A computational approach to fretting wear prediction at the head-stem taper junction of total hip replacements

Wear is one of the main reasons for failure of modular total hip replacements. Recent evidence suggests that fretting wear occurs at the taper junction which provides fixation between the prosthesis femoral head and stem components. The fine metallic wear debris that is released can lead to adverse soft-tissue reactions which can necessitate a revision surgery. The present study proposes a computational methodology utilising an energy wear law and a 3D finite element model to predict fretting wear at the taper junction. The method is novel in that it simulates the weakening of the initial taper ‘fixation’ (created at impaction of the head onto the stem in surgery) due to the wearing process. The taper fixation is modelled using a contact analysis with overlapped meshes at the taper junction. The reduction in fixation is modelled by progressive removal of the overlap between components based on calculated wear. The fretting wear analysis approach has been shown to model the evolution of wear effectively; however, it has been shown that accurate, quantitative values for wear are critically dependant on mesh refinement, wear scaling factor and fraction, wear coefficient used and knowledge of the device loading history. The method has been implemented with a 3D finite element model of the taper junction of a commercial total hip replacement. This has been used to determine taper wear patterns, wear damage and wear rates which have been shown to be consistant with those found from observation and measurement of retrieved prostheses. The numerical method could be used to consider the effect of design changes and clinical technique on subsequent fretting wear in modular prosthetic devices

Improving the geometry of manholes designed for separate sewer systems

The design of manholes dates back more than 100 years. However, there have been developments such as the use of new materials for the manufacture of manholes, and advances in inspection and maintenance technologies, allowing improvements to the shape of manholes. This paper presents an innovative design for manholes, created to overcome the challenges associated with the installation of separate sewer systems in narrow streets, common to both UK and EU cities. The traditional separate sewer system has two separate manholes. The proposed manhole combines these two manholes into one structure, with two separate chambers, to allow storm flow and foul flow to pass through the same manhole without mixing. The structural performance of the new design has been tested using mathematical modelling validated by experimental tests. The results are compared with the structural performance of traditional manholes. The new design shows an improved resistance to high live loads

Experimental data used to validate the FE model of the structural performance of two flexible pipes laid in a single trench.

The objective of the article is to describe the methodology followed to validate the finite element model for the new method of setting pipes in a separate sewer system, using one trench to accommodate the storm pipe over the sanitary pipe "doi.org/10.1016/j.tust.2019.103019" (Abbas et al., 2019). A physical model was established in the Liverpool John Moores University (LJMU) lab to test the structural performance of two PVC pipes buried in one trench. The results of the physical model were used to validate an FE model using the same material properties and boundary conditions used in the physical model. The validation process allowed the FE model to be upgraded to a 3D FE full-scale model for testing the novel method used to place the separate sewer system

Corticospinal excitability modulation by pairing peripheral nerve stimulation with cortical states of movement initiation

KEY POINTS: We compare the effects on corticospinal excitability of repeatedly delivering peripheral nerve stimulation at three time points (-30 ms, 0 ms, +50 ms) relative to muscle onset in a cue-guided task. Plastic changes in excitability are only observed when stimuli are delivered immediately before the time when muscles activate, while stimuli delivered at muscle onset or shortly later (0, +50 ms) have no effect. Plastic effects are abolished if there is ongoing volitional EMG activity in the muscles prior to onset of the phasic contraction. The plastic effects induced by timing peripheral stimulation relative to electromyographic markers of muscle activation are as effective as those that occur if stimulation is timed relative to electroencephalographic markers of motor cortical activation. We provide a simple alternative protocol to induce plasticity in people in whom EEG recording is difficult. ABSTRACT: Plastic changes in corticospinal excitability (CSE) and motor function can be induced in a targeted and long-term manner if afferent volleys evoked by peripheral nerve stimulation are repeatedly associated with the peak of premovement brain activity assessed with electroencephalography (EEG). Here we ask whether other factors might also characterise this optimal brain state for plasticity induction. In healthy human volunteers (N = 24) we find that the same reliable changes in CSE can be induced by timing peripheral afferent stimulation relative to the electromyography (EMG) onset rather than using the EEG peak. Specifically, we observed an increase in CSE when peripheral stimulation activated the cortex just before movement initiation. By contrast, there was no effect on CSE if the afferent input reached the cortex at the same time or after EMG onset, consistent with the idea that the temporal order of synaptic activation from afferent input and voluntary movement is important for production of plasticity. Finally, in 14 volunteers we found that background voluntary muscle activity prior to movement also abolished the effect on CSE. One possible explanation is that the intervention strengthens synapses that are inactive at rest, but change their activity in anticipation of movement, and that the intervention fails when the synapses are tonically active during background EMG activity. Overall, we demonstrate that, in individuals with voluntary control of muscles targeted by our intervention, EMG signals are a suitable alternative to EEG to induce plasticity by coupling movement-related brain states with peripheral afferent input. This article is protected by copyright. All rights reserved

Investigation of the structural performance of two flexible pipes set in one trench with a new placement method for separate sewer systems

Substantial research has been conducted on single flexible pipes buried in a trench. In contrast, the objective of this study is to determine the structural performance of two buried flexible sewer pipes positioned one over the other in a single trench. An innovative configuration is designed, based around the use of an innovative manhole structure which can accommodate both foul and surface water, to solve the challenges associated with constructing separate sewer systems in narrow streets while providing additional space for other infrastructure services. The behaviours of the two flexible pipes were tested using a 3D finite element (FE) model validated with experimental data from a laboratory investigation. A modified Drucker–Prager cap soil constitutive model was used to simulate the elasto-plastic soil behaviour. The results show that this approach comprising the use of a large-diameter flexible pipe set above a small-diameter flexible pipe mitigates the strain on the smaller pipe and decreases the total deflections of both pipes and the soil

Fluvial organic carbon flux from an eroding peatland catchment, southern Pennines, UK

International audienceThis study investigates for the first time the relative importance of dissolved organic carbon (DOC) and particulate organic carbon (POC) in the fluvial carbon flux from an actively eroding peatland catchment in the southern Pennines, UK. Event scale variability in DOC and POC was examined and the annual flux of fluvial organic carbon was estimated for the catchment. At the event scale, both DOC and POC were found to increase with discharge, with event based POC export accounting for 95% of flux in only 8% of the time. On an annual cycle, 40.8 t organic carbon (OC) is exported from the catchment, which represents an areal value of 107 gC m?2 a?1. POC was the most significant form of organic carbon export, accounting for ~82% of the estimated flux. This suggests that more research is required on both the fate of POC and the rates of POC export in eroding peatland catchments

GSH23.0-0.7+117, a neutral hydrogen shell in the inner Galaxy

GSH23.0-0.7+117 is a well-defined neutral hydrogen shell discovered in the VLA Galactic Plane Survey (VGPS). Only the blueshifted side of the shell was detected. The expansion velocity and systemic velocity were determined through the systematic behavior of the HI emission with velocity. The center of the shell is at (l,b,v)=(23.05,-0.77,+117 km/s). The angular radius of the shell is 6.8', or 15 pc at a distance of 7.8 kpc. The HI mass divided by the volume of the half-shell implies an average density n_H = 11 +/- 4 cm^{-3} for the medium in which the shell expanded. The estimated age of GSH23.0-0.7+117 is 1 Myr, with an upper limit of 2 Myr. The modest expansion energy of 2 * 10^{48} erg can be provided by the stellar wind of a single O4 to O8 star over the age of the shell. The 3 sigma upper limit to the 1.4 GHz continuum flux density (S_{1.4} < 248 mJy) is used to derive an upper limit to the Lyman continuum luminosity generated inside the shell. This upper limit implies a maximum of one O9 star (O8 to O9.5 taking into account the error in the distance) inside the HI shell, unless most of the incident ionizing flux leaks through the HI shell. To allow this, the shell should be fragmented on scales smaller than the beam (2.3 pc). If the stellar wind bubble is not adiabatic, or the bubble has burst (as suggested by the HI channel maps), agreement between the energy and ionization requirements is even less likely. The limit set by the non-detection in the continuum provides a significant challenge for the interpretation of GSH23.0-0.7+117 as a stellar wind bubble. A similar analysis may be applicable to other Galactic HI shells that have not been detected in the continuum.Comment: 18 pages, 6 figures. Figures 1 and 4 separately in GIF format. Accepted for publication in Astrophysical Journa

One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

BACKGROUND Previous studies conducted between 1997 and 2003 estimated that the risk of stroke or an acute coronary syndrome was 12 to 20% during the first 3 months after a transient ischemic attack (TIA) or minor stroke. The TIAregistry.org project was designed to describe the contemporary profile, etiologic factors, and outcomes in patients with a TIA or minor ischemic stroke who receive care in health systems that now offer urgent evaluation by stroke specialists. METHODS We recruited patients who had had a TIA or minor stroke within the previous 7 days. Sites were selected if they had systems dedicated to urgent evaluation of patients with TIA. We estimated the 1-year risk of stroke and of the composite outcome of stroke, an acute coronary syndrome, or death from cardiovascular causes. We also examined the association of the ABCD2 score for the risk of stroke (range, 0 [lowest risk] to 7 [highest risk]), findings on brain imaging, and cause of TIA or minor stroke with the risk of recurrent stroke over a period of 1 year. RESULTS From 2009 through 2011, we enrolled 4789 patients at 61 sites in 21 countries. A total of 78.4% of the patients were evaluated by stroke specialists within 24 hours after symptom onset. A total of 33.4% of the patients had an acute brain infarction, 23.2% had at least one extracranial or intracranial stenosis of 50% or more, and 10.4% had atrial fibrillation. The Kaplan–Meier estimate of the 1-year event rate of the composite cardiovascular outcome was 6.2% (95% confidence interval, 5.5 to 7.0). Kaplan–Meier estimates of the stroke rate at days 2, 7, 30, 90, and 365 were 1.5%, 2.1%, 2.8%, 3.7%, and 5.1%, respectively. In multivariable analyses, multiple infarctions on brain imaging, large-artery atherosclerosis, and an ABCD2 score of 6 or 7 were each associated with more than a doubling of the risk of stroke. CONCLUSIONS We observed a lower risk of cardiovascular events after TIA than previously reported. The ABCD2 score, findings on brain imaging, and status with respect to large-artery atherosclerosis helped stratify the risk of recurrent stroke within 1 year after a TIA or minor stroke. (Funded by Sanofi and Bristol-Myers Squibb.)Supported by an unrestricted grant from Sanofi and Bristol-Myers Squibb

The relation between body weight and wear in Total Hip Prosthesis: A finite element study

As the current obesity epidemic grows, an increased number of obese patients undergoing Total Hip Arthroplasty (THA) can be expected in the coming years. The National Health Service of the UK (NHS) recommends that an obese patient should undergo weight loss before THA. It is understood that an increased body weight would increase the wear rates on the prostheses, however, the extent of increased wear and the impact on the longevity of the prosthesis is unclear. The NHS found that 45% of THA failures in 2019 were caused by wear which led to a multitude of failures such as infection, aseptic loosening and dislocation such that a revision surgery is then needed. In this study, a finite element model was created to model a walking cycle and a newly developed wear algorithm was used to perform a series of computational wear analyses to investigate the effect of different patient weights on the evolution of wear in THAs up to 5 million cycles. The wear rates shown in this study are closely comparable to previous literature. The XLPE volumetric wear rates were found to be between 15 – 35mm3/yr (range: 1.5 – 57.6mm3/yr) and femoral head taper surface volumetric wear rates were between 0.174 – 0.225mm3/yr (range: 0.01 – 3.15mm3/yr). The results also showed that an increased weight of 140kg can increase the metallic wear by 26% and polyethylene wear by 30% when compared to 100kg body weight. As increased wear can lead to a multitude of failure such as aseptic loosening, dislocation and metallosis, from this study, it is recommended that obese patients undergo recommended weight loss and maintain this lesser weight to reduce wear and prolong the life of the THA