Site selection of the Colombian antarctic research station based on fuzzy-topsis algorithm

By 2025 the Republic of Colombia aims to be an advisory member of the Antarctic Treaty System (ATS) and the installation of a scientific station is necessary to upscale the scientific capabilities. The aim of this paper is showing the results of the implementation of a Fuzzy TOPSIS algorithm for site selection of the Colombian Antarctic Scientific Station. A three-phase methodology was AQ1 proposed, and the obtained results allowed to identify the optimum location for the station, considering key success factors and regulatory constraints

Investigation of primary school teacher candidates' metacognitive awareness level

People are equipped with the ability to learn something new every moment in their educational life and daily life. In the learning process, a great number of processes are applied to get the expected behaviour. Cognitive processes are the main point of our learning process. Cognitive development starts from the birth. Learning occurs by adding new information on the previously learnt information. At this point, metacognitive process includes a person's knowing his own actions, become aware of them, supervise them, think about them, draw conclusions and plan them. These skills also make learning process easier. It is highly important for our education system and students that the teachers have those skills, too. In that sense, primary school teacher candidates' metacognitive awareness level has been analyzed in this study. In the study, scanning method has been used to describe the current situation. Our sample includes the 1st, 2nd, 3rd and 4th grade students who study at two Education Faculty in 2015-2016 academic year in Turkey. 370 teacher candidates participated in this study. As the data collection tool, Metacognition Awareness Inventory which was developed by Schraw and Dennison (1994) and adapted to Turkish by Akin, Abaci and çetin (2007) has been used. SPSS16 program has been used for data analysis. As a result of the study, it was found that primary teacher candidates have high level of metacognitive awareness and the correlation among parameters has been analyzed with Metacognition Awareness Inventory. © 2015 Journal for the Education of Gifted Young Scientists

Meme kanserli olgularda 3 alanlı koplanar teknikle tüm meme ışınlamasının kalp ve LAD dozlarına etkisi

Objectives We evaluate the effect of two conformal technique at Turkish women contour which developed order to reduce the lung dose in whole breast radiotherapy at European breast cancer patients. Methods CTV, PTV, lung, heart, contralateral breast and LAD were contoured on 20 patients referred for breast radiotherapy. Treatment planning were made as conventional technique (2F-C), two field non-coplanar conformal technical (2F-NC), 3 field coplanar conformal technique (3F-C) at Varian Eclipse TPS. Critical doses were evaluated at DVH. Conformity and homogeneity index was calculated. Comparison of three groups made by Kruskal-Wallis test, two separate groups by Mann-Whitney U test. Results Statistically significant differences in favor of 3F-C were detected on hearth, LAD, contralateral breast doses. Homogeneity and conformity index was higher for all patients in 3F-C technique. Conclusion 3F-C technique is adequate for dosimetric aspects and can be considered in Turkish women especially have coronary artery disease. © 2014 Turkish Society for Radiation Oncology

Detection of impaired cognitive function in rat with hepatosteatosis model and improving effect of GLP-1 analogs (exenatide) on cognitive function in hepatosteatosis

PubMed ID: 24741367The aims of the study were to evaluate (1) detection of cognitive function changing in rat with hepatosteatosis model and (2) evaluate the effect of GLP-1 analog (exenatide) on cognitive function in hepatosteatosis. In the study group, 30% fructose was given in nutrition water to perform hepatosteatosis for 8 weeks to 18 male rats. Six male rats were chosen as control group and had normal nutrition. Fructose nutrition group were stratified into 3 groups. In first group (n = 6), intracerebroventricular (ICV) infusion of exenatide (n = 6) was given. ICV infusion of NaCl (n = 6) was given to second group. And also, the third group had no treatment. And also, rats were evaluated for passive avoidance learning (PAL) and liver histopathology. Mean levels of latency time were statistically significantly decreased in rats with hepatosteatosis than those of normal rats (P < 0.00001). However, mean level of latency time in rats with hepatosteatosis treated with ICV exenatide was statistically significantly increased than that of rats treated with ICV NaCl (P < 0.001). Memory performance falls off in rats with hepatosteatosis feeding on fructose (decreased latency time). However, GLP-1 ameliorates cognitive functions (increased latency time) in rats with hepatosteatosis and releated metabolic syndrome. © 2014 Oytun Erbaş et al

Therapeutic Effects of Liraglutide, Oxytocin and Granulocyte Colony-Stimulating Factor in Doxorubicin-Induced Cardiomyopathy Model: An Experimental Animal Study

###EgeUn###Doxorubicin-induced (DXR) cardiomyopathy is a serious health issue in oncology patients. Effective treatment of this clinical situation still remains to be discovered. In this experimental animal study, we aimed to define therapeutic effects of liraglutide, oxytocin and granulocyte colony-stimulating factor in DXR-induced cardiomyopathy model. 40 male Sprague–Dawley rats were included to study. 32 rats were given doxorubicin (DXR) for cardiomyopathy model. DXR was administered intraperitonally (i.p.) at every other day of 2.5 mg/kg/day at six times. Eight rats were taken as normal group and no treatment was performed. 32 rats given doxorubicin were divided into 4 groups. Group 1 rats were assigned to a placebo group and was given with a 0.9% NaCl saline solution at a dose of 1 ml/kg/day i.p. (DXR + saline), Group 2 rats were given with 1.8 mg/kg/day of Liraglutide i.p. (DXR + LIR), Group 3 rats were given with 160 µg/kg/day oxytocin i.p. (DXR + OX), Group 4 rats were given with 100 µg/kg/day filgrastim i.p. (DXR + G-CSF). All medications were given for 15 days. On day 16, under anesthesia, ECG was recorded from derivation I. After that, blood samples were taken by tail vein puncture for biochemical analysis. Finally, the animals were euthanized and the heart removed and prepared for immunohistochemical examination. All three treatments were shown to ameliorate the toxic effect of doxorubicin in cardiac tissue with the best results in DXR + OX group. DXR + OX group had the most preserved tissue integrity examined by light microscopy, least immune expression level of CASPASE-3 (5.3 ± 0.9) (p < 0.001) the highest ECG QRS wave voltage amplitude (0.21 ± 0.008 mV) (p < 0.00001) least plasma MDA (115.3 ± 19.8 nm) (p < 0.001), TNF-alpha (26.6 ± 3.05 pg/ml) (p < 0.001), pentraxin-3 (2.7 ± 0.9 ng/ml) (p < 0.001), Troponin T (1.4 ± 0.08 pg/ml) (p < 0.001), pro-BNP (11.1 ± 3.6 pg/ml) (p < 0.001) levels among all three treatment groups. Consistent with previous literature, we found that OX treatment decreased oxidative, apoptotic and inflammatory activity in DXR-induced cardiomyopathy rat model as well as provided better tissue integrity and better results in clinically relevant measures of ECG assessment, plasma Troponin T and pro-BNP levels. LIR and G-CSF treatment caused similar results with less powerful effects. Our findings suggest that with the best results in OX treatment group, all three agents including LIR and G-CSF attenuates DXR-induced cardiomyopathy in this rat model. © 2019, Springer Science+Business Media, LLC, part of Springer Nature