An Analysis of Cynicism Within Law Enforcement

An investigation and analysis of the concept of cynicism as part of a social process involving other sociological variables within two law enforcement agencies was undertaken. The major theoretical contention of this study was that within the law enforcement setting one consequence of employing certain organizational control mechanisms has been an accompanying generation of social strain relative to such control mechanisms. The Niederhoffer scale was employed as an objective measure of cynicism. Extended interviews were conducted with those who scored high on the cynicism scale. Two major sources of social strain were indicated by the interview responses: (a) the area of promotion and the related power struggles; (b) the area of judicial processes and recent court decisions

Systematics of the Cephalopod family Gonatidae from the southeastern Bering Sea

Thesis (M.S.) University of Alaska Fairbanks, 1981The systematic relationships within the cephalopod family Gonatidae were examined utilizing specimens collected from the southeastern Bering Sea. Ten species; Gonatus onyx, Gonatus madokai, Gonatus tinro, Gonatus berryi, Gonatus pyros, Gonatus sp., Gonatus type A, Berryteuthis magister, Berryteuthis anonychus, and Gonatopsis borealis; were identified. Included in these are the identification of a probable new species, Gonatus sp., the verification of a questionable species, Gonatus tinro, and the classification of previously described but unclassified developmental stages. Morphometric characters were used for a retrogression analysis of each species' development. The developmental stages for those species found in the study area are described and illustrated in detail. The taxonomic and morphometric characters of the species are compared. Two closely allied species, Gonatus berryi and Gonatus sp. are compared and contrasted. A brief analysis of the growth and development of the genus Gonatus is also given

Coupling biological detection to liquid chromatography

La forma habitual de probar la actividad biológica de una planta dada es a partir de una extracto crudo y, si resultase de interés, continuar con la tediosa y costosa y laboriosas tareas de fraccionamiento, purificación y análisis sistemático de cada fracción resultante. Este procedimiento es actualmente el mismo para mezclas complejas resultantes de métodos sintéticos modernos como la química combinatoria. El procedimiento para la caracterización del fármaco se verá beneficiada si se puede restringir el estudio a solo aquellas fracciones donde la actividad biológica estaba presente.CONACYT – Consejo Nacional de Ciencia y TecnologíaPROCIENCI

Pharmacological evaluation of Prosopis ruscifolia extract on lipid profile in hyperglycemic and hyperlipidemic mice

La diabetes es una patología crónica grave, con efectos a largo plazo que incluyen daño a los vasos sanguíneos o dislipidemia diabética. La dislipidemia diabética se caracteriza por el aumento de las concentraciones de triglicéridos de baja densidad y lipoproteínas y una disminución de las lipoproteínas de alta densidad HDL-colesterol (HDL-c). Este estudio tuvo como objetivo evaluar el efecto de Prosopis ruscifolia sobre el perfil lipídico en ratones suizos albinos con hiperglucemia e hiperlipidemia.CONACYT – Consejo Nacional de Ciencia y TecnologíaPROCIENCI

Negotiating topic changes:native and non-native English speakers in conversation

There is a tendency to view conversations involving non‐native speakers (NNSs) as inevitably fraught with problems, including an inability to handle topic management. This article, in contrast, will focus on effective topic changes made by non‐native speakers during informal conversations with native speakers of English. A micro‐analysis of ten conversations revealed several ways of shifting conversational topics; however, the article concentrates on those strategies which the participants used to effect a particular type of topic move, namely ‘marked topic changes’, where there is no connection at all with previous talk. The findings show how these topic changes were jointly negotiated, and that the non‐native speakers’ contributions to initiating new topics were competently managed

Membrane binding of antimicrobial peptides is modulated by lipid charge modification

Peptide interactions with lipid bilayers play a key role in a range of biological processes and depend on electrostatic interactions between charged amino acids and lipid headgroups. Antimicrobial peptides (AMPs) initiate the killing of bacteria by binding to and destabilizing their membranes. The multiple peptide resistance factor (MprF) provides a defense mechanism for bacteria against a broad range of AMPs. MprF reduces the negative charge of bacterial membranes through enzymatic conversion of the anionic lipid phosphatidyl glycerol (PG) to either zwitterionic alanyl-phosphatidyl glycerol (Ala-PG) or cationic lysyl-phosphatidyl glycerol (Lys-PG). The resulting change in the membrane charge is suggested to reduce the binding of AMPs to membranes, thus impeding downstream AMP activity. Using coarse-grained molecular dynamics to investigate the effects of these modified lipids on AMP binding to model membranes, we show that AMPs have substantially reduced affinity for model membranes containing Ala-PG or Lys-PG. More than 5000 simulations in total are used to define the relationship between lipid bilayer composition, peptide sequence (using five different membrane-active peptides), and peptide binding to membranes. The degree of interaction of a peptide with a membrane correlates with the membrane surface charge density. Free energy profile (potential of mean force) calculations reveal that the lipid modifications due to MprF alter the energy barrier to peptide helix penetration of the bilayer. These results will offer a guide to the design of novel peptides, which addresses the issue of resistance via MprF-mediated membrane modification

Diquat Derivatives: Highly Active, Two-Dimensional Nonlinear Optical Chromophores with Potential Redox Switchability

In this article, we present a detailed study of structure−activity relationships in diquaternized 2,2′-bipyridyl (diquat) derivatives. Sixteen new chromophores have been synthesized, with variations in the amino electron donor substituents, π-conjugated bridge, and alkyl diquaternizing unit. Our aim is to combine very large, two-dimensional (2D) quadratic nonlinear optical (NLO) responses with reversible redox chemistry. The chromophores have been characterized as their PF_6^− salts by using various techniques including electronic absorption spectroscopy and cyclic voltammetry. Their visible absorption spectra are dominated by intense π → π^* intramolecular charge-transfer (ICT) bands, and all show two reversible diquat-based reductions. First hyperpolarizabilities β have been measured by using hyper-Rayleigh scattering with an 800 nm laser, and Stark spectroscopy of the ICT bands affords estimated static first hyperpolarizabilities β_0. The directly and indirectly derived β values are large and increase with the extent of π-conjugation and electron donor strength. Extending the quaternizing alkyl linkage always increases the ICT energy and decreases the E_(1/2) values for diquat reduction, but a compensating increase in the ICT intensity prevents significant decreases in Stark-based β_0 responses. Nine single-crystal X-ray structures have also been obtained. Time-dependent density functional theory clarifies the molecular electronic/optical properties, and finite field calculations agree with polarized HRS data in that the NLO responses of the disubstituted species are dominated by ‘off-diagonal’ β_(zyy) components. The most significant findings of these studies are: (i) β_0 values as much as 6 times that of the chromophore in the technologically important material (E)-4′-(dimethylamino)-N-methyl-4-stilbazolium tosylate; (ii) reversible electrochemistry that offers potential for redox-switching of optical properties over multiple states; (iii) strongly 2D NLO responses that may be exploited for novel practical applications; (iv) a new polar material, suitable for bulk NLO behavior

Evolution of Linear Absorption and Nonlinear Optical Properties in V-Shaped Ruthenium(II)-Based Chromophores

In this article, we describe a series of complexes with electron-rich cis-{Ru^(II)(NH_3)_4}^(2+) centers coordinated to two pyridyl ligands bearing N-methyl/arylpyridinium electron-acceptor groups. These V-shaped dipolar species are new, extended members of a class of chromophores first reported by us (Coe, B. J. et al. J. Am. Chem. Soc. 2005, 127, 4845−4859). They have been isolated as their PF_6− salts and characterized by using various techniques including ^1H NMR and electronic absorption spectroscopies and cyclic voltammetry. Reversible Ru^(III/II) waves show that the new complexes are potentially redox-switchable chromophores. Single crystal X-ray structures have been obtained for four complex salts; three of these crystallize noncentrosymmetrically, but with the individual molecular dipoles aligned largely antiparallel. Very large molecular first hyperpolarizabilities β have been determined by using hyper-Rayleigh scattering (HRS) with an 800 nm laser and also via Stark (electroabsorption) spectroscopic studies on the intense, visible d → π^* metal-to-ligand charge-transfer (MLCT) and π → π^* intraligand charge-transfer (ILCT) bands. The latter measurements afford total nonresonant β_0 responses as high as ca. 600 × 10^(−30) esu. These pseudo-C_(2v) chromophores show two substantial components of the β tensor, β_(zzz) and β_(zyy), although the relative significance of these varies with the physical method applied. According to HRS, β_(zzz) dominates in all cases, whereas the Stark analyses indicate that β_(zyy) is dominant in the shorter chromophores, but β_(zzz) and β_(zyy) are similar for the extended species. In contrast, finite field calculations predict that β_(zyy) is always the major component. Time-dependent density functional theory calculations predict increasing ILCT character for the nominally MLCT transitions and accompanying blue-shifts of the visible absorptions, as the ligand π-systems are extended. Such unusual behavior has also been observed with related 1D complexes (Coe, B. J. et al. J. Am. Chem. Soc. 2004, 126, 3880−3891)

Birth outcomes in Colorado's undocumented immigrant population

BACKGROUND: The birth outcomes of undocumented women have not been systematically studied on a large scale. The growing number of undocumented women giving birth in the United States has important implications for clinical care and public health policy. The objective of this study was to describe birth outcomes of undocumented immigrants in Colorado. METHODS: Retrospective descriptive study of singleton births to 5961 undocumented women using birth certificate data for 1998–1999. RESULTS: Undocumented mothers were younger, less educated, and more likely to be single. They had higher rates of anemia, were less likely to gain enough weight, and less likely to receive early prenatal care. They were much less likely to use alcohol or tobacco. Undocumented women had a lower rate of low birth weight (5.3% v 6.5%, P < .001) or preterm infants (12.9% v 14.5%; p = .001). Undocumented women experienced higher rates of labor complications including excessive bleeding (2.3% v 0.8%, p < .001) and fetal distress (8.7% v 3.6%, p < .001). CONCLUSION: Undocumented women have lower rates of preterm delivery and low birth weight infants, but higher rates of pregnancy related risk factors. Higher prevalence of some risk factors which are amenable to medical intervention reveals the need for improved prenatal care in this group