Influence of Metabolic Accumulation of Products of Hydrogenomonas Cells on Their Continued Growth Progress Report, 1 May - 31 Oct. 1966

Fructose metabolism by Hydrogenomas eutropha, auxotrophic mutants which produce polysaccharides, and large batch culture apparatu

Influence of metabolic accumulation of products of hydrogenomonas cells on their continued growth, 1 July 1964 - 30 June 1969

Effects of metabolic products on growth of Hydrogenomonas cells in closed ecological bioregenerative system

Preparation of yttrium flouride using fluorine

This report deals with the preparation of a low oxygen content yttrium fluoride using commercial fluorine gas. It was shown that the purity of yttrium fluoride prepared using hydrogen fluoride gas could be improved by treating it with fluorine (1) at a temperature of 600°c under pressures in the range 20 - 25 psig or, to a lesser degree, (2) at 25°C and 1 atmosphere pressure. Preparation of yttrium fluoride by direct fluorination of yttrium oxide was found to be a spontaneous process which ceases short of equilibrium under the conditions studied. Fluorination of yttrium chloride resulted in a more complete conversion than that obtained with the oxide, but the degree of conversion was not high enough to be of interest. Calculations made using the best data available at this time show the reaction of yttrium oxide with fluorine gas is a highly exothermic reaction which would be expected to proceed spontaneously to almost complete conversion. A theory is presented which attempts to explain why this did not occur under the conditions imposed. It was demonstrated that fluorine gas supplied in pressure cylinders can be safely handled in a laboratory hood under the conditions cited above if proper precautions are taken

Mortality of Patients with Hematological Malignancy after Admission to the Intensive Care Unit

Background: The admission of patients with malignancies to an intensive care unit (ICU) still remains a matter of substantial controversy. The identification of factors that potentially influence the patient outcome can help ICU professionals make appropriate decisions. Patients and Methods: 90 adult patients with hematological malignancy (leukemia 47.8%, high-grade lymphoma 50%) admitted to the ICU were analyzed retrospectively in this single-center study considering numerous variables with regard to their influence on ICU and day-100 mortality. Results: The median simplified acute physiology score (SAPS) II at ICU admission was 55 (ICU survivors 47 vs. 60.5 for non-survivors). The overall ICU mortality rate was 45.6%. With multivariate regression analysis, patients admitted with sepsis and acute respiratory failure had a significantly increased ICU mortality (sepsis odds ratio (OR) 9.12, 95% confidence interval (CI) 1.1-99.7, p = 0.04; respiratory failure OR 13.72, 95% CI 1.39-136.15, p = 0.025). Additional factors associated with an increased mortality were: high doses of catecholamines (ICU: OR 7.37, p = 0.005; day 100: hazard ratio (HR) 2.96, p < 0.0001), renal replacement therapy (day 100: HR 1.93, p = 0.026), and high SAPS II (ICU: HR 1.05, p = 0.038; day 100: HR 1.2, p = 0.027). Conclusion: The decision for or against ICU admission of patients with hematological diseases should become increasingly independent of the underlying malignant disease

Somatostatin receptor PET/CT in restaging of typical and atypical lung carcinoids

Background To assess the role of somatostatin receptor (SR) PET/CT using Ga-68 DOTATOC or DOTATATE in staging and restaging of typical (TC) and atypical (AC) lung carcinoids. Methods Clinical and PET/CT data were retrospectively analyzed in 27 patients referred for staging (N = 5; TC, N = 4; AC, N = 1) or restaging (N = 22; TC, N = 8; AC, N = 14). Maximum standardized uptake value (SUVmax) of SR-positive lesions was normalized to the SUVmax of the liver to generate SUVratio; SR PET was compared to contrast-enhanced (ce) CT. The classification system proposed by Rindi et al. (Endocr Relat Cancer. 2014;21(1):1-16, 2014) was used for classification of patients in TC and AC groups. Results Only 18/27 patients were found to have metastases on PET/CT. Of the 186 lesions, 101 (54.3 %) were depicted on both PET and CT, 53 (28.5 %) lesions only on CT, and 32 (17.2 %) only on PET. SUVratio of lesions was significantly higher in AC as compared to TC (p < 0.001). In patients referred for restaging, additional findings on PET lead to upstaging with change in management strategy in 5/22 (22.7 %) patients (AC, N = 5; TC, N = 1). In four patients (all AC) referred for restaging and in one patient (TC) referred for staging, additional findings on CT missed on PET lead to correct staging. Conclusions Typical and atypical carcinoid patients have complex patterns of metastases which make it necessary to combine functional SR PET and contrast- enhanced CT for appropriate restaging. In patients referred for restaging SR, PET may have a relevant impact on treatment strategy in up to 22.7 of patients with typical and atypical lung carcinoids

Oxalobacter formigenes: a potential tool for the treatment of primary hyperoxaluria type 1

Primary hyperoxaluria is characterized by severe urolithiasis, nephrocalcinosis, and early renal failure. As treatment options are scarce, we aimed for a new therapeutic tool using colonic degradation of endogenous oxalate by Oxalobactor formigenes. Oxalobacter was orally administered for 4 weeks as frozen paste (IxOC-2) or as enteric-coated capsules (IxOC-3). Nine patients (five with normal renal function, one after liver–kidney transplantation, and three with renal failure) completed the IxOC-2 study. Seven patients (six with normal renal function and one after liver–kidney transplantation) completed the IxOC-3 study. Urinary oxalate or plasma oxalate in renal failure was determined at baseline, weekly during treatment and for a 2-week follow-up. The patients who showed >20% reduction both at the end of weeks 3 and 4 were considered as responders. Under IxOC-2, three out of five patients with normal renal function showed a 22–48% reduction of urinary oxalate. In addition, two renal failure patients experienced a significant reduction in plasma oxalate and amelioration of clinical symptoms. Under IxOC-3 treatment, four out of six patients with normal renal function responded with a reduction of urinary oxalate ranging from 38.5 to 92%. Although all subjects under IxOC-2 and 4 patients under IxOC-3 showed detectable levels of O. formigenes in stool during treatment, fecal recovery dropped directly at follow up, indicating only transient gastrointestinal-tract colonization. The preliminary data indicate that O. formigenes is safe, leads to a significant reduction of either urinary or plasma oxalate, and is a potential new treatment option for primary hyperoxaluria

Lifetime prevalence and determinants of hand eczema in an adolescent population in Germany: 15-year follow-up of the LISA cohort study

Background Hand eczema is a common inflammatory skin disorder in both adolescence and adulthood. Objectives We sought to assess the lifetime prevalence of hand eczema and associated exogenous and endogenous risk factors among adolescents in Germany. Methods This was a cross-sectional study embedded into a prospective population-based birth cohort in four regions of Germany, which recruited healthy neonates born between November 1997 and January 1999. We included 1736 participants who had completed the 15-year follow-up from birth cohort and 84.6% (1468/1736) had clearly reported whether they have ever had hand eczema. All the data were based on questionnaires and blood tests (immunoglobulin E). Multivariable logistic regression analysis was used to examine endogenous and exogenous factors in relation to the lifetime prevalence of hand eczema among adolescents. Results One thousand four hundred and sixty-eight adolescents (715 girls, 48.7%) were included in the final analysis. The lifetime prevalence of hand eczema among adolescents at the age of 15 was 10.4% (95% confidence interval [CI]: 8.9%-12.1%), with a significantly higher lifetime prevalence among girls than boys (12.7% vs. 8.2%, P = 0.005). Multivariable logistic regression analysis indicated statistically significant associations between the lifetime prevalence of hand eczema and having ever been diagnosed with atopic dermatitis (aOR = 1.8, 95% CI: 1.1-2.8) or having ever had dry skin (aOR = 1.9, 95% CI: 1.1-3.1), respectively. No statistically significant independent associations were found between asthma, hay fever, allergy-related clinical symptoms, immunoglobulin E positivity and other exogenous factors in relation to hand eczema. Conclusion Our study fills a research gap on the epidemiological burden of hand eczema among adolescents. One out of ten ever suffered from hand eczema until age 15 years indicating that hand eczema constitutes a significant burden in paediatric populations. The role of atopic dermatitis in hand eczema reinforces previous findings. Exogenous risk factors warrant further investigation

Epidemiologie akuter Verletzungen und Überlastungsschäden im Unterwasser-Rugby

Fragestellung: Unterwasser-Rugby (UWR) ist ein anspruchsvoller Mannschaftssport; Athleten benötigen dabei ein hohes Maß an Kraft, Ausdauer, Schnelligkeit und Koordination. Intensive Zweikämpfe sind ein wesentlicher Bestandteil des Sports und können zu Verletzungen führen. Derzeit gibt es nur wenig Daten bzgl. des Auftretens von Verletzungen im UWR-Sport. Ziel der vorliegenden Studie war es daher, die Art und Häufigkeit von Verletzungen im UWR-Sport zu untersuchen. Methodik: Zwischen 11/2020 und 03/2021 wurden UWR-Athleten mittels Online-Fragebogen (SurveyMonkey) zu Trainingsgewohnheiten, Verletzungen und chronischen Beschwerden befragt. Der Fragebogen (n = 32 bis 111 Fragen, abhängig von der Anzahl zurückliegender Verletzungen) umfasste: allgemeine und gesundheitsbezogene Daten (n = 10 Fragen), Trainingsgewohnheiten (n = 15 Fragen), Informationen über chronische Beschwerden (n = 9 Fragen) und akute Verletzungen (n = 21 bis 77 Fragen). Zur Bewertung chronischer Überlastungsschäden wurde der Oslo Sports Trauma Research Centre (OSTRC) Score verwendet. Ergebnisse und Schlussfolgerung: Insgesamt wurden 161 aktive Sportler (Ø 36,1 Jahre; Ø180,7 cm, 82,7 kg; männlich: 119, weiblich 39) in die Studie aufgenommen. Das Leistungsniveau war: 1. deutsche Bundesliga: 73x, 2. Bundesliga: 46x, Landesliga: 17x, Bezirksliga: 1x, keine Liga: 24x. Das sportartspezifische Trainingspensum betrug Ø 5,6 Stunden pro Woche, darunter UWR-Training, zusätzliches Schwimmtraining (n = 71), Krafttraining (n = 70) oder Ausdauertraining (n = 102). Zurückliegende akute Verletzungen mit einer Trainingspause und/oder einem Arztbesuch wurden bei 78,8% der Athleten festgestellt. Es handelte sich dabei um Hand/Finger- (42,2%), Hand/Ohr- (Gehirnerschütterung, gerissenes Trommelfell; 18,1%), Handgelenk- (5,5%) oder Halswirbelsäulenverletzungen (5,0%). Chronische Beschwerden wurden von 42,8% der Teilnehmer angegeben, vor allem an Hand/Finger (18,8%), Schulter/Schlüsselbein (14,1%), Halswirbelsäule und Handgelenk (je 10,7%), Kopf/Gesicht (8,7%), Sprunggelenk und Knie (je 6,7%). Die vorliegende Studie an Athleten unterschiedlicher Leistungsstufen analysiert die Verteilung von Verletzungen bei UWR. Führende Verletzungsregionen sind Hand-/Fingerverletzungen, Kopf-/Ohrverletzungen, Handgelenk- und Halswirbelsäulenverletzungen. Die gewonnenen Erkenntnisse können als Grundlage für Präventionskonzepte dienen