Spin-isospin nuclear response using the existing microscopic Skyrme functionals

Our paper aims at providing an answer to the question whether one can reliably describe the properties of the most important spin-isospin nuclear excitations, by using the available non-relativistic Skyrme energy functionals. Our method, which has been introduced in a previous publication devoted to the Isobaric Analog states, is the self-consistent Quasiparticle Random Phase Approximation (QRPA). The inclusion of pairing is instrumental for describing a number of experimentally measured spherical systems which are characterized by open shells. We discuss the effect of isoscalar and isovector pairing correlations. Based on the results for the Gamow-Teller resonance in $^{90}$Zr, in $^{208}$Pb and in few Sn isotopes, we draw definite conclusions on the performance of different Skyrme parametrizations, and we suggest improvements for future fits. We also use the spin-dipole resonance as a benchmark of our statements.Comment: Submitted to Phys. Rev.

The fully self-consistent quasiparticle random phase approximation and its application to the isobaric analog resonances

A microscopic model aimed at the description of charge-exchange nuclear excitations along isotopic chains which include open-shell systems, is developed. It consists of quasiparticle random phase approximation (QRPA) made on top of Hartree-Fock-Bardeen-Cooper-Schrieffer (HF-BCS). The calculations are performed by using the Skyrme interaction in the particle-hole channel and a zero-range, density-dependent pairing force in the particle-particle channel. At variance with the (many) versions of QRPA which are available in literature, in our work special emphasis is put on the full self-consistency. Its importance, as well as the role played by the charge-breaking terms of the nuclear Hamiltonian, like the Coulomb interaction, the charge symmetry and charge independence breaking (CSB-CIB) forces and the electromagnetic spin-orbit, are elucidated by means of numerical calculations of the isobaric analog resonances (IAR). The theoretical energies of these states along the chain of the Sn isotopes agree well with the experimental data in the stable isotopes. Predictions for unstable systems are presented.Comment: 15 pages, 6 figure

The Perspective of Sustainable Agriculture in the European Union. Possible Relations between the Multifunctionality and the Provision of Public Goods

Since the 90s the CAP reform has begun to focus on the environmental sustainability of the agricultural production cycle. Indeed, the current model of agriculture is based on the topic of multifunctionality, introduced for the first time by the reform named "Agenda 2000". This model is related to the inherent characteristics of the agricultural production and provides a wide range of public goods. Referring to the theory of public goods, this study suggests a classification of goods through a public utility level and analyzes the criteria that can be used for this one. It also provides a list of public goods associated with agriculture and examines the relationship between agricultural multifunctionality and provision of public goods

Spin-orbit splitting and the tensor component of the Skyrme interaction

We study the role of the tensor term of the Skyrme effective interactions on the spin-orbit splittings in the N=82 isotones and Z=50 isotopes. The different role of the triplet-even and triplet-odd tensor forces is pointed out by analyzing the spin-orbit splittings in these nuclei. The experimental isospin dependence of these splittings cannot be described by Hartree-Fock calculations employing the usual Skyrme parametrizations, but is very well accounted for when the tensor interaction is introduced. The capability of the Skyrme forces to reproduce binding energies and charge radii in heavy nuclei is not destroyed by the introduction of the tensor term. Finally, we also discuss the effect of the tensor force on the centroid of the Gamow-Teller states.Comment: Submitted to Phys. Lett.

Functional neurological disorders as seen by a cohort of general practitioners in northern italy: Evidence from an online survey

General practitioners (GPs) provide primary care and advise their patients on which diagnostic and therapeutic pathways they judge most appropriate. For patients with functional neurological disorders (FND), receiving a proper explanation of diagnosis by their GP from the very beginning may drastically improve prognosis. Novel approaches to the diagnosis and treatment of FND have important implications for effective management. The aim of this study was to investigate Italian GP opinion and knowledge about FND in light of new approaches to the illness. To do this, we evaluated the responses to a 13-item web-based survey completed by 133 GPs practicing in northern Italy. Psychological terms to describe FND were more frequently used than functional neurological disorder and mental illness was considered an important predictor of diagnosis. Referral to a neurologist rather than to a psychiatrist was largely preferred, while physiotherapy consultation was seldom recognized as a valuable approach to treating FND. Overall, the survey findings suggest that knowledge about novel approaches to FND is somewhat lacking. Currently, GPs appear to be transitioning from a classical psychological view of the disorder toward a more modern conceptualization, in which neurobiological, psychological, and social factors all play an important role. Professional education during this transition would be an advantageous way to optimize physician management of FND and to enhance diagnosis, explanation, and management across primary and secondary care pathways

Anti-PSMA CAR-engineered NK-92 Cells: An Off-the-shelf Cell Therapy for Prostate Cancer

Prostate cancer (PCa) has become the most common cancer among males in Europe and the USA. Adoptive immunotherapy appears a promising strategy to control the advanced stages of the disease by specifically targeting the tumor, in particular through chimeric antigen receptor T (CAR-T) cell therapy. Despite the advancements of CAR-T technology in the treatment of hematological malignancies, solid tumors still represent a challenge. To overcome current limits, other cellular effectors than T lymphocytes are under study as possible candidates for CAR-engineered cancer immunotherapy. A novel approach involves the NK-92 cell line, which mediates strong cytotoxic responses against a variety of tumor cells but has no effect on non-malignant healthy counterparts. Here, we report a novel therapeutic approach against PCa based on engineering of NK-92 cells with a CAR recognizing the human prostate-specific membrane antigen (PSMA), which is overexpressed in prostatic neoplastic cells. More importantly, the potential utility of NK-92/CAR cells to treat PCa has not yet been explored. Upon CAR transduction, NK-92/CAR cells acquired high and specific lytic activity against PSMA-expressing prostate cancer cells in vitro, and also underwent degranulation and produced high levels of IFN-\u3b3 in response to antigen recognition. Lethal irradiation of the effectors, a safety measure requested for the clinical application of retargeted NK-92 cells, fully abrogated replication but did not impact on phenotype and short-term functionality. PSMA-specific recognition and antitumor activity were retained in vivo, as adoptive transfer of irradiated NK-92/CAR cells in prostate cancer-bearing mice restrained tumor growth and improved survival. Anti-PSMA CAR-modified NK-92 cells represent a universal, off-the-shelf, renewable, and cost-effective product endowed with relevant potentialities as a therapeutic approach for PCa immunotherapy

Effect of Tensor Correlations on Gamow-Teller States in 90Zr and 208Pb

The tensor terms of the Skyrme effective interaction are included in the self-consistent Hartree-Fock plus Random Phase Approximation (HF+RPA) model. The Gamow-Teller (GT) strength function of 90Zr and 208Pb are calculated with and without the tensor terms. The main peaks are moved downwards by about 2 MeV when including the tensor contribution. About 10% of the non-energy weighted sum rule is shifted to the excitation energy region above 30 MeV by the RPA tensor correlations. The contribution of the tensor terms to the energy weighted sum rule is given analytically, and compared to the outcome of RPA.Comment: 13 pages, 2 figures,2 table

Neural correlates of egocentric and allocentric frames of reference combined with metric and non-metric spatial relations

Spatial relations (SRs: coordinate/metric vs categorical/non metric) and frames of reference (FoRs: egocentric/body vs allocentric/external element) represent the building blocks underlying any spatial representation. In the present 7-T fMRI study we have identified for the first time the neural correlates of the spatial representations emerging from the combination of the two dimensions. The direct comparison between the different spatial representations revealed a bilateral fronto-parietal network, mainly right sided, that was more involved in the egocentric categorical representations. A right fronto-parietal circuitry was specialized for egocentric coordinate representations. A bilateral occipital network was more involved in the allocentric categorical representations. Finally, a smaller part of this bilateral network (i.e. Calcarine Sulcus and Lingual Gyrus), along with the right Supramarginal and Inferior Frontal gyri, supported the allocentric coordinate representations. The fact that some areas were more involved in a spatial representation than in others reveals how our brain builds adaptive spatial representations in order to effectively react to specific environmental needs and task demands

Vortex pinning in Au-irradiated FeSe0.4Te0.6 crystals from the static limit to gigahertz frequencies

Fe(Se,Te) is one of the simplest compounds of iron-based superconductors, but it shows a variety of vortex pinning phenomena both in thin-film and single-crystal forms. These properties are particularly important in light of its potential for applications ranging from the development of coated conductors for high-field magnets to topological quantum computation exploiting the Majorana particles found in the superconducting vortex cores. In this paper, we characterize the pinning properties of FeSe 0.4 Te 0.6 single crystals, both pristine and Au-irradiated, with a set of characterization techniques ranging from the static limit to the GHz frequency range by using dc magnetometry, ac susceptibility measurements of both the fundamental and the third harmonic signals, and by microwave coplanar waveguide resonator measurements of London and Campbell penetration depths. We observed signatures of single vortex pinning that can be modeled by a parabolic pinning potential, dissipation caused by flux creep, and a general enhancement of the critical current density after 320 MeV Au ion irradiation

PSMA-Specific CAR-Engineered T Cells Eradicate Disseminated Prostate Cancer in Preclinical Models.

Immunology-based interventions have been proposed as a promising curative chance to effectively attack postoperative minimal residual disease and distant metastatic localizations of prostate tumors. We developed a chimeric antigen receptor (CAR) construct targeting the human prostate-specific membrane antigen (hPSMA), based on a novel and high affinity specific mAb. As a transfer method, we employed last-generation lentiviral vectors (LV) carrying a synthetic bidirectional promoter capable of robust and coordinated expression of the CAR molecule, and a bioluminescent reporter gene to allow the tracking of transgenic T cells after in vivo adoptive transfer. Overall, we demonstrated that CAR-expressing LV efficiently transduced short-term activated PBMC, which in turn were readily stimulated to produce cytokines and to exert a relevant cytotoxic activity by engagement with PSMA+ prostate tumor cells. Upon in vivo transfer in tumor-bearing mice, CAR-transduced T cells were capable to completely eradicate a disseminated neoplasia in the majority of treated animals, thus supporting the translation of such approach in the clinical setting