Temperature Behaviour and Uniformity of SCT Barrels during Assembly and Reception Testing

This note presents temperature studies of the barrel SemiConductor Tracker (SCT) modules during the barrel assembly at Oxford University and the barrel reception at CERN. At Oxford, warm and/or cold tests have been performed on each of the four SCT barrels comprising a total of 2112 silicon strip modules. After macro-assembly, the barrels were shipped to CERN where reception tests took place before the inner detector integration phase. We present the temperature uniformity of the different barrels under changing operating conditions. Estimates of the errors contributing to the temperature measurements will be discussed. We introduce corrections for several systematic effects. We finally identify modules operating at higher temperatures and discuss possible reasons for their deteriorated thermal performance

Renewable Energy Optimization Report for Naval Station Newport

In 2008, the U.S. Environmental Protection Agency (EPA) launched the RE-Powering America's Land initiative to encourage the development of renewable energy (RE) on potentially contaminated land and mine sites. As part of this effort, EPA is collaborating with the U.S. Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL) to evaluate RE options at Naval Station (NAVSTA) Newport in Newport, Rhode Island. NREL's Renewable Energy Optimization (REO) tool was utilized to identify RE technologies that present the best opportunity for life-cycle cost-effective implementation while also serving to reduce energy-related carbon dioxide emissions and increase the percentage of RE used at NAVSTA Newport. The technologies included in REO are daylighting, wind, solar ventilation preheating (SVP), solar water heating, photovoltaics (PV), solar thermal (heating and electric), and biomass (gasification and cogeneration). The optimal mix of RE technologies depends on several factors including RE resources; technology cost and performance; state, utility, and federal incentives; and economic parameters (discount and inflation rates). Each of these factors was considered in this analysis. Technologies not included in REO that were investigated separately per NAVSTA Newport request include biofuels from algae, tidal power, and ground source heat pumps (GSHP)

Designing tools to predict and mitigate impacts on water quality following the Australian 2019/2020 wildfires: Insights from Sydney's largest water supply catchment

The 2019/20 Australian bushfires (or wildfires) burned the largest forested area in Australia's recorded history, with major socio‐economic and environmental consequences. Among the largest fires was the 280,000 ha Green Wattle Creek Fire which burned large forested areas of the Warragamba catchment. This protected catchment provides critical ecosystem services for Lake Burragorang, one of Australia's largest urban supply reservoirs delivering ~85 % of the water used in Greater Sydney. WaterNSW is the utility responsible for managing water quality in Lake Burragorang. Its postfire risk assessment, carried out in collaboration with researchers in Australia, the UK and USA, involved i) identifying pyrogenic contaminants in ash and soil; ii) quantifying ash loads and contaminant concentrations across the burned area; and iii) estimating the probability and quantity of soil, ash and associated contaminants entrainment for different rainfall scenarios. The work included refining the capabilities of the new WEPPcloud‐WATAR‐AU model (Water Erosion Prediction Project cloud‐Wildfire Ash Transport And Risk‐Australia) for predicting sediment, ash and contaminants transport, aided by outcomes from previous collaborative post‐fire research in the catchment. Approximately two weeks after the Green Wattle Creek Fire was contained, an extreme rainfall event (~276 mm in 72 h), caused extensive ash and sediment delivery into the reservoir. The risk assessment informed on‐ground monitoring and operational mitigation measures (deployment of debris‐catching booms and adjustment of the water supply system configuration), ensuring the continuity of safe water supply to Sydney. WEPPcloud‐WATAR‐AU outputs can prioritize recovery interventions for managing water quality risks by quantifying contaminants on the hillslopes, anticipating water contamination risk, and identifying areas with high susceptibility to ash and sediment transport. This collaborative interaction among scientists and water managers, aimed also at refining model capabilities and outputs to meet managers’ needs, exemplifies the successful outcomes that can be achieved at the interface of industry and science

Targeting serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy

Despite progress in the treatment of acute lymphoblastic leukemia (ALL), T-cell ALL (T-ALL) has limited treatment options, particularly in the setting of relapsed/refractory disease. Using an unbiased genome-scale CRISPR-Cas9 screen we sought to identify pathway dependencies for T-ALL which could be harnessed for therapy development. Disruption of the one-carbon folate, purine and pyrimidine pathways scored as the top metabolic pathways required for T-ALL proliferation. We used a recently developed inhibitor of SHMT1 and SHMT2, RZ-2994, to characterize the effect of inhibiting these enzymes of the one-carbon folate pathway in T-ALL and found that T-ALL cell lines were differentially sensitive to RZ-2994, with the drug inducing a S/G2 cell cycle arrest. The effects of SHMT1/2 inhibition were rescued by formate supplementation. Loss of both SHMT1 and SHMT2 was necessary for impaired growth and cell cycle arrest, with suppression of both SHMT1 and SHMT2 inhibiting leukemia progression in vivo. RZ-2994 also decreased leukemia burden in vivo and remained effective in the setting of methotrexate resistance in vitro. This study highlights the significance of the one-carbon folate pathway in T-ALL and supports further development of SHMT inhibitors for treatment of T-ALL and other cancers

NAFTA Students'Whistle-blowing Perceptions: A Case of Sexual Harassment (La percepción advertidora de Ios alumnos en TLC: un caso de acoso sexual

Abstract, Whistle-blowing mechanisms in the U.S. have gained more prominence as an element of legal compliance and antifraud programs. Sexual harassment is asignificant business risk in terms of financial costs and the loss of reputation. lt is important for corporations to develop sexual harassment policies and to provide mechanisms for employees toreport sexual harassment behaviors to upper level management. This paper reports on business students' responses to a possible Sexual Harassment scenario from Arthur Andersen's Business Ethics Program and the actions that the characters in the video should take in terms of whistle-blowing. l fall 2004,78 students from two U.S. universities and one Mexican and one Canadian university participated in the project as part of the NAFIA Challenges of Accounting and Busrness Sysfems Granf funded by the United States Department of Education Fund for the lmprovement of PostSecondary Education (FIPSE), Human Resources Development Canada (HRDC), and Mexico's Secretaría de Educación Pública (SEP). Students from the three NAFTA countries were shown the vignette and asked to respond to a pre-questionnaire concerning the characters' behaviors and possible actions. The students were then asked to discuss the situation and write a report from the ooints of view of the three characters in the vignette and also to find a copy of an organizations' sexual harassment policy from the Internet. At the end of the project the students responded to a postquestionnaire. The students were asked to consider whether the characters should report the possible harasser iotheir supervisor, end thus engage in whistle-blowing behavior. Hypoiheses are formulated for the three NAFTA countries based on Hofstede's cultural dimensions and comparisons are made based on overall responses to the pre-and posfquestionnaire. There were significant differences, but in some cases not in the direction expected. Gender differences are also explored, but there were few significant differences. The authors are working under the NAFTA Challenges of Accounting and Busrness Sysfems Grant from the United States Depaftment of Education Fund for the lmprovement of PosfSecondary Education (FIPSE), Human Resources Development Canada (HRDC), and Mexico's Secretaría de Educación Pública (SEP). Resúmen. Los llamados "mecanismos de silbato de alerta" en los Estados Unidos han ganado más prominencia como elemento de la conformidad legal y de los programas antifraude. El hostigamiento sexual es un riesgo significativo del negocio en términos de costos financieros y la pérdida de reputación. Esimportante que las corporaciones desarrollen políticas para prevenir y sancionar el hostigamiento sexual en los centros de trabajo y proporcionen los mecanismos para los empleados sobre los comportamientos de hostigamiento sexual y ofrezcan información al respecto a la gerencia. Esta investigaciónnternacional por medio de sus resultadosfrece las respuestas de los estudiantes de las escuelas de negocios de México, Canadá y Estados Unidos sobre un panorama de posible hostigamiento sexual, y forma parte del programa del ética de negocio de promover en las Universidades la firma internacional de consultoría Arturo Andersen y de las acciones que se observaron elos caracteresn un vídeo realizado para este propósito, y que acciones deben tomar en términos de la utilización del "silbato de altera". En otoño del 2004, 78 estudiantes de dos universidades EEUU, una universidad mexicana y una canadiense participaron en el proyecto como parte de los Retos de NAFTA de los sistemas Grant de contabilidad y negocios financiados por el departamento de Educación delos Estados Unidos Secretaría Poste-Secundario de Educación Pública (SEPT) de la educación (FIPSE), del desarrollo de recursos humanos en Canadá (HRDC), y de México. Mediante uso de video y escenificación que fue enviado y posteriormente fueron recibidas las respuestas de los estudiantes delos tres países de NAFTA además de responder a un cuestionario referente a los comportamientos y a las acciones posibles de los caracteres del video. Posteriormente y mediante el uso de Internet, los estudiantes pudieron discutir lasituación y escribir un informe de los puntos de la vista de los tres caracteres en el video y elaborar una propuesta de una política sobre hostigamiento sexual de las organizaciones. Al final del proyecto los estudiantes respondieron a un cuestionario. Pidieron considerar si los caracteres deben divulgar el hostigamiento posible a su supervisor, y como los estudiantes se comprometían a utilizar el mecanismo de silbato de alerta. Las hipótesis se formulan para los tres países del NAFTA basados en las dimensiones culturales de Hofstede y se hacen las comparaciones baado en respuestas totales a los cuestionarios. Se encontraron diferencias significativas, pero en algunos casos no en la dirección esperada. Las diferencias del género también se exploran, pero había pocas diferencias significativas. Los autor autores están trabajando bajo desafíos de NAFTA de los sistemas Grant de la contabilidad y del negocio del departamento de Estados Unidos del fondo de la educación para la mejora de Secretaría Poste-Secundario de Educación Pública (SEPT) de lp educación (FIPSE), del desarrollo de recursos humanos Canadá (HRDC), y de México

NAFTA Students'Whistle-blowing Perceptions: A Case of Sexual Harassmen

Key words: Sexual harrasment, NAFTA, organizations, policiesAbstract. Whistle-blowing mechanisms in the U.S. have gained more prominence as an element of legal compliance and antifraud programs. Sexual harassment is a significant business risk in terms of financial costs and the loss of reputation. lt is important for corporations to develop sexual harassment policies and to provide mechanisms for employees toreport sexual harassment behaviors to upper level management. This paper reports on business students' responses to a possible Sexual Harassment scenario from Arthur Andersen's Business Ethics Program and the actions that the characters in the video should take in terms of whistle-blowing. l fall 2004,78 students from two U.S. universities and one Mexican and one Canadian university participated in the prolect as part of the NAFIA Challenges of Accounting and Buslness Sysfems Granf funded by the United States Department of Education Fund for the lmprovement of PostSecondary Education (FIPSE), Human Resources Develópment Canada (HRDC), and Mexico's Secretaría de Educación Pública (SEP). Students from the three NAFTA countries were shown the vignette and asked to respond to a pre-questionnaire concerning the characters' behaviors and possible actions. The students were then asked to discuss the situation and write a reoort from the points of view of the three characters in the vigneite and also to find a copy of an organizations' sexual harassment policy from the Internet. At the end of the project the students responded to a post questionnaire. The students were asked to consider whether the characters should report the possible harasser totheir supervisor, and thus engage in whistle-blowing behavior. Hypotheses are formulated for the three NAFTA'countries based on Hofstede's cultural dimensions and comparisons are made based on overall responses to the pre-and posfquestionnaire. There were significant differences, but in some cases not in the direction expected. Gender differences are also explored, but there were few significant differences. The authors are working under the NAFTA Challenges of Accounting and Busrness Sysferns Grant from the United States Department of Education Fund for the lmprovement of PostSecondary Education (FIPSE), Human Resources Development Canada (HRDC), and Mexico's Secretaría de Educación Pública (SEP).Palabras claves: Hostigamiento sexual, NAFTA, organizaciones, políticasResúmen. Los llamados "mecanismos de silbato de alerta" en los Estados Unidos han ganado más prominencia como elemento de Ia conformidad legal y de los programasntifraude. El hostigamiento sexual es un riesgo significativo del negocio en términos de costos financieros y la pérdida de reputación. Esimportante que las corporaciones desarrollen políticas para prevenir y sancionar el hostigamiento sexual en los centros de trabajo y proporcionen los mecanismos para los empleados sobre los comportamientos de hostigamiento sexual y ofrezcan información al respecto a la gerencia. Esta investigaciónnternacional por medio de sus resultados frece las respuestas delos estudiantes de las escuelas de negocios de México, Canadá y Estados Unidos sobre un panorama de posible hostigamiento sexual, y forma parte del programa del ética de negocio de promover en las Universidades la firma internacional de consultoría Arturo Andersen y de las acciones que se observaron elos caracteresn un vídeo realizado para este propósito, y que acciones deben tomar en términos de la utilización del "silbato de altera". En otoño del 2004, 78 estudiantes de dos universidades EEUU, una universidad mexicana y una canadiense participaron en el proyecto como parte de los Retos de NAFTA de los sistemas Grant de contabilidad y negocios financiados por el departamento de Educación delos Estados Unidos Secretaría Poste-Secundario de Educación Pública (SEPT) de la educación (FIPSE), del desanollo de recursos humanos en Canadá (HRDC), y de México. Mediante uso de video y escenificación que fue enviado y posteriormente fueron recibidas las respuestas de los estudiantes delos tres países de NAFTA además de responder a un cuestionario referente a los comportamientos y a las acciones posibles de los caracteres del video. Posteriormente y mediante el uso de Internet, los estudiantes pudieron discutir lasituación y escribir un informe de los puntos de la vista de los tres caracteres en el video y elaborar una propuesta de una política sobre hostigamiento sexual de las organizaciones. Al final del proyecto ls estudiantes respondieron a un cuestionario. Pidieron considerar si los caracteres deben divulgar el hostigamiento posible a su supervisor, y como los estudiantes se comprometían a utilizar el mecanismo desilbato de alerta, Las hipótesis se formulan para los tres paÍses del NAFTA basados en las dimensiones culturales de Hofstede y se hacen las comparaciones baado en respuestas totales alos cuestionarios. Se encontraron diferencias significativas, pero en algunos casos no en la dirección esperada. Las diferencias del género también se exploran, pero había pocas diferencias significativas. Los autorautores están trabajando bajo desafíos de NAFTA de los sistemas Grant de la contabilidad y del negocio del departamento de Estados Unidos del fondo de la educación para la mejora de Secretaría Poste-Secundario de Educación Pública (SEPT) de lA educación (FIPSE), del desarrollo de recursos humanos Canadá (HRDC), y de México

Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection

Salmonella Typhimurium causes a self-limiting gastroenteritis that may lead to systemic disease. Bacteria invade the small intestine, crossing the intestinal epithelium from where they are transported to the mesenteric lymph nodes (MLNs) within migrating immune cells. MLNs are an important site at which the innate and adaptive immune responses converge but their architecture and function is severely disrupted during S. Typhimurium infection. To further understand host-pathogen interactions at this site, we used mass spectrometry imaging (MSI) to analyse MLN tissue from a murine model of S. Typhimurium infection. A molecule, identified as palmitoylcarnitine (PalC), was of particular interest due to its high abundance at loci of S. Typhimurium infection and MLN disruption. High levels of PalC localised to sites within the MLNs where B and T cells were absent and where the perimeter of CD169+ sub capsular sinus macrophages was disrupted. MLN cells cultured ex vivo and treated with PalC had reduced CD4+CD25+ T cells and an increased number of B220+CD19+ B cells. The reduction in CD4+CD25+ T cells was likely due to apoptosis driven by increased caspase-3/7 activity. These data indicate that PalC significantly alters the host response in the MLNs, acting as a decisive factor in infection outcome

Achieving sustainable construction within Private Finance Initiative (PFI) road projects in the UK

The construction industry is facing the challenge of increasing demands of its sustainability performance. The construction and maintenance of the built environment has substantial impact on the sustainability of the environment. Whist, public sector clients are increasingly asking for a sustainable approach in their specification and procurement decisions, sustainability is still seen as a novel concept within the construction industry in many parts of the world without a settled definition. The premise of this study is that the interaction between road projects realized by the private finance initiative and their delivery in the UK improve sustainability. The paper, based on case study research, explains the sustainability implementation in a PFI road project and demonstrates that the PFI mechanism facilitates sustainable implementation to a far greater extent than is achievable using traditional procurement methods