The changing role of the state in the economy: Changes in comprehension of state from 18th century to present

Yüksek Lisans TeziBir arada yaşamanın doğal bir sonucu olarak ortaya çıkmış kurumların en büyüğü olan devlet örgütünün üstlenmesi gereken rolün ne olduğu konusundaki tartışma, iktisatçıları ve sosyal bilimcileri araştırmaya yönelten en önemli tartışmalardan biridir. Devletin görev alanını iç ve dış güvenlik, adalet ve diplomasi olarak belirleyerek ekonomik hayata müdahalesini sınırlı tutan tarafsız devlet anlayışı 18. ve 19.yy boyunca dünyaya hâkim olmuştur. Ancak 20.yy'da yaşanan savaşlar gibi politik nedenler, krizler gibi ekonomik nedenler, marksist ve sosyalist tezlerin yarattığı ideolojik nedenler ve ayrıca yaşanan iktisadi ve teknolojik gelişmeler ve değişen yönetim anlayışı ile devletin ekonomideki rolü gittikçe genişlemiştir. Devletin ekonomideki payının hızla genişlemesinde özellikle Keynesyen teori, sosyal politikalar ve iktisadi kalkınma amaçlı müdahaleler etkili olmuştur. Refah devleti şeklinde ortaya çıkan bu yeni devlet biçimi, 20.yy son çeyreğinde karşı karşıya kalınan petrol krizleri ile yeniden yapılanma göstermiştir. Bu bağlamda etkin devlet arayışları devletin yeniden yapılandırılmasına yönelik olarak ortaya atılmıştır. Çalışma yukarıda belirtilen tarihsel aşamaları dikkate alarak 18. yy'dan günümüze devletin ekonomik hayattaki rolüne ilişkin değişimleri açıklamaktadır.The state can be defined as an authority derived naturally as a result of living together. The main question which made economists and social scientists discuss on is what the state's role should be in economy. Neutral state approach that limits the influence of the state on the economy and defines the responsibility areas of the state as security, diplomacy and justice was the most accepted state model during 18th and 19th centuries. However the influence of state in the economy increased in the 20th century as a result of technological and political changes such as wars, crisis, politics and the cold war, the ideologies such as marxism and socialism. Keynesians approaches, social policies and interventions carried out in order to create economic development raised the influence of state on the economy in the 20th century. This approach is entitled as welfare state model and this model is restructured after the petroleum crisis at the end of 20th century. In this context searches of effective state are based on the restructuring the state. In this research the changing role of the state from 18th century to present has been explained considering the historical milestones mentioned above

Forage yield and lodging traits in peas (Pisum sativum L.) with different leaf types

Two semi-leafless and four leafed pea (Pisum sativum L.) genotypes were evaluated for plant height, lodging scores, and forage yield in eight diverse locations with typical Mediterranean or Mediterranean-type climate in the 2001-2002 and 2002-2003 growing seasons. The genotypes used in this study were forage type with indeterminate growing habit. Significant differences among pea genotypes were found for all traits over years and locations. All interactions which related to G x E interaction showed significance (P>0.01) for all traits. The forage yield of the pea genotypes averaged 26605 kg ha(-1) and the highest yield was obtained from the leafed genotype Urunlu. Its forage yield reached to 35970 kg ha(-1) yield level at Samsun location

Genotype x nvironment interaction and stability analysis for dry matter and seed yield in field pea (Pisum sativum L.)

The objectives of this study were to evaluate dry matter (DM) yield and seed yield of six leafed and semi-leafless pea (Pisum sativum L.) genotypes, and to compare them for these traits. Evaluation of genotype x environment (G x E) interaction, stability and cluster analysis were also carried out at eight diverse locations with typical Mediterranean and Mediterranean-type climate during the 2001-2002 and 2002-2003 growing seasons. Significant differences were found among the pea genotypes for DM and seed yield on individual years and combined over years, and in all locations. All interactions which related to G x E interaction showed significance (P>0.001) for DM and seed yield. The highest yield (4789 kg ha(-1)) was obtained from the leafed genotype 'Urunlu'. However, stability analysis indicated that for DM yield, the leafed genotypes 'Golyazi' and 'Urunlu' should be grown in low yielding and high yielding environments, respectively. Cluster analysis, based on grouping locations, showed that P101 was the preferred variety in low yielding environments, and P98, in high yielding ones. It was suggested that the use of both stability and cluster analyses might give better results. Comparison of cluster and stability analyses showed that the stability analysis fails to recommend cultivars to different regions where yield potential showed significant differences. It seems, however, that cluster analysis could be a powerful tool to examine G x E interaction. If the number of environments was sufficient, a separate stability analysis could be run in each cluster

Naiv hepatit C enfeksiyonlu hastaların on-altı yıllık prognozu

Objectives: In this study, we aimed to evaluate the clinical course of treatment-naive patients infected with hepatitis C virus (HCV) who were followed up in various centers in Turkey. Materials and Methods: This was a retrospective study performed with the participation of 15 centers. Patients aged 18 years and older with HCV infection were included. Results: A total of 391 treatment-naive patients infected with HCV were included in this study. During the follow-up period, the final values of alanine aminotransferase, aspartate transaminase, and total protein were significantly decreased when compared to the initial values (p<0.001, p<0.001, and p=0.005, respectively). In the study group, 19.2% of the patients underwent liver biopsy and 4.1% underwent transient elastography (FibroScan). An increased histological activity index (HAI) score and fibrosis in the second biopsy were observed in one patient, only increased HAI in two patients and increased fibrosis in one patient, as shown on the FibroScan. In the 16 years of the study period, cirrhosis was radiologically detected in only one patient. Conclusion: Even if rapid progression is not observed, close monitoring of the clinical findings related to liver failure and fibrosis with invasive or non-invasive methods may be useful.Amaç: Bu çalışmada ülkemizin çeşitli merkezlerinde takip edilen naiv hepatit C virüs (HCV) ile enfekte hastaların klinik seyrini değerlendirmeyi amaçladık. Gereç ve Yöntemler: Bu çalışma retrospektif olarak 15 merkezin katılımıyla gerçekleştirilmiştir. Çalışmaya 18 yaş üstü, HCV enfeksiyonu olan hastalar dahil edilmiştir. Bulgular: Çalışmada 391 tedavi-naiv HCV enfeksiyonlu hasta yer almıştır. Hastaların takip süresinde son alanine aminotransferase, aspartate transaminase ve total protein değerleri ilk düzeyine göre önemli düzeyde azalmıştır (sırasıyla p<0,001, p<0,001, p=0,005). Çalışma grubunda hastaların %19,2’sine karaciğer biyopsisi, %4,1’ine elastografi (FibroScan) uygulanmıştır. Takip esnasında bir hastada ikinci biyopside histolojik aktivite indeksi (HAI) ve fibroziste artma, iki hastada sadece HAI’da artma, birinde FibroScan ile fibrozis değerinde artma olduğu gözlenmiştir. Bir hastada 16 yıl içinde radyolojik olarak siroz saptanmıştır. Sonuç: Hızlı progresyon gözlenmemekle birlikte hastaların izleminde karaciğer yetmezliği ile ilgili klinik bulguların ve invaziv veya noninvaziv yöntemlerle fibrozisin yakın takibi yararlı olabilir

Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behcet's disease

Behcet's disease is a genetically complex disease of unknown etiology characterized by recurrent inflammatory attacks affecting the orogenital mucosa, eyes and skin. We performed a genome-wide association study with 311,459 SNPs in 1,215 individuals with Behcet's disease (cases) and 1,278 healthy controls from Turkey. We confirmed the known association of Behcet's disease with HLA-B*51 and identified a second, independent association within the MHC Class I region. We also identified an association at IL10 (rs1518111, P = 1.88 x 10(-8)). Using a meta-analysis with an additional five cohorts from Turkey, the Middle East, Europe and Asia, comprising a total of 2,430 cases and 2,660 controls, we identified associations at IL10 (rs1518111, P = 3.54 x 10(-18), odds ratio = 1.45, 95% CI 1.34-1.58) and the IL23R-IL12RB2 locus (rs924080, P = 6.69 x 10(-9), OR = 1.28, 95% CI 1.18-1.39). The disease-associated IL10 variant (the rs1518111 A allele) was associated with diminished mRNA expression and low protein production

In a real-life setting, direct-acting antivirals to people who inject drugs with chronic hepatitis c in Turkey

Background: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting. Methods: We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed. Results: Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%). Conclusion: Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization’s objective of eliminating viral hepatitis

Diagnosis of comorbid migraine without aura in patients with idiopathic/genetic epilepsy based on the gray zone approach to the International Classification of Headache Disorders 3 criteria

BackgroundMigraine without aura (MwoA) is a very frequent and remarkable comorbidity in patients with idiopathic/genetic epilepsy (I/GE). Frequently in clinical practice, diagnosis of MwoA may be challenging despite the guidance of current diagnostic criteria of the International Classification of Headache Disorders 3 (ICHD-3). In this study, we aimed to disclose the diagnostic gaps in the diagnosis of comorbid MwoA, using a zone concept, in patients with I/GEs with headaches who were diagnosed by an experienced headache expert.MethodsIn this multicenter study including 809 consecutive patients with a diagnosis of I/GE with or without headache, 163 patients who were diagnosed by an experienced headache expert as having a comorbid MwoA were reevaluated. Eligible patients were divided into three subgroups, namely, full diagnosis, zone I, and zone II according to their status of fulfilling the ICHD-3 criteria. A Classification and Regression Tree (CART) analysis was performed to bring out the meaningful predictors when evaluating patients with I/GEs for MwoA comorbidity, using the variables that were significant in the univariate analysis.ResultsLonger headache duration (&lt;4 h) followed by throbbing pain, higher visual analog scale (VAS) scores, increase of pain by physical activity, nausea/vomiting, and photophobia and/or phonophobia are the main distinguishing clinical characteristics of comorbid MwoA in patients with I/GE, for being classified in the full diagnosis group. Despite being not a part of the main ICHD-3 criteria, the presence of associated symptoms mainly osmophobia and also vertigo/dizziness had the distinguishing capability of being classified into zone subgroups. The most common epilepsy syndromes fulfilling full diagnosis criteria (n = 62) in the CART analysis were 48.39% Juvenile myoclonic epilepsy followed by 25.81% epilepsy with generalized tonic-clonic seizures alone.ConclusionLonger headache duration, throbbing pain, increase of pain by physical activity, photophobia and/or phonophobia, presence of vertigo/dizziness, osmophobia, and higher VAS scores are the main supportive associated factors when applying the ICHD-3 criteria for the comorbid MwoA diagnosis in patients with I/GEs. Evaluating these characteristics could be helpful to close the diagnostic gaps in everyday clinical practice and fasten the diagnostic process of comorbid MwoA in patients with I/GEs