8,392 research outputs found
Quantum information analysis of electronic states at different molecular structures
We have studied transition metal clusters from a quantum information theory
perspective using the density-matrix renormalization group (DMRG) method. We
demonstrate the competition between entanglement and interaction localization.
We also discuss the application of the configuration interaction based
dynamically extended active space procedure which significantly reduces the
effective system size and accelerates the speed of convergence for complicated
molecular electronic structures to a great extent. Our results indicate the
importance of taking entanglement among molecular orbitals into account in
order to devise an optimal orbital ordering and carry out efficient
calculations on transition metal clusters. We propose a recipe to perform DMRG
calculations in a black-box fashion and we point out the connections of our
work to other tensor network state approaches
The ROCK inhibitor Fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus
Indexación: Web of Science; Scopus.Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply modifications in dendritic cytoskeleton. Rho GTPases are regulators of actin dynamics through their effector Rho kinase. We have reported that chronic stress promotes depressive-like behaviors in rats along with dendritic spine loss in apical dendrites of hippocampal pyramidal neurons, changes associated with Rho kinase activation. The present study proposes that the Rho kinase inhibitor Fasudil may prevent the stress-induced behavior and dendritic spine loss. Methods: Adult male Sprague-Dawley rats were injected with saline or Fasudil (i.p., 10 mg/kg) starting 4 days prior to and maintained during the restraint stress procedure (2.5 h/d for 14 days). Nonstressed control animals were injected with saline or Fasudil for 18 days. At 24 hours after treatment, forced swimming test, Golgi-staining, and immuno-western blot were performed. Results: Fasudil prevented stress-induced immobility observed in the forced swimming test. On the other hand, Fasudiltreated control animals showed behavioral patterns similar to those of saline-treated controls. Furthermore, we observed that stress induced an increase in the phosphorylation of MYPT1 in the hippocampus, an exclusive target of Rho kinase. This change was accompanied by dendritic spine loss of apical dendrites of pyramidal hippocampal neurons. Interestingly, increased pMYPT1 levels and spine loss were both prevented by Fasudil administration. Conclusion: Our findings suggest that Fasudil may prevent the development of abnormal behavior and spine loss induced by chronic stress by blocking Rho kinase activity.https://academic.oup.com/ijnp/article/20/4/336/263217
Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats
Indexación: Web of Science; Scopus.Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared the effect of repeated stress on the expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor subunits in dorsal and ventral hippocampus (VH). Adult male Sprague-Dawley rats were randomly divided into control and stressed groups, and were daily restrained in their motion (2.5 h/day) during 14 days. We found that chronic stress promotes an increase in c-Fos mRNA levels in both hippocampal areas, although it was observed a reduction in the immunoreactivity at pyramidal cell layer. Furthermore, Arc mRNAs levels were increased in both dorsal and VH, accompanied by an increase in Arc immunoreactivity in dendritic hippocampal layers. Furthermore, stress triggered a reduction in PSD-95 and NR1 protein levels in whole extract of dorsal and VH. Moreover, a reduction in NR2A/NR2B ratio was observed only in dorsal pole. In synaptosomal fractions, we detected a rise in NR1 in dorsal hippocampus (DH). By indirect immunofluorescence we found that NR1 subunits rise, especially in neuropil areas of dorsal, but not VH. In relation to AMPA receptor (AMPAR) subunits, chronic stress did not trigger any change, either in dorsal or ventral hippocampal areas. These data suggest that DH is more sensitive than VH to chronic stress exposure, mainly altering the expression of NMDA receptor (NMDAR) subunits, and probably favors changes in the configuration of this receptor that may influence the function of this area.https://www.frontiersin.org/articles/10.3389/fnmol.2017.00244/ful
On microphysical processes of noctilucent clouds (NLC): Observations and modeling of mean and width of the particle size-distribution
Noctilucent clouds (NLC) in the polar summer mesopause region have been observed in Norway (69° N, 16° E) between 1998 and 2009 by 3-color lidar technique. Assuming a mono-modal Gaussian size distribution we deduce mean and width of the particle sizes throughout the clouds. We observe a quasi linear relationship between distribution width and mean of the particle size at the top of the clouds and a deviation from this behavior for particle sizes larger than 40 nm, most often in the lower part of the layer. The vertically integrated particle properties show that 65% of the data follows the linear relationship with a slope of 0.42±0.02 for mean particle sizes up to 40 nm. For the vertically resolved particle properties (Δz = Combining double low line 0.15 km) the slope is comparable and about 0.39±0.03. For particles larger than 40 nm the distribution width becomes nearly independent of particle size and even decreases in the lower part of the layer. We compare our observations to microphysical modeling of noctilucent clouds and find that the distribution width depends on turbulence, the time that turbulence can act (cloud age), and the sampling volume/time (atmospheric variability). The model results nicely reproduce the measurements and show that the observed slope can be explained by eddy diffusion profiles as observed from rocket measurements. © 2010 Author(s)
Finding local community structure in networks
Although the inference of global community structure in networks has recently
become a topic of great interest in the physics community, all such algorithms
require that the graph be completely known. Here, we define both a measure of
local community structure and an algorithm that infers the hierarchy of
communities that enclose a given vertex by exploring the graph one vertex at a
time. This algorithm runs in time O(d*k^2) for general graphs when is the
mean degree and k is the number of vertices to be explored. For graphs where
exploring a new vertex is time-consuming, the running time is linear, O(k). We
show that on computer-generated graphs this technique compares favorably to
algorithms that require global knowledge. We also use this algorithm to extract
meaningful local clustering information in the large recommender network of an
online retailer and show the existence of mesoscopic structure.Comment: 7 pages, 6 figure
Approximating Spectral Impact of Structural Perturbations in Large Networks
Determining the effect of structural perturbations on the eigenvalue spectra
of networks is an important problem because the spectra characterize not only
their topological structures, but also their dynamical behavior, such as
synchronization and cascading processes on networks. Here we develop a theory
for estimating the change of the largest eigenvalue of the adjacency matrix or
the extreme eigenvalues of the graph Laplacian when small but arbitrary set of
links are added or removed from the network. We demonstrate the effectiveness
of our approximation schemes using both real and artificial networks, showing
in particular that we can accurately obtain the spectral ranking of small
subgraphs. We also propose a local iterative scheme which computes the relative
ranking of a subgraph using only the connectivity information of its neighbors
within a few links. Our results may not only contribute to our theoretical
understanding of dynamical processes on networks, but also lead to practical
applications in ranking subgraphs of real complex networks.Comment: 9 pages, 3 figures, 2 table
Finding community structure in very large networks
The discovery and analysis of community structure in networks is a topic of
considerable recent interest within the physics community, but most methods
proposed so far are unsuitable for very large networks because of their
computational cost. Here we present a hierarchical agglomeration algorithm for
detecting community structure which is faster than many competing algorithms:
its running time on a network with n vertices and m edges is O(m d log n) where
d is the depth of the dendrogram describing the community structure. Many
real-world networks are sparse and hierarchical, with m ~ n and d ~ log n, in
which case our algorithm runs in essentially linear time, O(n log^2 n). As an
example of the application of this algorithm we use it to analyze a network of
items for sale on the web-site of a large online retailer, items in the network
being linked if they are frequently purchased by the same buyer. The network
has more than 400,000 vertices and 2 million edges. We show that our algorithm
can extract meaningful communities from this network, revealing large-scale
patterns present in the purchasing habits of customers
Stanilov-Tsankov-Videv Theory
We survey some recent results concerning Stanilov-Tsankov-Videv theory,
conformal Osserman geometry, and Walker geometry which relate algebraic
properties of the curvature operator to the underlying geometry of the
manifold.Comment: This is a contribution to the Proceedings of the 2007 Midwest
Geometry Conference in honor of Thomas P. Branson, published in SIGMA
(Symmetry, Integrability and Geometry: Methods and Applications) at
http://www.emis.de/journals/SIGMA
Updated NNLO QCD predictions for the weak radiative B-meson decays
Weak radiative decays of the B mesons belong to the most important flavor
changing processes that provide constraints on physics at the TeV scale. In the
derivation of such constraints, accurate standard model predictions for the
inclusive branching ratios play a crucial role. In the current Letter we
present an update of these predictions, incorporating all our results for the
O(alpha_s^2) and lower-order perturbative corrections that have been calculated
after 2006. New estimates of nonperturbative effects are taken into account,
too. For the CP- and isospin-averaged branching ratios, we find B_{s gamma} =
(3.36 +_ 0.23) * 10^-4 and B_{d gamma} = 1.73^{+0.12}_{-0.22} * 10^-5, for
E_gamma > 1.6GeV. Both results remain in agreement with the current
experimental averages. Normalizing their sum to the inclusive semileptonic
branching ratio, we obtain R_gamma = ( B_{s gamma} + B_{d gamma})/B_{c l nu} =
(3.31 +_ 0.22) * 10^-3. A new bound from B_{s gamma} on the charged Higgs boson
mass in the two-Higgs-doublet-model II reads M_{H^+} > 480 GeV at 95%C.L.Comment: journal version, 5 pages, no figure
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