Medindo cidades sustentáveis na Rússia: análise crítica de metodologias-chave

The paper provides insights on the critical analysis of the current methodologies of the sustainability cities measurement for the present-day Russia. Based on meta-analysis of more than 90 peer-reviewed papers published in Russian and English, we examined both authoring and corporate methodologies such as the SGM methodology for Russian sustainable cities, the environmental rating of Russian cities, and the rating of the environmental governance of the Russian cities, the environmental efficacy index and several authoring methodologies. The analysis showed that most of the calculation methods are based on quantitative (statistical) data, what is their advantage, on the one hand, making their results as objective as possible, but on the other hand, it is a disadvantage, because in connection with the delay in publication of statistics or even its absence, it does not allow the annual dynamics to observe. In addition, the difficulty in choosing the most suitable methodology lies in the significant differences in the development of large, medium and small cities in Russia, and many rating methods are developed exclusively for one of the types of cities. Authors concluded that in spite of the high level of the existing methodologies development, there was a shortage of comprehensive studies carried out in the qualitative-quantitative paradigm that would, in addition to index assessment and mathematical models generation, explain complex causal relationships and processes within a city.El documento proporciona información sobre el análisis crítico de las metodologías actuales de la medición de ciudades de sostenibilidad para la Rusia actual. Con base en el metanálisis de más de 90 artículos revisados por pares publicados en ruso e inglés, examinamos tanto las metodologías de autoría y corporativas como la metodología SGM para ciudades sostenibles rusas, la calificación ambiental de las ciudades rusas y la calificación de la gobernanza ambiental de las ciudades rusas, el índice de eficacia ambiental y varias metodologías de autoría. El análisis mostró que la mayoría de los métodos de cálculo se basan en datos cuantitativos (estadísticos), lo que es su ventaja, por un lado, hacer que sus resultados sean lo más objetivos posible, pero por otro lado, es una desventaja, porque en conexión con el retraso en la publicación de las estadísticas o incluso su ausencia, no permite observar la dinámica anual. Además, la dificultad de elegir la metodología más adecuada radica en las diferencias significativas en el desarrollo de ciudades grandes, medianas y pequeñas en Rusia, y muchos métodos de calificación se desarrollan exclusivamente para uno de los tipos de ciudades. Los autores concluyeron que, a pesar del alto nivel de desarrollo de las metodologías existentes, había una escasez de estudios exhaustivos llevados a cabo en el paradigma cualitativo-cuantitativo que, además de la evaluación del índice y la generación de modelos matemáticos, explicaran relaciones y procesos causales complejos dentro de una ciudad.O artigo fornece insights sobre a análise crítica das metodologias atuais da medição das cidades de sustentabilidade para a Rússia atual. Com base na meta-análise de mais de 90 artigos revisados por pares publicados em russo e inglês, examinamos metodologias de autoria e corporativas, como a metodologia SGM para cidades russas sustentáveis, a classificação ambiental de cidades russas e a classificação da governança ambiental. das cidades russas, o índice de eficácia ambiental e várias metodologias de autoria. A análise mostrou que a maioria dos métodos de cálculo são baseados em dados quantitativos (estatísticos), o que é sua vantagem, por um lado, tornando seus resultados tão objetivos quanto possível, mas, por outro lado, é uma desvantagem, porque em com o atraso na publicação das estatísticas ou mesmo sua ausência, não permite que a dinâmica anual observe. Além disso, a dificuldade em escolher a metodologia mais adequada reside nas diferenças significativas no desenvolvimento de grandes, médias e pequenas cidades na Rússia, e muitos métodos de classificação são desenvolvidos exclusivamente para um dos tipos de cidades. Os autores concluíram que, apesar do alto nível de desenvolvimento das metodologias existentes, houve escassez de estudos abrangentes realizados no paradigma qualitativo-quantitativo que, além da avaliação de índices e da geração de modelos matemáticos, explicariam relações e processos causais complexos Uma cidade

Пенсионное страхование в России: современное состояние и возможности трансформации

 The article examines and analyzes the essence of pension relations in modern Russia. The aim of the article is to study and test the hypothesis that an important factor in ensuring the effectiveness of the Russian pension system is a clear definition of the essence of economic relations in it, as well as adequate legal and organizational formalization of these relations. The scientific novelty of the study lies in the analysis of the validity and adequacy of applying (from terminological to organizational and practical levels) the classical insurance principles in the organization of the pension system, as well as the possibilities of increasing the efficiency of this system on the basis of the insurance sector. The research methodology is based on the analysis of the genesis and current state of the Russian pension system. The results of the study indicate that the structure of the Russian pension system requires serious reorganization, in particular, a clear distinction between the insurance (pension insurance) and non-insurance (pension provision) segments. The authors substantiated that pension insurance should be based on the classical principles of life insurance, and insurers who have an appropriate license obtained under the Law “On the organization of insurance business in the Russian Federation” should be involved in the implementation of this insurance. At the same time, non-state pension funds must either be transformed into life insurers, or acquire new functionality within the framework of pension provision (the non-insurance part of the pension system). The practical implementation of the research results and related recommendations will allow, according to the authors, to organically structure the insurance and non-insurance segments of the Russian pension system and increase its efficiency. The authors conclude that the construction of pension insurance on the basis of the classical principles of life insurance will make it possible to fully use the accumulated global and domestic experience of using life insurance as a reliable instrument for financing pensions. At the same time, it is necessary to extend to pension relations the norms of regulation of the insurance market and state insurance supervision, which have proven their effectiveness.  Авторы анализируют сущность пенсионных отношений в современной России. Цель исследования — проверка гипотезы о том, что важным фактором обеспечения эффективности российской пенсионной системы является четкое определение сущности экономических отношений внутри нее, а также их адекватное правовое и организационное оформление. Научная новизна исследования заключается в анализе обоснованности и адекватности использования (от терминологического до организационно-практического уровней) классических страховых принципов в организации пенсионной системы, а также возможностей повышения  эффективности этой системы на основе страхового дела. В основе методологии исследования лежит анализ генезиса и современного состояния российской пенсионной системы. Показано, что структура российской пенсионной системы требует серьезной реорганизации, в частности четкого разграничения страхового (пенсионное страхование) и нестрахового (пенсионное обеспечение) сегментов. Обосновано, что пенсионное страхование должно основываться на классических принципах страхования жизни, а реализацией данного страхования должны заниматься страховщики, имеющие соответствующую лицензию, полученную в рамках Закона  «Об организации страхового дела в РФ». При этом негосударственные пенсионные фонды должны либо быть преобразованы в страховщиков жизни, либо приобрести новый функционал в  рамках пенсионного обеспечения (нестраховой части пенсионной системы). Практическая реализация  результатов исследования и связанных с ними рекомендаций позволит, по мнению авторов, органично структурировать страховой и нестраховой блоки российской пенсионной системы и  повысит ее эффективность. Авторы делают вывод, что построение пенсионного страхования на базе классических принципов страхования жизни позволит в полной мере использовать накопленный мировой и отечественный опыт использования страхования жизни как надежного инструмента финансирования пенсий. При этом на пенсионные отношения необходимо распространить подтвердившие свою эффективность нормы регулирования страхового рынка и государственного страхового надзора.

Fixed and separate combination of solifenacin and tamsulosin in urinary disorders associated with benign prostatic hyperplasia: a choice based on price and value comparison

Objective. To determine the consequences of the use of a fi xed combination of solifenacin and tamsulosin in patients whom recommended the prescription of these drugs. Methods. Analysis of prices of drugs solifenacin + tamsulosin controlled release (Vasomni), solifenacin (Vesicare), tamsulosin controlled release (Omnic Okas) and tamsulosin modifi ed-release (several registered trade names of the drug) conducted on the basis of information from several sources: 1 — the register of maximum ex-works prices of manufacturers of vital and essential medicines, 2 — data on average prices in pharmacies of Moscow (as of 15.02.2018), 3 — weighted average prices of public procurement for 2018 according to the monitoring of the pharmaceutical market. To determine the points of relative value of drugs, a survey of experts was conducted: 1 — to determine the values of the criteria for the drugs under consideration — urologists; 2 — to determine the weight of the criteria — persons involved in the decision-making on the selection and purchase of drugs. Results. We found that the cost of the equivalent course dose of Vesomni was on 40-42 % lower than the combination of drugs Vesicar and Omnik Okas. Compared with the non-fi xed combination of solifenacin with tamsulosin in a drug form with modifi ed release, no signifi cant diff erences in price levels were found. At the same time, the relative value of a fi xed combination is 5-6 percentage points higher compared to non-fi xed combinations, mainly due to ease of use. Conclusion. Use of a fi xed combination of solifenacin + tamsulosin can lead to budget savings with an increase in the level of relative value

Flow-injection systems for determining iron(III) and iodide with the use of catalytic reactions

Flow-injection systems with spectrophotometric detection were developed on the basic of catalytic reactions, namely, the Fe(III)-catalyzed oxidation of methanol with hydrogen peroxide and the iodide-catalyzed cerium-arsenite reaction. The developed systems were used to analyze industrial and natural waters. The detection limits attained were as low as 0.02 μg/mL of Fe(III) and 0.2 μg/mL of I- at relative standard deviations of 2-7% with the throughoutput of 35 and 25 h-1, respectively. © 1997 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Single and molecular ion irradiation-induced effects in GaN : experiment and cumulative MD simulations

An investigation of mechanisms of enhancement of irradiation-induced damage formation in GaN under molecular in comparison to monatomic ion bombardment is presented. Ion-implantation-induced effects in wurtzite GaN bombarded with 0.6 keV amu(-1) F, P, PF2, PF4, and Ag ions at room temperature are studied experimentally and by cumulative MD simulation in the correct irradiation conditions. In the low dose regime, damage formation is correlated with a reduction in photoluminescence decay time, whereas in the high dose regime, it is associated with the thickness of the amorphous/disordered layer formed at the sample surface. In all the cases studied, a shift to molecular ion irradiation from bombardment by its monatomic constituents enhances the damage accumulation rate. Implantation of a heavy Ag ion, having approximately the same mass as the PF4 molecule, is less effective in surface damage formation, but leads to noticeably higher damage accumulation in the bulk. The cumulative MD simulations do not reveal any significant difference in the total amount of both point defects and small defect clusters produced by light monatomic and molecular ions. On the other hand, increased production of large defect clusters by molecular PF4 ions is clearly seen in the vicinity of the surface. Ag ions produce almost the same number of small, but more large defect clusters compared to the others. These findings show that the higher probability of formation of large defect clusters is important mechanism of the enhancement of stable damage formation in GaN under molecular, as well as under heavy monatomic ion irradiation.Peer reviewe

The investigation of dangerous geological processes resulting in land subsidence while designing the main gas pipeline in South Yakutia

The number of gas main accidents has increased recently due to dangerous geological processes in underdeveloped areas located in difficult geological conditions. The paper analyses land subsidence caused by karst and thermokarst processes in the right of way, reveals the assessment criteria for geological hazards and creates zoning schemes considering the levels of karst and thermorkarst hazards

Anti-vortex state in cross-like nanomagnets

We report on results of computer micromodelling of anti-vortex states in asymmetrical cross-like ferromagnetic nanostructures and their practical realization. The arrays of cobalt crosses with 1 mkm branches, 100 nm widths of the branches and 40 nm thicknesses were fabricated using e-beam lithography and ion etching. Each branch of the cross was tapered at one end and bulbous at the other. The stable formation of anti-vortex magnetic states in these nanostructures during magnetization reversal was demonstrated experimentally using magnetic force microscopy.Comment: 19 pages, 9 figure

Основные направления анализа экономических затрат при оказании онкологической помощи населению

Introduction. The economic aspects of providing cancer care to the public attract increasing attention of scientists, economists, physicians and other healthcare professionals. Currently, the healthcare economics of oncological institutions is defined as part of the national economy that implements cancer care programs and provide a wide range of medical and pharmaceutical services to the public.Aim. The study was conducted as part of the program for improvement of financial spending in order to facilitate cancer care for Moscow residents. The aim of this study was to identify the crucial areas of the cost analysis and thus improve the public health service.Materials and methods. We used the methodology of targeted and consistent search of the literature. The data search and analysis was carried out using the US National Medical Library (PubMed database), National Electronic Library (e-LIBRARY, Russia), and other Internet resources. Whenever possible, articles on the most common and socially significant types of cancer (breast, colon, prostate, lung etc.) were selected. In addition, we focused on significant studies conducted either on the national or international level.Results and discussion. In principle, the structure of total costs is determined by the health policy regarding the cancer care system. Six main areas of oncological care that require careful economic analysis have been identified: those are prevention, oncoscreening, diagnosis, treatment, rehabilitation, and palliative care. In order to implement the economic goals of the healthcare system, the cost of cancer treatment should be discussed. The relevant programs are expected to be based on 1) prevalence and incidence; 2) impact on health; 3) results of the integrative methodological approach to cancer treatment; 4) implementation of comprehensive measures of medical and social assistance; 5) use of financial mechanisms and their impact on economic indicators.Conclusion. The set of measures related to the direct costs as identified in this study include the development, planning and provision of cancer care. These specific features of the direct cost analysis are important for organizing medical care in oncological institutions.Введение. Экономические вопросы обеспечения онкологической помощи населению привлекают все большее внимание со стороны ученых-экономистов, врачей-организаторов здравоохранения, медицинских менеджеров. В настоящее время под экономикой здравоохранения учреждений онкологического профиля понимается прежде всего отраслевая экономика народного хозяйства, реализующая программы по сохранению и укреплению общего здоровья граждан, профилактики онкозаболеваний и их распространения, предоставления широкого ряда медицинских и фармацевтических услуг по заданным направлениям медицинской помощи.Цель – идентификация наиболее важных направлений для анализа экономических затрат, влияющих на эффективность оказания медицинских услуг пациентам с онкологическими заболеваниями.Материалы и методы. В работе применена методология целевого и смыслового поиска источников литературы. Поиск и анализ данных проведен с использованием Национальной медицинской библиотеки США (база данных PubMed), интернет-ресурсов, Национальной электронной библиотеки (НЭБ) e-LIBRARY (Россия). Отбирались статьи, посвященные наиболее распространенным и социально значимым видам рака (рак молочной железы, ободочной кишки, предстательной железы, рак легкого и т. д.). Кроме того, во внимание, главным образом, принимались крупные исследования, проведенные на уровне отдельных государств или обобщающие опыт нескольких стран.Результаты и обсуждение. Принципы формирования общих затрат продиктованы политикой здравоохранения в отношении системы оказания онкологической помощи. Идентифицировано шесть основных направлений онкологической помощи, на обеспечение которых распределяются финансовые средства, подлежащие тщательному экономическому анализу: профилактика, онкоскрининг, диагностика, лечение, реабилитация, паллиативная помощь. В целях реализации экономических задач системы здравоохранения следует обсуждать перспективные программы, посвященные вопросам затрат на лечение рака. Эти программы формируются на основании таких коррелирующих данных, как: 1) распространенность и заболеваемость; 2) показатели воздействия на здоровье; 3) результаты внедрения интегративного методического подхода к лечению рака; 4) исходы применения всесторонних мер по оказанию медицинской и социальной помощи; 5) результаты внедрения финансовых механизмов и их влияние на экономические показатели.Заключение. В современную профессиональную деятельность всех участников медицинской отрасли входит разработка, планирование и обеспечение комплекса мер, связанных, главным образом, с прямыми затратами на идентифицированные в нашей работе направления. Выявление наиболее важных для последующего исследования особенностей прямых затрат на организацию работы основных направлений медицинской помощи в совокупности с ассоциированными показателями эффективности может способствовать совершенствованию деятельности учреждений здравоохранения онкологического профиля

Ocrelizumab in treatment of primary-progressive multiple sclerosis: systematic review

Aim. To analyze the efficacy, safety and pharmacoeconomic indicators of ocrelizumab in adult patients with primary progressive multiple sclerosis (PPMS). Methods. An information search was conducted in the databases Embase, PubMed, Cochrane and eLibrary.ru. The levels of evidence were determined in the studies. Results. Therapy with ocrelizumab compared with placebo characterized by a decrease in the rate of progression of the disease. Treatment with ocrelizumab was associated with a significant slowdown in progression compared to other drugs: rituximab, fingolimod, myelin basic protein peptide 82–98, intravenous immunoglobulin; plasmapheresis / plasma metabolism, corticosteroids, general irradiation of lymphoid tissue, and other most common adverse events: infusion reactions, nasopharyngitis, upper tract respiratory and urinary tract infections, headaches. Life years and quality-adjusted life years for patients receiving ocrelizumab were 16.11 and 3.33, compared with 15.61 and 2.75 for patients receiving better supportive care, respectively. The annual average potential impact on the budget for 1 patient with PPMS in the treatment of ocrelizumab for 5 years ranged from $ 18,300 to 44 200. Conclusions. Ocrelizumab is the only drug that has proven its clinical efficacy in the previously non-curable type of multiple sclerosis, PPC, with risk profile acceptable with respect to clinical benefits