Synthesis of [3-C-13]-2,3-dihydroxy-4-methoxybenzaldehyde

An efficient synthesis of [3-13C]-2,3-dihydroxy-4-methoxybenzaldehyde, an isotopically labelled probe of a common intermediate used in the synthesis of a number of biologically relevant molecules, has been achieved in 9 steps from an acyclic, non-aromatic precursor. A 13C label for molecular imaging was introduced in a linear synthesis from the reaction of [13C]-labelled methyl iodide with glutaric monomethyl ester chloride. Cyclisation then aromatisation gave 1,3-dimethoxybenzene and an additional methoxy group was introduced by a formylation/Baeyer–Villiger/hydrolysis/methylation sequence. Subsequent ortho-formylation and selective demethylation yielded the desired [3-13C]-2,3-dihydroxy-4-methoxybenzaldehyde

Physical Mechanisms of Tropical Climate Feedbacks Investigated Using Temperature and Moisture Trends

ArticleOpen access articleTropical climate feedback mechanisms are assessed using satellite-observed and model-simulated trends in tropical tropospheric temperature from the MSU/AMSU instruments and upper-tropospheric humidity from the HIRS instruments. Despite discrepancies in the rates of tropospheric warming between observations and models, both are consistent with constant relative humidity over the period 1979--2008. Because uncertainties in satellite-observed tropical-mean trends preclude a constraint on tropical-mean trends in models we also explore regional features of the feedbacks. The regional pattern of the lapse rate feedback is primarily determined by the regional pattern of surface temperature changes, as tropical atmospheric warming is relatively horizontally uniform. The regional pattern of the water vapor feedback is influenced by the regional pattern of precipitation changes, with variations of 1--2 W m-2 K-1 across the Tropics (compared to a tropical-mean feedback magnitude of 3.3--4 W m-2 K-1). Thus the geographical patterns of water vapor and lapse rate feedbacks are not correlated, but when the feedbacks are calculated in precipitation percentiles rather than in geographical space they are anti-correlated, with strong positive water vapor feedback associated with strong negative lapse rate feedback. The regional structure of the feedbacks is not related to the strength of the tropical-mean feedback in a subset of the climate models from the CMIP5 archive. Nevertheless the approach constitutes a useful process-based test of climate models and has the potential to be extended to constrain regional climate projections.Natural Environment Research Council (NERC

Target Fragmentation in Semi-Inclusive DIS: Fracture Functions, Cut Vertices and the OPE

We discuss semi-inclusive Deep Inelastic Scattering (DIS) in the z -> 1 limit, in particular the relationship between fracture functions, generalised cut vertices and Green functions of the composite operators arising in the OPE. The implications, in the spin-polarised case, for testing whether the "proton spin" effect is target-independent are explored. Explicit calculations in (phi^3)_6 theory are presented which are consistent with our observations.Comment: 22 pages, 25 figures, LaTeX 2e; uses graphics packag

Differential Equations for Definition and Evaluation of Feynman Integrals

It is shown that every Feynman integral can be interpreted as Green function of some linear differential operator with constant coefficients. This definition is equivalent to usual one but needs no regularization and application of $R$-operation. It is argued that presented formalism is convenient for practical calculations of Feynman integrals.Comment: pages, LaTEX, MSU-PHYS-HEP-Lu2/9

Modeling Operating Speed and Deceleration on Two-Lane Rural Roads with Global Positioning System Data

[EN] In the road design process, speed variation along the road segment is an important issue to consider in adapting road geometry to drivers' expectations. To achieve this objective, speed criteria are used to evaluate road consistency. Being able to estimate the operating speed in the design phase can lead to safer road alignment. With this objective, several researchers have developed operating speed models. Most of these models are based on collected spot speed data. They assume constant speed on curves and, therefore, deceleration that occurs entirely on the approach tangent. According to these assumptions, spot speed data are collected at the center of the horizontal curve and at the midpoint of the preceding tangent to obtain operating speed models. This paper presents a new methodology based on the use of Global Positioning System devices that allow continuous collecting and processing of speed data. With this new methodology, not only can new and more accurate operating speed models he developed, but cited hypotheses can also be checked. Observed speed continuous profiles allow studies that previously could not be done, especially as related to deceleration and speed variations. This study calibrated new speed models, including three for horizontal curves with a radius curve and the curvature change rate of a single curve as explanatory variables, and one for tangents that incorporates the curve speed model. Tangent-curve speed variations are evaluated, with comparison of Delta(85)V and Delta V(85), analysis of the deceleration length occurring on a curve, and development of two deceleration models.The authors thank the Center for Studies and Experimentation of Public Works of the Spanish Ministry of Public Works, which partially subsidized the research. The authors also thank the Infrastructure and Transportation Department, General Directorate of Public Works, Valencian Government, Spain; the Valencian Provincial Council; and the Ministry of the Interior, General Directorate of Traffic, Spain, for their cooperation in field data gathering.Pérez Zuriaga, AM.; García García, A.; Camacho-Torregrosa, FJ.; D'attoma, P. (2010). Modeling Operating Speed and Deceleration on Two-Lane Rural Roads with Global Positioning System Data. Transportation Research Record. 2171:11-20. doi:10.3141/2171-02S1120217

Renormalization of composite operators

The blocked composite operators are defined in the one-component Euclidean scalar field theory, and shown to generate a linear transformation of the operators, the operator mixing. This transformation allows us to introduce the parallel transport of the operators along the RG trajectory. The connection on this one-dimensional manifold governs the scale evolution of the operator mixing. It is shown that the solution of the eigenvalue problem of the connection gives the various scaling regimes and the relevant operators there. The relation to perturbative renormalization is also discussed in the framework of the $\phi^3$ theory in dimension $d=6$.Comment: 24 pages, revtex (accepted by Phys. Rev. D), changes in introduction and summar

A 14-year experience with kidney transplantation.

Between November, 1962 and August, 1975, 668 kidney transplants were done in 556 consecutive patients at Denver, Colorado. The Denver experience has been divided into 7 periods of time, according to the conditions of care during each period. The results in related transplantation have changed little during the decade beginning in 1966. The results in unrelated transplantation have not materially changed since 1968. The long-term patient survival after related transplantation has been better than after cadaver transplantation. The results of transplantation in 57 children ages 3 to 18 years have been slightly better than the results of adult transplantation. The outcome of kidney transplantation and the feasibility of improving this therapy with present techniques are limited by our inability to accurately match each patient with the immunologically best donor and by our inability to precisely control the immune system of the recipient. Rejection is still the main reason for graft loss, and sepsis remains the main cause of patient mortality. More specific and less toxic means of achieving graft acceptance are needed before a higher level of patient service can be realized. However, even with the tools now available, thousands of recipients throughout the world have been returned to useful lives

Recursive Polynomial Remainder Sequence and the Nested Subresultants

We give two new expressions of subresultants, nested subresultant and reduced nested subresultant, for the recursive polynomial remainder sequence (PRS) which has been introduced by the author. The reduced nested subresultant reduces the size of the subresultant matrix drastically compared with the recursive subresultant proposed by the authors before, hence it is much more useful for investigation of the recursive PRS. Finally, we discuss usage of the reduced nested subresultant in approximate algebraic computation, which motivates the present work.Comment: 12 pages. Presented at CASC 2005 (Kalamata, Greece, Septermber 12-16, 2005

Effect of different standing poses on whole body volume acquisition by three-dimensional photonic scanning

The present study compared whole body volumes obtained by three-dimensional (3D) photonic scanning of two different poses and discussed its effect on body composition estimation. Pose A with large angles of shoulder abduction and feet separated and Pose B with shoulders abducted slightly, the elbows extended and heels together. 16 male and 13 female participants were scanned twice in each pose using a 3D scanner. The mean of whole body volume and the mean of body composition obtained with Pose B was corrected by a regression equation and compared with the results obtained from Pose A. After correction, the whole body volumes acquired with these two poses were similar [limit of agreement = (-0.71 l,0.71 l)] but the body compositions obtained with Pose A and Pose B were different [limit of agreement = (-4.4%, 4.4%)]. The results indicated that scanning using either pose gives reliable estimations for whole body volume and body composition. The whole body volume obtained from different poses can be adjusted using the regression equation but small volumetric differences translate into much more substantial differences in body fat percentage. Hence, it is recommended to use the same scanning pose consistently when monitoring individuals longitudinally

First lattice QCD estimate of the g_{D^* D pi} coupling

We present the results of the first lattice QCD study of the strong coupling g_{D^* D pi}. From our simulations in the quenched approximation, we obtain g_{D^* D pi} = 18.8 +/- 2.3^{+1.1}_{-2.0} and hat(g)_c = 0.67 +/- 0.08^{+0.04}_{-0.06}. Whereas previous theoretical studies gave different predictions, our result favours a large value for hat(g)_c. It agrees very well with the recent experimental value by CLEO. hat(g) varies very little with the heavy mass and we find in the infinite mass limit hat(g)_infinity = 0.69(18).Comment: 24 pages, 7 figures; references added, corrected typos, Comments added about the continuum limi