surface are explicitly incorporated. For
parameters roughly corresponding to lysozyme, we find that first
decreases with added salt concentration up to a threshold concentration, then
increases to a maximum, and then decreases again upon further raising the ionic
strength. Our studies demonstrate that the existence of a discrete charge
pattern on the protein surface profoundly influences the effective interactions
and that non-linear Poisson Boltzmann and Derjaguin-Landau-Verwey-Overbeek
(DLVO) theory fail for large ionic strength. The observed non-monotonicity of
is compared to experiments. Implications for protein crystallization are
discussed.Comment: 43 pages, including 17 figure
Effective interaction between helical bio-molecules
The effective interaction between two parallel strands of helical
bio-molecules, such as deoxyribose nucleic acids (DNA), is calculated using
computer simulations of the "primitive" model of electrolytes. In particular we
study a simple model for B-DNA incorporating explicitly its charge pattern as a
double-helix structure. The effective force and the effective torque exerted
onto the molecules depend on the central distance and on the relative
orientation. The contributions of nonlinear screening by monovalent counterions
to these forces and torques are analyzed and calculated for different salt
concentrations. As a result, we find that the sign of the force depends
sensitively on the relative orientation. For intermolecular distances smaller
than it can be both attractive and repulsive. Furthermore we report a
nonmonotonic behaviour of the effective force for increasing salt
concentration. Both features cannot be described within linear screening
theories. For large distances, on the other hand, the results agree with linear
screening theories provided the charge of the bio-molecules is suitably
renormalized.Comment: 18 pages, 18 figures included in text, 100 bibliog