207 research outputs found

    Investigations in the Field of the Ultra-Short Electromagnetic Waves I. The Generator for the Production of Ultra-Short Undamped Waves

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    A description of apparatus for the production of ultra-short undamped electromagnetic waves by the method of Barkhausen and Kurz is given. An investigation has been made of the method of detecting the oscillations by observing the current in the plate circuit of the generator. At a constant plate potential the current is approximately proportional to the amplitude of the oscillations. A comparison of generators with one and with two tubes shows the advantages of the former. In certain cases the energy of oscillations produced by generators with one tube can be considerably increased by a suitable choice of the "ballast" capacity of the generator

    Investigations in the Field of the Ultra-Short Electromagnetic Waves II. The Normal Waves and the Dwarf Waves

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    The results are presented of an investigation of the production of ultra-short undamped electromagnetic waves by using the method of H. Barkhausen and K. Kurz. Method of working diagrams. Normal waves and dwarf waves. A method is developed for the graphic representation of the work of generators of ultra-short waves. This method is based on the construction of special "working diagrams." These diagrams define the location of "regions of oscillations," which show the values of the natural periods of the oscillating circuits and the values of the grid potentials at which oscillations are generated. Vacuum tubes can generate two kinds of ultra-short waves. The first kind have a wave-length approximating that computed by Barkhausen's formula Ξ»^2Eg=da^210^6. Their period is nearly equal to the time required for the electrons to move from the filament to the plate and back (normal waves). The second kind of waves are considerably shorter (dwarf waves). Both kinds of waves satisfy the equation Ξ»^2Eg=const. for points on the working diagram where the plate current (the amplitude of the oscillations) has its maximum value. Complex working diagrams. Dwarf waves of higher orders. Vacuum tubes can have complex working diagrams with a large number of regions of oscillations. In such a case the tube generates different dwarf waves. Their length is two, three and four times shorter than that of the normal waves. Dwarf waves are accordingly divided into waves of the 1st, 2nd, 3rd, etc. orders. The shortest dwarf waves of the 4th order, generated by tubes of the type R5, had a wave-length Ξ»=9.4 cm. The presence of dwarf waves of higher orders shows that vacuum tubes can generate oscillations of a frequency considerably greater than the frequency of the electronic oscillations. Both the normal and dwarf waves belong to the same type of GM-oscillations. Limits were determined within which Barkhausen's formula is applicable. It is shown that the difference in the number of regions of oscillations on the working diagrams depends on the difference in the time required for the electrons to pass in different directions within the tube. The latter depends on the asymmetry in the arrangement of the electrodes. The nature of dwarf waves. Dwarf waves are oscillations of the circuits within the tube or coupled with the tube which are excited in such a manner that during the time Ο„ it takes for the electrons to pass from the filament to the plate and back, the circuits perform two complete oscillations (dwarf waves of the 1st order), three complete oscillations (dwarf waves of the 2nd order) etc. Thus the wave-lengths are equal to: Ξ»0=c0Ο„ (normal waves), Ξ»1=c0Ο„/2 (dwarf waves of the 1st order), Ξ»2=c0Ο„/3 (dwarf waves of the 2nd order), Ξ»3=c0Ο„/4 (dwarf waves of the 3rt order), etc. Dwarf waves 9.5-18.5 cm long originate in oscillating circuits, which are inside the tube. The advantages of dwarf waves of higher orders are shown, owing to the possibility of using lower grid potentials, which leads to a greater steadiness in the operation of the tube

    Bulk-boundary correspondence in three dimensional topological insulators

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    We discuss the relation between bulk topological invariants and the spectrum of surface states in three dimensional non-interacting topological insulators. By studying particular models, and considering general boundary conditions for the electron wavefunction on the crystal surface, we demonstrate that using experimental techniques that probe surface states, only strong topological and trivial insulating phases can be distinguished; the latter state being equivalent to a weak topological insulator. In a strong topological insulator, only the {\it parity} of the number of surface states, but not the number itself, is robust against time-reversal invariant boundary perturbations. Our results suggest a \z definition of the bulk-boundary correspondence, compatible with the \z classification of topological insulators.Comment: TeXLive (Unix), revtex4-1, 7 pages, 3 figure

    Дискурс ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠ·ΠΌΠ° ΠΈ социалистичСская языковая Π»ΠΈΡ‡Π½ΠΎΡΡ‚ΡŒ: риторичСский аспСкт

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    Within the conception of the Sochi Linguistic & Rhetorical School the paper argues for the idea of discourse of Communism as a cover term for the Β«officialeseΒ» in the Soviet Union and former Socialist countries singling out four periods of its development: origin, formation, official existence, dismantling. The article pays special attention to the heterogeneity of the longest period of the discourse's official existence, which consists of the alternating stages: rise in the revolutionary and post-revolutionary years, during war and past-war time with the expansion of the discourse of Communism to other countries; and fall with the massive reprisals of 1930s and the β€œstagnation” epoch. During the period of its official existence three of its facets – official, public and real – reflect contradictions between the Communist ideas imposed by the authorities and the state of the Socialist linguistic personality confronting the meanness of daily life. The paper reveals those contrasts drawing on the diaries of Olga Berggolts and Alexander Dovzhenko as well as the destinies of Mikhail Prishvin, Alexey Tolstoy and Alexander Fadeyev.Dentro de la concepciΓ³n de la Escuela LingΓΌΓ­stica y RetΓ³rica de Sochi, el artΓ­culo argumenta a favor de la idea del discurso del comunismo como un tΓ©rmino de cobertura para los Β«officialeseΒ» en la UniΓ³n SoviΓ©tica y los ex paΓ­ses socialistas que seΓ±alan cuatro perΓ­odos de su desarrollo: origen, formaciΓ³n, oficial existencia, desmantelamiento. El artΓ­culo presta especial atenciΓ³n a la heterogeneidad del perΓ­odo mΓ‘s largo de la existencia oficial del discurso, que consiste en las etapas alternas: ascenso en los aΓ±os revolucionario y posrevolucionario, durante la guerra y el tiempo de la guerra pasada con la expansiΓ³n del discurso del comunismo. a otros paΓ­ses; y caer con las represalias masivas de 1930 y la Γ©poca de "estancamiento". Durante el perΓ­odo de su existencia oficial, tres de sus facetas, oficial, pΓΊblica y real, reflejan contradicciones entre las ideas comunistas impuestas por las autoridades y el estado de la personalidad lingΓΌΓ­stica socialista que confronta la mezquindad de la vida cotidiana. El documento revela esos contrastes basados ​​en los diarios de Olga Berggolts y Alexander Dovzhenko, asΓ­ como los destinos de Mikhail Prishvin, Alexey Tolstoy y Alexander Fadeyev.Π’ руслС ΠΊΠΎΠ½Ρ†Π΅ΠΏΡ†ΠΈΠΈ Бочинской лингвориторичСской ΡˆΠΊΠΎΠ»Ρ‹ ΡΡ‚Π°Ρ‚ΡŒΡ обосновываСт идСю дискурса ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠ·ΠΌΠ°, ΠΎΠ±ΠΎΠ±Ρ‰Π°ΡŽΡ‰ΡƒΡŽ ΠΈΠ½Ρ‚Π΅Ρ€ΠΏΡ€Π΅Ρ‚Π°Ρ†ΠΈΠΈ Β«ΠΎΡ„ΠΈΡ†ΠΈΠΎΠ»Π΅ΠΊΡ‚Π°Β» Π² БовСтском БоюзС ΠΈ Π² Π±Ρ‹Π²ΡˆΠΈΡ… странах социализма, ΠΈ выдСляСт Ρ‡Π΅Ρ‚Ρ‹Ρ€Π΅ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π° Π΅Π³ΠΎ развития: Π·Π°Ρ€ΠΎΠΆΠ΄Π΅Π½ΠΈΠ΅, Ρ„ΠΎΡ€ΠΌΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅, расцвСт ΠΈ угасаниС. ΠžΡ‚ΠΌΠ΅Ρ‡Π΅Π½Π° Π½Π΅ΠΎΠ΄Π½ΠΎΡ€ΠΎΠ΄Π½ΠΎΡΡ‚ΡŒ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΈ Π·Π½Π°Ρ‡ΠΈΠΌΠΎΠ³ΠΎ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π° расцвСта, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΉ состоит ΠΈΠ· Ρ‡Π΅Ρ€Π΅Π΄ΡƒΡŽΡ‰ΠΈΡ…ΡΡ этапов: вознСсСния Π² Ρ€Π΅Π²ΠΎΠ»ΡŽΡ†ΠΈΠΎΠ½Π½Ρ‹Π΅ ΠΈ ΠΏΠΎΡΠ»Π΅Ρ€Π΅Π²ΠΎΠ»ΡŽΡ†ΠΈΠΎΠ½Π½Ρ‹Π΅ Π³ΠΎΠ΄Ρ‹, Π² Π²ΠΎΠ΅Π½Π½ΠΎΠ΅ ΠΈ послСвоСнноС врСмя, ΡΠΎΠΏΡ€ΠΎΠ²ΠΎΠΆΠ΄Π°Π²ΡˆΠ΅Π΅ΡΡ Ρ€Π°ΡΡˆΠΈΡ€Π΅Π½ΠΈΠ΅ΠΌ Π³Ρ€Π°Π½ΠΈΡ† дискурса ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠ·ΠΌΠ° Π½Π° Π΄Ρ€ΡƒΠ³ΠΈΠ΅ страны; ΠΈ ΡƒΠΏΠ°Π΄ΠΊΠ°, с ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌ соотносятся массовыС рСпрСссии ΠΊΠΎΠ½Ρ†Π° 30-Ρ… Π³ΠΎΠ΄ΠΎΠ² ΠΈ эпоха «застоя». На всСх этапах расцвСта дискурса ΠΊΠΎΠΌΠΌΡƒΠ½ΠΈΠ·ΠΌΠ° Π΅Π³ΠΎ Ρ‚Ρ€ΠΈ ипостаси – ΠΎΡ„ΠΈΡ†ΠΈΠ°Π»ΡŒΠ½Π°Ρ, публичная ΠΈ Ρ€Π΅Π°Π»ΡŒΠ½Π°Ρ – ΠΎΡ‚Ρ€Π°ΠΆΠ°Π»ΠΈ ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΡ€Π΅Ρ‡ΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρƒ коммунистичСскими идСями, навязываСмыми властями, ΠΈ состояниСм социалистичСской языковой личности, ΡΡ‚Π°Π»ΠΊΠΈΠ²Π°ΡŽΡ‰Π΅ΠΉΡΡ с прСвратностями повсСднСвной Ρ€Π΅Π°Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ. Π£ΠΊΠ°Π·Π°Π½Π½Ρ‹Π΅ контрасты Ρ€Π°ΡΠΊΡ€Ρ‹Π²Π°ΡŽΡ‚ΡΡ Π² ΡΡ‚Π°Ρ‚ΡŒΠ΅ Π½Π° ΠΌΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Π΅ Π΄Π½Π΅Π²Π½ΠΈΠΊΠΎΠ² Ольги Π‘Π΅Ρ€Π³Π³ΠΎΠ»ΡŒΡ† ΠΈ АлСксандра Π”ΠΎΠ²ΠΆΠ΅Π½ΠΊΠΎ, Π° Ρ‚Π°ΠΊΠΆΠ΅ Π½Π° ΠΏΡ€ΠΈΠΌΠ΅Ρ€Π΅ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Π½Ρ‹Ρ… судСб ΠœΠΈΡ…Π°ΠΈΠ»Π° ΠŸΡ€ΠΈΡˆΠ²ΠΈΠ½Π°, АлСксСя Волстого ΠΈ АлСксандра Π€Π°Π΄Π΅Π΅Π²Π°

    Tunable unconventional Kondo effect on topological insulator surfaces

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    We study Kondo physics of a spin-12 impurity in electronic matter with strong spin-orbit interaction, which can be realized by depositing magnetic adatoms on the surface of a three-dimensional topological insulator. We show that magnetic properties of topological surface states and the very existence of Kondo screening strongly depend on details of the bulk material, and specifics of surface preparation encoded in time-reversal preserving boundary conditions for electronic wavefunctions. When this tunable Kondo effect occurs, the impurity spin is screened by purely orbital motion of surface electrons. This mechanism gives rise to a transverse magnetic response of the surface metal, and to spin textures that can be used to experimentally probe signatures of a Kondo resonance. Our predictions are particularly relevant for STM measurements in PbTe-class crystalline topological insulators, but we also discuss implications for other classes of topological materials

    ΠžΠΏΡ‚ΠΈΠΌΠΈΠ·Π°Ρ†ΠΈΡ Ρ‚Π΅ΠΏΠ»ΠΎΠ²ΠΎΠ³ΠΎ Ρ€Π΅ΠΆΠΈΠΌΠ° ΠΈΠ·ΠΎΠ»ΠΈΡ€ΡƒΡŽΡ‰Π΅Π³ΠΎ Π΄Ρ‹Ρ…Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠ³ΠΎ Π°ΠΏΠΏΠ°Ρ€Π°Ρ‚Π° Π½Π° химичСски связанном кислородС

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    It is proved that the main prospects for improving the insulating means of respiratory protection are related to the chemical method of oxygen reservation. To increase the efficiency of its use, it is necessary to use the resource of the dead layer of the chemosorbent and prevent the sintering of the granules of the oxygen-containing product under the action of exothermic heat. This is achieved by faster pulsed passage of exhaled air through the frontal layers of the chemosorbent and its slow filtration through the rest of the regenerative cartridge. To evaluate the effectiveness of such a technical solution, a mathematical model of air regeneration in an insulating breathing apparatus with an uneven rate of exhalation filtration through a regenerative cartridge is constructed. The dependencies on the time and coordinate of the concentration of CO2 molecules in the air stream and the share of the use of the protective resource of the regenerative cartridge are obtained. Using numerical experiments, the optimal coordinate of the air flow filtration rate jump was determined to prevent sintering of the granules. Depending on the amount of pressure damping on exhalation and inspiration for the RHS respirator, an increase in the protective effect of the device was determined and a decrease in the power of exothermic heat sources in the frontal layers of the oxygen-containing product was calculated. The results obtained confirm the effectiveness of the considered improvements of the design, which make it possible to increase the reliability of insulating breathing apparatus on chemically bound oxygen and to increase the efficiency of using their protective resource.Обосновано, Ρ‡Ρ‚ΠΎ Π³Π»Π°Π²Π½Ρ‹Π΅ пСрспСктивы ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΡ ΠΈΠ·ΠΎΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… срСдств Π·Π°Ρ‰ΠΈΡ‚Ρ‹ дыхания связаны с химичСским способом рСзСрвирования кислорода. Для ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΡ эффСктивности Π΅Π³ΠΎ использования Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎ Π·Π°Π΄Π΅ΠΉΡΡ‚Π²ΠΎΠ²Π°Ρ‚ΡŒ рСсурс ΠΌΠ΅Ρ€Ρ‚Π²ΠΎΠ³ΠΎ слоя хСмосорбСнта ΠΈ ΠΏΡ€Π΅Π΄ΠΎΡ‚Π²Ρ€Π°Ρ‚ΠΈΡ‚ΡŒ спСканиС Π³Ρ€Π°Π½ΡƒΠ» кислородсодСрТащСго ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Π° ΠΏΠΎΠ΄ дСйствиСм экзотСрмичСского Ρ‚Π΅ΠΏΠ»Π°. Π­Ρ‚ΠΎ достигаСтся Π±ΠΎΠ»Π΅Π΅ быстрым ΠΈΠΌΠΏΡƒΠ»ΡŒΡΠ½Ρ‹ΠΌ пропусканиСм Π²Ρ‹Π΄Ρ‹Ρ…Π°Π΅ΠΌΠΎΠ³ΠΎ Π²ΠΎΠ·Π΄ΡƒΡ…Π° Ρ‡Π΅Ρ€Π΅Π· Π»ΠΎΠ±ΠΎΠ²Ρ‹Π΅ слои хСмосорбСнта ΠΈ Π΅Π³ΠΎ ΠΌΠ΅Π΄Π»Π΅Π½Π½ΠΎΠΉ Ρ„ΠΈΠ»ΡŒΡ‚Ρ€Π°Ρ†ΠΈΠ΅ΠΉ Ρ‡Π΅Ρ€Π΅Π· ΠΎΡΡ‚Π°Π»ΡŒΠ½ΡƒΡŽ Ρ‡Π°ΡΡ‚ΡŒ Ρ€Π΅Π³Π΅Π½Π΅Ρ€Π°Ρ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠ°Ρ‚Ρ€ΠΎΠ½Π°. Для ΠΎΡ†Π΅Π½ΠΊΠΈ эффСктивности Ρ‚Π°ΠΊΠΎΠ³ΠΎ тСхничСского Ρ€Π΅ΡˆΠ΅Π½ΠΈΡ построСна матСматичСская модСль Ρ€Π΅Π³Π΅Π½Π΅Ρ€Π°Ρ†ΠΈΠΈ Π²ΠΎΠ·Π΄ΡƒΡ…Π° Π² ΠΈΠ·ΠΎΠ»ΠΈΡ€ΡƒΡŽΡ‰Π΅ΠΌ Π΄Ρ‹Ρ…Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎΠΌ Π°ΠΏΠΏΠ°Ρ€Π°Ρ‚Π΅ с Π½Π΅Ρ€Π°Π²Π½ΠΎΠΌΠ΅Ρ€Π½ΠΎΠΉ ΡΠΊΠΎΡ€ΠΎΡΡ‚ΡŒΡŽ Ρ„ΠΈΠ»ΡŒΡ‚Ρ€Π°Ρ†ΠΈΠΈ Π²Ρ‹Π΄ΠΎΡ…Π° Ρ‡Π΅Ρ€Π΅Π· Ρ€Π΅Π³Π΅Π½Π΅Ρ€Π°Ρ‚ΠΈΠ²Π½Ρ‹ΠΉ ΠΏΠ°Ρ‚Ρ€ΠΎΠ½. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Ρ‹ зависимости ΠΎΡ‚ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ ΠΈ ΠΊΠΎΠΎΡ€Π΄ΠΈΠ½Π°Ρ‚Ρ‹ ΠΊΠΎΠ½Ρ†Π΅Π½Ρ‚Ρ€Π°Ρ†ΠΈΠΈ ΠΌΠΎΠ»Π΅ΠΊΡƒΠ» БО2 Π² Π²ΠΎΠ·Π΄ΡƒΡˆΠ½ΠΎΠΌ ΠΏΠΎΡ‚ΠΎΠΊΠ΅ ΠΈ Π΄ΠΎΠ»ΠΈ использования Π·Π°Ρ‰ΠΈΡ‚Π½ΠΎΠ³ΠΎ рСсурса Ρ€Π΅Π³Π΅Π½Π΅Ρ€Π°Ρ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΏΠ°Ρ‚Ρ€ΠΎΠ½Π°. Π‘ ΠΏΠΎΠΌΠΎΡ‰ΡŒΡŽ числСнных экспСримСнтов ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π° ΠΎΠΏΡ‚ΠΈΠΌΠ°Π»ΡŒΠ½Π°Ρ для прСдотвращСния спСкания Π³Ρ€Π°Π½ΡƒΠ» ΠΊΠΎΠΎΡ€Π΄ΠΈΠ½Π°Ρ‚Π° скачка скорости Ρ„ΠΈΠ»ΡŒΡ‚Ρ€Π°Ρ†ΠΈΠΈ Π²ΠΎΠ·Π΄ΡƒΡˆΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡ‚ΠΎΠΊΠ°. Π’ зависимости ΠΎΡ‚ Π²Π΅Π»ΠΈΡ‡ΠΈΠ½Ρ‹ дСмпфирования давлСния Π½Π° Π²Ρ‹Π΄ΠΎΡ…Π΅ ΠΈ Π²Π΄ΠΎΡ…Π΅ для рСспиратора Π Π₯Π‘ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ прирост Π·Π°Ρ‰ΠΈΡ‚Π½ΠΎΠ³ΠΎ дСйствия Π°ΠΏΠΏΠ°Ρ€Π°Ρ‚Π° ΠΈ рассчитано сниТСниС мощности источников экзотСрмичСского Ρ‚Π΅ΠΏΠ»Π° Π² Π»ΠΎΠ±ΠΎΠ²Ρ‹Ρ… слоях кислородсодСрТащСго ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ‚Π°. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π°ΡŽΡ‚ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ рассматриваСмых ΡƒΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΠΉ конструкции, благодаря Ρ‡Π΅ΠΌΡƒ ΠΌΠΎΠ³ΡƒΡ‚ Π±Ρ‹Ρ‚ΡŒ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½Ρ‹ Π½Π°Π΄Π΅ΠΆΠ½ΠΎΡΡ‚ΡŒ ΠΈΠ·ΠΎΠ»ΠΈΡ€ΡƒΡŽΡ‰ΠΈΡ… Π΄Ρ‹Ρ…Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Π°ΠΏΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² Π½Π° химичСски связанном кислородС ΠΈ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ использования ΠΈΡ… Π·Π°Ρ‰ΠΈΡ‚Π½ΠΎΠ³ΠΎ рСсурса

    ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ритуксимаба Π² Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ Π΄ΠΈΠ·ΠΈΠΌΠΌΡƒΠ½Π½Ρ‹Ρ… ΠΏΠΎΠ»ΠΈΠ½Π΅ΠΉΡ€ΠΎΠΏΠ°Ρ‚ΠΈΠΉ: описаниС клиничСских случаСв ΠΈ ΠΎΠ±Π·ΠΎΡ€ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹

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    Dysimmune neuropathies are heterogeneous group of acquired immune-mediated diseases, accompanied by damage to the peripheral nervousΒ system. As a standard therapy, prednisolone and intravenous immunoglobulins are used. Also encouraging efficacy is demonstratedΒ by the use of a genetically engineered chimeric monoclonal antibody to the CD20 antigen found on the surface of normal and malignantΒ B-cells – rituximab. Rituximab shows encouraging results. We reviewed the use of rituximab for dysimmune polyneuropathies and describedΒ our experience in administration of Lewis–Sumner syndrome and myelin-associated glycoprotein related neuropathy with rituximab.Π”ΠΈΠ·ΠΈΠΌΠΌΡƒΠ½Π½Ρ‹Π΅ ΠΏΠΎΠ»ΠΈΠ½Π΅ΠΉΡ€ΠΎΠΏΠ°Ρ‚ΠΈΠΈ – гСтСрогСнная Π³Ρ€ΡƒΠΏΠΏΠ° ΠΏΡ€ΠΈΠΎΠ±Ρ€Π΅Ρ‚Π΅Π½Π½Ρ‹Ρ… иммуноопосрСдованных Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΡΠΎΠΏΡ€ΠΎΠ²ΠΎΠΆΠ΄Π°ΡŽΡ‰ΠΈΡ…ΡΡΒ ΠΏΠΎΡ€Π°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ пСрифСричСской Π½Π΅Ρ€Π²Π½ΠΎΠΉ систСмы. Π’ качСствС стандартной Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΡŽΡ‚ ΠΏΡ€Π΅Π΄Π½ΠΈΠ·ΠΎΠ»ΠΎΠ½ ΠΈ Π²Π½ΡƒΡ‚Ρ€ΠΈΠ²Π΅Π½Π½Ρ‹Π΅ ΠΈΠΌΠΌΡƒΠ½ΠΎΠ³Π»ΠΎΠ±ΡƒΠ»ΠΈΠ½Ρ‹, Π° Ρ‚Π°ΠΊΠΆΠ΅ ΠΎΠ±Π½Π°Π΄Π΅ΠΆΠΈΠ²Π°ΡŽΡ‰ΡƒΡŽ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΏΠΎΠΊΠ°Π·Ρ‹Π²Π°Π΅Ρ‚ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π³Π΅Π½Π½ΠΎ-ΠΈΠ½ΠΆΠ΅Π½Π΅Ρ€Π½ΠΎΠ³ΠΎ Ρ…ΠΈΠΌΠ΅Ρ€Π½ΠΎΠ³ΠΎ моноклонального Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π° ΠΊ CD20‑антигСну, ΠΎΠ±Π½Π°Ρ€ΡƒΠΆΠΈΠ²Π°Π΅ΠΌΠΎΠΌΡƒ Π½Π° повСрхности Π½ΠΎΡ€ΠΌΠ°Π»ΡŒΠ½Ρ‹Ρ… ΠΈ ΠΌΠ°Π»ΠΈΠ³Π½ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Ρ… Π’-Π»ΠΈΠΌΡ„ΠΎΡ†ΠΈΡ‚ΠΎΠ² – ритуксимаба. Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ прСдставлСн ΠΎΠ±Π·ΠΎΡ€ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ‹ ΠΏΠΎ использованию ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Π° Π² Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ Π΄ΠΈΠ·ΠΈΠΌΠΌΡƒΠ½Π½Ρ‹Ρ… ΠΏΠΎΠ»ΠΈΠ½Π΅ΠΉΡ€ΠΎΠΏΠ°Ρ‚ΠΈΠΉΒ ΠΈ описан собствСнный ΠΎΠΏΡ‹Ρ‚ Π΅Π³ΠΎ примСнСния ΠΏΡ€ΠΈ синдромС Π›ΡŒΡŽΠΈΡΠ°β€“Π‘Π°ΠΌΠ½Π΅Ρ€Π° ΠΈ ΠΏΠΎΠ»ΠΈΠ½Π΅ΠΉΡ€ΠΎΠΏΠ°Ρ‚ΠΈΠΈ, ассоциированной с Π°Π½Ρ‚ΠΈΡ‚Π΅Π»Π°ΠΌΠΈΒ ΠΊ миСлинассоциированному Π³Π»ΠΈΠΊΠΎΠΏΡ€ΠΎΡ‚Π΅ΠΈΠ½Ρƒ

    The using of quality indicators of Scots pine’s seeds for bioindication of anthropogenic pollution

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    The quality of Scots pine’s seeds (Pinus sylvestris L.) was analyzed in conditions of industrial emissions magnesite productionΠŸΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π½ΠΎ качСство сСмян сосны ΠΎΠ±Ρ‹ΠΊΠ½ΠΎΠ²Π΅Π½Π½ΠΎΠΉ (Pinus sylvestris L.) Π² условиях ΠΏΡ€ΠΎΠΌΡ‹ΡˆΠ»Π΅Π½Π½Ρ‹Ρ… выбросов ΠΌΠ°Π³Π½Π΅Π·ΠΈΡ‚ΠΎΠ²ΠΎΠ³ΠΎ производств

    Glia, sympathetic activity and cardiovascular disease

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    New Findings What is the topic of this review? In this review, we discuss recent findings that provide a novel insight into the mechanisms that link glial cell function with the pathogenesis of cardiovascular disease, including systemic arterial hypertension and chronic heart failure. What advances does it highlight? We discuss how glial cells may influence central presympathetic circuits, leading to maladaptive and detrimental increases in sympathetic activity and contributing to the development and progression of cardiovascular disease. Increased activity of the sympathetic nervous system is associated with the development of cardiovascular disease and may contribute to its progression. Vasomotor and cardiac sympathetic activities are generated by the neuronal circuits located in the hypothalamus and the brainstem. These neuronal networks receive multiple inputs from the periphery and other parts of the CNS and, at a local level, may be influenced by their non-neuronal neighbours, in particular glial cells. In this review, we discuss recent experimental evidence suggesting that astrocytes and microglial cells are able to modulate the activity of sympathoexcitatory neural networks in disparate physiological and pathophysiological conditions. We focus on the chemosensory properties of astrocytes residing in the rostral ventrolateral medulla oblongata and discuss signalling mechanisms leading to glial activation during brain hypoxia and inflammation. Alterations in these mechanisms may lead to heightened activity of sympathoexcitatory CNS circuits and contribute to maladaptive and detrimental increases in sympathetic tone associated with systemic arterial hypertension and chronic heart failure
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