Violent quenching : Molecular Gas Blown to 1000 km s -1 during a Major Merger

Accepted for publication in ApJ LettersWe present Atacama Large Millimeter/submillimeter Array observations of a massive () compact ( pc) merger remnant at z = 0.66 that is driving a 1000 km s -1 outflow of cool gas, with no observational trace of an active galactic nucleus (AGN). We resolve molecular gas on scales of approximately 1-2 kpc, and our main finding is the discovery of a wing of blueshifted CO J(2 → 1) emission out to-1000 km s -1 relative to the stars. We argue that this is the molecular component of a multiphase outflow, expelled from the central starburst within the past 5 Myr through stellar feedback, although we cannot rule out previous AGN activity as a launching mechanism. If the latter is true, then this is an example of a relic multiphase AGN outflow. We estimate a molecular mass outflow rate of approximately 300 M o yr -1, or about one third of the 10 Myr-Averaged star formation rate. This system epitomizes the multiphase "blowout" episode following a dissipational major merger-a process that has violently quenched central star formation and supermassive black hole growth.Peer reviewedFinal Accepted Versio

Population genetic analysis of a medicinally significant Australian rainforest tree, Fontainea picrosperma C.T. White (Euphorbiaceae): biogeographic patterns and implications for species domestication and plantation establishment

Background: Fontainea picrosperma, a subcanopy tree endemic to the rainforests of northeastern Australia, is of medicinal significance following the discovery of the novel anti-cancer natural product, EBC-46. Laboratory synthesis of EBC-46 is unlikely to be commercially feasible and consequently production of the molecule is via isolation from F. picrosperma grown in plantations. Successful domestication and plantation production requires an intimate knowledge of a taxon’s life-historyattributes and genetic architecture, not only to ensure the maximum capture of genetic diversity from wild source populations, but also to minimise the risk of a detrimental loss in genetic diversity via founder effects during subsequent breeding programs designed to enhance commercially significant agronomic traits. Results: Here we report the use of eleven microsatellite loci (PIC = 0.429; PID = 1.72 × 10−6 ) to investigate the partitioning of genetic diversity within and among seven natural populations of F. picrosperma. Genetic variation among individuals and within populations was found to be relatively low (A = 2.831; HE = 0.407), although there was marked differentiation among populations (PhiPT = 0.248). Bayesian, UPGMA and principal coordinates analyses detected three main genotypic clusters (K = 3), which were present at all seven populations. Despite low levels of historical gene flow (Nm = 1.382), inbreeding was negligible (F = -0.003); presumably due to the taxon’s dioecious breeding system. Conclusion: The data suggests that F. picrosperma was previously more continuously distributed, but that rainforest contraction and expansion in response to glacial-interglacial cycles, together with significant anthropogenic effects have resulted in significant fragmentation. This research provides important tools to support plantation establishment, selection and genetic improvement of this medicinally significant Australian rainforest species

Achievement goals, self-handicapping, and performance: A 2 × 2 achievement goal perspective

Elliot and colleagues (2006) examined the effects of experimentally induced achievement goals, proposed by the trichotomous model, on self-handicapping and performance in physical education. Our study replicated and extended the work of Elliot et al. by experimentally promoting all four goals proposed by the 262 model (Elliot & McGregor, 2001), measuring the participants’ own situational achievement goals, using a relatively novel task, and testing the participants in a group setting. We used a randomized experimental design with four conditions that aimed to induce one of the four goals advanced by the 262 model. The participants (n¼138) were undergraduates who engaged in a dart-throwing task. The results pertaining to self-handicapping partly replicated Elliot and colleagues’ findings by showing that experimentally promoted performance-avoidance goals resulted in less practice. In contrast, the promotion of mastery-avoidance goals did not result in less practice compared with either of the approach goals. Dart-throwing performance did not differ among the four goal conditions. Personal achievement goals did not moderate the effects of experimentally induced goals on selfhandicapping and performance. The extent to which mastery-avoidance goals are maladaptive is discussed, as well as the interplay between personal and experimentally induced goals

Monte Carlo energy and variance minimization techniques for optimizing many-body wave functions

We investigate Monte Carlo energy and variance minimization techniques for optimizing many-body wave functions. Several variants of the basic techniques are studied, including limiting the variations in the weighting factors which arise in correlated sampling estimations of the energy and its variance. We investigate the numerical stability of the techniques and identify two reasons why variance minimization exhibits superior numerical stability to energy minimization. The characteristics of each method are studied using a non-interacting 64-electron model of crystalline silicon. While our main interest is in solid state systems, the issues investigated are relevant to Monte Carlo studies of atoms, molecules and solids. We identify a robust and efficient variance minimization scheme for optimizing wave functions for large systems.Comment: 14 pages, including 7 figures. To appear in Phys. Rev. B. For related publications see http://www.tcm.phy.cam.ac.uk/Publications/many_body.htm

Perfectionism and achievement goals in young Finnish ice-hockey players aspiring to make the Under-16 national team

Research on perfectionism suggests that is it useful to differentiate between perfectionistic strivings and perfectionistic concerns. Regarding the 2 x 2 achievement goal framework, the usefulness of this differentiation was recently demonstrated in a study with university student athletes (Stoeber, Stoll, Pescheck, & Otto, 2008, Study 2), in which it was found that perfectionistic strivings were associated with mastery-approach and performance-approach goals and perfectionistic concerns with mastery-avoidance, performance-approach, and performance-avoidance goals. Because the study was largely exploratory and only used non-elite athletes, the aim of the present research was to replicate and extend these findings by investigating a sample of 138 young, elite ice-hockey players, while adding further measures of perfectionism and using structural equation modelling (SEM) to confirm the relationships between perfectionistic strivings, perfectionistic concerns,and the 2 x 2 achievement goals. The SEM results showed that, in elite athletes also, perfectionistic strivings are associated with mastery-approach and performance-approach goals, whereas perfectionistic concerns are associated with masteryavoidance, performance-approach, and performance-avoidance goals. Our findings corroborate the importance of differentiating between perfectionistic strivings and perfectionistic concerns when studying perfectionism in sports, because only perfectionistic concerns (and not perfectionistic strivings) are associated with maladaptive patterns of achievement goals

Drug-like antagonists of P2Y receptors — from lead identification to drug development

P2Y receptors are expressed in virtually all cells and tissue types and mediate an astonishing array of biological functions, including platelet aggregation, smooth muscle cell proliferation, and immune regulation. The P2Y receptors belong to the G protein-coupled receptor superfamily and are composed of eight members encoded by distinct genes that can be subdivided into two groups on the basis of their coupling to specific G-proteins. Extensive research has been undertaken to find modulators of P2Y receptors, although to date only a limited number of small-molecule P2Y receptor antagonists have been approved by drug/medicines agencies. This Perspective reviews the known P2Y receptor antagonists, highlighting oral drug-like receptor antagonists, and considers future opportunities for the development of small molecules for clinical evaluation

A Substantial Population of Low Mass Stars in Luminous Elliptical Galaxies

The stellar initial mass function (IMF) describes the mass distribution of stars at the time of their formation and is of fundamental importance for many areas of astrophysics. The IMF is reasonably well constrained in the disk of the Milky Way but we have very little direct information on the form of the IMF in other galaxies and at earlier cosmic epochs. Here we investigate the stellar mass function in elliptical galaxies by measuring the strength of the Na I doublet and the Wing-Ford molecular FeH band in their spectra. These lines are strong in stars with masses <0.3 Msun and weak or absent in all other types of stars. We unambiguously detect both signatures, consistent with previous studies that were based on data of lower signal-to-noise ratio. The direct detection of the light of low mass stars implies that they are very abundant in elliptical galaxies, making up >80% of the total number of stars and contributing >60% of the total stellar mass. We infer that the IMF in massive star-forming galaxies in the early Universe produced many more low mass stars than the IMF in the Milky Way disk, and was probably slightly steeper than the Salpeter form in the mass range 0.1 - 1 Msun.Comment: To appear in Natur