Phase II study of Gemcitabine and Curcumin (Meriva®) as first line treatment for locally advanced or metastatic pancreatic cancer: preliminary results

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Proceedings of the Merck & Elsevier Young Chemists Symposium (MEYCS 2018)

Dear participants, welcome to the 18th edition of the Merck & Elsevier Young Chemists Symposium, formerly SAYCS and MYCS. This conference is an international scientific event organized by the Young Group of the Italian Chemical Society (SCI Giovani) with the financial support of Merck and Elsevier. This symposium is fully devoted to young researchers, such as MSc and PhD students, post-doc fellows and young researchers in companies. All the disciplines of Chemistry are covered: analytical, physical, industrial, organic, inorganic, theoretical, pharmaceutical, biological, environmental, macromolecular and electrochemistry. This year, a special emphasis will be given to chemistry from knowledge to innovation: how chemistry is increasingly present in all of the fields that are essential for human life, and how chemical fundamentals are pushing novel technologies? This year we have the exceptional number of 212 participants; we thank you for the great trust shown towards SCI Giovani, Merck and Elsevier. Enjoy the conference

Atezolizumab plus bevacizumab versus lenvatinib or sorafenib in non-viral unresectable hepatocellular carcinoma: an international propensity score matching analysis

A growing body of evidence suggests that non-viral hepatocellular carcinoma (HCC) might benefit less from immunotherapy

Shedding light on the dark side of the genome : overlapping genes in higher eukaryotes

Gene overlap, consisting of two or more adjacent genes with partially or totally overlapping expressible units,has very recently emerged as a common feature, rather than an exception to the rule, in a significant portion of eukaryotic genomes. Considering the lack of strong evolutionary pressure on genome size in eukaryotes, the frequent recurrence of such a gene disposition is unexpected. However, these findings, along with the recent estimate that fewer genes than expected are encoded in the human genome, strengthen the hypothesis that organism complexity may reside in the interaction within and among genome, transcriptome and proteome. In this context, overlapping genes could represent a hidden source of complexity to modulate gene expression. In fact, overlapping genes, when transcribed in the opposite directions, give rise to sense-antisense transcript pairs, which often exhibit reciprocal expression patterns. These natural antisense transcripts (NATs) have been demonstrated to play a role in a variety of processes, including mRNA splicing and stability, RNA editing, genomic imprinting and control of translation. Here we present the first review on eukaryotic overlapping genes, an attempt of shedding light on this dark side of the genome. We also report the most interesting and well-studied cases and depict a general frame of this phenomenon

Modeling the superplastic behavior of Mg alloy sheets under tension using a continuum damage theory

The present paper is concerned with the modeling of superplasticity phenomenon in tensile tests of Mg alloy sheets using a continuum damage theory. The goal is to propose a one-dimensional phenomenological model, as simple as possible, able to perform a physically realistic description of strain hardening, strain softening, strain rate sensitivity and damage (nucleation and growth of voids) observed in tensile tests performed at different strain rates. Examples concerning the modeling of tensile tests of AZ31 Mg alloy sheets at different strain rates are presented and analyzed. They show a very good agreement between experimental results and model prevision