Lossy/Lossless Floating/Grounded Inductance Simulation Using One DDCC

In this work, we present new topologies for realizing one lossless grounded inductor and two floating, one lossless and one lossy, inductors employing a single differential difference current conveyor (DDCC) and a minimum number of passive components, two resistors, and one grounded capacitor. The floating inductors are based on ordinary dual-output differential difference current conveyor (DO-DDCC) while the grounded lossless inductor is based one a modified dual-output differential difference current conveyor (MDO-DDCC). The proposed lossless floating inductor is obtained from the lossy one by employing a negative impedance converter (NIC). The non-ideality effects of the active element on the simulated inductors are investigated. To demonstrate the performance of the proposed grounded inductance simulator as an example, it is used to construct a parallel resonant circuit. SPICE simulation results are given to confirm the theoretical analysis

Natural stone masonry characterization for the shaking-table test of a scaled building specimen

This paper discusses the material characterization tests on stone masonry specimens, and the in-plane cyclic shear-compression tests on four half-scale unreinforced stone masonry piers, which complement a shaking-table test on a half-scale building aggregate prototype. Material characterization tests allowed defining a mortar composition suitable for satisfying the similitude relationships associated with the half-scale tests. Vertical and diagonal compression tests provided a complete description of the mechanical properties of masonry assemblies, while in-plane cyclic shear-compression tests allow determining the hysteretic behavior of masonry piers with different aspect ratios and axial compression levels. Strength and displacement capacities corresponding to the observed damage mechanisms and failure modes were also identified and associated with the specimens geometric and loading conditions. These activities are part of an experimental and numerical research project jointly carried by the University of Pavia, Italy, and the École Polytechnique Fédérale de Lausanne, Switzerland, which aims at assessing the seismic vulnerability of natural stone masonry building aggregates of the historical center of Basel, Switzerland

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates

© 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have agonist action at both mu opioid peptide (MOP) and nociceptin/orphanin FQ peptide (NOP) receptors. BU10038 is a recently identified bifunctional MOP/NOP partial agonist. The aim of this study was to determine the functional profile of systemic or spinal delivery of BU10038 in primates after acute and chronic administration. Methods: A series of behavioural and physiological assays have been established specifically to reflect the therapeutic (analgesia) and side-effects (abuse potential, respiratory depression, itch, physical dependence, and tolerance) of opioid analgesics in rhesus monkeys. Results: After systemic administration, BU10038 (0.001–0.01 mg kg −1 ) dose-dependently produced long-lasting antinociceptive and antihypersensitive effects. Unlike the MOP agonist oxycodone, BU10038 lacked reinforcing effects (i.e. little or no abuse liability), and BU10038 did not compromise the physiological functions of primates including respiration, cardiovascular activities, and body temperature at antinociceptive doses and a 10–30-fold higher dose (0.01–0.1 mg kg −1 ). After intrathecal administration, BU10038 (3 μg) exerted morphine-comparable antinociception and antihypersensitivity without itch scratching responses. Unlike morphine, BU10038 did not cause the development of physical dependence and tolerance after repeated and chronic administration. Conclusions: These in vivo findings demonstrate the translational potential of bifunctional MOP/NOP receptor agonists such as BU10038 as a safe, non-addictive analgesic with fewer side-effects in primates. This study strongly supports that bifunctional MOP/NOP agonists may provide improved analgesics and an alternative solution for the ongoing prescription opioid crisis.Peer reviewedFinal Published versio

single grain grinding an experimental and fem assessment

Abstract Peripheral grinding is inherently complex due to peculiar factors such as: the non deterministic microgeometry of the grinding wheel, the composition of the grinding wheel, essentially non homogeneous, the cutting process dynamics, where the grains' cutting edges operate on a surface whose microgeometry is the result of the cutting actions of the preceding abrasive grains. This paper compares the results of the experimental analysis of the effect of single cutting grains on the actual microgeometry of worked surfaces, and the results obtained by a FEM cutting model where the measured microgeometry of the cutting grains is considered

Effect of Anode Dielectric Coating on Hall Thruster Operation

An interesting phenomenon observed in the near-anode region of a Hall thruster is that the anode fall changes from positive to negative upon removal of the dielectric coating, which is produced on the anode surface during the normal course of Hall thruster operation. The anode fall might affect the thruster lifetime and acceleration efficiency. The effect of the anode coating on the anode fall is studied experimentally using both biased and emissive probes. Measurements of discharge current oscillations indicate that thruster operation is more stable with the coated anode

Synthesis of novel cognition enhancer with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at gamma-aminobutyric acid type A (GABAA) receptor.

Memory dysfunction associated with aging, neurodegenerative and psychiatric disorders represents an increasing medical need. Advances in research exploring the biological mechanisms underlying learning and memory have opened new potential approaches for development of memory-enhancing therapies addressed to selective neuronal targets. In this work, we synthesized some derivatives with a pyrazolo[5,1-c][1,2,4]benzotriazine core to identify ligands on GABA A receptors subtype (benzodiazepine site on GABAA- receptor) endowed with the potential of enhancing cognition activity without the side effects usually associated with non-selective GABAA modulators. In fact, there is much evidence that GABAA-R (γ-aminobutyric acid, type A receptor) subtype ligands have relevance in learning and memory. In vitro and in vivo tests have been performed. Pharmacological data indicate that compounds 7, 13, 14 and 22 act as dual functional modulators of GABA A-Rs (promnemonic and anxiolytic agents) while only compounds 3 and 10 stand out as selectively displaying good antiamnesic and procognitive activity (1 and 3 mg/kg, respectively). © 2013 Elsevier Ltd. All rights reserved

Current-mode Biquadratic Universal Filter Design with Two Terminal Unity Gain Cells

A grounded parallel lossy active inductor and two current-mode (CM) universal filters are presented in this paper. All the circuits use two voltage followers (VFs) and a current follower (CF). The parallel lossy active inductor includes a grounded capacitor which is attractive in integrated circuit (IC) technology. The CM universal filters have one input and standard three outputs such as band-pass (BP), low-pass (LP) and high-pass (HP) responses. All-pass and notch outputs can be obtained by adding extra one CF. Suggested structures in this paper can be constructed with commercially available active devices such as AD844s. Non-ideal gain and intrinsic X-terminal parasitic resistor effects are examined. Several computer simulations with SPICE program and experimental results by employing AD844s are drawn to verify theoretical ones