User's guide to image processing applications of the NOAA satellite HRPT/AVHRR data. Part 1: Introduction to the satellite system and its applications. Part 2: Processing and analysis of AVHRR imagery

The use of NOAA Advanced Very High Resolution Radar/High Resolution Picture Transmission (AVHRR/HRPT) imagery for earth resource applications is provided for the applications scientist for use within the various Earth science, resource, and agricultural disciplines. A guide to processing NOAA AVHRR data using the hardware and software systems integrated for this NASA project is provided. The processing steps from raw data on computer compatible tapes (1B data format) through usable qualitative and quantitative products for applications are given. The manual is divided into two parts. The first section describes the NOAA satellite system, its sensors, and the theoretical basis for using these data for environmental applications. Part 2 is a hands-on description of how to use a specific image processing system, the International Imaging Systems, Inc. (I2S) Model 75 Array Processor and S575 software, to process these data

Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation.

Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell-intrinsic mechanism, and identified the GSK-3 inhibitor CHIR99021 as a potent radioprotector. CHIR99021 treatment improved Lgr5+ cell survival and crypt regeneration after radiation in culture and mice. CHIR99021 treatment specifically blocked apoptosis and PUMA induction and K120 acetylation of p53 mediated by acetyl-transferase Tip60, while it had no effect on p53 stabilization, phosphorylation or p21 induction. CHIR99021 also protected human intestinal cultures from radiation by PUMA but not p21 suppression. These results demonstrate that p53 posttranslational modifications play a key role in the pathological and apoptotic response of the intestinal stem cells to radiation and can be targeted pharmacologically

Deep infrared observations of the puzzling central X-ray source in RCW103

1E 161348-5055 (1E 1613) is a point-like, soft X-ray source originally identified as a radio-quiet, isolated neutron star, shining at the center of the 2000 yr old supernova remnant RCW103. 1E 1613 features a puzzling 6.67 hour periodicity as well as a dramatic variability over a time scale of few years. Such a temporal behavior, coupled to the young age and to the lack of an obvious optical counterpart, makes 1E 1613 a unique source among all compact objects associated to SNRs. It could either be the first low-mass X-ray binary system discovered inside a SNR, or a peculiar isolated magnetar with an extremely slow spin period. Analysis of archival IR observations, performed in 2001 with the VLT/ISAAC instrument, and in 2002 with the NICMOS camera onboard HST unveils a very crowded field. A few sources are positionally consistent with the refined X-ray error region that we derived from the analysis of 13 Chandra observations. To shed light on the nature of 1E 1613, we have performed deep IR observations of the field with the NACO instrument at the ESO/VLT, searching for variability. We find no compelling reasons to associate any of the candidates to 1E 1613. On one side, within the frame of the binary system model for the X-ray source, it is very unlikely that one of the candidates be a low-mass companion star to 1E 1613. On the other side, if the X-ray source is an isolated magnetar surrounded by a fallback disc, we cannot exclude that the IR counterpart be hidden among the candidates. If none of the potential counterparts is linked to the X-ray source, 1E 1613 would remain undetected in the IR down to Ks>22.1. Such an upper limit is consistent only with an extremely low-mass star (an M6-M8 dwarf) at the position of 1E 1613, and makes rather problematic the interpretation of 1E 1613 as an accreting binary system.Comment: 26 pages, 5 figures. Accepted for publication in Ap

The 69 ms Radio Pulsar Near the Supernova Remnant RCW 103

We report the detection of the radio pulsar counterpart to the 69 ms X-ray pulsar discovered near the supernova remnant RCW 103 (G332.4-0.4). Our detection confirms that the pulsations arise from a rotation-powered neutron star, which we name PSR J1617-5055. The observed barycentric period derivative confirms that the pulsar has a characteristic age of only 8 kyr, the sixth smallest of all known pulsars. The unusual apparent youth of the pulsar and its proximity to a young remnant requires that an association be considered. Although the respective ages and distances are consistent within substantial uncertainties, the large inferred pulsar transverse velocity is difficult to explain given the observed pulsar velocity distribution, the absence of evidence for a pulsar wind nebula, and the symmetry of the remnant. Rather, we argue that the objects are likely superposed on the sky; this is reasonable given the complex area. Without an association, the question of where is the supernova remnant left behind following the birth of PSR J1617-5055 remains open. We also discuss a possible association between PSR J1617-5055 and the gamma-ray source 2CG 333+01. Though an association is energetically plausible, it is unlikely given that EGRET did not detect 2CG 333+01.Comment: 18 pages, 2 encapsulated Postscript figures, uses AAS LaTeX style files. Accepted for publication in The Astrophysical Journal Letter

Normal modes and discovery of high-order cross-frequencies in the DBV white dwarf GD 358

We present a detailed mode identification performed on the 1994 Whole Earth Telescope (WET) run on GD 358. The results are compared with that obtained for the same star from the 1990 WET data. The two temporal spectra show very few qualitative differences, although amplitude changes are seen in most modes, including the disappearance of the mode identified as k=14 in the 1990 data. The excellent coverage and signal-to-noise ratio obtained during the 1994 run lead to the secure identification of combination frequencies up to fourth order, i.e. peaks that are sums or differences of up to four parent frequencies, including a virtually complete set of second-order frequencies, as expected from harmonic distortion. We show how the third-order frequencies are expected to affect the triplet structure of the normal modes by back-interacting with them. Finally, a search for ℓ=2 modes was unsuccessful, not verifying the suspicion that such modes had been uncovered in the 1990 data set

Pattern of Disease after Murine Hepatitis Virus Strain 3 Infection Correlates with Macrophage Activation and Not Viral Replication

Murine hepatitis virus strain (MHV-3) produces a strain-dependent pattern of disease which has been used as a model for fulminant viral hepatitis. This study was undertaken to examine whether there was a correlation between macrophage activation and susceptibility or resistance to MHV-3 infection. Peritoneal macrophages were isolated from resistant A/J and susceptible BALB/cJ mice and, following stimulation with MHV-3 or lipopolysaccharide (LPS), analyzed for transcription of mRNA and production of interleukin-1 (IL-1), tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta (TGF-beta), mouse fibrinogen-like protein (musfiblp), tissue factor (TF), leukotriene B4, and prostaglandin E2 (PGE2). Macrophages from BALB/cJ mice produced greater amounts of IL-1, TNF-alpha, TGF-beta, leukotriene B4, and musfiblp following MHV-3 infection than macrophages from resistant A/J mice, whereas in response to LPS, equivalent amounts of IL-1, TNF-alpha, TGF-beta, and TF were produced by macrophages from both strains of mice. Levels of mRNA of IL-1, TNF-alpha, and musfiblp were greater and more persistent in BALB/cJ than in A/J macrophages, whereas the levels and kinetics of IL-1, TNF-alpha, and TF mRNA following LPS stimulation were identical in macrophages from both strains of mice. Levels of production of PGE2 by MHV-3-stimulated macrophages from resistant and susceptible mice were equivalent; however, the time course for induction of PGE2, differed, but the total quantity of PGE2 produced was insufficient to inhibit induction of musfiblp, a procoagulant known to correlate with development of fulminant hepatic necrosis in susceptible mice. These results demonstrate marked differences in production of inflammatory mediators to MHV-3 infection in macrophages from resistant A/J and susceptible BALB/cJ mice, which may explain the marked hepatic necrosis and fibrin deposition and account for the lethality of MHV-3 in susceptible mice

Typical equilibrium state of an embedded quantum system

We consider an arbitrary quantum system coupled non perturbatively to a large arbitrary and fully quantum environment. In [G. Ithier and F. Benaych-Georges, Phys. Rev. A 96, 012108 (2017)] the typicality of the dynamics of such an embedded quantum system was established for several classes of random interactions. In other words, the time evolution of its quantum state does not depend on the microscopic details of the interaction. Focusing at the long time regime, we use this property to calculate analytically a new partition function characterizing the stationary state and involving the overlaps between eigenvectors of a bare and a dressed Hamiltonian. This partition function provides a new thermodynamical ensemble which includes the microcanonical and canonical ensembles as particular cases. We check our predictions with numerical simulations.Comment: 1 figure, 5 pages. This article supersedes the part on the equilibrium state in arXiv:1510.0435

Older Babies - More Active Mothers? How Maternal Labor Supply Changes as the Child Grows

Female labor market activity is dependent on the presence and the age of a child, but how do the determinants develop in magnitude and significance with the child's age? Using German SOEP data from 1991 to 2006 for mothers with young children, the change in maternal labor supply when the child is one, two, and three years old is explicitly addressed. According to the tobit regression results for precise working hours, maternal labor supply becomes increasingly responsive to economic incentives - mainly to imputed wages - as the child grows