31 research outputs found
Use of Sensors in the Treatment and Follow-up of Patients with Diabetes Mellitus
Glucose control is the cornerstone of Diabetes Mellitus (DM) treatment. Although self-regulation using capillary glycemia (SRCG) still remains the best procedure in clinical practice, continuous glucose monitoring systems (CGM) offer the possibility of continuous and dynamic assessment of interstitial glucose concentration. CGM systems have the potential to improve glycemic control while decreasing the incidence of hypoglycemia but the efficiency, compared with SRCG, is still debated. CGM systems have the greatest potential value in patients with hypoglycemic unawareness and in controlling daily fluctuations in blood glucose. The implementation of continuous monitoring in the standard clinical setting has not yet been established but a new generation of open and close loop subcutaneous insulin infusion devices are emerging making insulin treatment and glycemic control more reliable
Estimating Plasma Glucose from Interstitial Glucose: The Issue of Calibration Algorithms in Commercial Continuous Glucose Monitoring Devices
Evaluation of metabolic control of diabetic people has been classically performed measuring glucose concentrations in blood samples. Due to the potential improvement it offers in diabetes care, continuous glucose monitoring (CGM) in the subcutaneous tissue is gaining popularity among both patients and physicians. However, devices for CGM measure glucose concentration in compartments other than blood, usually the interstitial space. This means that CGM need calibration against blood glucose values, and the accuracy of the estimation of blood glucose will also depend on the calibration algorithm. The complexity of the relationship between glucose dynamics in blood and the interstitial space, contrasts with the simplistic approach of calibration algorithms currently implemented in commercial CGM devices, translating in suboptimal accuracy. The present review will analyze the issue of calibration algorithms for CGM, focusing exclusively on the commercially available glucose sensors
Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform
Translating cognitive neuroscience to the driverâs operational environment: A neuroergonomic approach
A General Organocatalyzed MichaelâMichael Cascade Reaction Generates Functionalized Cyclohexenes
Real-Time Continuous Glucose Monitoring in an Intensive Care Unit: Better Accuracy in Patients with Septic Shock
Synthesis and Potent Antimalarial Activity of Kalihinol B
Of the 50+ kalihinane diterpenoids
reported to date, only five
had been tested for antimalarial activity, in spite of the fact that
kalihinol A is the most potent among the members of the larger family
of antimalarial isocyanoterpenes. We have validated a strategy designed
to access many of the kalihinanes with a 12-step enantioselective
synthesis of kalihinol B, the tetrahydrofuran isomer of kalihinol
A (a tetrahydropyran). Kalihinol B shows similarly high potency against
chloroquine-resistant Plasmodium falciparum