The Trajectory Model for Track Fitting and Alignment

This note introduces the concept of Trajectories. The LHCb trajectory model and the implementation in the track fitting and tracking sub-detector code as in Brunel v31r2 are described. The possible use of trajectories for alignment is outlined

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

Multitarget design offers access to bioactive small molecules with potentially superior efficacy and safety. Particularly multifactorial chronic inflammatory diseases demand multiple pharmacological interventions for stable treatment. By minor structural changes, we have developed a close analogue of the cysteinyl-leukotriene receptor antagonist zafirlukast that simultaneously inhibits soluble epoxide hydrolase and activates peroxisome proliferator-activated receptor \u3b3. The triple modulator exhibits robust anti-inflammatory activity in vivo and highlights the therapeutic potential of designed multitarget agents

Terrace Standard, March, 01, 1995

Observation has lead to a conclusion that the physics analysis jobs run by LHCb physicists on a local computing farm (i.e. non-grid) require more efficient access to the data which resides on the Grid. Our experiments have shown that the I/O bound nature of the analysis jobs in combination with the latency due to the remote access protocols (e.g. rfio, dcap) cause a low CPU efficiency of these jobs. In addition to causing a low CPU efficiency, the remote access protocols give rise to high overhead (in terms of amount of data transferred). This paper gives an overview of the concept of pre-fetching and caching of input files in the proximity of the processing resources, which is exploited to cope with the I/O bound analysis jobs. The files are copied from Grid storage elements (using GridFTP), while concurrently performing computations, inspired from a similar idea used in the ATLAS experiment. The results illustrate that this file staging approach is relatively insensitive to the original location of the data, and a significant improvement can be achieved in terms of the CPU efficiency of an analysis job. Dealing with scalability of such a solution on the Grid environment is discussed briefly

Improved performance of the LHCb Outer Tracker in LHC Run 2

The LHCb Outer Tracker is a gaseous detector covering an area of $5\times 6 m^2$ with 12 double layers of straw tubes. The performance of the detector is presented based on data of the LHC Run 2 running period from 2015 and 2016. Occupancies and operational experience for data collected in $p p$, pPb and PbPb collisions are described. An updated study of the ageing effects is presented showing no signs of gain deterioration or other radiation damage effects. In addition several improvements with respect to LHC Run 1 data taking are introduced. A novel real-time calibration of the time-alignment of the detector and the alignment of the single monolayers composing detector modules are presented, improving the drift-time and position resolution of the detector by 20\%. Finally, a potential use of the improved resolution for the timing of charged tracks is described, showing the possibility to identify low-momentum hadrons with their time-of-flight.Comment: 29 pages, 20 figures, minor changes to match the published versio

In vitro Efficacy of a Novel Guanosine-Analog Phosphonate

Actinic keratosis, a frequent carcinoma in situ of non-melanoma skin cancer (NMSC), can transform into life-threatening cutaneous squamous cell carcinoma. Current treatment is limited due to low complete clearance rates and asks for novel therapeutic concepts; the novel purine nucleotide analogue OxBu may be an option. In order to enhance skin penetration, solid lipid nanoparticles (SLN, 136-156 nm) were produced with an OxBu entrapment efficiency of 96.5 ± 0.1%. For improved preclinical evaluation, we combined tissue engineering with clinically used keratin-18 quantification. Three doses of 10-3 mol/l OxBu, dissolved in phosphate-buffered saline as well as loaded to SLN, were effective on reconstructed NMSC. Tumour response and apoptosis induction were evaluated by an increase in caspase-cleaved fragment of keratin-18, caspase-7 activation as well as by reduced expression of matrix metallopeptidase-2 and Ki-67. OxBu efficacy was superior to equimolar 5-fluorouracil solution, and thus the drug should be subjected to the next step in preclinical evaluation