Probing 3D Density and Velocity Fields of ISM in Centers of Galaxies with Future X-Ray Observations

Observations of bright and variable "reflected" X-ray emission from molecular clouds located within inner hundred parsec of our Galaxy have demonstrated that the central supermassive black hole, Sgr A*, experienced short and powerful flares in the past few hundred years. These flares offer a truly unique opportunity to determine 3D location of the illuminated clouds (with ~10 pc accuracy) and to reveal their internal structure (down to 0.1 pc scales). Short duration of the flare(s), combined with X-rays high penetration power and insensitivity of the reflection signal to thermo- and chemo-dynamical state of the gas, ensures that the provided diagnostics of the density and velocity fields is unbiased and almost free of the projection and opacity effects. Sharp and sensitive snapshots of molecular gas accessible with aid of future X-ray observatories featuring large collecting area and high angular (arcsec-level) and spectral (eV-level) resolution cryogenic bolometers will present invaluable information on properties of the supersonic turbulence inside the illuminated clouds, map their shear velocity field and allow cross-matching between X-ray data and velocity-resolved emission of various molecular species provided by ALMA and other ground-based facilities. This will highlight large and small-scale dynamics of the dense gas and help uncovering specifics of the ISM lifecycle and high-mass star formation under very extreme conditions of galactic centers. While the former is of particular importance for the SMBH feeding and triggering AGN feedback, the latter might be an excellent test case for star formation taking place in high-redshift galaxies.Comment: White paper submitted to the Astro2020 Decadal Surve

Muscle fatty infiltration in rotator cuff tears: Descriptive analysis of 1688 cases

SummaryIntroductionFatty infiltration (FI) is an important prognosis factor in the anatomical and functional outcomes of rotator cuff repairs. The objective of this study was to analyze the natural history of muscle FI and better evaluate its onset and aggravation time frame.Material and methodsA total of 1688 medical charts of patients operated on for rotator cuff tear and whit a preoperative CT arthrogram (82%) or an MRI (18%) were reviewed. Surgery was performed between 1988 and 2005. The FI of each muscle was assessed as minimal (in Goutallier's stages 0 and 1), intermediate (in stage 2), and severe (in stages 3 and 4). Regarding supraspinatus, we retained the mean FI observed in the sagittal, coronal, and axial planes; for the infraspinatus and the subscapularis, we retained the observed mean on two views at the upper and lower levels of the glenoid in the axial plane.ResultsWe found a statistically significant correlation (p<0.0005) between FI, the type of tendon lesion, and patient age for the supraspinatus, the infraspinatus, and the subscapularis. Statistically, the FI significantly increased (p<0.0005) with time elapsed for the supraspinatus and the infraspinatus but not significantly for the subscapularis. The mean time to tendon rupture observed for intermediate FI was three years for the supraspinatus and 2.5 years for the infraspinatus and the subscapularis when their tendons ruptured. The mean time observed to severe FI was five, four, and three years for the supraspinatus, the infraspinatus, and the subscapularis, respectively.Discussion and conclusionThe more extensive the lesion, the longer the time following rupture, and the older the patient is, the more severe the FI is. The objective of surgery is to intervene before intermediate FI sets in, which means irreversible functional loss.Level of evidence: Level IV. Diagnostic Retrospective Study

The hierarchical fragmentation of filaments and the role of sub-filaments

Recent observations have revealed the presence of small fibres or sub-filaments within larger filaments. We present a numerical fragmentation study of fibrous filaments investigating the link between cores and sub-filaments using hydrodynamical simulations performed with the moving-mesh code Arepo. Our study suggests that cores form in two environments: (i) as isolated cores, or small chains of cores, on a single sub-filament, or (ii) as an ensemble of cores located at the junction of sub-filaments. We term these isolated and hub cores respectively. We show that these core populations are statistically different from each other. Hub cores have a greater mean mass than isolated cores, and the mass distribution of hub cores is significantly wider than isolated cores. This fragmentation is reminiscent of parsec-scale hub-filament systems, showing that the combination of turbulence and gravity leads to similar fragmentation signatures on multiple scales, even within filaments. Moreover, the fact that fragmentation proceeds through sub-filaments suggests that there exists no characteristic fragmentation length-scale between cores. This is in opposition to earlier theoretical works studying fibre-less filaments which suggest a strong tendency towards the formation of quasi-periodically spaced cores, but in better agreement with observations. We also show tentative signs that global collapse of filaments preferentially form cores at both filament ends, which are more massive and dense than other cores.Comment: Accepted in MNRAS. 13 pages and 13 figures, 8 page appendix and 7 figure

Antioxidant Capacity and Polyphenolic Composition as Quality Indicators for Aqueous Infusions of Salvia officinalis L. (sage tea)

Sage (Salvia officinalis L.) is used as an herbal medicinal product, with the most typical form of application as infusion with boiling water (sage tea). The well-established traditional uses include symptomatic treatment of mild dyspeptic complaints, the treatment of inflammations in the mouth and the throat, and relief of excessive sweating and relief of minor skin inflammations. In this study, sage teas prepared from commercially available products were chemically analyzed for polyphenolic content using liquid chromatography, for antioxidant potential using the oxygen radical absorbance capacity method, and for the Folin–Ciocalteu (FC) index. The sage teas showed a high variation for all parameters studied (up to 20-fold differences for rosmarinic acid). Univariate and multivariate analyses showed that the antioxidant potential, which varied between 0.4 and 1.8 mmol trolox equivalents/100 mL, was highly dependent on rosmarinic acid and its derivatives. The FC index also showed a high correlation to these polyphenols, and could therefore be used as a screening parameter for sage tea quality. The considerable differences in polyphenolic composition and antioxidant capacity between the brands lead to a demand for quality standardization, especially if these sage teas are to be used for therapeutic purposes. Further research also appears to be necessary to characterize the dose–benefit relationship, as sage may also contain a constituent (thujone) with potentially adverse effects

Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.)

BACKGROUND: The sage plant Salvia officinalis L. is used as ingredient in foods and beverages as well as in herbal medicinal products. A major use is in the form of aqueous infusions as sage tea, which is legal to be sold as either food or medicine. Sage may contain two health relevant substances, thujone and camphor. The aim of this study was to develop and validate an analytical methodology to determine these active principles of sage and give a first overview of their concentrations in a wide variety of sage foods and medicines. RESULTS: A GC/MS procedure was applied for the analysis of α- and β-thujone and camphor with cyclodecanone as internal standard. The precision was between 0.8 and 12.6%, linearity was obtained from 0.1 - 80 mg/L. The recoveries of spiked samples were between 93.7 and 104.0% (average 99.1%). The time of infusion had a considerable influence on the content of analytes found in the teas. During the brewing time, thujone and camphor show an increase up to about 5 min, after which saturation is reached. No effect was found for preparation with or without a lid on the pot used for brewing the infusion. Compared to extracts with ethanol (60% vol), which provide a maximum yield, an average of 30% thujone are recovered in the aqueous tea preparations. The average thujone and camphor contents were 4.4 mg/L and 16.7 mg/L in food tea infusions and 11.3 mg/L and 25.4 mg/L in medicinal tea infusions. CONCLUSIONS: The developed methodology allows the efficient determination of thujone and camphor in a wide variety of sage food and medicine matrices and can be applied to conduct surveys for exposure assessment. The current results suggest that on average between 3 and 6 cups of sage tea could be daily consumed without reaching toxicological thresholds

Conversion of total shoulder arthroplasty to reverse shoulder arthroplasty made possible by custom humeral adapter

AbstractReverse shoulder arthroplasty (RSA) is increasingly being used to revise anatomical total shoulder arthroplasty cases. This procedure's high complication rate has been reduced by the availability of modular shoulder systems, which allows the humeral component to be preserved during the conversion. This case report describes the revision of an anatomical shoulder implant inserted in 1998. Polyethylene wear and the resulting metal-on-metal contact had caused metallosis. Since the existing humeral implant was not compatible with standard conversion products, the manufacturer provided a custom humeral adapter that allowed the humeral stem to be preserved. This approach greatly simplified the surgical procedure and resulted in good anatomical and clinical outcomes after 9 months of follow-up

Influence of surgical approach on functional outcome in reverse shoulder arthroplasty

SummaryIntroductionReverse shoulder arthroplasties (RSA) can be performed using a Deltopectoral (DP) or alternatively a Transdeltoid (TD) approach.HypothesisAlthough the humeral cut is lower by TD approach, this should not affect postoperative functional results.Material and methodsThis retrospective multicentric study evaluated the complete medical records of RSA implanted between October 2003 and December 2008. Inclusion criteria were: follow-up of at least 1year, a complete file including a comparative radiological work-up making it possible to analyze eventual arm and humeral lengthening. Evaluation of postoperative function was based on Active Anterior Elevation (AAE).ResultsWe studied 144 RSA in 142 patients. One hundred and nine RSA were implanted by the DP approach and 35 by the TD approach. Mean lengthening of the humerus compared to the controlateral side by DP approach was 0.5±1.3cm while there was a mean shortening of −0.5±1.0cm by TD approach (P<0.001). The difference in cut was partially compensated by using thicker polyethylene inserts with the TD approach. Mean arm lengthening compared to the controlateral side was 1.7±1.7cm by DP approach and 1.2±1.4cm by TD approach (mean difference 0.5cm; (95% CI −0.1; 1.2). AAE for RSA by DP approach was 145±22° and 135±29° by TD approach (mean difference 10°, 95% CI −1; 21).DiscussionRSA results in improved AAE because of restored deltoid tension and an increase in the deltoid lever arm. The humeral cut by TD is lower, but this was partially corrected in this study by the use of thicker polyethylene inserts. Nevertheless there is no significant clinical difference in postoperative function between the two approaches.Level of EvidenceLevel IV. Retrospective therapeutic study

Evaluation of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in pure mineral hydrocarbon-based cosmetics and cosmetic raw materials using ¹H NMR spectroscopy

Mineral hydrocarbons consist of two fractions, mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH). MOAH is a potential public health hazard because it may include carcinogenic polycyclic compounds. In the present study, 400 MHz nuclear magnetic resonance (NMR) spectroscopy was introduced, in the context of official controls, to measure MOSH and MOAH in raw materials or pure mineral hydrocarbon final products (cosmetics and medicinal products). Quantitative determination (qNMR) has been established using the ERETIC methodology (electronic reference to access in vivo concentrations) based on the PULCON principle (pulse length based concentration determination). Various mineral hydrocarbons (e.g., white oils, paraffins or petroleum jelly) were dissolved in deuterated chloroform. The ERETIC factor was established using a quantification reference sample containing ethylbenzene and tetrachloronitrobenzene. The following spectral regions were integrated: MOSH δ 3.0 – 0.2 ppm and MOAH δ 9.2 - 6.5, excluding solvent signals. Validation showed a sufficient precision of the method with a coefficient of variation <6% and a limit of detection <0.1 g/100 g. The applicability of the method was proven by analysing 27 authentic samples with MOSH and MOAH contents in the range of 90-109 g/100 g and 0.02-1.10 g/100 g, respectively. It is important to distinguish this new NMR-approach from the hyphenated liquid chromatography-gas chromatography methodology previously used to characterize MOSH/MOAH amounts in cosmetic products. For mineral hydrocarbon raw materials or pure mineral hydrocarbon-based cosmetic products, NMR delivers higher specificity without any sample preparation besides dilution. Our sample survey shows that previous methods may have overestimated the MOAH amount in mineral oil products and opens new paths to characterize this fraction. Therefore, the developed method can be applied for routine monitoring of consumer products aiming to minimize public health risks

Holistic Control of Herbal Teas and Tinctures Based on Sage (Salvia officinalis L.) for Compounds with Beneficial and Adverse Effects using NMR Spectroscopy

A methodology that utilizes 1H-NMR spectroscopy has been developed to simultaneously analyze toxic terpenes (thujone and camphor), major polyphenolic compounds, the total antioxidant capacity (ORAC) and the Folin-Ciocalteu (FC) index in foods and medicines containing sage. The quantitative determination of rosmarinic acid (limit of detection (LOD) = 10 mg/L) and total thujone (LOD = 0.35 mg/L) was possible using direct integration of the signals. For other parameters (derivatives of rosmarinic acid, carnosol and flavone glycosides, ORAC and FC index), chemometric regression models obtained separately for alcohol-based tinctures (R2 = 0.94–0.98) and aqueous tea infusions (R2 = 0.79–0.99) were suitable for screening analysis. The relative standard deviations for authentic samples were below 10%. The developed methodology was applied for the analysis of a wide variety of sage products (n = 108). The total thujone content in aqueous tea infusions was found to be in the range of not detectable (nd) to 37.5 mg/L (average 9.2 mg/L), while tinctures contained higher levels (range nd—409 mg/L, average 107 mg/L). The camphor content varied from 2.1 to 43.7 mg/L in aqueous infusions and from not detectable to 748 mg/L in tinctures (averages were 14.1 and 206 mg/L, respectively). Phenolic compounds were also detected in the majority of the investigated products. 1H-NMR spectroscopy was proven to have the ability to holistically control all important adverse and beneficial compounds in sage products in a single experiment, considerably saving time, resources and costs as NMR replaces four separate methodologies that were previously needed to analyze the same parameters

Radiation Driven Implosion and Triggered Star Formation

We present simulations of initially stable isothermal clouds exposed to ionizing radiation from a discrete external source, and identify the conditions that lead to radiatively driven implosion and star formation. We use the Smoothed Particle Hydrodynamics code SEREN (Hubber et al. 2010) and the HEALPix-based photoionization algorithm described in Bisbas et al. (2009). We find that the incident ionizing flux is the critical parameter determining the evolution: high fluxes simply disperse the cloud, whereas low fluxes trigger star formation. We find a clear connection between the intensity of the incident flux and the parameters of star formation.Comment: 4 pages, 2 figures, conference proceedings, IAU Symposium 270 (eds. Alves, Elmegreen, Girart, Trimble