The Political Component of COVID-19 Vaccine Choice. Results from a Conjoint Experiment

OBJECTIVES: Prior research highlights the role of efficacy, vaccine safety, and availability in vaccine hesitancy. Research is needed to better understand the political driving forces behind COVID-19 vaccine uptake. We examine the effects of the origin of a vaccine, and approval status within the EU on vaccine choice. We also test if these effects differ by party affiliation among Hungarians. STUDY DESIGN: We utilise a conjoint experimental design to assess multiple causal relationships. Respondents choose between two hypothetical vaccine profiles randomly generated from ten attributes. The data were gathered from an online panel in September 2022. We applied a quota for vaccination status and party preference. 324 respondents evaluated 3,888 randomly generated vaccine profiles. METHODS: We analyse the data using an OLS estimator with standard errors clustered across respondents. To further nuance our results, we test for task, profile, and treatment heterogeneity effects. RESULTS: By origin, respondents prefer German (MM 0.55; 95% CI 0.52– 0.58) and Hungarian (0.55; 0.52 – 0.59) vaccines over US (0.49; 0.45– 0.52) and Chinese vaccines (0.44; 0.41 – 0.47). By approval status, vaccines approved by the EU (0.55, 0.52–0.57) or pending authorization (0.5, 0.48–0.53) are preferred over unauthorised ones (0.45, 0.43–0.47). Both effects are conditional on party affiliation. Government voters especially prefer Hungarian vaccines (0.6; 0.55 - 0.65) over others. CONCLUSIONS: The complexity of vaccination decisions calls for the usage of information shortcuts. Our findings demonstrate a strong political component which motivates vaccine choice. We demonstrate that politics and ideology have broken into fields of individual-level decisions such as health

Modes of wording direct into indirect speech in intercultural communication

This paper aims to determine the modes of wording indirec

Modeling of negative Poisson’s ratio (auxetic) crystalline cellulose Iβ

Energy minimizations for unstretched and stretched cellulose models using an all-atom empirical force field (Molecular Mechanics) have been performed to investigate the mechanism for auxetic (negative Poisson’s ratio) response in crystalline cellulose Iβ from kraft cooked Norway spruce. An initial investigation to identify an appropriate force field led to a study of the structure and elastic constants from models employing the CVFF force field. Negative values of on-axis Poisson’s ratios nu31 and nu13 in the x1-x3 plane containing the chain direction (x3) were realized in energy minimizations employing a stress perpendicular to the hydrogen-bonded cellobiose sheets to simulate swelling in this direction due to the kraft cooking process. Energy minimizations of structural evolution due to stretching along the x3 chain direction of the ‘swollen’ (kraft cooked) model identified chain rotation about the chain axis combined with inextensible secondary bonds as the most likely mechanism for auxetic response

Stressful life events, social health issues and low birthweight in an Australian population-based birth cohort: challenges and opportunities in antenatal care

Background: Investment in strategies to promote 'a healthy start to life' has been identified as having the greatest potential to reduce health inequalities across the life course. The aim of this study was to examine social determinants of low birthweight in an Australian population-based birth cohort and consider implications for health policy and health care systems. Methods: Population-based survey distributed by hospitals and home birth practitioners to >8000 women six months after childbirth in two states of Australia. Participants were women who gave birth to a liveborn infant in Victoria and South Australia in September/October 2007. Main outcome measures included stressful life events and social health issues, perceived discrimination in health care settings, infant birthweight. Results: 4,366/8468 (52%) of eligible women returned completed surveys. Two-thirds (2912/4352) reported one or more stressful life events or social health issues during pregnancy. Women reporting three or more social health issues (18%, 768/4352) were significantly more likely to have a low birthweight infant (< 2500 grams) after controlling for smoking and other socio-demographic covariates (Adj OR = 1.77, 95% CI 1.1-2.8). Mothers born overseas in non-English speaking countries also had a higher risk of having a low birthweight infant (Adj OR = 1.85, 95% CI 1.2-2.9). Women reporting three or more stressful life events/social health issues were more likely to attend antenatal care later in pregnancy (OR = 2.06, 95% CI 1.3-3.1), to have fewer antenatal visits (OR = 2.17, 95% CI 1.4-3.4) and to experience discrimination in health care settings (OR = 2.69, 95% CI 2.2-3.3). Conclusions: There is a window of opportunity in antenatal care to implement targeted preventive interventions addressing potentially modifiable risk factors for poor maternal and infant outcomes. Developing the evidence base and infrastructure necessary in order for antenatal services to respond effectively to the social circumstances of women's lives is long overdue.Stephanie J Brown, Jane S Yelland, Georgina A Sutherland, Peter A Baghurst and Jeffrey S Robinso

The association of neighbourhood and individual social capital with consistent self-rated health: a longitudinal study in Brazilian pregnant and postpartum women.

BACKGROUND: Social conditions, social relationships and neighbourhood environment, the components of social capital, are important determinants of health. The objective of this study was to investigate the association of neighbourhood and individual social capital with consistent self-rated health in women between the first trimester of pregnancy and six months postpartum. METHODS: A multilevel cohort study in 34 neighbourhoods was performed on 685 Brazilian women recruited at antenatal units in two cities in the State of Rio de Janeiro, Brazil. Self-rated health (SRH) was assessed in the 1st trimester of pregnancy (baseline) and six months after childbirth (follow-up). The participants were divided into two groups: 1. Good SRH--good SRH at baseline and follow-up, and, 2. Poor SRH--poor SRH at baseline and follow-up. Exploratory variables collected at baseline included neighbourhood social capital (neighbourhood-level variable), individual social capital (social support and social networks), demographic and socioeconomic characteristics, health-related behaviours and self-reported diseases. A hierarchical binomial multilevel analysis was performed to test the association between neighbourhood and individual social capital and SRH, adjusted for covariates. RESULTS: The Good SRH group reported higher scores of social support and social networks than the Poor SRH group. Although low neighbourhood social capital was associated with poor SRH in crude analysis, the association was not significant when individual socio-demographic variables were included in the model. In the final model, women reporting poor SRH both at baseline and follow-up had lower levels of social support (positive social interaction) [OR 0.82 (95% CI: 0.73-0.90)] and a lower likelihood of friendship social networks [OR 0.61 (95% CI: 0.37-0.99)] than the Good SRH group. The characteristics that remained associated with poor SRH were low level of schooling, Black and Brown ethnicity, more children, urinary infection and water plumbing outside the house. CONCLUSIONS: Low individual social capital during pregnancy, considered here as social support and social network, was independently associated with poor SRH in women whereas neighbourhood social capital did not affect women's SRH during pregnancy and the months thereafter. From pregnancy and up to six months postpartum, the effect of individual social capital explained better the consistency of SRH over time than neighbourhood social capital

The Relationship of Social Determinants and Distress in Newly Diagnosed Cancer Patients

INTRODUCTION: Patients with a new cancer diagnosis can experience distress when diagnosed. There is disparity in treatment of cancer patients based on social determinants, but minimal research exists on the relationship of those social determinants and distress after a new cancer diagnosis. Our goals were to determine the social determinants associated with distress after a new cancer diagnosis and determine the relationship of distress with outcome. METHODS: Patients with a new cancer diagnosis at one institution from January 2019 to December 2020 were analyzed. Patients were given the National Comprehensive Cancer Network (NCCN) distress thermometer during their first visit. Demographics, tumor characteristics, clinical variables and survival were recorded. Patients were also asked to share specific factors which led to distress, including: financial, transportation, childcare and religious. RESULTS: A total of 916 patients returned distress thermometers. Mean age was 59.1 years. Women comprised 71.3 (653/916) percent of the cohort. The Figure shows the distress score distribution. On multivariate analysis, the following factors were associated with increased distress level: female (p \u3c 0.01), younger age (p \u3c 0.01), uninsured (p \u3c 0.01) and unemployed (p \u3c 0.01). Patients with higher distress scores also experienced worse overall survival (p \u3c 0.01). CONCLUSION: Women, younger patients, uninsured patients, and unemployed patients experience more distress after a new cancer diagnosis. Increased distress is independently associated with worse overall survival. Social determinants can be used to predict which patients may require focused intervention to reduce distress after a new cancer diagnosis