Dissipative and nonaxisymmetric standard-MRI in Kepler disks

Deviations from axial symmetry are necessary to maintain self-sustained MRI-turbulence. We define the parameters region where nonaxisymmetric MRI is excited and study dependence of the unstable modes structure and growth rates on the relevant parameters. We solve numerically the linear eigenvalue problem for global axisymmetric and nonaxisymmetric modes of standard-MRI in Keplerian disks with finite diffusion. For small magnetic Prandtl number the microscopic viscosity completely drops out from the analysis so that the stability maps and the growth rates expressed in terms of the magnetic Reynolds number Rm and the Lundquist number S do not depend on the magnetic Prandtl number Pm. The minimum magnetic field for onset of nonaxisymmetric MRI grows with Rm. For given S all nonaxisymmetric modes disappear for sufficiently high Rm. This behavior is a consequence of the radial fine-structure of the nonaxisymmetric modes resulting from the winding effect of differential rotation. It is this fine-structure which presents severe resolution problems for the numerical simulation of MRI at large Rm. For weak supercritical magnetic fields only axisymmetric modes are unstable. Nonaxisymmetric modes need stronger fields and not too fast rotation. If Pm is small its real value does not play any role in MRI.Comment: 4 pages, 6 figures, A&A Lette

MHD simulations of the magnetorotational instability in a shearing box with zero net flux. II. The effect of transport coefficients

We study the influence of the choice of transport coefficients (viscosity and resistivity) on MHD turbulence driven by the magnetorotational instability (MRI) in accretion disks. We follow the methodology described in paper I: we adopt an unstratified shearing box model and focus on the case where the net vertical magnetic flux threading the box vanishes. For the most part we use the finite difference code ZEUS, including explicit transport coefficients in the calculations. However, we also compare our results with those obtained using other algorithms (NIRVANA, the PENCIL code and a spectral code) to demonstrate both the convergence of our results and their independence of the numerical scheme. We find that small scale dissipation affects the saturated state of MHD turbulence. In agreement with recent similar numerical simulations done in the presence of a net vertical magnetic flux, we find that turbulent activity (measured by the rate of angular momentum transport) is an increasing function of the magnetic Prandtl number Pm for all values of the Reynolds number Re that we investigated. We also found that turbulence disappears when the Prandtl number falls below a critical value Pm_c that is apparently a decreasing function of Re. For the limited region of parameter space that can be probed with current computational resources, we always obtained Pm_c>1. We conclude that the magnitudes of the transport coefficients are important in determining the properties of MHD turbulence in numerical simulations in the shearing box with zero net flux, at least for Reynolds numbers and magnetic Prandtl numbers that are such that transport is not dominated by numerical effects and thus can be probed using current computational resources.Comment: 10 pages, 13 figures, accepted in A&A. Numerical results improved, minor changes in the tex

Impact of dimensionless numbers on the efficiency of MRI-induced turbulent transport

The magneto-rotational instability is presently the most promising source of turbulent transport in accretion disks. However, some important issues still need to be addressed to quantify the role of MRI in disks; in particular no systematic investigation of the role of the physical dimensionless parameters of the problem on the dimensionless transport has been undertaken yet. First, we complete existing investigations on the field strength dependence by showing that the transport in high magnetic pressure disks close to marginal stability is highly time-dependent and surprisingly efficient. Second, we bring to light a significant dependence of the global transport on the magnetic Prandtl number, with $\alpha\propto Pm^\delta$ for the explored range: $0.12<Pm<8$ and $200<Re<6400$ ($\delta$ being in the range 0.25 to 0.5). We show that the dimensionless transport is not correlated to the dimensionless linear growth rate, contrarily to a largely held expectation. More generally, these results stress the need to control dissipation processes in astrophysical simulations.Comment: 11 pages, 11 figures, accepted to MNRA

Transition from collisionless to collisional MRI

Recent calculations by Quataert et al. (2002) found that the growth rates of the magnetorotational instability (MRI) in a collisionless plasma can differ significantly from those calculated using MHD. This can be important in hot accretion flows around compact objects. In this paper we study the transition from the collisionless kinetic regime to the collisional MHD regime, mapping out the dependence of the MRI growth rate on collisionality. A kinetic closure scheme for a magnetized plasma is used that includes the effect of collisions via a BGK operator. The transition to MHD occurs as the mean free path becomes short compared to the parallel wavelength 2\pi/k_{\Par}. In the weak magnetic field regime where the Alfv\'en and MRI frequencies $\omega$ are small compared to the sound wave frequency k_{\Par} c_0, the dynamics are still effectively collisionless even if $\omega \ll \nu$, so long as the collision frequency \nu \ll k_{\Par} c_{0}; for an accretion flow this requires \nu \lsim \Omega \sqrt{\beta}. The low collisionality regime not only modifies the MRI growth rate, but also introduces collisionless Landau or Barnes damping of long wavelength modes, which may be important for the nonlinear saturation of the MRI.Comment: 20 pages, 4 figures, submitted to ApJ with a clearer derivation of anisotropic pressure closure from drift kinetic equatio

Increased expression of the tight junction protein TJP1/ZO-1 is associated with upregulation of TAZ-TEAD activity and an adult tissue stem cell signature in carfilzomib-resistant multiple myeloma cells and high-risk multiple myeloma patients

Tight junction protein 1 (TJP1) has recently been proposed as a biomarker to identify multiple myeloma (MM) patients most likely to respond to bortezomiband carfilzomib-based proteasome inhibitor regimens. Herein we report increased expression of TJP1 during the adaptive response mediating carfilzomib resistance in the LP-1/Cfz MM cell line. Moreover, increased TJP1 expression delineated a subset of relapsed/refractory MM patients on bortezomib-based therapy sharing an LP-1/Cfzlike phenotype characterized by activation of interacting transcriptional effectors of the Hippo signaling cascade (TAZ and TEAD1) and an adult tissue stem cell signature. siRNA-mediated knockdown of TJP1 or TAZ/TEAD1 partially sensitized LP-1/Cfz cells to carfilzomib. Connectivity Map analysis identified translation inhibitors as candidate therapeutic agents targeting this molecular phenotype. We confirmed this prediction by showing that homoharringtonine (omacetaxine mepesuccinate) — the first translation inhibitor to be approved by the U.S. Food and Drug Administration — displayed potent cytotoxic activity on LP-1/Cfz cells. Homoharringtonine treatment reduced the levels of TAZ and TEAD1 as well as the MM-protective proteins Nrf2 and MCL1. Thus, our data suggest the importance of further studies evaluating translation inhibitors in relapsed/refractory MM. On the other hand, use of TJP1 as a MM biomarker for proteasome inhibitor sensitivity requires careful consideration