The multifocal pattern electroretinogram in chloroquine retinopathy

Purpose: Optimal screening for ocular toxicity caused by chloroquine and hydroxychloroquine is still controversial. With the multifocal pattern electroretinogram (mfPERG), a new electrophysiological technique has recently become available to detect early changes of ganglion cells. In this study this new technique is applied to a series of 10 patients seen consecutively receiving long-term chloroquine medication. Methods: In 10 patients receiving chloroquine medication, clinical examination, Amsler visual field testing and computerized color vision testing were performed. If toxicity was suspected, automated perimetry was carried out. In addition, in all patients conventional pattern electroretinogram (PERG) and mfPERG testing were performed. Results: On clinical examination 8 patients showed no chloroquine-associated maculopathy, while 2 patients did. Of these 2, only 1 reported abnormalities when viewing the Amsler chart, while automated perimetry showed typical, ring-like paracentral scotomas in both affected patients and color vision was significantly abnormal. In the normal patients, 4 of 8 had a mild color vision disturbance, which correlated to age-related macular changes. The amplitudes of the PERG and the central (approximately 10degrees) responses of the mfPERG were markedly reduced in chloroquine maculopathy, while the latencies were unchanged. The peripheral rings of mfPERG (ranging to 48degrees) were not affected by chloroquine toxicity. Both PERG and mfPERG were less affected by age-related macular changes. Conclusions: The reduction of PERG and central mfPERG responses in chloroquine maculopathy may help with the early detection of toxicity. Copyright (C) 2004 S. Karger AG, Basel

Haldane's rule revisited : do hybrid females have a shorter lifespan? : survival of hybrids in a recent contact zone between two large gull species

Haldane’s rule predicts that particularly high fitness reduction should affect the heterogametic sex of interspecific hybrids. Despite the fact that hybridization is widespread in birds, survival of hybrid individuals is rarely addressed in studies of avian hybrid zones, possibly because of methodological constraints. Here, having applied capture-mark-recapture models to an extensive, 19-year-long dataset on individually marked birds, we estimate annual survival rates of hybrid individuals in the hybrid zone between herring (Larus argentatus) and Caspian (L. cachinnans) gulls. In both parental species, males have a slightly higher survival rate than females (model-weighted mean ± SE: herring gull males 0.88 ± 0.01, females 0.87 ± 0.01, Caspian gull males 0.88 ± 0.01, females 0.87 ± 0.01). Hybrid males do not survive for a shorter time than non-hybrid ones (0.88 ± 0.01), whereas hybrid females have the lowest survival rate among all groups of individuals (0.83 ± 0.03). This translates to a shorter adult (reproductive) lifespan (on average by 1.7-1.8 years, i.e. ca 25%) compared to non-hybrid females. We conclude that, in line with Haldane’s rule, the lower survival rate of female hybrids may contribute to selection against hybrids in this hybrid zone

Properties of mass-loading shocks, 2. Magnetohydrodynamics

The one-dimensional magnetohydrodynamics of shocked flows subjected to significant mass loading are considered. Recent observations at comets Giacobini-Zinner and Halley suggest that simple nonreacting MHD is an inappropriate description for active cometary bow shocks. The thickness of the observed cometary shock implies that mass loading represents an important dynamical process within the shock itself, thereby requiring that the Rankine-Hugoniot condition for the mass flux possess a source term. In a formal sense, this renders mass-loading shocks qualitatively similar to combustion shocks, except that mass loading induces the shocked flow to shear. Nevertheless, a large class of stable shocks exist, identified by means of the Lax conditions appropriate to MHD. Thus mass-loading shocks represent a new and interesting class of shocks, which, although found frequently in the solar system, both at the head of comets and, under suitable conditions, upsteam of weakly magnetized and nonmagnetized planets, has not been discussed in any detail. Owing to the shearing of the flow, mass-loading shocks can behave like switch-on shocks regardless of the magnitude of the plasma beta. Thus the behavior of the magnetic field in mass-loading shocks is significantly different from that occurring in nonreacting classical MHD shocks. It is demonstrated that there exist two types of mass-loading fronts for which no classical MHD analogue exists, these being the fast and slow compound mass-loading shocks. These shocks are characterized by an initial deceleration of the fluid flow to either the fast or the slow magnetosonic speed followed by an isentropic expansion to the final decelerated downstream state. Thus these transitions take the flow from a supersonic to a supersonic, although decelerated, downstream state, unlike shocks which occur in classical MHD or gasdynamics. It is possible that such structures have been observed during the Giotto-Halley encounter, and a brief discussion of the appropriate Halley parameters is therefore given, together with a short discussion of the determination of the shock normal from observations. A further interesting new form of mass-loading shock is the “slow-intermediate” shock, a stable shock which possesses many of the properties of intermediate MHD shocks yet which propagates like a slow mode MHD shock. An important property of mass-loading shocks is the large parameter regime (compared with classical MHD) which does not admit simple or stable transitions from a given upstream to a downstream state. This suggests that it is often necessary to construct compound structures consisting of shocks, slip waves, rarefactions, and fast and slow compound waves in order to connect given upstream and downstream states. Thus the Riemann problem is significantly different from that of classical MHD

Mass-loading and parallel magnetized shocks

Recent observations at comets Giacobini-Zinner and Halley suggest that simple non-reacting gas dynamics or MHD is an inappropriate description for the bow shock. The thickness of the observed (sub)shock implies that mass-loading is an important dynamical process within the shock itself, thereby requiring that the Rankine-Hugoniot conditions possess source terms. This leads to shocks with properties similar to those of combustion shocks. We consider parallel magnetized shocks subjected to mass-loading, describe some properties which distinguish them from classical MHD parallel shocks, and establish the existence of a new kind of MHD compound shock. These results will be of importance both to observations and numerical simulations of the comet-solar wind interaction

Hypervelocity dust particle impacts observed by the Giotto Magnetometer and Plasma Experiments

We report thirteen very short events in the magnetic field of the inner magnetic pile‐up region of comet Halley observed by the Giotto magnetometer experiment together with simultaneous plasma data obtained by the Johnstone plasma analyzer and the ion mass spectrometer experiments. The events are due to dust impacts in the milligram range on the spacecraft at the relative velocity between the cemetery dust and the spacecraft of 68 km/sec. They are generally consistent with dust impact events derived from spacecraft attitude perturbations by the Giotto camera [Curdt and Keller, private communication]. Their characteristic shape generally involves a sudden decrease in magnetic field magnitude, a subsequent overshoot beyond initial field values and an asymptotic approach to the initial field somewhat reminiscent of the magnetic field signature after the AMPTE releases in the solar wind. These observations give a new way of analyzing ultra‐fast dust particles incident on a spacecraft

Global Saturation of Regularization Methods for Inverse Ill-Posed Problems

In this article the concept of saturation of an arbitrary regularization method is formalized based upon the original idea of saturation for spectral regularization methods introduced by A. Neubauer in 1994. Necessary and sufficient conditions for a regularization method to have global saturation are provided. It is shown that for a method to have global saturation the total error must be optimal in two senses, namely as optimal order of convergence over a certain set which at the same time, must be optimal (in a very precise sense) with respect to the error. Finally, two converse results are proved and the theory is applied to find sufficient conditions which ensure the existence of global saturation for spectral methods with classical qualification of finite positive order and for methods with maximal qualification. Finally, several examples of regularization methods possessing global saturation are shown.Comment: 29 page

Can a Home-based Cardiac Physical Activity Program Improve the Physical Function Quality of Life in Children with Fontan Circulation?

Objective Patients after Fontan operation for complex congenital heart disease (CHD) have decreased exercise capacity and report reduced health-related quality of life (HRQOL). Studies suggest hospital-based cardiac physical activity programs can improve HRQOL and exercise capacity in patients with CHD; however, these programs have variable adherence rates. The impact of a home-based cardiac physical activity program in Fontan survivors is unclear. This pilot study evaluated the safety, feasibility, and benefits of an innovative home-based physical activity program on HRQOL in Fontan patients. Methods A total of 14 children, 8–12 years, with Fontan circulation enrolled in a 12-week moderate/high intensity home-based cardiac physical activity program, which included a home exercise routine and 3 formalized in-person exercise sessions at 0, 6, and 12 weeks. Subjects and parents completed validated questionnaires to assess HRQOL. The Shuttle Test Run was used to measure exercise capacity. A Fitbit Flex Activity Monitor was used to assess adherence to the home activity program. Results Of the 14 patients, 57% were male and 36% had a dominant left ventricle. Overall, 93% completed the program. There were no adverse events. Parents reported significant improvement in their child\u27s overall HRQOL (P \u3c .01), physical function (P \u3c .01), school function (P = .01), and psychosocial function (P  \u3c .01). Patients reported no improvement in HRQOL. Exercise capacity, measured by total shuttles and exercise time in the Shuttle Test Run and calculated VO2max, improved progressively from baseline to the 6 and 12 week follow up sessions. Monthly Fitbit data suggested adherence to the program. Conclusion This 12-week home-based cardiac physical activity program is safe and feasible in preteen Fontan patients. Parent proxy-reported HRQOL and objective measures of exercise capacity significantly improved. A 6-month follow up session is scheduled to assess sustainability. A larger study is needed to determine the applicability and reproducibility of these findings in other age groups and forms of complex CHD

Automated external defibrillators on board merchant vessels? Preliminary report Article for discussion

Objectives &#8211; Acute heart diseases are the most frequent causes for fatalities on merchant vessels. Presently there is no sufficient therapy available to treat ventricular fibrillation. The aim of this study was to test whether common automated external defibrillators [AED] may be appropriate for the use aboard merchant vessels. Methods &#8211; In 2005, nine seafarers were introduced to four common models of AED (HeartStartFR2+, Lifepak500, AEDplus, FREDeasy) using standard video or DVD presentations. AED handling by the subjects was tested in standardized simulated emergency scenarios. After training, they subjectively rated each AED on 24 factors involved in the introduction and handling of the device. An actual ECG was then obtained with each AED at a site located beside the ship&#8217;s main engine to test under maximum vibration. The ECG data were extracted and sent as an e-mail attachment via satellite to the German Telemedical Maritime Assistance Service [TMAS] in Cuxhaven. Results and conclusions &#8211; All subjects handled the AED correctly. The AED received a total amount of points in the range between 2125 to 2241 (of 2400 possible). The subjects preferred AED with coloured as well as light marked buttons which gave a feedback (e.g. audible tones) when they were pressed. All AED were able to register an ECG in the vibrating ambient. Due to interface problems it was only possible to extract three ECG files, and only two files (data < 300 kB) could be sent as e-mail attachment via satellite to the German TMAS. In noisy areas the AED must guide the user, e.g. by screen massages and/or pictograms. Displays should provide additional data to help assess resuscitation effectiveness. A special procedure is necessary to ensure that ships and TMAS own the same software to read the transmitted ECG files, which are not allowed to exceed a size of 300 kB

Faiblesse de l’effort français pour la recherche dans le domaine de l’Agriculture Biologique : approche scientométrique

La France est la première puissance agricole européenne et le troisième marché pour l'alimentation biologique. Pourtant elle ne se situe qu'au 25ème rang mondial en terme de pourcentage de la surface agricole consacrée à l'agriculture biologique, et importe plus de la moitié de sa consommation. Un fort développement de la recherche en ce domaine est réclamé par les associations afin de répondre aux défis écologiques, économiques, énergétiques et sociaux posés à l'agriculture du XXIème siècle. Quelle est exactement la place consacrée à l’agriculture biologique dans la recherche agronomique des différents pays européens ? La reconnaissance de la pertinence de l’agriculture biologique comme domaine de recherche par l'INRA depuis 1999 a-t-elle conduit à une meilleure priorisation de la recherche en agriculture biologique ? Une analyse bibliométrique par mots-clés des publications scientifiques recensées dans la base de données ISI Web of Science de Thomson Scientific permet de construire des indicateurs suffisamment pertinents pour une comparaison des efforts de recherche nationaux sur la période 2000-2006, et ainsi de juger du niveau de priorisation réel de la recherche en agriculture biologique. Les résultats obtenus confirment le retard de la France, et sont à mettre en relation avec le manque de soutien institutionnel, de moyens humains et financiers consacrés à l’agriculture biologique au sein des organismes en charge de la recherche agronomique française, et ce, malgré les ambitions affichées