Critical Steps of Plasmodium falciparum Ookinete Maturation

The egress and fertilization of Plasmodium gametes and development of a motile ookinete are the first crucial steps that mediate the successful transmission of the malaria parasites from humans to the Anopheles vector. However, limited information exists about the cell biology and regulation of this process. Technical impediments in the establishment of in vitro conditions for ookinete maturation in Plasmodium falciparum and other human malaria parasites further constrain a detailed characterization of ookinete maturation. Here, using fluorescence microscopy and immunolabeling, we compared P. falciparum ookinete maturation in Anopheles coluzzii mosquitoes in vivo and in cell culture in vitro. Our results identified two critical steps in ookinete maturation that are regulated by distinct mosquito factors, thereby highlighting the role of the mosquito environment in the transmission efficiency of malaria parasites

A Quality-Aware Approach to Web Services Procurement

Web services bring programmers a new way to develop advanced applications able to integrate any group of services on the Internet into a single solution. Web services procurement (WSP) is focussed on the acquisition of web services, including some complex tasks such as the specification of demands, the search for available offers, and the best choice selection. Although the technology to support them already exists, there are only a few approaches wherein qualityof- service in demands and offers is taken into account, in addition to functionality. In this paper, we present some implementation issues on a quality-aware approach to WSP, whose solution is mainly based on using mathematical constraints to define quality-of-service in demands and offers.Ministerio de Ciencia y Tecnología TIC2000-1106-C02-01Ministerio de Ciencia y Tecnología FIT-150100-2001-78Junta de Comunidades de Castilla La Mancha PCB-02-00

Integral measurement of the 12C(n, p)12B reaction up to 10 GeV

The integral measurement of the 12C(n, p)12B reaction was performed at the neutron time-offlight facility n TOF at CERN. The total number of 12B nuclei produced per neutron pulse of the n TOF beam was determined using the activation technique in combination with a time-of-flight technique. The cross section is integrated over the n TOF neutron energy spectrum from reaction threshold at 13.6 MeV to 10 GeV. Having been measured up to 1 GeV on basis of the 235U(n, f) reaction, the neutron energy spectrum above 200 MeV has been re-evaluated due to the recent extension of the cross section reference for this particular reaction, which is otherwise considered a standard up to 200 MeV. The results from the dedicated GEANT4 simulations have been used to evaluate the neutron flux from 1 GeV up to 10 GeV. The experimental results related to the 12C(n, p)12B reaction are compared with the evaluated cross sections from major libraries and with the predictions of different GEANT4 models, which mostly underestimate the 12B production. On the contrary, a good reproduction of the integral cross section derived from measurements is obtained with TALYS-1.6 calculations, with optimized parameters.European Atomic Energy Communitys (Euratom) Seventh Framework Programme FP7/2007-2011-CHANDA (No. 605203)Narodowe Centrum Nauki (NCN)-UMO-2012/04/M/ST2/00700Croatian Science Foundation-No. 168

Non-extremal Black Holes, Harmonic Functions, and Attractor Equations

We present a method which allows to deform extremal black hole solutions into non-extremal solutions, for a large class of supersymmetric and non-supersymmetric Einstein-Vector-Scalar type theories. The deformation is shown to be largely independent of the details of the matter sector. While the line element is dressed with an additional harmonic function, the attractor equations for the scalars remain unmodified in suitable coordinates, and the values of the scalar fields on the outer and inner horizon are obtained from their fixed point values by making specific substitutions for the charges. For a subclass of models, which includes the five-dimensional STU-model, we find explicit solutions.Comment: 33 page

Marginal bone loss around implants placed in maxillary native bone or grafted sinuses: a retrospective cohort study

Objectives To assess differences in marginal bone loss around implants placed in maxillary pristine bone and implants placed following maxillary sinus augmentation over a period of 3 years after functional loading. Material and methods Two cohorts of subjects (Group 1: Subjects who received sinus augmentation with simultaneous implant placement; Group 2: Subjects who underwent conventional implant placement in posterior maxillary pristine bone) were included in this retrospective study. Radiographic marginal bone loss was measured around one implant per patient on digitized panoramic radiographs that were obtained at the time of prosthesis delivery (baseline) and 12, 24, and 36 months later. The influence of age, gender, smoking habits, history of periodontal disease, and type of prosthetic connection (internal or external) on marginal bone loss was analyzed in function of the type of osseous support (previously grafted or pristine). Results A total of 105 subjects were included in this study. Cumulative radiographic marginal bone loss ranged from 0 mm to 3.9 mm after 36 months of functional loading. There were statistically significant differences in marginal bone loss between implants placed in grafted and pristine bone at the 12‐month assessment, but not in the subsequent progression rate. External prosthetic connection, smoking, and history of periodontitis negatively influenced peri‐implant bone maintenance, regardless of the type of osseous substrate. Conclusions Implants placed in sites that received maxillary sinus augmentation exhibited more marginal bone loss than implants placed in pristine bone, although marginal bone loss mainly occurred during the first 12 months after functional loading. Implants with external implant connection were strongly associated with increased marginal bone loss overtime.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/102685/1/clr12122.pd

Stellar parameters for stars of the CoRoT exoplanet field

Aims:To support the computation and evolutionary interpretation of periods associated with the rotational modulation, oscillations, and variability of stars located in the CoRoT fields, we are conducting a spectroscopic survey for stars located in the fields already observed by the satellite. These observations allow us to compute physical and chemical parameters for our stellar sample. Method: Using spectroscopic observations obtained with UVES/VLT and Hydra/Blanco, and based on standard analysis techniques, we computed physical and chemical parameters ($T_{\rm{eff}}$, $\log \,(g)$, $\rm{[Fe/H]}$, $v_{\rm{mic}}$, $v_{\rm{rad}}$, $v \sin \,(i)$, and $A(\rm{Li})$) for a large sample of CoRoT targets. Results: We provide physical and chemical parameters for a sample comprised of 138 CoRoT targets. Our analysis shows the stars in our sample are located in different evolutionary stages, ranging from the main sequence to the red giant branch, and range in spectral type from F to K. The physical and chemical properties for the stellar sample are in agreement with typical values reported for FGK stars. However, we report three stars presenting abnormal lithium behavior in the CoRoT fields. These parameters allow us to properly characterize the intrinsic properties of the stars in these fields. Our results reveal important differences in the distributions of metallicity, $T_{\rm eff}$, and evolutionary status for stars belonging to different CoRoT fields, in agreement with results obtained independently from ground-based photometric surveys. Conclusions: Our spectroscopic catalog, by providing much-needed spectroscopic information for a large sample of CoRoT targets, will be of key importance for the successful accomplishment of several different programs related to the CoRoT mission, thus it will help further boost the scientific return associated with this space mission.Comment: 43 pages, 17 figures, accepted for publication in A&

Tourism income and economic growth in Greece: Empirical evidence from their cyclical components

This paper examines the relationship between the cyclical components of Greek GDP and international tourism income for Greece for the period 1976–2004. Using spectral analysis the authors find that cyclical fluctuations of GDP have a length of about nine years and that international tourism income has a cycle of about seven years. The volatility of tourism income is more than eight times the volatility of the Greek GDP cycle. VAR analysis shows that the cyclical component of tourism income is significantly influencing the cyclical component of GDP in Greece. The findings support the tourism-led economic growth hypothesis and are of particular interest and importance to policy makers, financial analysts and investors dealing with the Greek tourism industry

Fracturas estallido de columna toracolumbar: Evaluación clinicoradiológica y terapéutica de 90 casos

Presentamos un estudio retrospectivo de 90 fracturas toracolumbares tipo estallido con un seguimiento mínimo de 12 meses. Se realizó tratamiento ortopédico en 43 casos y en 47 se indicó una artrodesis instrumentada. Realizamos una evaluación clínico-radiológica en base al dolor residual y evolución del ángulo de cifosis con el objetivo de valorar el tratamiento ortopédico como opción terapéutica y la necesidad de distinguir fracturas estallido con afectación de 2 ó 3 columnas. No apreciamos diferencias estables significativas en el dolor y la lesión de las tres columnas. El aumento de cifosis angular media en las fracturas estallido estable no operadas es de 4.7º y de 5.2º en las fracturas estallido inestables tratadas ortopédicamente. Observamos una alta incidencia de complicaciones relacionadas con la fijación (21%) cuando la fractura asentaba en la charnela y se instrumentaba a un solo nivel. El tratamiento ortopédico es una opción aceptable en las fracturas estallido en pacientes neurológicamente indemnes.Ninety burst fractures of the thoracolumbar spine were retrospectively assessed with a minum follow-up of 12 months. Conservative treatment was indicated in 43 cases, and reduction and surgical stabilization in 47. The aim was to compare the two treatment modalities according to fracture stability. Clinical and radiological evaluation included chronic pain and kyphotic angle progression. No statistical differences were found between stable and unstable fractures as to chronic pain. The kyphotic angle average progression for stable burst fractures was 4.7º and 5.2º for unstable fractures conservatively treated. There was a high rate of complications related to instrumentation (21%) particularly when the fracture was at the thoracolumbar junction and a single level was fixed. The orthopaedic treatment is an acceptable alternative treatment for stable burst fractures without neurological injury