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Geological and geophysical study of the origin of the warm springs in Bath County, Virginia. Final report, June 1, 1975--April 30, 1976
The results of heat flow determinations and a reconnaissance dipole electrical resistivity survey in Bath County are described. A geologic map was compiled based on published maps and supported by reconnaissance geologic mapping in areas where published maps were not available. A regional bipole--dipole electrical resistivity survey was made in order to detect the presence of resistivity lows that might be associated with a geothermal system at depth. A single hole was drilled to a depth of approximately 300 m (approx. 1000 feet) to obtain a heat flow value that is representative of the area. The data were used to attempt to arrive at a model that unambiguously explains the origin of the thermal springs
Understanding consumer demand for new transport technologies and services, and implications for the future of mobility
The transport sector is witnessing unprecedented levels of disruption.
Privately owned cars that operate on internal combustion engines have been the
dominant modes of passenger transport for much of the last century. However,
recent advances in transport technologies and services, such as the development
of autonomous vehicles, the emergence of shared mobility services, and the
commercialization of alternative fuel vehicle technologies, promise to
revolutionise how humans travel. The implications are profound: some have
predicted the end of private car dependent Western societies, others have
portended greater suburbanization than has ever been observed before. If
transport systems are to fulfil current and future needs of different
subpopulations, and satisfy short and long-term societal objectives, it is
imperative that we comprehend the many factors that shape individual behaviour.
This chapter introduces the technologies and services most likely to disrupt
prevailing practices in the transport sector. We review past studies that have
examined current and future demand for these new technologies and services, and
their likely short and long-term impacts on extant mobility patterns. We
conclude with a summary of what these new technologies and services might mean
for the future of mobility.Comment: 15 pages, 0 figures, book chapte
Hydrologically-driven crustal stresses and seismicity in the New Madrid Seismic Zone
The degree to which short-term non-tectonic processes, either natural and anthropogenic, influence the occurrence of earthquakes in active tectonic settings or ‘stable’ plate interiors, remains a subject of debate. Recent work in plate-boundary regions demonstrates the capacity for long-wavelength changes in continental water storage to produce observable surface deformation, induce crustal stresses and modulate seismicity rates. Here we show that a significant variation in the rate of microearthquakes in the intraplate New Madrid Seismic Zone at annual and multi-annual timescales coincides with hydrological loading in the upper Mississippi embayment. We demonstrate that this loading, which results in geodetically observed surface deformation, induces stresses within the lithosphere that, although of small amplitude, modulate the ongoing seismicity of the New Madrid region. Correspondence between surface deformation, hydrological loading and seismicity rates at both annual and multi-annual timescales indicates that seismicity variations are the direct result of elastic stresses induced by the water load
Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy.
PURPOSE: Pathogenic autosomal recessive variants in CAD, encoding the multienzymatic protein initiating pyrimidine de novo biosynthesis, cause a severe inborn metabolic disorder treatable with a dietary supplement of uridine. This condition is difficult to diagnose given the large size of CAD with over 1000 missense variants and the nonspecific clinical presentation. We aimed to develop a reliable and discerning assay to assess the pathogenicity of CAD variants and to select affected individuals that might benefit from uridine therapy. METHODS: Using CRISPR/Cas9, we generated a human CAD-knockout cell line that requires uridine supplements for survival. Transient transfection of the knockout cells with recombinant CAD restores growth in absence of uridine. This system determines missense variants that inactivate CAD and do not rescue the growth phenotype. RESULTS: We identified 25 individuals with biallelic variants in CAD and a phenotype consistent with a CAD deficit. We used the CAD-knockout complementation assay to test a total of 34 variants, identifying 16 as deleterious for CAD activity. Combination of these pathogenic variants confirmed 11 subjects with a CAD deficit, for whom we describe the clinical phenotype. CONCLUSIONS: We designed a cell-based assay to test the pathogenicity of CAD variants, identifying 11 CAD-deficient individuals who could benefit from uridine therapy
The interior of the SNR RX J0852.0-4622 (Vela Jr) at radio wavelengths
Aim: We observed the center of the supernova remnant Vela Jr in radio
continuum in order to search for a counterpart to the compact central X-ray
source CXOU J085201.4-461753, possibly a neutron star candidate which could be
the remnant of the supernova explosion. Method: Observations were made with the
Australia Telescope Compact Array at 13 and 20 cm. Spectral indices were
obtained using flux density correlations of the data which were spatially
filtered to have the same u-v coverage. A multiwavelength search for
counterparts to the compact central X-ray source was made. Results: We compiled
a new catalogue of 31 small diameter radio sources, including the previously
known source PMN J0853-4620, listing the integrated flux densities at 20 cm
and, for half of the sources, the flux densities at 13 cm with the
corresponding spectral indices. All sources are unresolved at the present
angular resolution except for Source 18, which is clearly elongated and lies
strikingly close to CXOU J085201.4-461753. Our observations show no evidence
for the existence of a pulsar wind driven nebula associated with the point
X-ray source. Furthermore, Source 18 has a thermal spectrum with index +0.8 +/-
0.4, and appears to be the counterpart of the optical source Wray 16-30. In
spite of the absence of OIII emission lines as reported in the literature, we
find that this object could be explained as a low emission planetary nebula
belonging to the ``butterfly'' morphological class. Conclusions: We conclude
that if the radio source 18 is actually a planetary nebula, then CXOU
J085201.4-461753 is more likely to be related to it rather than to Vela Jr.Comment: 9 pages, 4 figures, to appear in Astronomy and Astrophysic
Expanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor
Multiple TREX mRNA export complex subunits (e.g., THOC1, THOC2, THOC5, THOC6, THOC7) have now been implicated in neurodevelopmental disorders (NDDs), neurodegeneration and cancer. We previously implicated missense and splicing-defective THOC2 variants in NDDs and a broad range of other clinical features. Here we report 10 individuals from nine families with rare missense THOC2 variants including the first case of a recurrent variant (p.Arg77Cys), and an additional individual with an intragenic THOC2 microdeletion (Del-Ex37-38). Ex vivo missense variant testing and patient-derived cell line data from current and published studies show 9 of the 14 missense THOC2 variants result in
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