Ökolandbau in Bulgarien–vor allem Arznei- und Aromapflanzen sowie Waldfrüchte, Obst und Bio-Honig für den Export

The statistical data of the Bulgarian Ministry of Agriculture show an certified growing area of 9 370 ha in near 80 farm holdings for organic plant production, 2 in mixed plant and animal production and 5 organic livestock breeding farms. Much bigger area of ca. 155 793 ha is certified grassland and protected areas for wild collection of herbs and wild berries. The average agricultural holdings cover 0,5 ha. Two hubs in South and North Bulgaria launched the pilot Organic Herbs initiative in an UNDP JOBS project at the end of 2002. Now 8 support centers have nurseries for organic seeds and seedlings, trail plots, demonstration and production fields, driers and primary processing facilities. The main products are sage, lemon balm, peppermint, valerian, mountain tea, savory, chamomile, dog-rose, lavender, thyme, hyssop and marigold

Accelerator as an Instrument of Interaction Between Innovative Projects with Partner Enterprises

В данной статье рассмотрены существующие форматы реализации инновационной деятельности и особенности взаимодействия инновационных проектов и предприятий - партнеров в рамках акселерационных программ.This article considers the existing formats of innovation activity implementation and peculiarities of interaction between innovation projects and partner enterprises within the framework of accelerator programmes

Is there an informal employment wage premium? Evidence from Tajikistan

This paper defines informal sector employment and decomposes the difference in earnings between formal and informal sector employees in Tajikistan for 2007. Using quantile regression decomposition technique proposed by JAE, 20:445-465, 2005and considering self-selection of individuals into different employment types, we find a significant informal employment wage premium across the whole earnings distribution. Taking advantage of RES, 90:290-299, 2008matching approach and considering the possibility of misleading results due to different observed characteristics of formal and informal workers, we still find a wage gap in favour of informal sector workers

Online courses as the individual educational trajectory of the student

The article describes the features of the individual educational trajectory of the student presented in the format of open educational resources, in particular, online courses; presents the results of a survey of students and draws conclusions from these data on the opinion formed about the courses, about the expectations from it.В статье рассмотрены особенности индивидуальной образовательной траектории студента, представленные в формате открытых образовательных ресурсов, в частности, онлайн курсов; представлены результаты анкетирования студентов и сделаны выводы по этим данным о мнении, сформировавшемся о курсах, об ожиданиях от их прохождения

Black sea observing system

The ultimate goal of modern operational oceanography are end user oriented products with high scientific quality. Beneficiaries are the governmental services, coast and offshore based enterprises and research institutions that make use of the products generated by operational oceanography. Direct users are coastal managers, shipping, search and rescue, oil spill combat, offshore industry, ports, fishing, tourism, and recreation industry. Indirect beneficiaries, through climate forecasting based on ocean observations, are food, energy, water and medical suppliers. Availability of updated information on the actual state as well as forecast of marine environment is essential for the success and safety of maritime operations in the offshore industry. Various systems for the collection and presentation of marine data for the needs of different users have been developed and put in operation in the Black Sea. The systems are located both along the coast and in the open sea and the information they provide is used by both the maritime industry and the widest range of users. The Black Sea Monitoring and Forecasting Center in the frame of the Copernicus Marine Service is providing regular and systematic information about the physical state of the ocean, marine ecosystem and wave conditions in the Black Sea area, assimilating observations, keeping efficient operations, advanced technology and high quality modeling products. Combining and optimizing in situ, remote sensing, modeling and forecasting into a Black Sea observing system is a task that has to be solved, and that will allow to get a more complete and comprehensive picture of the state of the marine environment as well as to forecast future changes of physical and biogeochemical state of the Black Sea and the Black Sea ecosystem

HST/WFPC2 Color-Magnitude Diagrams for Globular Clusters in M31

We report new HST/WFPC2 photometry for 10 globular clusters (GC) in M31 observed in F5555W(V) and F814W(I). Additionally we have reanalyzed HST archival data of comparable quality for 2 more GCs. Extraordinary care is taken to account for the effects of blended stellar images and required field subtraction. We thus reach 1 mag fainter than the horizontal branch (HB) even in unfavorable cases. We present the color-magnitude diagrams (CMDs) and discuss their main features also in comparison with the properties of the Galactic GCs. This analysis is augmented with CMDs previously obtained and discussed by Fusi Pecci et al. (1996) on 8 other M31 clusters. We report the following significant results: 1. The locus of the red giant branches give reliable metallicity determinations which compare generally very well with ground-based integrated spectroscopic and photometric measures, as well as giving good reddening estimates. 2. The HB morphologies show the same behavior with metallicity as the Galactic GCs, with indications that the 2nd-parameter effect can be present in some GCs of our sample. However, at [Fe/H] ~ -1.7 we observe a number of GCs with red HB morphology such that the HB type versus [Fe/H] relation is offset from the MW and resembles that of the Fornax dwarf spheroidal galaxy. One explanation for the offset is that they are younger than their MW counterparts by 1-2 Gyr. 3. The Mv(HB)-[Fe/H] relationship has been determined and the slope (~0.20) is very similar to the values derived from RR Lyrae stars in the MW and the LMC. The zero-point of this relation based on the assumed distance modulus (m-M)o(M31)=24.47+/-0.03 is consistent with (m-M)o(LMC)=18.55.Comment: 50 pages, 12 figures (one in jpeg format), 8 tables, accepted for publication in The A

Polycation-π Interactions Are a Driving Force for Molecular Recognition by an Intrinsically Disordered Oncoprotein Family

Molecular recognition by intrinsically disordered proteins (IDPs) commonly involves specific localized contacts and target-induced disorder to order transitions. However, some IDPs remain disordered in the bound state, a phenomenon coined "fuzziness", often characterized by IDP polyvalency, sequence-insensitivity and a dynamic ensemble of disordered bound-state conformations. Besides the above general features, specific biophysical models for fuzzy interactions are mostly lacking. The transcriptional activation domain of the Ewing's Sarcoma oncoprotein family (EAD) is an IDP that exhibits many features of fuzziness, with multiple EAD aromatic side chains driving molecular recognition. Considering the prevalent role of cation-π interactions at various protein-protein interfaces, we hypothesized that EAD-target binding involves polycation- π contacts between a disordered EAD and basic residues on the target. Herein we evaluated the polycation-π hypothesis via functional and theoretical interrogation of EAD variants. The experimental effects of a range of EAD sequence variations, including aromatic number, aromatic density and charge perturbations, all support the cation-π model. Moreover, the activity trends observed are well captured by a coarse-grained EAD chain model and a corresponding analytical model based on interaction between EAD aromatics and surface cations of a generic globular target. EAD-target binding, in the context of pathological Ewing's Sarcoma oncoproteins, is thus seen to be driven by a balance between EAD conformational entropy and favorable EAD-target cation-π contacts. Such a highly versatile mode of molecular recognition offers a general conceptual framework for promiscuous target recognition by polyvalent IDPs. © 2013 Song et al

Wissenschaftliche Monitoringkonzepte für die Deutsche Bucht (WIMO) - Abschlussbericht

The state and development of coastal marine systems and an understanding of the interaction of organisms, sea floor, water column, and biochemical and physical processes can only be obtained by a combination of long-term monitoring and modelling approaches of different complexity. A need for the development and evaluation of monitoring strategies is driven by a framework of different European and German regulations. The research project WIMO (Scientific Monitoring Concepts for the German Bight) has developed concepts and methods that aim at a fundamental scientific understanding of marine systems and also meet monitoring requirements of European legislation and regulations like the EU Marine Strategy Framework Directive. In this final report examples of common descriptors of ecosystem state like seabed integrity, eutrophication, and biodiversity are discussed. It has been assessed to what extent established measuring procedures used to survey the characteristics of the sea floor, and newly developed technologies are eligible for governmental monitoring. The significance of integrative modelling for linking and visualising results of measurements and models is illustrated. It is shown how new concepts have been implemented into governmental monitoring in the form of web based data sheets. These insights enable continuous analyses and developments in the future

Balkans' Asteraceae Species as a Source of Biologically Active Compounds for the Pharmaceutical and Food Industry

Herbal drugs are a useful source of different bioactive compounds. Asteraceae species, as the most widespread vascular plants, can be used both as food and as medicine due to the great diversity of recorded chemical components - different phenolic compounds, terpenes, carotenoids, vitamins, alkaloids, etc. The Balkan Peninsula is characterized by great diversity of plants from Asteraceae family, including presence of rare and endemic species. In this review, results of the survey of chemical composition and biological activity, mainly focusing on antioxidant, antimicrobial and anticancer effects of selected Balkans' Asteraceae species were provided. In addition, information on edible plants from Asteraceae family is presented, due to growing interest for the so-called 'healthy diet' and possible application of Balkans' Asteraceae species as food of high nutritional value or as a source of functional food ingredients.This is peer-reviewed version of the following article: Kostić, A.; Janacković, P.; Kolasinac, S. M.; Dajić-Stevanović, Z. Balkans’ Asteraceae Species as a Source of Biologically Active Compounds for the Pharmaceutical and Food Industry. Chemistry & Biodiversity 2020, 17 (6). [https://doi.org/10.1002/cbdv.202000097

Binding Free Energy Landscape of Domain-Peptide Interactions

Peptide recognition domains (PRDs) are ubiquitous protein domains which mediate large numbers of protein interactions in the cell. How these PRDs are able to recognize peptide sequences in a rapid and specific manner is incompletely understood. We explore the peptide binding process of PDZ domains, a large PRD family, from an equilibrium perspective using an all-atom Monte Carlo (MC) approach. Our focus is two different PDZ domains representing two major PDZ classes, I and II. For both domains, a binding free energy surface with a strong bias toward the native bound state is found. Moreover, both domains exhibit a binding process in which the peptides are mostly either bound at the PDZ binding pocket or else interact little with the domain surface. Consistent with this, various binding observables show a temperature dependence well described by a simple two-state model. We also find important differences in the details between the two domains. While both domains exhibit well-defined binding free energy barriers, the class I barrier is significantly weaker than the one for class II. To probe this issue further, we apply our method to a PDZ domain with dual specificity for class I and II peptides, and find an analogous difference in their binding free energy barriers. Lastly, we perform a large number of fixed-temperature MC kinetics trajectories under binding conditions. These trajectories reveal significantly slower binding dynamics for the class II domain relative to class I. Our combined results are consistent with a binding mechanism in which the peptide C terminal residue binds in an initial, rate-limiting step