Naphthoquinone derivatives and lignans from the Paraguayan crude drug

Schmeda-Hirschmann,G. Laboratorio de Quımica de Productos Naturales,Instituto de Quımica de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile.The Paraguayan crude drug “tayı¨ pyta´” is used to treat cancer, wounds and inflammation. It consist of the bark and trunkwood of Tabebuia heptaphylla (Bignoniaceae). A phytochemical study of the crude drug gave, in addition to previously described naphthoquinones and the known lignans cycloolivil and secoisolariciresinol, three new lapachenol (lapachonone)-, two naphthofuran-, a chromone and a naphthalene derivative. The structures were elucidated by means of high field NMR spectroscopy. The biological activity of the main compound lapachol and the related α-lapachone as well as the lignans cycloolivil and secoisolariciresinol can explain, at least in part, the effect atributed to the crude drug in Paraguayan folk medicine

Talking Democracy at the United Nations. Power, Regime Type, and the Democratization of International Rule

Institutions, Decisions and Collective Behaviou

To be or not to be? Lebensdynamiken internationaler Organisationen im Spannungsfeld von internationaler Autorität und nationalstaatlicher Souveränität

Die Forschung zu internationalen Organisationen (IOs), die sich bisher überwie‐gend mit der Entstehung und dem Design von IOs beschäftigte, steht aufgrund desBrexits und der Ankündigung verschiedener Staaten aus dem Internationalen Straf‐gerichtshof auszutreten vor neuen Herausforderungen. Austritte von Mitgliedsstaa‐ten sind nur eine Form von staatlichem Handeln, das die Autorität von IOs beein‐trächtigt. Dieser Beitrag argumentiert, dass neben Austritten auch Budgetkürzun‐gen, Personalblockaden, Mandatsbeschränkungen und die Verletzung zentralerNormen IOs unter Druck setzen. Die zentrale Frage hierbei ist, wie IOs selbst mitdiesen Herausforderungen umgehen. Basierend auf Theorien der Multilateralis‐mus- und der Organisationsforschung analysiert dieser Beitrag Nicht-Reaktion,Vermeiden von Aufmerksamkeit, Anpassung und Resilienz-Bildung. Diese Heraus‐forderungen und Reaktionen werden anhand des historischen Beispiels des Völker‐bundes illustriert. Abschließend werden mögliche Annahmen hinsichtlich des insti‐tutionellen Designs von IOs, der Art der Herausforderung, des Status des heraus‐fordernden Staates und der Positionen der übrigen Mitgliedsstaaten diskutiert, umdie Varianz in den Reaktionen von IOs zu erklären. Institutions, Decisions and Collective Behaviou

Biotransformations of imbricatolic acid by Aspergillus niger and Rhizopus nigricans cultures

Guillermo Schmeda-Hirschmann and Carlos Aranda Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile. Jaime A. Rodríguez and Cristina Theoduloz. Depto. de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, ChileMicrobial transformation of imbricatolic acid (1) by Aspergillus niger afforded 1α-hydroxyimbricatolic acid (2), while transformation with Rhizopus nigricans yielded 15- hydroxy-8,17-epoxylabdan-19-oic acid (3). When the diterpene 1 was added to a Cunninghamella echinulata culture, the main products were the microbial metabolites mycophenolic acid (4) and its 3-hydroxy derivative 5. All the structures were elucidated by spectroscopic methods. The cytotoxicity of these compounds towards human lung fibroblasts and AGS cells was assessed. While 4 and 5 showed low cytotoxicity, with IC50 values > 1000 μM against AGS cells and fibroblasts, 1α-hydroxyimbricatolic acid (2) presented moderate toxicity towards these targets, with IC50 values of 307 and 631 μM, respectively. The structure of 2 is presented for the first time

The cosmic growth of the active black hole population at 1<z<2 in zCOSMOS, VVDS and SDSS

We present a census of the active black hole population at 1<z<2, by constructing the bivariate distribution function of black hole mass and Eddington ratio, employing a maximum likelihood fitting technique. The study of the active black hole mass function (BHMF) and the Eddington ratio distribution function (ERDF) allows us to clearly disentangle the active galactic nuclei (AGN) downsizing phenomenon, present in the AGN luminosity function, into its physical processes of black hole mass downsizing and accretion rate evolution. We are utilizing type-1 AGN samples from three optical surveys (VVDS, zCOSMOS and SDSS), that cover a wide range of 3 dex in luminosity over our redshift interval of interest. We investigate the cosmic evolution of the AGN population as a function of AGN luminosity, black hole mass and accretion rate. Compared to z = 0, we find a distinct change in the shape of the BHMF and the ERDF, consistent with downsizing in black hole mass. The active fraction or duty cycle of type-1 AGN at z~1.5 is almost flat as a function of black hole mass, while it shows a strong decrease with increasing mass at z=0. We are witnessing a phase of intense black hole growth, which is largely driven by the onset of AGN activity in massive black holes towards z=2. We finally compare our results to numerical simulations and semi-empirical models and while we find reasonable agreement over certain parameter ranges, we highlight the need to refine these models in order to match our observations.Comment: 31 pages, 28 figures, accepted for publication in MNRA

Rotating magnetic solution in three dimensional Einstein gravity

We obtain the magnetic counterpart of the BTZ solution, i.e., the rotating spacetime of a point source generating a magnetic field in three dimensional Einstein gravity with a negative cosmological constant. The static (non-rotating) magnetic solution was found by Clement, by Hirschmann and Welch and by Cataldo and Salgado. This paper is an extension of their work in order to include (i) angular momentum, (ii) the definition of conserved quantities (this is possible since spacetime is asymptotically anti-de Sitter), (iii) upper bounds for the conserved quantities themselves, and (iv) a new interpretation for the magnetic field source. We show that both the static and rotating magnetic solutions have negative mass and that there is an upper bound for the intensity of the magnetic field source and for the value of the angular momentum. The magnetic field source can be interpreted not as a vortex but as being composed by a system of two symmetric and superposed electric charges, one of the electric charges is at rest and the other is spinning. The rotating magnetic solution reduces to the rotating uncharged BTZ solution when the magnetic field source vanishes.Comment: Latex (uses JHEP3.cls), 12 pages. Published versio

Critical behavior of gravitating sphalerons

We examine the gravitational collapse of sphaleron type configurations in Einstein--Yang--Mills--Higgs theory. Working in spherical symmetry, we investigate the critical behavior in this model. We provide evidence that for various initial configurations, there can be three different critical transitions between possible endstates with different critical solutions sitting on the threshold between these outcomes. In addition, we show that within the dispersive and black hole regimes, there are new possible endstates, namely a stable, regular sphaleron and a stable, hairy black hole.Comment: Latex, 14 pages, 8 figure

Earth’s carbon deficit caused by early loss through irreversible sublimation

Carbon is an essential element for life, but its behavior during Earth’s accretion is not well understood. Carbonaceous grains in meteoritic and cometary materials suggest that irreversible sublimation, and not condensation, governs carbon acquisition by terrestrial worlds. Through astronomical observations and modeling, we show that the sublimation front of carbon carriers in the solar nebula, or the soot line, moved inward quickly so that carbon-rich ingredients would be available for accretion at 1 astronomical unit after the first million years. On the other hand, geological constraints firmly establish a severe carbon deficit in Earth, requiring the destruction of inherited carbonaceous organics in the majority of its building blocks. The carbon-poor nature of Earth thus implies carbon loss in its precursor material through sublimation within the first million years

Electric multipole plasmons in deformed sodium clusters

The random-phase-approximation (RPA) method with separable residual forces (SRPA) is proposed for the description of multipole electric oscillations of valence electrons in deformed alkali metal clusters. Both the deformed mean field and residual interaction are derived self-consistently from the Kohn-Sham functional. SRPA drastically simplifies the computational effort which is urgent if not decisive for deformed systems. The method is applied to the description of dipole, quadrupole and octupole plasmons in deformed sodium clusters of a moderate size. We demonstrate that, in clusters with the size N>50, Landau damping successfully competes with deformation splitting and even becomes decisive in forming the width and gross structure of the dipole plasmon. Besides, the plasmon is generated by excitations from both ground state and shape isomers. In such clusters familiar experimental estimates for deformation splitting of dipole plasmon are useless.Comment: 27 pages, 10 figure