First principles theory of fluctuations in vortex liquids and solids

Consistent perturbation theory for thermodynamical quantities in type II superconductors in magnetic field at low temperatures is developed. It is complementary to the existing expansion valid at high temperatures. Magnetization and specific heat are calculated to two loop order and compare well to existing Monte Carlo simulations and experiments.Comment: 3 .ps fig. In press Phys. Rev.

Manipulation of micro-components using vacuum grippers.

SUMMARY. During the past decades several microproducts have been fabricated for a great variety of applications in the traditional fields, including the medical and biomedical sectors, automotive, aeronautics and aerospace, Information Technology and telecommunication as well as in more innovative areas, such as household appliances, entertainment and sport equipment. Nevertheless, hybrid three dimensional micro products have still great difficulty in penetrating the market, mainly due to the limits of the fabrication processes that require manipulation and final assembly of microcomponents. These processes, being not yet automated, strongly affect the cost of products. Therefore, new market perspectives can be reached automating the assembly phase. The main challenge is due to the new physical scenario that appears when dealing with the assembly of millimetric and sub-millimetric parts. Indeed, at the microscale the high surface to volume ratio leads to the predominance of the superficial forces (e.g. electrostatic, van der Waals and surface tension forces) over the gravitational force; this results in an unpredictable behaviour of the traditional manipulating mechanisms, whereas an efficient and precise control of the grasp and release of thousands of microscopic and fragile parts is required. For this reason the downscaling of traditional handling strategies and the development of new handling techniques require further studies. Several solutions can be found in literature, with their advantages and limitations, i.e.: friction and jaw microgrippers, magnetic and electrical fields used to levitate objects, adhesive grippers exploiting capillary force. Also vacuum grippers can be miniaturized. Due to their intrinsic simplicity, vacuum grippers are very cheap and appear a promising solution for industrial applications, if some improvements are carried out. In this context, an experimental setup for the automatic manipulation of microcomponents through some vacuum grippers was developed. Moreover, an innovative design of a nozzle for a vacuum gripper was fabricated and tested, comparing its performance with traditional needles. The design was conceived in order to reduce the frequency of occlusions of the nozzle and handle a wide range of particles. The tests described in this paper concern mainly the success and the precision of the release of objects from the gripper. Indeed, this is one the crucial aspect of micromanipulation because microparts tend to stick to the gripper preventing the successful performance of manipulation tasks

First-line erlotinib and fixed dose-rate gemcitabine for advanced pancreatic cancer

AIM: To investigate activity, toxicity, and prognostic factors for survival of erlotinib and fixed dose-rate gemcitabine (FDR-Gem) in advanced pancreatic cancer. METHODS: We designed a single-arm prospective, multicentre, open-label phase II study to evaluate the combination of erlotinib (100 mg/d, orally) and weekly FDR-Gem (1000 mg/m2, infused at 10 mg/m2per minute) in a population of previously untreated patients with locally advanced, inoperable, or metastatic pancreatic cancer. Primary endpoint was the rate of progression-free survival at 6 mo (PFS-6); secondary endpoints were overall response rate (ORR), response duration, tolerability, overall survival (OS), and clinical benefit. Treatment was not considered to be of further interest if the PFS-6 was < 20% (p0 = 20%), while a PFS-6 > 40% would be of considerable interest (p1 = 40%); with a 5% rejection error (α = 5%) and a power of 80%, 35 fully evaluable patients with metastatic disease were required to be enrolled in order to complete the study. Analysis of prognostic factors for survival was also carried out. RESULTS: From May 2007 to September 2009, 46 patients were enrolled (male/female: 25/21; median age: 64 years; median baseline carbohydrate antigen 19-9 (CA 19-9): 897 U/mL; locally advanced/metastatic disease: 5/41). PFS-6 and median PFS were 30.4% and 14 wk (95%CI: 10-19), respectively; 1-year and median OS were 20.2% and 26 wk (95%CI: 8-43). Five patients achieved an objective response (ORR: 10.9%, 95%CI: 1.9-19.9); disease control rate was 56.5% (95%CI: 42.2-70.8); clinical benefit rate was 43.5% (95%CI: 29.1-57.8). CA 19-9 serum levels were decreased by > 25% as compared to baseline in 14/23 evaluable patients (63.6%). Treatment was well-tolerated, with skin rash being the most powerful predictor of both longer PFS (P < 0.0001) and OS (P = 0.01) at multivariate analysis (median OS for patients with or without rash: 42 wk vs 15 wk, respectively, Log-rank P = 0.03). Additional predictors of better outcome were: CA 19-9 reduction, female sex (for PFS), and good performance status (for OS). CONCLUSION: Primary study endpoint was not met. However, skin rash strongly predicted erlotinib efficacy, suggesting that a pharmacodynamic-based strategy for patient selection deserves further investigation

Why the lowest Landau level approximation works in strongly type II superconductors

Higher than the lowest Landau level contributions to magnetization and specific heat of superconductors are calculated using Ginzburg - Landau equations approach. Corrections to the excitation spectrum around solution of these equations (treated perturbatively) are found. Due to symmetries of the problem leading to numerous cancellations the range of validity of the LLL approximation in mean field is much wider then a naive range and extends all the way down to $H = {H_{c2}(T)}/13$. Moreover the contribution of higher Landau levels is significantly smaller compared to LLL than expected naively. We show that like the LLL part the lattice excitation spectrum at small quasimomenta is softer than that of usual acoustic phonons. This enhanses the effect of fluctuations. The mean field calculation extends to third order, while the fluctuation contribution due to HLL is to one loop. This complements the earlier calculation of the LLL part to two loop order.Comment: 20 pages, Latex file, three figure

Detection of serum antibodies to hepatitis E virus in domestic pigs in Italy using a recombinant swine HEV capsid protein

Background: The hepatitis E virus (HEV) has been detected in both humans and animals, particularly pigs, worldwide. Several evidences, including human infection following consumption of raw contaminated meat, suggest a zoonotic transmission of HEV. In Italy, large circulation of genotype 3 HEV has been reported in swine, and recent studies have confirmed the involvement of this genotype in autochthonous human cases. Result: In this study 111 sera collected from healthy pigs in two Italian regions were tested for anti-HEV IgG antibodies. For specific HEV antibody detection in swine, we developed ELISA and Western blotting methods, using a truncated capsid (ORF2) protein lacking the first 111 amino acids of a swine HEV genotype 3 strain. The ORF2-based ELISA revealed anti-HEV antibodies in 104 out of 111 pigs compared with 102 detected with a commercial ELISA kit. A lower number of sera reacted with the recombinant ORF2 protein in a Western blotting format (81/111). Using a Latent class analysis (LCA), the estimated sensitivities for ELISA-ORF2 and ELISA-kit tests were 0.961 and 0.936, respectively, whereas specificities were 0.599 and 0.475. The estimated sensitivity of Western blotting was 0.775, and the specificity was 0.944. Conclusions: The overall results confirm the high prevalence of HEV seropositive healthy pigs in Italy. Through comparisons with a commercial ELISA test, the swine genotype 3 HEV antigen produced in this study was proven suitable to detect anti-HEV antibodies in pig sera by both ELISA and Western Blotting

Multivariate Hierarchical Modelling of Household Air Pollution

This is the author accepted manuscript. The final version is available from the Statistical Modelling Society via the link in this recordExposure to household air pollution has been attributed to an estimated 3.8 million deaths per year. A major contributor to this exposure is the reliance on various polluting fuels for cooking by almost half of all households in low and middle-income countries. We present a multivariate hierarchical model for surveys of the proportion of people relying on each fuel type, for the period 1990-2017, addressing several challenges with modelling the data including incomplete surveys and sampling bias.Natural Environment Research Council (NERC)World Health Organizatio

Rotavirus induces a biphasic enterotoxic and cytotoxic response in human-derived intestinal enterocytes, which is inhibited by human immunoglobulins.

The mechanisms of diarrhea due to rotavirus infection in humans are not fully understood; no specific therapy is available, but orally administered human serum immunoglobulins are effective in blocking stool output. We aimed to investigate the effect of rotavirus on ion transport and the role of NSP4 in human-derived enterocytes, and to test the efficacy of human serum immunoglobulin in a model of rotavirus infection. Soon after infection, rotavirus induces active chloride secretion in enterocytes. This effect is evident before viral replication leads to cell damage and correlates with NSP4 production. Inhibition of NSP4 prevents the early secretory phase but not cell damage. Incubation with human serum immunoglobulin blocks both ion secretion and cell damage. Rotavirus exerts an early NSP4-dependent ion secretion and subsequent tissue damage. The combined enterotoxic and cytotoxic effects may be responsible for the increased severity of diarrhea due to rotavirus infection, and both are counteracted by human serum immunoglobulin

Strategic decision-making support for distribution system planning with flexibility alternatives

The ongoing power system transformation requires rethinking the planning and operation practices of the different segments to accommodate the necessary changes and take advantage of the forthcoming opportunities. This paper concerns novel approaches for appraising initiatives involving the use of flexibility from grid-connected users. This paper proposes a Decision Theory based Multi-Criteria Cost-Benefit Analysis (DT-MCA-CBA) methodology for smart grid initiatives that capture the complexity of the distribution system planning activities in which flexibility competes with grid expansion. Based on international guidelines, the proposed DT-MCA-CBA methodology systematically assesses tangible and intangible impacts, considering multiple conflicting criteria. The DT-MCA-CBA methodology relies on a novel approach that combines MCA and Decision Theory to identify the most valuable option in a complex decision-making problem by modelling the stakeholder perspective with the MiniMax regret decision rule. The proposed DT-MCA-CBA methodology is applied to a comparative case study concerning four different approaches for distribution system planning. A web-based software which implements the proposed decision-making framework and the DT-MCA-CBA methodology is developed to provide a novel decision-making support tool for strategical smart distribution system planning