Uma estética chica-rioca em desenvolvimento: uma conversa poética entre Guillermo Gómez-Peña and Marcela Levi

The following text was developed online as a multi-dimentional conversation between Mexican performance artist Guillermo Gómez-Peña and Brazilian choreographer Marcela Levi, in preparation for a performance in Panorama (Rio de Janeiro)

Fatigue response of MoS2 with controlled introduction of atomic vacancies

Fatigue-induced failure resulting from repetitive stress-strain cycles is a critical concern in the development of robust and durable nanoelectromechanical devices founded on 2D semiconductors. Defects, such as vacancies and grain boundaries, inherent in scalable materials can act as stress concentrators and accelerate fatigue fracture. Here, we investigate MoS2 with controlled atomic vacancies, to elucidate its mechanical reliability and fatigue response as a function of atomic defect density. High-quality MoS2 demonstrates an exceptional fatigue response, enduring 109 cycles at 80% of its breaking strength (13.5 GPa), surpassing the fatigue resistance of steel and approaching that of graphene. The introduction of atomic defect densities akin to those generated during scalable synthesis processes (∼1012 cm-2) reduces the fatigue strength to half the breaking strength. Our findings also point toward a sudden defect reconfiguration prior to global failure as the primary fatigue mechanism, offering valuable insights into structure-property relationshipsS2018/NMT-432

Improved graphene blisters by ultrahigh pressure sealing

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To acces final work see “Improved Graphene Blisters by Ultrahigh Pressure Sealing”, ACS Applied Materials and Interfaces 12.33 (2020): 37750-37756, 10.1021/acsami.0c09765Graphene is a very attractive material for nanomechanical devices and membrane applications. Graphene blisters based on silicon oxide microcavities are a simple but relevant example of nanoactuators. A drawback of this experimental setup is that gas leakage through the graphene-SiO2 interface contributes significantly to the total leak rate. Here, we study the diffusion of air from pressurized graphene drumheads on SiO2 microcavities and propose a straightforward method to improve the already strong adhesion between graphene and the underlying SiO2 substrate, resulting in reduced leak rates. This is carried out by applying controlled and localized ultrahigh pressure (>10 GPa) with an atomic force microscopy diamond tip. With this procedure, we are able to significantly approach the graphene layer to the SiO2 surface around the drumheads, thus enhancing the interaction between them, allowing us to better seal the graphene-SiO2 interface, which is reflected in up to ∼4 times lower leakage rates. Our work opens an easy way to improve the performance of graphene as a gas membrane on a technological relevant substrate such as SiO2We acknowledge financial support from the Spanish Ministry of Science and Innovation, through the “Marı́ ́ a de Maeztu” Programme for Units of Excellence in R&D (CEX2018- 000805-M), projects PID2019-106268GB, S2018/NMT-451, and FLAG-ERA JTC2017, and the Ramon Areces Foundation. G.L.-P. acknowledges financial support through the “Juan de la Cierva” Fellowship FJCI-2017-3237

Evidence for a developing plate boundary in the western Mediterranean

Acknowledgements The authors acknowledge support from the Spanish Ministry of Economy and Competitiveness through the Complementary Action ESF TopoEurope TOPOMED (CGL2008- 03474-E/BTE) and national project EVENT (CGL2006-12861-C02-02). L.G.P. was funded by the Spanish Ministry of Education, Culture and Sport through the FPU fellowship AP2012-1579 and a Short-Term Scientific Mission (COST-STSM-ECOST-STSM-ES1301- 180814-045667) inside the COST Action ES1301. This study benefited from a Marie Skłodowska-Curie Individual Fellowship to L.G.P. (H2020-MSCA-IF-2017 796013), the project “MORPHOMED” (PID2019-107138RB-I00) funded by MCIN/SRA (State Research Agency/10.13039/501100011033), FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/Projects (B-RNM-305-UGR18, A-RNM-508-UGR20 and P18-RT-3632), and acknowledges the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S) and C.R.R. project PID2019-109559RB-I00 of the Spanish “Ministerio de Ciencia e Innovación”.We thank the reviewers (JoaoDuarte and anonymous) for their insightful comments. This work has been carried out within Grup de Recerca Consolidat de la Generalitat de Catalunya “Barcelona Center for Subsurface Imaging” (2017 SGR 1662).Additional information Supplementary information The online version contains supplementary material available at https://doi.org/10.1038/s41467-022-31895-z.The current diffuse-strain model of the collision between Africa and Eurasia in the western Mediterranean predicts a broad region with deformation distributed among numerous faults and moderate-magnitude seismicity. However, the model is untested because most deformation occurs underwater, at poorly characterized faults of undetermined slip. Here we assess the diffuse-strain model analysing two active offshore fault systems associated with the most prominent seafloor relief in the region. We use pre-stack depth migrated seismic images to estimate, for the first time, the total Plio-Holocene slip of the right-lateral Yusuf and reverse Alboran Ridge structurally linked fault system. We show that kinematic restoration of deformational structures predicts a slip of 16 ± 4.7 km for the Alboran Ridge Fault and a minimum of 12 km for the Yusuf Fault. Thus, this fault system forms a well-defined narrow plate boundary that has absorbed most of the 24 ± 5 km Plio-Holocene Africa-Eurasia convergence and represents an underappreciated hazard.MCIN Projects A-RNM-508-UGR20, B-RNM-305-UGR18, P18-RT-3632H2020 Marie Skłodowska-Curie Actions H2020-MSCA-IF-2017 796013, PID2019-107138RB-I00Society for Research on AdolescenceGeneralitat de Catalunya 2017 SGR 1662Ministerio de Educación, Cultura y Deporte AP2012-1579, COST-STSM-ECOST-STSM-ES1301-180814-045667, ES1301 MECDMinisterio de Economía y CompetitividadMinisterio de Ciencia e InnovaciónSevero Ochoa Centre of Excellence CEX2019-000928-S, PID2019-109559RB-I0

Numerical and clinical precision of continuous glucose monitoring in Colombian patients treated with insulin infusion pump with automated suspension in hypoglycemia

Objetivo La terapia con bomba de insulina asociada a monitorización continua de glucosa ha demostrado tener un impacto clínico positivo en el control de la diabetes y en la reducción de los episodios de hipoglucemia. Aunque existen descripciones del rendimiento del dispositivo en otras poblaciones, se desconoce su desempeño en Colombia y Latinoamérica en el contexto de la terapia ambulatoria usual. Métodos Se analizaron los registros de 33 pacientes con diabetes mellitus tipo 1 y 2 en terapia con monitorización continua de glucosa integrada al infusor de insulina con suspensión automática en hipoglucemia (MiniMed Paradigm® Veo™) utilizando el Sensor Sof-Sensor™ (Medtronic, Northridge, California) manejados en el Hospital Universitario San Ignacio (Bogotá, Colombia) y que venían recibiendo tratamiento ambulatorio. Se compararon datos simultáneos provenientes de glucometría capilar y monitorización continua de glucosa, calculando su validez por diferentes técnicas, incluyendo un análisis clínico utilizando la gradilla de error de Clarke. Resultados Basados en 2.262 datos pareados se encontró una media de la diferencia absoluta relativa para todas las mediciones del 20,1%, siendo mayor a 23% en las mediciones ≤75 mg/dl. El cumplimiento global de los criterios ISO fue de 64,9%, siendo mejor en las mediciones >75 mg/dl (68,3%, 1.308 de 1.916 lecturas), que en aquellas ≤ 75 mg/dl (49,4%, 171 de 346 lecturas). El porcentaje combinado en zonas A y B de la gradilla de error de Clarke fue del 91,77% (75,6% para hipoglucemia). Conclusiones Se observó un buen desempeño numérico para las determinaciones intersticiales en situaciones de normo- e hiperglucemia, persistiendo poca precisión en el rango de hipoglucemia. La precisión clínica del dispositivo es adecuada, sin comprometer de forma significativa la seguridad de los pacientes.Artículo original485-492Objective Insulin pump therapy associated with continuous glucose monitoring has shown a positive clinical impact on diabetes control and reduction of hypoglycemia episodes. There are descriptions of the performance of this device in other populations, but its precision and accuracy in Colombia and Latin America are unknown, especially in the routine outpatient setting. Methods Data from 33 type 1 and type 2 diabetes patients with sensor-augmented pump therapy with threshold suspend automation, MiniMed Paradigm® Veo™ (Medtronic, Northridge, California), managed at Hospital Universitario San Ignacio (Bogotá, Colombia) and receiving outpatient treatment, were analyzed. Simultaneous data from continuous glucose monitoring and capillary blood glucose were compared, and their precision and accuracy were calculating with different methods, including Clarke error grid. Results Analyses included 2,262 continuous glucose monitoring -reference paired glucose values. A mean absolute relative difference of 20.1% was found for all measurements, with a value higher than 23% for glucose levels ≤75 mg/dL. Global compliance with the ISO criteria was 64.9%. It was higher for values >75 mg/dl (68.3%, 1,308 of 1,916 readings), than for those ≤ 75 mg/dl (49.4%, 171 of 346 readings). Clinical accuracy, as assessed by the Clarke error grid, showed that 91.77% of data were within the A and B zones (75.6% in hypoglycemia). Conclusions A good numerical accuracy was found for continuous glucose monitoring in normo and hyperglycemia situations, with low precision in hypoglycemia. The clinical accuracy of the device was adequate, with no significant safety concerns for patients

Efficacy and Safety of New B Cell-Targeted Biologic Agent for the Treatment of Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

Background: B cells are central to the pathogenesis of systemic lupus erythematosus (SLE). We aimed to analyze the efficacy and safety of new B cell-targeted drug therapies for SLE. Methods: A systematic review of randomized controlled trials (RCTs) and reference lists of relevant articles published from inception to 2022 were selected from PubMed, Scopus andWeb of Science databases. Random effects meta-analyses were performed to estimate an overall effect size for the risk of adverse events (AEs) and serious adverse events (SAEs) with belimumab and tabalumab treatment. Heterogeneity was assessed using the I2 statistic and meta-regression. Funnel asymmetry was evaluated using Egger’s test. Results: This study included 13 RCTs, of which three showed high risk of bias. Egger’s test showed no asymmetry. The risk of SAEs and AEs was lower in the treatment group with belimumab treatment. The risk of AEs for tabalumab treatment was lower in the treatment group and lower for SAEs. Conclusion: Belimumab and tabalumab therapies are effective and safe in the treatment of SLE, although tabalumab does not show sufficient statistical power. Advances in understanding the underlying mechanisms of SLE will be directed towards correlating clinical manifestations with specific pathogenic pathways and the development of precision medicine