87 research outputs found
Understanding and Mitigating Biases when Studying Inhomogeneous Emission Spectra with JWST
Exoplanet emission spectra are often modelled assuming that the hemisphere
observed is well represented by a horizontally homogenised atmosphere. However
this approximation will likely fail for planets with a large temperature
contrast in the James Webb Space Telescope (JWST) era, potentially leading to
erroneous interpretations of spectra. We first develop an analytic formulation
to quantify the signal-to-noise ratio and wavelength coverage necessary to
disentangle temperature inhomogeneities from a hemispherically averaged
spectrum. We find that for a given signal-to-noise ratio, observations at
shorter wavelengths are better at detecting the presence of inhomogeneities. We
then determine why the presence of an inhomogeneous thermal structure can lead
to spurious molecular detections when assuming a fully homogenised planet in
the retrieval process. Finally, we quantify more precisely the potential biases
by modelling a suite of hot Jupiter spectra, varying the spatial contributions
of a hot and a cold region, as would be observed by the different instruments
of JWST/NIRSpec. We then retrieve the abundances and temperature profiles from
the synthetic observations. We find that in most cases, assuming a homogeneous
thermal structure when retrieving the atmospheric chemistry leads to biased
results, and spurious molecular detection. Explicitly modelling the data using
two profiles avoids these biases, and is statistically supported provided the
wavelength coverage is wide enough, and crucially also spanning shorter
wavelengths. For the high contrast used here, a single profile with a dilution
factor performs as well as the two-profile case, with only one additional
parameter compared to the 1-D approach.Comment: Accepted for publication by MNRA
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The Long-Term Evolution of the Atmosphere of Venus: Processes and Feedback Mechanisms: Interior-Exterior Exchanges
This work reviews the long-term evolution of the atmosphere of Venus, and modulation of its composition by interior/exterior cycling. The formation and evolution of Venus’s atmosphere, leading to contemporary surface conditions, remain hotly debated topics, and involve questions that tie into many disciplines. We explore these various inter-related mechanisms which shaped the evolution of the atmosphere, starting with the volatile sources and sinks. Going from the deep interior to the top of the atmosphere, we describe volcanic outgassing, surface-atmosphere interactions, and atmosphere escape. Furthermore, we address more complex aspects of the history of Venus, including the role of Late Accretion impacts, how magnetic field generation is tied into long-term evolution, and the implications of geochemical and geodynamical feedback cycles for atmospheric evolution. We highlight plausible end-member evolutionary pathways that Venus could have followed, from accretion to its present-day state, based on modeling and observations. In a first scenario, the planet was desiccated by atmospheric escape during the magma ocean phase. In a second scenario, Venus could have harbored surface liquid water for long periods of time, until its temperate climate was destabilized and it entered a runaway greenhouse phase. In a third scenario, Venus’s inefficient outgassing could have kept water inside the planet, where hydrogen was trapped in the core and the mantle was oxidized. We discuss existing evidence and future observations/missions required to refine our understanding of the planet’s history and of the complex feedback cycles between the interior, surface, and atmosphere that have been operating in the past, present or future of Venus
The long-term evolution of the atmosphere of Venus: processes and feedback mechanisms
In this chapter, we focus on the long-term evolution of the atmosphere of
Venus, and how it has been affected by interior/exterior cycles. The formation
and evolution of Venus's atmosphere, leading to the present-day surface
conditions, remain hotly debated and involve questions that tie into many
disciplines. Here, we explore the mechanisms that shaped the evolution of the
atmosphere, starting with the volatile sources and sinks. Going from the deep
interior to the top of the atmosphere, we describe fundamental processes such
as volcanic outgassing, surface-atmosphere interactions, and atmosphere escape.
Furthermore, we address more complex aspects of the history of Venus, including
the role of meteoritic impacts, how magnetic field generation is tied into
long-term evolution, and the implications of feedback cycles for atmospheric
evolution. Finally, we highlight three plausible end-member evolutionary
pathways that Venus might have followed, from the accretion to its present-day
state, based on current modeling and observations. In a first scenario, the
planet was desiccated early-on, during the magma ocean phase, by atmospheric
escape. In a second scenario, Venus could have harbored surface liquid water
for long periods of time, until its temperate climate was destabilized and it
entered a runaway greenhouse phase. In a third scenario, Venus's inefficient
outgassing could have kept water inside the planet, where hydrogen was trapped
in the core and the mantle was oxidized. We discuss existing evidence and
future observations/missions needed to refine our understanding of the planet's
history and of the complex feedback cycles between the interior, surface, and
atmosphere that operate in the past, present or future of Venus
Surface and Temporal Biosignatures
Recent discoveries of potentially habitable exoplanets have ignited the
prospect of spectroscopic investigations of exoplanet surfaces and atmospheres
for signs of life. This chapter provides an overview of potential surface and
temporal exoplanet biosignatures, reviewing Earth analogues and proposed
applications based on observations and models. The vegetation red-edge (VRE)
remains the most well-studied surface biosignature. Extensions of the VRE,
spectral "edges" produced in part by photosynthetic or nonphotosynthetic
pigments, may likewise present potential evidence of life. Polarization
signatures have the capacity to discriminate between biotic and abiotic "edge"
features in the face of false positives from band-gap generating material.
Temporal biosignatures -- modulations in measurable quantities such as gas
abundances (e.g., CO2), surface features, or emission of light (e.g.,
fluorescence, bioluminescence) that can be directly linked to the actions of a
biosphere -- are in general less well studied than surface or gaseous
biosignatures. However, remote observations of Earth's biosphere nonetheless
provide proofs of concept for these techniques and are reviewed here. Surface
and temporal biosignatures provide complementary information to gaseous
biosignatures, and while likely more challenging to observe, would contribute
information inaccessible from study of the time-averaged atmospheric
composition alone.Comment: 26 pages, 9 figures, review to appear in Handbook of Exoplanets.
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The Detectability of Earth's Biosignatures Across Time
Over the past two decades, enormous advances in the detection of exoplanets
have taken place. Currently, we have discovered hundreds of earth-sized
planets, several of them within the habitable zone of their star. In the coming
years, the efforts will concentrate in the characterization of these planets
and their atmospheres to try to detect the presence of biosignatures. However,
even if we discovered a second Earth, it is very unlikely that it would present
a stage of evolution similar to the present-day Earth. Our planet has been far
from static since its formation about 4.5 Ga ago; on the contrary, during this
time, it has undergone multiple changes in it's atmospheric composition, it's
temperature structure, it's continental distribution, and even changes in the
forms of life that inhabit it. All these changes have affected the global
properties of Earth as seen from an astronomical distance. Thus, it is of
interest not only to characterize the observables of the Earth as it is today,
but also at different epochs. Here we review the detectability of the Earth's
globally-averaged properties over time. This includes atmospheric composition
and biosignatures, and surface properties that can be interpreted as sings of
habitability (bioclues). The resulting picture is that truly unambiguous
biosignatures are only detectable for about 1/4 of the Earth's history. The
rest of the time we rely on detectable bioclues that can only establish an
statistical likelihood for the presence of life on a given planet.Comment: To appear in "Handbook of Exoplanets", eds. Deeg, H.J. & Belmonte,
J.A, Springer (2018). arXiv admin note: text overlap with
arXiv:astro-ph/0609398 by other author
Chimeric aptamers in cancer cell-targeted drug delivery
Aptamers are single-stranded structured oligonucleotides (DNA or RNA) that can bind to a wide range of targets ("apatopes") with high affinity and specificity. These nucleic acid ligands, generated from pools of random-sequence by an in vitro selection process referred to as systematic evolution of ligands by exponential enrichment (SELEX), have now been identified as excellent tools for chemical biology, therapeutic delivery, diagnosis, research, and monitoring therapy in real-time imaging. Today, aptamers represent an interesting class of modern Pharmaceuticals which with their low immunogenic potential mimic extend many of the properties of monoclonal antibodies in diagnostics, research, and therapeutics. More recently, chimeric aptamer approach employing many different possible types of chimerization strategies has generated more stable and efficient chimeric aptamers with aptamer-aptamer, aptamer-nonaptamer biomacromolecules (siRNAs, proteins) and aptamer-nanoparticle chimeras. These chimeric aptamers when conjugated with various biomacromolecules like locked nucleic acid (LNA) to potentiate their stability, biodistribution, and targeting efficiency, have facilitated the accurate targeting in preclinical trials. We developed LNA-aptamer (anti-nucleolin and EpCAM) complexes which were loaded in iron-saturated bovine lactofeerin (Fe-blf)-coated dopamine modified surface of superparamagnetic iron oxide (Fe3O4) nanoparticles (SPIONs). This complex was used to deliver the specific aptamers in tumor cells in a co-culture model of normal and cancer cells. This review focuses on the chimeric aptamers, currently in development that are likely to find future practical applications in concert with other therapeutic molecules and modalities
ADAM2 Interactions with Mouse Eggs and Cell Lines Expressing α4/α9 (ITGA4/ITGA9) Integrins: Implications for Integrin-Based Adhesion and Fertilization
Integrins are heterodimeric cell adhesion molecules, with 18 α (ITGA) and eight β (ITGB) subunits forming 24 heterodimers classified into five families. Certain integrins, especially the α(4)/α(9) (ITGA4/ITGA9) family, interact with members of the ADAM (a disintegrin and metalloprotease) family. ADAM2 is among the better characterized and also of interest because of its role in sperm function. Having shown that ITGA9 on mouse eggs participates in mouse sperm-egg interactions, we sought to characterize ITGA4/ITGA9-ADAM2 interactions.An anti-β(1)/ITGB1 function-blocking antibody that reduces sperm-egg binding significantly inhibited ADAM2 binding to mouse eggs. Analysis of integrin subunit expression indicates that mouse eggs could express at least ten different integrins, five in the RGD-binding family, two in the laminin-binding family, two in the collagen-binding family, and ITGA9-ITGB1. Adhesion assays to characterize ADAM2 interactions with ITGA4/ITGA9 family members produced the surprising result that RPMI 8866 cell adhesion to ADAM2 was inhibited by an anti-ITGA9 antibody, noteworthy because ITGA9 has only been reported to dimerize with ITGB1, and RPMI 8866 cells lack detectable ITGB1. Antibody and siRNA studies demonstrate that ITGB7 is the β subunit contributing to RPMI 8866 adhesion to ADAM2.These data indicate that a novel integrin α-β combination, ITGA9-ITGB7 (α(9)β(7)), in RPMI 8866 cells functions as a binding partner for ADAM2. ITGA9 had previously only been reported to dimerize with ITGB1. Although ITGA9-ITGB7 is unlikely to be a widely expressed integrin and appears to be the result of "compensatory dimerization" occurring in the context of little/no ITGB1 expression, the data indicate that ITGA9-ITGB7 functions as an ADAM binding partner in certain cellular contexts, with implications for mammalian fertilization and integrin function
Future Exoplanet Research: Science Questions and How to Address Them
Started approximately in the late 1980s, exoplanetology has up to now
unveiled the main gross bulk characteristics of planets and planetary systems.
In the future it will benefit from more and more large telescopes and advanced
space missions. These instruments will dramatically improve their performance
in terms of photometric precision, detection speed, multipixel imaging,
high-resolution spectroscopy, allowing to go much deeper in the knowledge of
planets. Here we outline some science questions which should go beyond these
standard improvements and how to address them. Our prejudice is that one is
never too speculative: experience shows that the speculative predictions
initially not accepted by the community have been confirmed several years later
(like spectrophotometry of transits or circumbinary planets).Comment: Invited review, accepte
Earth: Atmospheric Evolution of a Habitable Planet
Our present-day atmosphere is often used as an analog for potentially
habitable exoplanets, but Earth's atmosphere has changed dramatically
throughout its 4.5 billion year history. For example, molecular oxygen is
abundant in the atmosphere today but was absent on the early Earth. Meanwhile,
the physical and chemical evolution of Earth's atmosphere has also resulted in
major swings in surface temperature, at times resulting in extreme glaciation
or warm greenhouse climates. Despite this dynamic and occasionally dramatic
history, the Earth has been persistently habitable--and, in fact,
inhabited--for roughly 4 billion years. Understanding Earth's momentous changes
and its enduring habitability is essential as a guide to the diversity of
habitable planetary environments that may exist beyond our solar system and for
ultimately recognizing spectroscopic fingerprints of life elsewhere in the
Universe. Here, we review long-term trends in the composition of Earth's
atmosphere as it relates to both planetary habitability and inhabitation. We
focus on gases that may serve as habitability markers (CO2, N2) or
biosignatures (CH4, O2), especially as related to the redox evolution of the
atmosphere and the coupled evolution of Earth's climate system. We emphasize
that in the search for Earth-like planets we must be mindful that the example
provided by the modern atmosphere merely represents a single snapshot of
Earth's long-term evolution. In exploring the many former states of our own
planet, we emphasize Earth's atmospheric evolution during the Archean,
Proterozoic, and Phanerozoic eons, but we conclude with a brief discussion of
potential atmospheric trajectories into the distant future, many millions to
billions of years from now. All of these 'Alternative Earth' scenarios provide
insight to the potential diversity of Earth-like, habitable, and inhabited
worlds.Comment: 34 pages, 4 figures, 4 tables. Review chapter to appear in Handbook
of Exoplanet
A randomised phase IIb trial to assess the efficacy of ReCharge ice cream in preventing chemotherapy-induced diarrhoea
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