Removal of organic dyes and tannins by electrochemical techniques.

Removal of organic dyes, tannins and phenol based molecules from aqueous solutions and the amenability of electrochemical techniques for the treatment of dye bath and tannery effluents was discussed. In the case of electro-coagulation/flotation, aluminum and steel were used as electrodes whereas graphite and IrO2 / TaO2/RuO2 coated Ti electrodes were tried for electro-oxidation. The degradation of dyes such as CI reactive blue 221 and CI Acid orange 10, phenol based tannins and phenolics such as resorcinol, pyrogallol, catechol and phloroglucinol was studied both by electrocoagulation and electro-oxidation techniques. The decolourization and degradation of the dye molecules was monitored by UV-Visible spectrophotometer and the mineralization trend of all these compounds was followed by chemical oxygen demand (COD) and total organic carbon (TOC) measurements. The effect of operating parameters such as nature of the electrolyte, pH, and applied current density were discussed. The generation of chlorine based insitu oxidants has been confirmed by cyclic voltammetric technique. Electro-oxidation of the dyes and tannin molecules was evaluated and found that the graphite material was effective to achieve the complete mineralization. Although, IrO2 / TaO2/RuO2 coated Ti anode is chemically inert and structurally stable, it fails to generate more molecular oxygen and hydroxyl radicals. The purification of textile and tannery effluent was successfully achieved by electrochemical treatment

Treatment of pharmaceutically active compounds by electrooxidation using boron doped diamond and platinum anodes

Clean and hygiene water is a critical environmental issue that touches the life of every human being. In recent years, presence of some pharmaceutical compounds and their metabolites in surface and ground water has become a potential health risk to human beings. Non-steroidal anti-inflammatory drugs (NSAID) are prescribed for muscle pain and inflammatory rheumatic disorders. Ketoprofen one of the NSAIOs, is categorized as a pharmaceutically active compound which resists both the abiotic and biotic degradation. Similarly, P-blockers are a class of drugs used for various indications particularly to control high blood pressure, anti-angina and cardiovascular diseases. One among the P-blockers, atenolol is most toxic to humans and aquatic organisms. The presence of both ketoprofen and atenolol in ground water has been reported at concentrations up to 10 figlL. A bench scale study was carried out to treat synthetically prepared pharmaceutical compounds (ketoprofen and atenolol) contaminated water in lower concentrations (fig/I) using boron doped diamond (BOD) and platinum anodes. The results were explained in terms of in situ generated of hydroxyl radical COH), peroxodisulfate (S20t), and active chlorine species (CI2, ocr and HOCI). The physisorbed 'OH on BOD was observed to trigger the combustion of pollutant molecules in to CO2 and H20. The BOD anode was found to be effective in the presence ofNa2S04 whereas Pt yields better removal in the presence of NaCI. The influence of electrolyte pH on the mineralization of ketoprofen molecules was found to be insignificant

Role of electrolyte on anodic mineralization of atenolol at boron doped diamond and Pt electrodes

Anodic oxidation of atenolol, known as -blocker, has been investigated using boron-doped diamond(BDD) and Pt electrodes. The mineralization trend of atenolol in the presence of NaCl, Na2SO4 and NaNO3 was followed using total organic carbon analyzer. The disappearance of chloride ions and generation of active chlorine (Cl2, HOCl, OCl−) were analysed by argentometric and iodometric methods, respectively. The BDD anode was found to be effective in the presence of Na2SO4 whereas Pt yields better removal in the presence of NaCl. The initial concentration of NaCl and applied current density on the mineralization of atenolol were found to be significant for both BDD and Pt anodes. These results are explained in terms of electrogenerated oxidants such as •OH, SO4•−, S2O8 2−, Cl2, HOCl and OCl−. The evolution of chlorine at BDD and Pt with respect to NaCl concentration was studied by means of cyclic voltammetric technique. Though the rate of mineralization was observed to be initially higher in the presence of Pt anode, the overall rate of mineralization is more or less similar beyond 15 h of electrooxidation. The slow degradation at the later stages of electrooxidation was attributed to the presence of residual chlorinated organic compounds which are very refractive. The complete mineralization was achieved in the presenceof Na2SO4 using BDD as anode

SYNTHESIS AND EVALUATION OF PHTHALATE ANALOGUE OF DICLOFENAC AGAINST FREUND’S COMPLETE ADJUVANT INDUCED ARTHRITIS IN RAT

Objective: The objective of the present study is to evaluate the effect of Phthalate analogues of diclofenac in Freund’s complete adjuvant (FCA) induced Arthritis in the rat. Methods: Twenty four female albino wistar rats were enrolled in this study and are divided into 4 groups (six each). The groups were designed as follows: Group I: vehicle control, Group II: arthritic control, Group III: diclofenac treated, Group IV: phthalate analogue of diclofenac treated. Various assessments such as anti-arthritic activity, biochemical estimations, haematological parameters, ulcerogenesis, radiological and histopathological studies were evaluated. Results: Arthritic control group exhibited significant increase in the level of paw volume, arthritic score (p<0.0001), Serum glutamic pyruvic transaminase (SGPT) (p<0.001), Serum glutamic oxaloacetic transaminase (SGOT) p<0.01), rheumatoid arthritis factor, C-reactive protein (CRP), White Blood Cells (WBC), Creatinine and uric acid and a significant decrease in Red Blood Cells (RBC). Increased swelling of joints, bony destruction and profound ulceration were observed in the Arthritic control group. All these conditions were reversed in diclofenac and phthalate analogue of diclofenac groups. Conclusion: We conclude that phthalate analogue of diclofenac shows potent anti-arthritic activity with milder ulceration when compared to diclofenac treatment

Anodic oxidation of ketofrofen-an anti-inflammatory drug using boron doped diamond electrode

The mineralization of ketoprofen (KP) by anodic oxidation was studied by employing boron doped diamond (BDD) and Pt electrodes. The redox behavior of KP molecule, fouling of electrodes, generation of oxygen and active chlorine species were studied by cyclic voltammetry. The effect of electrolyte, pH of aqueous medium and applied current density on the mineralization behavior of KP was also investigated. The degradation and mineralization were monitored by UV–vis spectrophotometer and total organic carbon analyzer, respectively. The results were explained in terms of in situ generation of hydroxyl radical (•OH), peroxodisulfate (S2O8 2−), and active chlorine species (Cl2, HOCl, OCl−). The physisorbed •OH on BDD was observed to trigger the combustion of KP in to CO2 and H2O. The poor mineralization at both BDDand Pt anodes in the presence of NaCl as supporting electrolyte was ascribed to the formation of chlorinated organic compounds which are refractory. Complete mineralization of KP molecule was achieved using Na2SO4 as supporting electrolyte

A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease

Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 expression on blood DC. Increased mesenteric fat and leptin occur early in Crohn's disease (CD), suggesting leptin-mediated change in intestinal CCR7 expression on DC as a pro-inflammatory mechanism. We have demonstrated CCR7 expression and capacity to migrate to its ligand macrophage inflammatory protein 3β in normal human ileal DC but not colonic or blood DC. In CD, functional CCR7 was expressed on DC from all sites. Only DC populations containing CCR7-expressing cells produced LepRb; in vitro exposure to leptin also increased expression of functional CCR7 in intestinal DC in a dose-dependent manner. In conclusion, leptin may regulate DC migration from gut, in homeostatic and inflammatory conditions, providing a link between mesenteric obesity and inflammation

National prospective cohort study of the burden of acute small bowel obstruction

Background Small bowel obstruction is a common surgical emergency, and is associated with high levels of morbidity and mortality across the world. The literature provides little information on the conservatively managed group. The aim of this study was to describe the burden of small bowel obstruction in the UK. Methods This prospective cohort study was conducted in 131 acute hospitals in the UK between January and April 2017, delivered by trainee research collaboratives. Adult patients with a diagnosis of mechanical small bowel obstruction were included. The primary outcome was in‐hospital mortality. Secondary outcomes included complications, unplanned intensive care admission and readmission within 30 days of discharge. Practice measures, including use of radiological investigations, water soluble contrast, operative and nutritional interventions, were collected. Results Of 2341 patients identified, 693 (29·6 per cent) underwent immediate surgery (within 24 h of admission), 500 (21·4 per cent) had delayed surgery after initial conservative management, and 1148 (49·0 per cent) were managed non‐operatively. The mortality rate was 6·6 per cent (6·4 per cent for non‐operative management, 6·8 per cent for immediate surgery, 6·8 per cent for delayed surgery; P = 0·911). The major complication rate was 14·4 per cent overall, affecting 19·0 per cent in the immediate surgery, 23·6 per cent in the delayed surgery and 7·7 per cent in the non‐operative management groups (P < 0·001). Cox regression found hernia or malignant aetiology and malnutrition to be associated with higher rates of death. Malignant aetiology, operative intervention, acute kidney injury and malnutrition were associated with increased risk of major complication. Conclusion Small bowel obstruction represents a significant healthcare burden. Patient‐level factors such as timing of surgery, acute kidney injury and nutritional status are factors that might be modified to improve outcomes