Trace and rare earth elements contents of a Sardinian sedimentary Mn-rich deposit: preliminary results.

Mn oxides are important scavengers of trace elements from waters. They often form deposits with high metals concentrations that sometimes have economic significance. Within a thick sedimentary deposits of northern Sardinia, Mn oxide mineralization was found as both matrix and coatings on clasts of a conglomeratic deposit, and subrounded nodules in residual clays. Lithiophorite and birnessite are the sole Mn phases that are also accompanied by variable amounts of Fe oxides and hydroxides, clay minerals, and phyllosilicates. Chemical analysis of the studied samples revealed high concentrations of most of trace metals (Co, Ni, Zn, Cu, Ba, Y, U and Pb) and all rare earth elements (REE). The latter were used to provide the first hypothesis regarding environmental conditions and chemical processes determining the precipitation of Mn oxides

CORRELATION BETWEEN CHRONIC MUCOSAL TRAUMA AND ORAL CANCER: A CASE REPORT AND REVIEW OF THE LITERATURE

Abstract – Objective: Squamous cell carcinoma is the most common malignancy in the oral cavity representing the 90% of all oral malignancies that affect oral cavity. Primary risk factors associated with oral cancer are alcohol and tobacco consumption. However, other emerging risk factors have been proposed in Literature, including chronic trauma of the oral mucosa related to dental prostheses and incongruous restorations. Therefore, the aim of this study was to review the literature on the correlation between oral carcinoma and chronic irritative trauma, with the help of a case report and with focus on clinical features and differential diagnosis. Materials and Methods: A literature search on MEDLINE, PubMed, ScienceDirect, Cochrane Database of Systematic Reviews and Wiley InterScience was performed, using the following words: Oral Cancer, chronic Trauma and Denture Trauma in various combinations. Results: The review produced 1356 results, but only 8 articles met the inclusion criteria and were involved in the review. No association has been proven between chronic mucosal trauma and oral cancer. Carcinoma has been shown to develop more frequently in trauma regions, particularly in the tongue. As for the data on the gender and age of affected patients, it emerges that most of the greatest incidence occurs around the sixth and seventh decade of life and men are more affected than women. Conclusions: Due to the heterogeneity of the different studies and the strong presence of other factors such as smoking and alcohol, the role of trauma in carcinogenesis is unclear. Further molecular, epidemiological and case-control studies are needed to define this correlation. It is advisable to carry out more restricted checks in patients at risk with dental prostheses

Low Cost True Monofiber Optical Probe for Local Void Fraction Measurements in Minichannels

Two phase flow inside minichannels is one of the most investigated research topic at present. The measurement of the flow rate parameters is fundamental to characterize the flow pattern and its evolution over time. This paper shows that an optical technique, well-known for large diameter pipes, can be applied to mini channels with a laminar mass flow rate. In particular, a Y-junction mono-fiber optic system with a chamfered tip probe has been built and tested. This method is applied to the local void fraction measurement in a copper capillary pipe with internal diameter of 2 mm and external diameter of 3.00 mm. Different probes have been developed and tested. The accuracy of the method depends on the size, the shape of the tip and on the tip distance from the pipe centre. Different distances and liquid flow rate have been tested. The two-phase flow pattern is also visualized and recorded by a high speed camera (FASTEC Troubleshooter 16000 fps) and post processed with an image analysis technique. A good agreement between the optical and the video signal has been observed

An Innovative Enhanced Wall to Reduce the Energy Demand in Buildings

Energy saving in buildings is one of most important issues for European countries. The 40% of the total European energy consumption is due to building Heating and conditioning. Although in the last years many studies have been carried out in order to reach the zero-consumption house by means of passive solar heating, ventilation or thermal insulation, the energy rate due to passive solar heating could be further enhanced. This paper proposes a method for increasing the energy rate absorbed by opaque walls by using a two phase loop thermosyphon connecting the internal and the external façade of a prefabricated house wall. The evaporator zone is located on the outside face and it is irradiated by the sunlight while the condenser zone is placed on the internal face and releases heat to the domestic environment. The temperature differences between the internal and external wall facades are lower than 30 K and the heat fluxes at the evaporator change during the day from 2 up to 7 x 104 W/m2 K. The thermosyphon has been preliminary designed and implanted into a wall for a prefabricated house in Italy. A thermal model of building equipped with the thermosiphon wall has been used in order to evaluate the impact in terms of energy saving and thermal comfort in a real prefabricated low consumption house. The transient behaviour of the building has been simulated day by day during the winter period by using the EnergyPlusTM software. This solution enhances the thermal comfort of the building by keeping the indoor temperature close to the thermal comfort standard for most of the day. The annual saving on the heating energy is higher than 50% in the case of a low consumption buildin

“CoVidentary”: An online exercise training program to reduce sedentary behaviours in children with type 1 diabetes during the COVID-19 pandemic

Aim: We explored the physical activity (PA) level and the variation in glycaemic control in children with type 1 diabetes (T1D) before and during the lockdown. Then, we proposed an online training program supported by sport-science specialists. Methods: Parents of children with T1D (<18 years) filled out an online survey. Anthropometric characteristics, PA, play, sport and sedentary time and the medical related outcomes were recorded. An adapted online program “Covidentary” was proposed through full-training (FT) and active breaks (AB) modality. Results: 280 youth (11.8 ± 3.3 years) were included in the analysis. We reported a decline in sport (-2.1 ± 2.1 h/week) and outdoor-plays (-73.9 ± 93.6 min/day). Moreover, we found an increase in sedentary time (+144.7 ± 147.8 min/day), in mean glycaemic values (+25.4 ± 33.4 mg/dL) and insulin delivery (71.8% of patients). 37% of invited patients attended the training program, 46% took part in AB and 54% in FT. The AB was carried out for 90% of the total duration, while the FT for 31%. Both types of training were perceived as moderate intensity effort. Conclusion: A decline of participation in sport activities and a subsequent increase of sedentary time influence the management of T1D of children, increasing the risk of acute/long-term complications. Online exercise program may contrast the pandemic's sedentary lifestyle

Opioids in chronic non cancer pain: rational and selection criteria

The therapeutic efficacy and appearance of side effects of opioid drugs is strongly conditioned by the patient’s individual characteristics. It is impossible to know the patient’s particular pharmacogenomic connotations which determine those phenotypic expressions that make the patient more or less sensitive to the administered drug, and that also determine the presence and signifi cance of side effects. Knowledge of the patient’s hepatic opioid metabolization can aid in the choice of a more personalised therapy. To reduce the unpredictability of favourable effects and side effects, it is preferable to choose drugs that are less affected by pharmacological interactions, and that can also compromise the efficacy of the many pharmacological associations that patients undergo, especially elderly patients, who often suffer from serious organ impairments

Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment

Abstract. – OBJECTIVE: The aim of this review is to describe the “hot points” of current clinical governance for oral HPV comprising the use of new diagnostic molecular procedures, namely, Pyrosequencing and Next Generation Sequencing. MATERIALS AND METHODS: The data on oral HPV was collected through two levels of research. First for all, we used the canonical medical search engines, PubMed, and Medline, followed by the study of current commercial tools for HPV diagnosis, particularly within commercial companies involved in the molecular procedures for HPV detecting and genotyping. RESULTS: Different medical procedures are now described and used throughout the world in HPV diagnosis and treatment. However, the laboratory methods are often validated and used for genital infections, and, in these cases, data are missing in the literature as regards the clinical approach for oral lesions. CONCLUSIONS: Dental care units are often the front line for a clinical evaluation of a possible HPV lesion in the oral cavity, which means that correct clinical governance could avoid a viral neoplastic progression of this disease with great advantages for the patient. In this case, the problem is due to the difficulty in lesion recognition but also and more especially the absence of correct laboratory diagnosis and subsequent treatment in the clinical course

Effect of the Ambient Temperature on the Start-Up of a Multi-Evaporator Loop Thermosyphon

Abstrac

deficit irrigation strategies in vitis vinifera l cv cannonau under mediterranean climate part i physiological responses growth yield and berry composition

The effect of deficit irrigation strategies on physiological performance, growth, source:sink balance, water productivity and berry composition of field-grown grapevines of Vitis vinifera L. cv. Cannonau (syn. Grenache)/1103P were investigated in Sardinia, Italy, in 2009. In two of the treatments, both sides of the root system received 50% and 25% crop evapotranspiration (ETc), referred to as strategies DI50 and DI25, respectively. In the third treatment, which included partial root-zone drying (strategy PRD), ETc was set at 50%. All three treatments were compared to a full irrigation control (strategy FI), thus 100% ETc. No severe water stress was imposed from berry development onwards. Strategies DI25 and PRD induced higher stomatal closure and leaf water-use efficiency. A slightly higher net assimilation rate was recorded in FI before veraison. During ripening, leaf area decreased in DI50 and DI25, but lateral shoots continued to grow in FI and PRD. Yield and pruning weight were higher in FI, but in all the treatments the vines were source:sink balanced and supported ripening. Irrigation water productivity was higher in DI25, and no significant differences in yield or water productivity were observed between PRD and DI50 irrigated with a similar volume of water. Full irrigation produced berries with a significantly higher fresh and dry weight, lower °Brix and higher malic acid at harvest, while PRD berries weighed less and had less titratable acidity, lower phenol content and a higher pH. Total anthocyanin contents were consistently lower in DI25 and PRD, with highest values measured in DI50. The treatments showed different anthocyanin profiles, with a higher concentration of acylated anthocyanin in DI25 and PRD

Beyond mobile phone displays: Flat panel display technology for biomedical applications

Organ-on-Chips (OoCs) have emerged as a human-specific experimental platform for preclinical research and therapeutics testing that will reduce the cost of pre-clinical drug development, provide better physiological relevance and replace animal testing. Yet, the lack of standardization and cost-effective fabrication technologies can hamper wide-spread adoption of OoCs. In this work we validate the use of flat panel display (FPD) technology as an enabling and cost-effective technology platform for biomedical applications by demonstrating facile integration of key OoC modules like microfluidics and micro electrode arrays (MEAs) in the standardized 96-well plate format. Individual and integrated modules were tested for their biological applicability in OoCs. For microelectrode arrays we demonstrate 90–95% confluency, 3 days after cell seeding and >70% of the initial mitochondrial cell activity for microfluidic devices. Thus highlighting the biocompatibility of these modules fabricated using FPD technology. Furthermore, we provide two examples of monolithically integrated microfluidics and microelectronics, i.e. integrated electronic valves and integrated MEAs, that showcase the strength of FPD technology applied to biomedical device fabrication. Finally, the merits and opportunities provided by FPD technology are discussed through examples of advanced structures and functionalities that are unique to this enabling platform