Fatalism, Social Support and Mental Health in Four Former Soviet Cultures

Research on social support has identified differences in levels of support between cultures, but has provided only a limited explanation of the role of values or beliefs in accounting for such variations. In this paper we examine the relationship between fatalism and perceived support amongst 2672 respondents in four former Soviet States (Russia, Georgia, Ukraine and Belorussia), with participants drawn from groups of manual workers, managers, civil servants, students and the retired in these four countries. We also examine the consequences of such social support for mental health across these nations. Findings indicate a small but significant moderator effect for fatalism on the relationship between social support and mental health. These results are discussed in the context of the continuing economic and social challenges facing the citizens of these nations

Truncating mutations in the Wilson disease gene ATP7B are associated with very low serum ceruloplasmin oxidase activity and an early onset of Wilson disease

<p>Abstract</p> <p>Background</p> <p>Mutations in the gene ATP7B cause Wilson disease, a copper storage disorder with a high phenotypic and genetic heterogeneity. We aimed to evaluate whether 'severe' protein-truncating ATP7B mutations (SMs) are associated with low serum ceruloplasmin oxidase activities and an early age of onset when compared to missense mutations (MMs).</p> <p>Methods</p> <p>The clinical phenotype of 59 genetically confirmed WD patients was analyzed retrospectively. Serum ceruloplasmin was measured by its oxidase activity with <it>o</it>-dianisidine dihydrochloride as substrate and immunologically.</p> <p>Results</p> <p>Thirty-nine patients had two MMs, 15 had the genotype SM/MM, and 5 patients had two SMs on their ATP7B alleles. Enzymatic and immunologic serum ceruloplasmin levels differed significantly between the three groups (P < 0.001 and P < 0.01, respectively). The lowest levels were measured in patients with two SMs (0.0 U/L; IQR, 0.0-0.0 U/L and 0.02 g/L; IQR, 0.01-0.02 g/L, respectively) and the highest in patients with two MMs (17.8 U/L; IQR, 5.8-35.1 U/L and 0.11 g/L; IQR,0.10-0.17 g/L, respectively). The age of onset was also significantly different between the three patient groups (P < 0.05), with SM/SM patients showing the earliest onset (13 years; IQR, 9-13 years) and patients with two MMs showing the latest onset (22 years; IQR, 14-27 years). By ROC curve analysis a ceruloplasmin oxidase level ≤ 5 U/L can predict the presence of at least one SM with a sensitivity of 80% and a specificity of 79.5%.</p> <p>Conclusions</p> <p>In our German study cohort truncating ATP7B mutations were associated with lower ceruloplasmin serum oxidase levels and an earlier age of onset when compared to MMs. Measurement of serum ceruloplasmin oxidase might help to predict presence of truncating ATP7B mutations and might facilitate the mutation analysis.</p

Changes in ocean vertical heat transport with global warming

Heat transport between the surface and deep ocean strongly influences transient climate change. Mechanisms setting this transport are investigated using coupled climate models and by projecting ocean circulation into the temperature-depth diagram. In this diagram, a “cold cell” cools the deep ocean through the downwelling of Antarctic waters and upwelling of warmer waters and is balanced by warming due to a “warm cell,” coincident with the interhemispheric overturning and previously linked to wind and haline forcing. With anthropogenic warming, the cold cell collapses while the warm cell continues to warm the deep ocean. Simulations with increasingly strong warm cells, set by their mean Southern Hemisphere winds, exhibit increasing deep-ocean warming in response to the same anthropogenic forcing. It is argued that the partition between components of the circulation which cool and warm the deep ocean in the preindustrial climate is a key determinant of ocean vertical heat transport with global warming

Delayed baroclinic response of the Antarctic circumpolar current to surface wind stress

Author Posting. © Science in China Press, 2008. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Science in China Series D: Earth Sciences 51 (2008): 1036-1043, doi:10.1007/s11430-008-0074-8.Antarctic Circumpolar Current (ACC) responds to the surface windstress via two processes, i.e., instant barotropic process and delayed baroclinic process. This study focuses on the baroclinic instability mechanism in ACC. That is, the strengthening of surface zonal windstress causes the enhanced tilting of the isopycnal surface, which leads to the intense baroclinic instability. Simultaneously, the mesoscale eddies resulting from the baroclinic instability facilitate the transformation of mean potential energy to eddy energy, which causes the remarkable decrease of the ACC volume transport with the 2-year lag time. This delayed negative correlation between the ACC transport and the zonal windstress may account for the steadiness of the ACC transport in these two decades.Supported by NSCF Outstanding Young Scientist Award (Grant No. 40625017) and the National Basic Research Program of China (Grant No. 2006CB403604). The research was also supported by W. Alan Clark Chair from Woods Hole Oceanographic Institution for RXH and NOAA GLERL contribution No. 1462 for J

RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design

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Enhanced warming over the global subtropical western boundary currents

Author Posting. © The Author(s), 2011. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature Climate Change 2 (2012): 161-166, doi:10.1038/nclimate1353.Subtropical western boundary currents are warm, fast flowing currents that form on the western side of ocean basins. They carry warm tropical water to the mid-latitudes and vent large amounts of heat and moisture to the atmosphere along their paths, affecting atmospheric jet streams and mid-latitude storms, as well as ocean carbon uptake. The possibility that these highly energetic and nonlinear currents might change under greenhouse gas forcing has raised significant concerns, but detecting such changes is challenging owing to limited observations. Here, using reconstructed sea surface temperature datasets and newly developed century-long ocean and atmosphere reanalysis products, we find that the post-1900 surface ocean warming rate over the path of these currents is two to three times faster than the global mean surface ocean warming rate. The accelerated warming is associated with a synchronous poleward shift and/or intensification of global subtropical western boundary currents in conjunction with a systematic change in winds over both hemispheres. This enhanced warming may reduce ocean's ability to absorb anthropogenic carbon dioxide over these regions. However, uncertainties in detection and attribution of these warming trends remain, pointing to a need for a long-term monitoring network of the global western boundary currents and their extensions.This work is supported by China National Key Basic Research Project (2007CB411800) and National Natural Science Foundation Projects (40788002, 40921004). WC is supported by the Australian Climate Change Science program and the Southeast Australia Climate Initiative. HN is supported in part by the Japanese Ministry of Education, Culture, Sports, Science and Technology through Grant-in-Aid for Scientific Research on Innovative Areas #2205 and by the Japanese Ministry of Environment through Global Environment Research Fund (S-5). MJM is supported by NOAA’s Climate Program Office.2012-07-2

Genomic Sequence around Butterfly Wing Development Genes: Annotation and Comparative Analysis

, where a whole-genome BAC library allows targeted access to large genomic regions. genes. Comparative analysis with orthologous regions of the lepidopteran reference genome allowed assessment of conservation of fine-scale synteny (with detection of new inversions and translocations) and of DNA sequence (with detection of high levels of conservation of non-coding regions around some, but not all, developmental genes)., both involved in multiple developmental processes including wing pattern formation

Rewriting a Deep Generative Model

A deep generative model such as a GAN learns to model a rich set of semantic and physical rules about the target distribution, but up to now, it has been obscure how such rules are encoded in the network, or how a rule could be changed. In this paper, we introduce a new problem setting: manipulation of specific rules encoded by a deep generative model. To address the problem, we propose a formulation in which the desired rule is changed by manipulating a layer of a deep network as a linear associative memory. We derive an algorithm for modifying one entry of the associative memory, and we demonstrate that several interesting structural rules can be located and modified within the layers of state-of-the-art generative models. We present a user interface to enable users to interactively change the rules of a generative model to achieve desired effects, and we show several proof-of-concept applications. Finally, results on multiple datasets demonstrate the advantage of our method against standard fine-tuning methods and edit transfer algorithms.Comment: ECCV 2020 (oral). Code at https://github.com/davidbau/rewriting. For videos and demos see https://rewriting.csail.mit.edu

Copy Number Alteration and Uniparental Disomy Analysis Categorizes Japanese Papillary Thyroid Carcinomas into Distinct Groups

The aim of the present study was to investigate chromosomal aberrations in sporadic Japanese papillary thyroid carcinomas (PTCs), concomitant with the analysis of oncogene mutational status. Twenty-five PTCs (11 with BRAFV600E, 4 with RET/PTC1, and 10 without mutation in HRAS, KRAS, NRAS, BRAF, RET/PTC1, or RET/PTC3) were analyzed using Genome-Wide Human SNP Array 6.0 which allows us to detect copy number alteration (CNA) and uniparental disomy (UPD), also referred to as copy neutral loss of heterozygosity, in a single experiment. The Japanese PTCs showed relatively stable karyotypes. Seven cases (28%) showed CNA(s), and 6 (24%) showed UPD(s). Interestingly, CNA and UPD were rarely overlapped in the same tumor; the only one advanced case showed both CNA and UPD with a highly complex karyotype. Thirteen (52%) showed neither CNA nor UPD. Regarding CNA, deletions tended to be more frequent than amplifications. The most frequent and recurrent region was the deletion in chromosome 22; however, it was found in only 4 cases (16%). The degree of genomic instability did not depend on the oncogene status. However, in oncogene-positive cases (BRAFV600E and RET/PTC1), tumors with CNA/UPD were less frequent (5/15, 33%), whereas tumors with CNA/UPD were more frequent in oncogene-negative cases (7/10, 70%), suggesting that chromosomal aberrations may play a role in the development of PTC, especially in oncogene-negative tumors. These data suggest that Japanese PTCs may be classified into three distinct groups: CNA+, UPD+, and no chromosomal aberrations. BRAFV600E mutational status did not correlate with any parameters of chromosomal defects