Corioamnionite e Morbilidade Neonatal

CHORIOAMNIONITIS AND NEONATAL MORBIDITY Introduction - Several studies highlight the association between perinatal infection/ inflammation and neonatal morbidity, mainly bronchopulmonary dysplasia and periventricular leukomalacia. Aim – To evaluate the role of histological chorioamnionitis on the overall morbidity of preterm newborns. Methods – A retrospective study on preterm newborns less than 34 weeks gestational age at birth, and respective mothers, at three tertiary medical centers (Hospital de São João, Maternidade Júlio Dinis and Centro Hospitalar de Vila Nova de Gaia) in the north of Portugal, between January 2001 and December 2002. We evaluated the association between histological chorioamnionitis and the overall neonatal morbidity. The association between histological chorioamnionitis and acute (respiratory distress syndrome) and chronic (bronchopulmonary dysplasia) lung damage was also evaluated in the subgroup of less than 1000 g birthweight preterm neonates. Results – 452 [ M 253 / F 217; birthweight 1440 (515 – 2620) g; gestational age 31 (23 – 33) weeks] preterm newborns were included. The association between histological chorioamnionitis and the overall neonatal morbidity was: respiratory distress syndrome OR 1,5 (95% CI 0,94 – 2,31); bronchopulmonary dysplasia OR 2,6 (95% CI 1,16 – 6,03); patent ductus arteriosus OR 2,5 (95% CI 1,17 – 5,44); sepsis OR 1,2 (95% CI 0,9 – 2,13); necrotizing enterocolitis OR 1,4 (95% CI 0,9 – 1,76); intraventricular hemorrhage grades III-IV OR 2,5 (1,20 – 5,11); cystic periventricular leukomalacia OR 3,0 (1,5 – 6,07); retinopathy of prematurity OR 1,4 (95% CI 0,8 – 1,35). The association adjusted to birthweight and gestational age was: bronchopulmonary dysplasia OR 1,2 (95% CI 0,51 – 2,95); patent ductus arteriosus OR 0,9 (95% CI 0,4 – 2,35); intraventricular hemorrhage grades III-IV OR 0,9 (95% CI 0,39 – 2,28); cystic periventricular leukomalacia OR 2,2 (95% CI 1,03 – 4,61). The association between histological chorioamnionitis and lung damage in the subgroup of less than 1000 g birthweight preterm neonates was: respiratory distress syndrome OR 0,23 (95% CI 0,01 – 2,51); bronchopulmonary dysplasia OR 1,61 (95% CI 0,38 – 6,97). Conclusion – This study confirms the association between histological chorioamnionitis and cystic periventricular leukomalacia of the preterm newborn

Sobre el polígono de área máxima inscripto en una circunferencia

En este trabajo se prueba que el polígono de N lados de mayor área inscripto en una circunferencia dada, es el polígono regular de N lados. Esto se obtendrá como corolario de un resultado más general: dado un sector circular, el polígono inscripto de N lados cuya área resulta mayor es aquel cuyos vértices se distribuyen en forma equidistantes entre si sobre el arco de circunferencia

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells

Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease response in chronic-phase CML. Omacetaxine mepesuccinate, a first in class cetaxine, has been evaluated by clinical trials in TKI-insensitive/resistant CML. Omacetaxine inhibits synthesis of anti-apoptotic proteins of the Bcl-2 family, including (myeloid cell leukaemia) Mcl-1, leading to cell death. Omacetaxine effectively induced apoptosis in primary CML stem cells (CD34<sup>+</sup>38<sup>lo</sup>) by downregulation of Mcl-1 protein. In contrast to our previous findings with TKIs, omacetaxine did not accumulate undivided cells <i>in vitro</i>. Furthermore, the functionality of surviving stem cells following omacetaxine exposure was significantly reduced in a dose-dependant manner, as determined by colony forming cell and the more stringent long-term culture initiating cell colony assays. This stem cell-directed activity was not limited to CML stem cells as both normal and non-CML CD34<sup>+</sup> cells were sensitive to inhibition. Thus, although omacetaxine is not leukaemia stem cell specific, its ability to induce apoptosis of leukaemic stem cells distinguishes it from TKIs and creates the potential for a curative strategy for persistent disease

CTEQ Parton Distributions and Flavor Dependence of Sea Quarks

This paper describes salient features of new sets of parton distributions obtained by the CTEQ Collaboration based on a comprehensive QCD global analysis of all available data. The accuracy of the new data on deep inelastic scattering structure functions obtained by the very high statistics NMC and CCFR experiments provides unprecedented sensitivity to the flavor dependence of the sea-quark distributions. In addition to much better determination of the small x dependence of all parton distributions, we found: (i) the strange quark distribution is much softer than the non-strange sea quarks and rises above the latter at small-x; and (ii) the difference $\bar d-\bar u$ changes sign as a function of x. A few alternative sets of viable distributions with conventional assumptions are also discussed.Comment: 13 pages with figures, MSUHEP-92-27, Fermilab-Pub-92/371, FSU-HEP-92-1225, ISU-NP-92-1

Iliac Artery Reconstruction with Femoral Vein After Bare Metal Stent Infection

INTRODUCTION: Primary infection of a bare metal stent is a rare condition, associated with significant morbidity and mortality. Definitive treatment includes stent removal and arterial reconstruction. REPORT: This study details a common iliac stent infection after re-intervention for iliac stent occlusion, complicated by pseudoaneurysm formation and septic embolisation. Potential risk factors for stent infection were identified. An open surgical resection of the affected artery along with all stent material was performed, followed by reconstruction with autologous interposition superficial femoral vein. There were no complications and no recurrent infection at 6 months follow-up. CONCLUSION: Although rare, bare metal stent infection may occur, and a high index of suspicion is required. Stent surgical removal and arterial in situ reconstruction with autologous femoral vein proved to be a definitive procedure with no mid-term morbidity.info:eu-repo/semantics/publishedVersio