A Study of the Dynamics of Cardiac Ischemia using Experimental and Modeling Approaches

The dynamics of cardiac ischemia was investigated using experimental studies and computer simulations. An experimental model consisting of an isolated and perfused canine heart with full control over blood flow rate to a targeted coronary artery was used in the experimental study and a realistically shaped computer model of a canine heart, incorporating anisotropic conductivity and realistic fiber orientation, was used in the simulation study. The phenomena investigated were: (1) the influence of fiber rotation on the epicardial potentials during ischemia and (2) the effect of conductivity changes during a period of sustained ischemia. Comparison of preliminary experimental and computer simulation results suggest that as the ischemic region grows from the endocardium towards the epicardium, the epicardial potential patterns follow the rotating fiber orientation in the myocardium. Secondly, in the experimental studies it was observed that prolonged ischemia caused a subsequent reduction in the magnitude of epicardial potentials. Similar results were obtained from the computer model when the conductivity of the tissue in the ischemic region was reduce

Upconversion of a relativistic Coulomb field terahertz pulse to the near infrared

We demonstrate the spectral upconversion of a unipolar subpicosecond terahertz (THz) pulse, where the THz pulse is the Coulomb field of a single relativistic electron bunch. The upconversion to the optical allows remotely located detection of long wavelength and nonpropagating components of the THz spectrum, as required for ultrafast electron bunch diagnostics. The upconversion of quasimonochromatic THz radiation has also been demonstrated, allowing the observation of distinct sum- and difference-frequency mixing components in the spectrum. Polarization dependence of first and second order sidebands at ωopt±ωTHz, and ωopt±2ωTHz, respectively, confirms the χ(2) frequency mixing mechanism

Longtitudinal electron beam diagnostics via upconversion of THz to visible radiation

Longitudinal electro-optic electron bunch diagnostics has been successfully applied at several accelerators. The electro-optic effect can be seen as an upconversion of the Coulomb field of the relativistic electron bunch (THz radiation) to the visible spectral range, where a variety of standard diagnostic tools are available. Standard techniques to characterise femtosecond optical laser pulses (auto- and cross-correlators) have led to the schemes that can measure electron bunch profiles with femtosecond resolution. These techniques require, however, well synchronized femtosecond laser pulses, in order to obtain the desired temporal resolution. Currently, we are exploring other electro-optic variants which require less advanced laser systems and will be more amenable to beam based longitudinal feedback applications. The first results of one such new scheme will be presented in this paper

Managing Grassy Woodlands: Balancing Production and Conservation of Resources

Eastern Australian eucalypt woodlands are important agricultural areas that have been widely modified during two centuries of European-style use. Despite this they contain important natural resources including significant biodiversity. Long term sustainability of production depends on maintaining resources and management must be for both production and conservation. A research program on four properties in south east Queensland showed the properties were in generally good condition although all had some problems, and has highlighted a number of significant costs and barriers to adopting a more balanced approach to production and conservation

Methanol Masers as Tracers of Circumstellar Disks

We show that in many methanol maser sources the masers are located in lines, with a velocity gradient along them which suggests that the masers are situated in edge-on circumstellar, or protoplanetary, disks. We present VLBI observations of the methanol maser source G309.92+0.48, in the 12.2 GHz transition, which confirm previous observations that the masers in this source lie along a line. We show that such sources are not only linear in space but, in many cases, also have a linear velocity gradient. We then model these and other data in both the 6.7 GHz and the 12.2 GHz transition from a number of star formation regions, and show that the observed spatial and velocity distribution of methanol masers, and the derived Keplerian masses, are consistent with a circumstellar disk rotating around an OB star. We consider this and other hypotheses, and conclude that about half of these methanol masers are probably located in edge-on circumstellar disks around young stars. This is of particular significance for studies of circumstellar disks because of the detailed velocity information available from the masers.Comment: 38 pages, 13 figures accepted by Ap

Practical constraints on real time Bayesian filtering for NDE applications

An experimental evaluation of Bayesian positional filtering algorithms applied to mobile robots for Non-Destructive Evaluation is presented using multiple positional sensing data – a real time, on-robot implementation of an Extended Kalman and Particle filter was used to control a robot performing representative raster scanning of a sample. Both absolute and relative positioning were employed – the absolute being an indoor acoustic GPS system that required careful calibration. The performance of the tracking algorithms are compared in terms of computational cost and the accuracy of trajectory estimates. It is demonstrated that for real time NDE scanning, the Extended Kalman Filter is a more sensible choice given the high computational overhead for the Particle filter

Developing a community-based intervention to improve quality of life in people with colorectal cancer: a complex intervention development study

Objectives: To develop and pilot a theory and evidence-based intervention to improve quality of life (QoL) in people with colorectal cancer. Design: A complex intervention development study. Setting: North East Scotland and Glasgow. Participants: Semistructured interviews with people with colorectal cancer (n=28), cancer specialists (n=16) and primary care health professionals (n=14) and pilot testing with patients (n=12). Interventions: A single, 1 h nurse home visit 6–12 weeks after diagnosis, and telephone follow-up 1 week later (with a view to ongoing follow-up in future). Primary and secondary outcome measures: Qualitative assessment of intervention feasibility and acceptability. Results: Modifiable predictors of QoL identified previously were symptoms (fatigue, pain, diarrhoea, shortness of breath, insomnia, anorexia/cachexia, poor psychological well-being, sexual problems) and impaired activities. To modify these symptoms and activities, an intervention based on Control Theory was developed to help participants identify personally important symptoms and activities; set appropriate goals; use action planning to progress towards goals; self-monitor progress and identify (and tackle) barriers limiting progress. Interview responses were generally favourable and included recommendations about timing and style of delivery that were incorporated into the intervention. The pilot study demonstrated the feasibility of intervention delivery. Conclusions: Through multidisciplinary collaboration, a theory-based, acceptable and feasible intervention to improve QoL in colorectal cancer patients was developed, and can now be evaluated

Electro-optic techniques for longitudinal electron bunch diagnostics

Electro-optic techniques are becoming increasingly important in ultrafast electron bunch longitudinal diagnostics and have been successfully implemented at various accelerator laboratories. The longitudinal bunch shape is directly obtained from a single-shot, non-intrusive measurement of the temporal electric field profile of the bunch. Further- more, the same electro-optic techniques can be used to measure the temporal profile of terahertz / far-infrared opti- cal pulses generated by a CTR screen, at a bending magnet (CSR), or by an FEL. This contribution summarizes the re- sults obtained at FELIX and FLASH

Merger of white dwarf-neutron star binaries: Prelude to hydrodynamic simulations in general relativity

White dwarf-neutron star binaries generate detectable gravitational radiation. We construct Newtonian equilibrium models of corotational white dwarf-neutron star (WDNS) binaries in circular orbit and find that these models terminate at the Roche limit. At this point the binary will undergo either stable mass transfer (SMT) and evolve on a secular time scale, or unstable mass transfer (UMT), which results in the tidal disruption of the WD. The path a given binary will follow depends primarily on its mass ratio. We analyze the fate of known WDNS binaries and use population synthesis results to estimate the number of LISA-resolved galactic binaries that will undergo either SMT or UMT. We model the quasistationary SMT epoch by solving a set of simple ordinary differential equations and compute the corresponding gravitational waveforms. Finally, we discuss in general terms the possible fate of binaries that undergo UMT and construct approximate Newtonian equilibrium configurations of merged WDNS remnants. We use these configurations to assess plausible outcomes of our future, fully relativistic simulations of these systems. If sufficient WD debris lands on the NS, the remnant may collapse, whereby the gravitational waves from the inspiral, merger, and collapse phases will sweep from LISA through LIGO frequency bands. If the debris forms a disk about the NS, it may fragment and form planets.Comment: 28 pages, 25 figures, 6 table