Effects of wheat and oat-based whole grain foods on serum lipoprotein size and distribution in overweight middle aged people : a randomised controlled trial

Peer reviewedPublisher PD

A spherical lamellar grating interferometer for airborne astronomical observations of far infrared objects

A lamellar grating has been developed to be used for very far infrared observations on the airborne observatory. The design characteristics and performance during laboratory testing and initial observations of Jupiter at wavelengths between 50 and 500 microns are presented

Changes in vitamin biomarkers during a 2-year intervention trial involving increased fruit and vegetable consumption by free-living volunteers

Peer reviewedPublisher PD

Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal

Peer reviewedPublisher PD

Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change : a randomised trial

This work was funded by The Scottish Government Rural and Environmental Science and Analytical Sciences Division (RESAS) and supported by the Rank Prize Funds.Peer reviewedPublisher PD

Forging a New Path: Fraud and White-Collar Crime in Mary Elizabeth Braddon’s 1870s Fiction

Janine Hatter examines Mary Elizabeth Braddon’s 1870s sensation fiction and the changing relationship between crime, genre, gender, class and the periodical press. Focusing on 'Taken at the Flood', 'The Cloven Foot', ‘Dr. Carrick’ and ‘Mr. and Mrs. de Fontenoy’, the chapter examines how Braddon updates her 1860s sensation fiction’s representation of the position of women and criminal activities in line with the changing historical context of the first Married Women’s Property Act (1870). The essay then considers how Braddon uses fraud and white-collar crime to emphasise male middle-class criminal strategies and ingenuity, highlighting their wider impact on society. The chapter concludes by considering syndication of Braddon’s work in provincial newspapers, gaining her a wider geographical and social readership for her warnings about white-collar crime

Adjuvants for Leishmania vaccines: from models to clinical application

Two million new cases of leishmaniasis occur every year, with the cutaneous leishmaniasis (CL) presentation accounting for approximately two-thirds of all cases. Despite the high incidence rates and geographic expansion of the disease, CL remains a neglected tropical disease without effective intervention strategies. Efforts to address this deficit have given rise to the experimental murine model of CL. By virtue of its simplicity and pliability, the CL model has been used to provide substantial information regarding cellular immunity, as well as in the discovery and evaluation of various vaccine adjuvants. The CL model has facilitated in vivo studies of the mechanism of action of many adjuvants, including the TLR4 agonist monophosphoryl lipid A, the TLR7/8 agonist imiquimod, the TLR9 agonist CpG, adenoviral vectors, and the immunostimulatory complexes. Together, these studies have helped to unveil the requirement for certain types of immune responses at specific stages of CL disease and provide a basis to aid the design of effective second-generation vaccines for human CL. This review focuses on adjuvants that have been tested in experimental CL, outlining how they have helped advance our understanding of the disease and ultimately, how they have performed when applied within clinical trials against human CL