3,565 research outputs found
THE FUTURE AUDIT OF INTERNET CASINOS (RSA): ANALYSIS CRUCIAL TO MITIGATING SIGNIFICANT RISK TO THE AUDITOR
Published ArticleThis paper synthesises, as its primary aim, through an integrative literature
review, a new perspective on two major implications of the proposed legalisation
of internet casinos in South Africa, which is: the effect on the auditor's business
risk as well as the effect on audit risk. As its secondary aim the paper argues that
legalisation of internet casinos in South Africa is imminent and that relative to
other business, heavy reliance will be placed on the external auditor to ensure
the internet casinos' compliance with various laws. The relevance and
application of an integrative literature review is motivated. International
perspectives are applied to the South African context. The paper demonstrates
the relationship between the concepts of the auditor's business risk and audit risk
by establishing that the auditor's business risk flows from possible accountability
that may stem from significant audit risk that is not addressed during the audit
engagement. The paper argues that the operational context of an internet casino
in South Africa will be relatively unique and that three interrelating factors will
create significant audit risk. The three significant factors are shown to be going
concern, regulatory and information technology impacts. Failure by the auditor to
recognise and respond appropriately to this audit risk may lead to serious
consequences for the practitioner which may include regulatory intervention,
reputational based losses or litigation. The impact of the International Standards
on Auditing in this context is explored throughout and it is concluded that
adherence to these standards will sufficiently mitigate significant audit risk as
well as the auditor's business risk
A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections
<p>Abstract</p> <p>Background</p> <p>During respiratory viral infections host injury occurs due in part to inappropriate host responses. In this study we sought to uncover the host transcriptional responses underlying differences between high- and low-pathogenic infections.</p> <p>Results</p> <p>From a compendium of 12 studies that included responses to influenza A subtype H5N1, reconstructed 1918 influenza A virus, and SARS coronavirus, we used meta-analysis to derive multiple gene expression signatures. We compared these signatures by their capacity to segregate biological conditions by pathogenicity and predict pathogenicity in a test data set. The highest-performing signature was expressed as a continuum in low-, medium-, and high-pathogenicity samples, suggesting a direct, analog relationship between expression and pathogenicity. This signature comprised 57 genes including a subnetwork of chemokines, implicating dysregulated cell recruitment in injury.</p> <p>Conclusions</p> <p>Highly pathogenic viruses elicit expression of many of the same key genes as lower pathogenic viruses but to a higher degree. This increased degree of expression may result in the uncontrolled co-localization of inflammatory cell types and lead to irreversible host damage.</p
ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex.
International audience; The ankyrin repeat-containing protein with a suppressor of cytokine signaling box-2 (ASB2) gene was identified as a retinoic acid-response gene and a target of the promyelocytic leukemia-retinoic acid receptor-alpha oncogenic protein characteristic of acute promyelocytic leukemia. Expression of ASB2 in myeloid leukemia cells inhibits growth and promotes commitment, recapitulating an early step known to be critical for differentiation. Here we show that ASB2, by interacting with the Elongin BC complex, can assemble with Cullin5.Rbx1 to form an E3 ubiquitin ligase complex that stimulates polyubiquitination by the E2 ubiquitin-conjugating enzyme Ubc5. This is a first indication that a member of the ASB protein family, ASB2, is a subunit of an ECS (Elongin C-Cullin-SOCS box)-type E3 ubiquitin ligase complex. Altogether, our results strongly suggest that ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate
Aggressive low grade middle ear adenocarcinoma with multiple recurrences: a case report
<p>Abstract</p> <p>Background</p> <p>Primary tumours of the middle ear are much less commonly encountered in clinical practice than non neoplastic lesions. Middle ear adenocarcinoma is a very rare, locally invasive neoplasm assumed to arise from the middle ear mucosa. Because the natural course and clinical behavior of this neoplasm are far from established, the sporadic reports of such cases continue to provide basis for better understanding.</p> <p>Case description</p> <p>A case of low grade adenocarcinoma of the middle ear is described in details with regard to its clinical presentation, radiological findings, histopathological, immunohistochemical and ultrastructural findings. The tumour recurred four times.</p
Jet Energy Density in Hadron-Hadron Collisions at High Energies
The average particle multiplicity density dN/deta is the dynamical quantity
which reflects some regularities of particle production in low-pT range. The
quantity is an important ingredient of z-scaling. Experimental results on
charged particle density are available for pp, pA and AA collisions while
experimental properties of the jet density are still an open question. The goal
of this work is to find the variable which will reflect the main features of
the jet production in low transverse energy range and play the role of the
scale factor for the scaling function psi(z) and variable z in data
z-presentation. The appropriate candidate is the variable we called "scaled jet
energy density". Scaled jet energy density is the probability to have a jet
with defined ET in defined xT and pseudorapidity regions. The PYTHIA6.2 Monte
Carlo generator is used for calculation of scaled jet energy density in
proton-proton collisions over a high energy range (sqrt s = 200-14000 GeV) and
at eta = 0. The properties of the new variable are discussed and sensitivity to
"physical scenarios" applied in the standard Monte Carlo generator is noted.
The results of scaled jet energy density at LHC energies are presented and
compared with predictions based on z-scaling.Comment: 11 pages, LaTeX, 8 figures, Presented at the XVII International
Baldin Seminar on High Energy Physics Problems "Relativistic Nuclear Physics
& Quantum Chromodynamics", Dubna, Russia, September 27 - October 2, 200
Response to Commentary by W. Jost on: Pharmaceutical, Biological, and Clinical Properties of Botulinum Neurotoxin Type A Products
Studies of multiplicity in relativistic heavy-ion collisions
In this talk I'll review the present status of charged particle multiplicity
measurements from heavy-ion collisions. The characteristic features of
multiplicity distributions obtained in Au+Au collisions will be discussed in
terms of collision centrality and energy and compared to those of p+p
collisions. Multiplicity measurements of d+Au collisions at 200 GeV
nucleon-nucleon center-of-mass energy will also be discussed. The results will
be compared to various theoretical models and simple scaling properties of the
data will be identified.Comment: "Focus on Multiplicity" Internationsl Workshop on Particle
Multiplicity in Relativistic Heavy Ion Collisions, Bari, Italy, June 17-19,
2003, 16 pages, 15 figure
Beef cows and calves, 1979: a summary of research
Response of fall-born calves to monensin on orchardgrass / alfalfa or tall fescue / alfalfa pastures / F. M. Byers, C. F. Parker, and R. W. Van Keuren -- Effects of forage system and breed type on the performance of fall calving cows / C. F. Parker and R. W. Van Keuren -- Forage management for beef production / R. W. Van Keuren, C. F. Parker, and E. W. Klosterman -- Breeding and management systems to optimize beef breeding herd productivity / E. W. Klosterman, R. W. Van Keuren, C. F. Parker, and F. M. Byers -- Voluntary feed intake of mature cows as related to breed type, condition, and forage quality / E. W. Klosterman, F. M. Byers, and C. F. Parker -- Weight and condition changes of pregnant beef cows wintered on corn stover stacks / G. R. Wilson, J. G. Gordon, J. H. Cline, K. M. Irvin, and E. W. Klosterman -- Estrus synchronization of beef cows and heifers with prostaglandin F2a under field conditions / G. R. Wilson, T. L. Benecke, K. M. Irvin, T. M. Ludwick, C. E. Marshall, and R. A. Wallac
Multiplicity Studies and Effective Energy in ALICE at the LHC
In this work we explore the possibility to perform ``effective energy''
studies in very high energy collisions at the CERN Large Hadron Collider (LHC).
In particular, we focus on the possibility to measure in collisions the
average charged multiplicity as a function of the effective energy with the
ALICE experiment, using its capability to measure the energy of the leading
baryons with the Zero Degree Calorimeters. Analyses of this kind have been done
at lower centre--of--mass energies and have shown that, once the appropriate
kinematic variables are chosen, particle production is characterized by
universal properties: no matter the nature of the interacting particles, the
final states have identical features. Assuming that this universality picture
can be extended to {\it ion--ion} collisions, as suggested by recent results
from RHIC experiments, a novel approach based on the scaling hypothesis for
limiting fragmentation has been used to derive the expected charged event
multiplicity in interactions at LHC. This leads to scenarios where the
multiplicity is significantly lower compared to most of the predictions from
the models currently used to describe high energy collisions. A mean
charged multiplicity of about 1000-2000 per rapidity unit (at ) is
expected for the most central collisions at .Comment: 12 pages, 19 figures. In memory of A. Smirnitski
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