De la capacidad para heredar y testar

El concepto de ¨patrimonio¨, ya sea que lo tomemos en su sentido general o particular, sólo nos permite ver los diferentes resultados de las actividades de un individuo o grupo de individuos en relación a sus bienes, cuando éstos son utilizados para fines propios o ajenos, que se obtienen ganancias o pérdidas: que en este caso, se verá al patrimonio en función puramente económica

Processes and Tools for enabling Interoperability between Citizen Science and Expert Biodiversity Data in Agriculture

The emerging OGC APIs aim to support anyone to provide and use geospatial data from a wide variety of domains on the web, and to integrate this data with any other type of information. In the H2020 project “Farmer clusters for Realising Agrobiodiversity Management across Ecosystems” (FRAMEwork), we develop and implement tools and processes that enable interoperability between Citizen Science data and Expert data in Farmer Clusters. A Farmer Cluster is a farmer-led group of farmers, specialising in different cropping and farming systems working together in their locality with the objective to ensure that their efforts are complementary and to work towards shared biodiversity goals. Biodiversity monitoring data is collected in several formats and through different applications in 11 pilot Farmer Clusters spread among 9 countries across Europe. This biodiversity monitoring data is consequently stored and curated in a Data Hub as metadata records and its associated biodiversity datasets. Such metadata is useful and understandable and it enables collaboration between the different stakeholders of the project. The Data Hub, hosted by CREAF, is a GeoNetwork repository which is an open-source catalogue application to manage spatially referenced resources. In case the data is public, it is transformed with tools that are developed and tested in the project. They are based on the OGC STAplus, an extension to the OGC SensorThings data model/API which has been developed and based on requirements from the Citizen Science community. STAplus was initially designed in the COS4Cloud project (Co-designed citizen observatories for the EOS-Cloud) and its use is also foreseen in the CitiObs project (Enhancing Citizen Observatories for healthy, sustainable, resilient and inclusive cities) as a mechanism to interoperate among air quality observatories. The nat2sta tool allows to transform iNaturalist observations into STAplus records, which in turn are uploaded and can be visualised and queried in map visualisations such as the MiraMon Map Browser. The STAplus instance is hosted by Secure Dimensions and it is based in their FROSTplus development available on GitHub. The nat2sta tool has been tested with biodiversity observations collected in one of the pilot Farmer Clusters during a BioBlitz in April 2022 in Born (Luxembourg), as part of the global City Nature Challenge. Data scientists can explore this data and different stakeholder groups can discover and query the data in the MiraMon Map Browser. They can perform analysis and statistics or build time series and observe evolution of biodiversity variables. Further tools, such as the csv2sta which recognises CSV observations and ingests them in a STAplus service instance, are developed to guarantee FAIR data principles and to ensure data interoperability with other formats of biodiversity data collected in the field. One goal is to link these tools and processes with an open access Information Hub to support FRAMEwork networks, sharing activities, information, data and resources across farmers, scientists, policy makers and citizens. The described processes and tools will facilitate sharing and harmonisation of farmer and citizen-based, high-quality information on biodiversity in farming contexts

Cyclic disulfide model of the major antigenic site of serotype-C foot-and-mouth disease virus Synthetic, conformational and immunochemical studies

AbstractA cyclic disulfide peptide representing antigenic site A of foot-and-mouth-disease virus (FMDV) strain C-S8cl (residues 134 to 155 of viral protein l (VP1) with Tyr136 and Arg153 replaced by cystine; TTCTASARGDLAHLTTTHACHL) was synthesized by solid phase methods. Formation of the cyclic disulfide was carried out by air oxidation of the fully deprotected and reduced bis-cysteine precursor, under high dilution conditions. The identity of the cyclic peptide was confirmed by both physical and enzymatic methods. A conformational study of the cyclic peptide and of its linear parent structure (YTASARGDLAHLTTTHARHLP, residues 136–156 of VP1 of FMDV C-S8cl) by circular dichroism in the presence of a structure-inducing solvent showed the cyclic disulfide analog to adopt lower levels of α-helix than its linear counterpart. In competitive ELISA assays both peptides reacted with similar affinity against a representative panel of neutralizing monoclonal antibodies directed towards antigenic site A. Thus, a high inherent flexibility of this loop may preclude a conformational restriction strong enough to alter recognition by anti-virus antibodies

Post-Hematopoietic Stem Cell Transplantation (HSCT) Outcomes in Patients With AML Transplanted Prior to Achieving Platelet Recovery

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Prediction of the Caspian Sea level using ECMWF seasonal forecasts and reanalysis

This article is made available through the Brunel Open Access Publishing Fund. This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.The hydrological budget of the Caspian Sea (CS) is investigated using the European Centre for Medium-Range Weather Forecasts interim reanalysis (ERAi) and seasonal forecast (FCST) data with the aim of predicting the Caspian Sea Level (CSL) some months ahead. Precipitation and evaporation are used. After precipitation events over the Volga River, the discharge (Volga River discharge (VRD)) follows with delays, which are parameterized. The components of the water budget from ERAi and FCSTs are integrated to obtain time series of the CSL. Observations of the CSL and the VRD are used for comparison and tuning. The quality of ERAi data is sufficiently good to calculate the time variability of the CSL with a satisfactory accuracy. Already the storage of water within the Volga Basin allows forecasts of the CSL a few months ahead, and using the FCSTs of precipitation improves the CSL forecasts. The evaporation in the seasonal forecasts is deficient due to unrealistic sea surface temperatures over the CS. Impacts of different water budget terms on the CSL variability are shown by a variety of validation tools. The importance of precipitation anomalies over the catchment of the Volga River is confirmed, but also impacts from the two southern rivers (Sefidrud and Kura River) and the evaporation over the CS become obvious for some periods. When pushing the FCSTs beyond the limits of the seasonal FCSTs to 1 year, considerable forecast skill can still be found. Validating only FCSTs by the present approach, which show the same trend as one based on a statistical method, significantly enhances the skill scores

Allogeneic Hematopoietic Stem Cell Transplant (HSCT) for Patients in the 6th and 7th Decades of Life with AML or MDS Using Myeloablative, Reduced Toxicity IV Busulfan/Fludarabine (BuFlu) Conditioning Regimen

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Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck

Background: Radiation dermatitis occurs to some degree in most patients receiving radiotherapy, with or without chemotherapy. Patients with squamous cell carcinoma of the head and neck (SCCHN) who receive radiotherapy in combination with epidermal growth factor receptor (EGFR) inhibitors, such as cetuximab, may develop a characteristic acne-like rash in addition to dermatitis. Design: An advisory board of 11 experienced radiation oncologists, medical oncologists and dermatologists discussed the management options for skin reactions in patients receiving EGFR inhibitors and radiotherapy for SCCHN. Skin toxicity was categorised according to the National Cancer Institute—Common Terminology Criteria for Adverse Events (version 3) grading. Results: Both general and grade-specific approaches for the management of dermatitis in this patient group are presented. It was concluded that where EGFR inhibitor-related acne-like rash and dermatitis coexist within irradiated fields, management should be based on the grade of dermatitis: for grade 1 (or no dermatitis), treatment recommendations for EGFR-related acne-like rash outside irradiated fields should be followed; for grades 2 and above, treatment recommendations for dermatitis were proposed. Conclusions: This paper presents comprehensive consensus guidelines for the treatment of dermatitis in patients with SCCHN receiving EGFR inhibitors in combination with radiotherap

Holocene glacial oscillations in the Tyroler Valley (NE Greenland)

Although the spatiotemporal oscillations of the Greenland Ice Sheet (GrIS) during the last millennia have played a prominent role in global environmental changes, its glacial response to the natural variability still needs to be better constrained. Here, we focused on the reconstruction of the glacial behavior and deglaciation process along the Tyroler Valley (74° N, 22° E), within the Northeast Greenland National Park. This NW-SE valley connects with the GrIS via the Pasterze Glacier and divides two ice caps (A.P. Olsen Land and Payer Land), this last one feeding two piedmont glaciers (Copeland and Kløft glaciers). For this study, we combined the interpretation of the spatial pattern of geomorphological features and the chronological framework defined by a new dataset of 15 Be cosmic-ray exposure (CRE) ages from glacially polished bedrock surfaces and moraine boulders together with one optically stimulated luminescence (OSL) age of a glaciolacustrine deposit. CRE ages indicate that the deglaciation of the lowest parts of the valley and the exposure of the highest slopes took place during the Early Holocene, at ca. 10–8.5 ka (ka = thousand year [BP]). Furthermore, this ice thinning also favored the disconnection of the valley tributary glaciers. Samples from the moraines of the two tributary glaciers indicate that the deglaciation was not continuous, but it was interrupted by at least three phases of glacial advance during the Neoglacial cooling (before ca. 5.9 ka), and the Little Ice Age (LIA, 0.6, and 0.3 ka). The larger piedmont glacier (Copeland Glacier) occupied the valley floor during these major advances, damming the river and allowing the formation of a proglacial glacial lake upvalley, as confirmed by the OSL date of lacustrine sediments that yielded an age of 0.53 ± 0.06 ka. In short, our study provides new evidence of the relative stability of GrIS and the regional ice caps in the area, in which glacial fronts have been rather stable since their advances during the Neoglacial and the LIA.This study was funded by the NEOGREEN (PID2020‐113798GB‐C31) and PALEOGREEN (CTM2017‐87976‐P) projects of the Spanish Ministerio de Economía y Competitividad. Field research was also supported by the research group ANTALP (Antarctic, Arctic, Alpine Environments; 2017‐SGR‐1102) funded by the Agència de Gestió d'Ajuts Universitaris i de Recerca of the Government of Catalonia. Julia Garcia‐Oteyza was supported by an FPI fellowship from the Spanish Ministry of Science, Innovation and Universities, and Marcelo Fernandes by a PhD fellowship of the Fundação para a Ciência e Tecnologia of Portugal (UIDB/00295/2020). The Be measurements were performed at the ASTER AMS national facility (CEREGE, Aix‐en‐Provence), which is supported by the INSU/CNRS and the ANR through the “Projets thématiques d'excellence” programme for the “Equipements d'excellence” ASTER‐CEREGE action and IRD