Soliton dual comb in crystalline microresonators

We present a novel compact dual-comb source based on a monolithic optical crystalline MgF$_2$ multi-resonator stack. The coherent soliton combs generated in two microresonators of the stack with the repetition rate of 12.1 GHz and difference of 1.62 MHz provided after heterodyning a 300 MHz wide radio-frequency comb. Analogous system can be used for dual-comb spectroscopy, coherent LIDAR applications and massively parallel optical communications.Comment: 5 pages, 5 figure

A latent variable ranking model for content-based retrieval

34th European Conference on IR Research, ECIR 2012, Barcelona, Spain, April 1-5, 2012. ProceedingsSince their introduction, ranking SVM models [11] have become a powerful tool for training content-based retrieval systems. All we need for training a model are retrieval examples in the form of triplet constraints, i.e. examples specifying that relative to some query, a database item a should be ranked higher than database item b. These types of constraints could be obtained from feedback of users of the retrieval system. Most previous ranking models learn either a global combination of elementary similarity functions or a combination defined with respect to a single database item. Instead, we propose a “coarse to fine” ranking model where given a query we first compute a distribution over “coarse” classes and then use the linear combination that has been optimized for queries of that class. These coarse classes are hidden and need to be induced by the training algorithm. We propose a latent variable ranking model that induces both the latent classes and the weights of the linear combination for each class from ranking triplets. Our experiments over two large image datasets and a text retrieval dataset show the advantages of our model over learning a global combination as well as a combination for each test point (i.e. transductive setting). Furthermore, compared to the transductive approach our model has a clear computational advantages since it does not need to be retrained for each test query.Spanish Ministry of Science and Innovation (JCI-2009-04240)EU PASCAL2 Network of Excellence (FP7-ICT-216886

Molecular genetic characteristics of gastric cancers from the surgeon’s point of view

Dubinina V. G., Mashukov A. A., Lukyanchuk O. V., Bilenko A. A., Zgura A. N., Raciborsky D. V., Lee S. N. Molecular genetic characteristics of gastric cancers from the surgeon’s point of view. Journal of Education, Health and Sport. 2016;6(11):592-621. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.200394 http://ojs.ukw.edu.pl/index.php/johs/article/view/4063 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015). 755 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2016; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.11.2016. Revised 22.11.2016. Accepted: 30.11.2016. MOLECULAR GENETIC CHARACTERISTICS OF GASTRIC CANCERS FROM THE SURGEON’S POINT OF VIEW V. G. Dubinina1, A. A. Mashukov2, O. V. Lukyanchuk2, A. A. Bilenko1, A. N. Zgura2, D. V. Raciborsky2, S. N. Lee2 1Odessa National Medical university 2Odessa Regional Oncology center Summary A study on the expression of oncoproteins in stomach` carcinomas, has been turned into a real research basically due to the abundance of results and their comprehensive interpretations. The study carried out on the abdominal onco-surgical department of Odessa Regional Oncology Center, included a study of 188 patients operated on for gastric cancer (GC) between 2007-2011. In all cases was performed the so-called lymphadenectomy for the principal reason of extensive preventive biopsy of visually unchanged lymph nodes. We spend a multivariate analysis of interactions between the expression of oncoproteins p53, VEGFR-3, erbB2, Ki67 and micro involvement of tumor vasculature (ly, v), the local growth (T), the presence of residual tumor tissue (the R), the degree of tumor differentiation (the G) the degree of regional lymph nodes involvement (N) and type of infiltration (Inf α, β, Inf Υ). Keywords: Stomach cancer, Immunohistochemistry and Oncoproteins

Statistical Mechanics of Semi-Supervised Clustering in Sparse Graphs

We theoretically study semi-supervised clustering in sparse graphs in the presence of pairwise constraints on the cluster assignments of nodes. We focus on bi-cluster graphs, and study the impact of semi-supervision for varying constraint density and overlap between the clusters. Recent results for unsupervised clustering in sparse graphs indicate that there is a critical ratio of within-cluster and between-cluster connectivities below which clusters cannot be recovered with better than random accuracy. The goal of this paper is to examine the impact of pairwise constraints on the clustering accuracy. Our results suggests that the addition of constraints does not provide automatic improvement over the unsupervised case. When the density of the constraints is sufficiently small, their only impact is to shift the detection threshold while preserving the criticality. Conversely, if the density of (hard) constraints is above the percolation threshold, the criticality is suppressed and the detection threshold disappears.Comment: 8 pages, 4 figure

Some novel ways of gastric cancer patients treatment personification

In this paper the authors perform the analysis of molecular and morphological factors influencing the survival of patients with gastric cancer (n = 221). They analyzed the survival rate in this group of patients based on the analysis of molecular markers VEGFR, p53, Her2, Ki-67. Measured role in the survival such factors as the degree of differentiation of primary gastric tumors, the presence of microscopic tumor involvement of perineural and perivascular spaces, the degree of invasion to gastric wall by T1 = 1 and to T4a = 4, T4b = 5, number of regional lymph nodes affected by metastasis, and other factors. As an arbitrator used survival curves calculated by the method of R. J. Cox, time of lifespan, measured in months, as well as a comparison of the areas under the curves of survival

Reducing the distortion in thin-sheet structures made from high-strength steel based on CAE-welded joint analysis

High competition in the field of mechanical engineering requires the manufacture of lightweight thin-sheet structures made of high-strength steels ensuring the geometry of a certain accuracy. Supporting a given geometry is achievable by improving methods to reduce residual deformations. Therefore, the purpose of the investigation is to reduce the distortion based on the analysis of the influence of clamping rigidity on the stress-strain state of the assembly using computer simulation by the finite element method. The result of the study is a clamping model that allows to adjust the level of residual stresses and deformations, confirmed experimentally. © 2019 IOP Publishing Ltd.Foundation for Assistance to Small Innovative Enterprises in Science and Technology, FASIE: 11995GU/2017The present study was supported by FASIE Grant №11995GU/2017. This work was done within the state order of IMP UB RAS on the subject “Laser”

Novel data according Will Roger`s phenomenon in stomach cancer patients

Mostly Will Roger`s phenomenon means existence of so-called "jumping" or "jumping over the stages" regional metastases in the stomach cancer patients. N1 in the 6th edition means 16 regional lymph nodes involvement, while the N1 seventh edition – only 1-2 of regional lymph nodes involvement. This means that T1N1Mo \ 6th and T1N1Mo \ 7th - not quite the same, and the survival of the two groups will be different. The study, made on the abdominal oncosurgical department of Odessa Regional Oncology Center, included 188 patients operated for gastric cancer in the period 2007-2011. The study included only radically treated patients. Comparison of survival in patients with gastric cancer between 6th revision groups of 7th has been reviewed. The classification mission is to provide differences in the survival rates between the groups. Regression multivariate Cox analysis showed that 7th UICC classification showed different capability of stratifying survival groups of UICC N classification (P \ 0.01)

Учет априорной информации при итерационной реконструкции изображений литейных изделий

Methods of restoring images and properties of non-destructive testing objects based on solving inverse problems (problems of restoring distribution functions of unknown characteristics of an object based on the results of indirect measurements) are considered. Management methods are based on solving inverse problems and allow you to get the most complete information about the distributed properties of an object. The need to attract additional information imposes serious restrictions on the development of universal applied algorithms for solving incorrectly set tasks. As a rule, individual additional information is available for each specific non-destructive testing task. An effective numerical algorithm for solving an incorrectly posed problem should be focused on taking this information into account at each stage of the solution search. When solving an applied problem, it is also necessary that the algorithm corresponds to both the measuring capabilities and the capabilities of available computing tools. The problem of low-projection X-ray tomography is always associated with a lack of initial data and can only be solved using a priori information. To introduce the necessary additional information into the numerical algorithm, the methods of iterative reconstruction of tomographic images are identified as the most suitable. One of the approaches to the presentation of this kind of information is described. A practical solution to this problem will expand the scope of the X-ray tomography method.Рассматриваются методы восстановления изображений и свойств объектов неразрушающего контроля, основанные на решении обратных задач (задач восстановления функций распределения неизвестных характеристик объекта по результатам косвенных измерений). Методы управления основаны на решении обратных задач и позволяют получить наиболее полную информацию о распределенных свойствах объекта. Необходимость привлечения дополнительной информации накладывает серьезные ограничения на разработку универсальных прикладных алгоритмов решения некорректно поставленных задач. Для каждой конкретной задачи неразрушающего контроля, как правило, имеется индивидуальная дополнительная информация. Эффективный численный алгоритм решения некорректно поставленной задачи должен быть ориентирован на учет этой информации на каждом этапе поиска решения. При решении прикладной задачи также необходимо, чтобы алгоритм соответствовал как измерительным возможностям, так и возможностям доступных вычислительных средств. Проблема низкопроекционной рентгеновской томографии всегда связана с недостатком исходных данных и может быть решена только с использованием априорной информации. Для введения необходимой дополнительной информации в численный алгоритм в качестве наиболее подходящих определены методы итеративной реконструкции томографических изображений. Описан один из подходов к представлению такого рода информации. Практическое решение указанной проблемы расширит область применения метода рентгеновской томографии

Analysis of survival after radical surgery for stomach cancer in odessa regional cancer center

The survival of patients with the locally advanced stage of stomach cancer (SC), who underwent various variants of preventive lymphatic nodes dissection, was considered. The survival of patients was compared with the stage and T, N indexes. Lymphadenectomy D2 were effective and increased cumulative survival in patient`s group T4aNoMo, stage IIB and T4aN1Mo, stage III A, and in groups of patients where D2 lymphadenectomy were ineffective - T4bNoMo, stage ІІІB, T4bN1Мo, stage ІІІB and T4aN2Мo, stage IIIB. D2 were more efficient operation in the case of tumor serosa invasion and invasion to the peritoneal cavity (SE) in the absence of multiple metastases to the regional lymph nodes (N1 according to the 7th revision of the classification - 1-2 metastatic lymph nodes), and when the tumor infiltrated the surrounding organs (SI) and the presence of multiple regional metastases, D2 lymphodissection did not gave positive results, comparising with D1

Evaluation advanced lymph node dissection impact on long-term survival rate of gastric cancer patients. Journal of Education

Over a period of 2007-2011 188 stomach cancer (SC) patients have been included in the research in abdominal oncosurgical department of Odessa regional oncological dispensary. It was retrospective, one-center, nonrandomized research. Volume of lymph node dissections differed by quantity of lymph nodes to be removed. All patients were divided into three groups. Patients with D1 or D1+ lymph node dissections have been performed, totally 90 patients are included in group of historical control. The main group includes 33 patients to whom D3 lymph node dissections is executed and, finally, control group – 65 patients dissected up to the D2 volume. In all cases so-called lymph node dissections for principal reasons have been executed. The multifactorial analysis of patients survival is implemented depending on a type of a lymph node dissections, a stage of the cancer, number of involved lymph nodes, involvement of the tumoral microcirculatory net (ly is carried out, v) signs of a perinevral invasion (Nev), availability of residual tumoral tissue (R), degree of a differentiation (G). Regardless of a disease stage, SC at 60% of patients, represented with initially hematologicaly disseminated disease. 40% of SC`s had no signs of intratumoral microcirculatory net involvement even in case of more than 15 regional lymph nodes are involved. In the absence of a SC perinevral invasion appeared to be the most precise predictive marker. The conclusion is made some brand new additional53 prognostic factors could play a crucial role in more accurate patients selection for expanded lymph node dissections