Drag cancellation by added-mass pumping

A submerged body subject to a sudden shape-change experiences large forces due to the variation of added-mass energy. While this phenomenon has been studied for single actuation events, application to sustained propulsion requires studying \textit{periodic} shape-change. We do so in this work by investigating a spring-mass oscillator submerged in quiescent fluid subject to periodic changes in its volume. We develop an analytical model to investigate the relationship between added-mass variation and viscous damping and demonstrate its range of application with fully coupled fluid-solid Navier-Stokes simulations at large Stokes number. Our results demonstrate that the recovery of added-mass kinetic energy can be used to completely cancel the viscous damping of the fluid, driving the onset of sustained oscillations with amplitudes as large as four times the average body radius $r_0$. A quasi-linear relationship is found to link the terminal amplitude of the oscillations $X$, to the extent of size change $a$, with $X/a$ peaking at values from 4 to 4.75 depending on the details of the shape-change kinematics. In addition, it is found that pumping in the frequency range of $1-\frac{a}{2r_0}<\omega^2/\omega_n^2<1+\frac{a}{2r_0}$ is required for sustained oscillations. The results of this analysis shed light on the role of added-mass recovery in the context of shape-changing bodies and biologically-inspired underwater vehicles.Comment: 10 pages, 6 Figures, under review in JFM Rapid

Mechanical Characterisation of Woven Pneumatic Active Textile

Active textiles have shown promising applications in soft robotics owing to their tunable stiffness and design flexibility. Given the breadth of the design space for planar and spatial arrangements of these woven structures, a rigorous and generalizable characterisation of these systems is not yet available. In order to characterize the response of a stereotypical woven pattern to actuation, we undertake a parametric study of plain weave active fabrics and characterise their mechanical properties in accordance with the relevant ISO standards for varying muscle densities and both monotonically increasing/decreasing pressures. Tensile and flexural tests were undertaken on five plain weave samples made of a nylon 6 (polyamide) warp and EM20 McKibben S-muscle weft, for input pressures ranging from 0.00 MPa to 0.60 MPa, at three muscle densities, namely 100 m−1 , 74.26 m−1 and 47.62 m−1 . Contrary to intuition, we find that a lower muscle density has a more prominent impact on the thickness, but a significantly lesser one on length, highlighting a critical dependency on the relative orientation among the loading, the passive textile and the muscle filaments. Hysteretic behaviour as large as 10% of the longitudinal contraction is observed on individual filaments and woven textiles, and its onset is identified in the shear between the rubber tube and the outer sleeve of the artificial muscle. Hysteresis is shown to be muscle density-dependent and responsible for a strongly asymmetrical response upon different pressure inputs. These findings provide new insights into the mechanical properties of active textiles with tunable stiffness, and may contribute to future developments in wearable technologies and biomedical devices

Flow processes and sedimentation in contourite channels on the northwestern South China Sea margin: A joint 3D seismic and oceanographic perspective

3D seismic data from the northwestern South China Sea margin, coupled with the quantification of oceanographic processes and morphological results, were used to infer three-dimensional flow processes and in turn sedimentation in contourite channels. Contour currents resulting from the Northern Pacific Deep Water (NPDW-CCs) flowing through the bends of contourite channels around a topographic high lead to an imbalance in the transverse direction, around the bend, between three competing forces (i.e., upslope directed Coriolis forces versus downslope directed centrifugal and pressure-gradient forces). The interface deflection of NPDW-CCs by Coriolis, pressure gradient, and centrifugal forces yields a helical flow cell consisting of upper return flows directed downslope and basal flows orientated upslope. Ekman boundary layers, at the base and flow interface, are also likely present leading to flows in the downslope direction. The helical flow cell in the bulk of contour currents, and Ekman boundary layers, constitute a Coriolis force-induced helical flow circulation, which we suggest promoted asymmetric intra-channel deposition (i.e., downslope deposition versus upslope erosion), forcing contourite channels to consistently migrate in an upslope direction. Such Coriolis force-induced helical flow circulation is evidenced by occurrence of volumetrically significant overbank deposits along downslope margins and by asymmetric channel cross-sections with steepened channel walls and truncation terminations along upslope margins. The Coriolis force-induced helical flow circulation exhibits subcritical flow conditions (represented by internal Froude numbers estimated as 0.04 to 0.19), and is sufficiently deep to spill out of the studied contourite channels, yielding overbank deposits along the downslope flanks of the contourite channels

Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials

Nanotechnologies have reached maturity and market penetration that require nano-specific changes in legislation and harmonization among legislation domains, such as the amendments to REACH for nanomaterials (NMs) which came into force in 2020. Thus, an assessment of the components and regulatory boundaries of NMs risk governance is timely, alongside related methods and tools, as part of the global efforts to optimise nanosafety and integrate it into product design processes, via Safe(r)-by-Design (SbD) concepts. This paper provides an overview of the state-of-the-art regarding risk governance of NMs and lays out the theoretical basis for the development and implementation of an effective, trustworthy and transparent risk governance framework for NMs. The proposed framework enables continuous integration of the evolving state of the science, leverages best practice from contiguous disciplines and facilitates responsive re-thinking of nanosafety governance to meet future needs. To achieve and operationalise such framework, a science-based Risk Governance Council (RGC) for NMs is being developed. The framework will provide a toolkit for independent NMs' risk governance and integrates needs and views of stakeholders. An extension of this framework to relevant advanced materials and emerging technologies is also envisaged, in view of future foundations of risk research in Europe and globally

A coculture model of the lung–blood barrier: the role of activated phagocytic cells

We developed a coculture model of the lung–blood barrier using human bronchial epithelial cells(16HBE14o-), monocytes (THP-1) and human lung microvascular endothelial cells (HLMVEC) in which several parameters can be assessed simultaneously. The epithelial and endothelial cells were grown on opposite sides of a microporous membrane. Electron and confocal microscopic pictures show the presence of the cells in their appropriate compartment and both cell types do not show evidence of growing through the pores. Out of three endothelial cell types (EAhy.926, HUVEC and HLMVEC), the last was chosen as the most appropriate cell type, best resembling the pulmonary endothelium and allowing the expression of functional tight junctions in the 16HBE14o- monolayer with sufficiently high transepithelial electrical resistance (TEER) values. Finally, monocytes were added to the apical compartment. PMA-activated macrophages significantly affected barrier integrity (73% TEER reduction compared to control after 24 h) and disrupted the epithelial tight junctions as shown by redistribution of ZO-1 labeling. Alternatively, monocytes could be activated using lipopolysaccharide, at a sub-toxic level int he apical compartment and only induced a small, though significant, reduction in TEER.This coculture system is a representative model of the lung–blood barrier with barrier integrity as the main toxicity endpoint.status: publishe

Semen characteristics and inflammatory mediators in infertile men with different clinical diagnoses

This study was aimed at investigating whether semen characteristics in different clinical diagnoses of infertility are associated with PMN elastase, IL-6, IL-8, IL-1b and TNFa levels detected in seminal plasma. Sixty-eight patients were divided into groups according to their clinical diagnosis: idiopathic infertility (group I), varicocele with infections (group II), varicocele (group III), infections (group IV), controls (group V). Physical examination and scrotal Eco-color Doppler was used to detect the varicocele. Patients with positive bacteriological semen analysis were considered as having an infection of the male reproductive tract. Samples were examined by light microscopy and transmission electron microscopy (TEM). TEM data were quantified with a mathematical formula furnishing a fertility index and the percentage of sperm apoptosis, immaturity and necrosis. PMN elastase ⁄ a1-PI complex levels were determined by ELISA and IL-6, IL-8, IL-1b, TNFa by Bio-Plex Cytokine assay. Sperm concentration (I-II: p &lt; 0.005; III-IV: p &lt; 0.0001), motility (I-IV: p &lt; 0.0001) and the fertility index (I: p &lt; 0.005; II-IV: p &lt; 0.0001) were significantly lower in the groups vs. controls, whereas sperm pathologies, except for apoptosis, were significantly higher in group I and apoptosis and necrosis were higher in group III. An increase in immaturity (p &lt; 0.005) with a decrease in necrosis (p &lt; 0.005) were observed in group III vs. group IV. Significantly higher levels of inflammatory mediators were detected in groups III and IV vs. controls. Despite a broad relationship among different inflammatory mediators, no correlation was found among them and the semen parameters, including indices from TEM analysis. In conclusion, patients with idiopathic infertility showed altered semen quality and normal levels of inflammatory mediators. Genitourinary infection and varicocele induced an inflammatory effect which could play a detrimental role in spermatogenesis, revealed by a decrease in sperm motility and the fertility index, concomitant with an increase in immaturity mainly in varicocele and necrosis in infection

Different saccadic profile in bulbar versus spinal-onset 1 amyotrophic lateral sclerosis

Two clinical phenotypes characterize the onset of amyotrophic lateral sclerosis (ALS): the spinal variant, with symptoms beginning in the limbs, and the bulbar variant, affecting firstly speech and swallowing. The two variants show some distinct features in the histopathology, localization and prognosis, but to which extent they really differ clinically and pathologically remains to be clarified. Recent neuropathological and neuroimaging studies have indicated a broader spreading of the neurodegenerative process in ALS, extending beyond the motor areas, toward other cortical and subcortical regions, many of which are involved in visual processing and saccadic control. Indeed, a wide range of eye movement deficits have been reported in ALS, but they have never been used to distinguish the two ALS variants. Since quantifying eye movements is a very sensitive and specific method for the study of brain networks, we compared different saccadic and visual search behaviours across spinal ALS patients (n = 12), bulbar ALS patients (n = 6) and healthy control subjects (n = 13), along with cognitive and MRI parameters, with the aim to define more accurately the two patients subgroups and possibly clarify a different underlying neural impairment. We found separate profiles of visually guided saccades between spinal (short saccades) and bulbar (slow saccades) ALS, which could result from the pathologic involvement of different pathways. We suggest an early involvement of the parieto-collicular-cerebellar network in spinal ALS and the fronto-brainstem circuit in bulbar ALS. Overall, our data confirm the diagnostic value of the eye movements analysis in ALS and add new insight on the involved neural networks