Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: systematic review, meta-analysis, and indirect treatment comparisons

Objective To analyse clinical outcomes with new oral anticoagulants for prophylaxis against venous thromboembolism after total hip or knee replacement

On the system performance of DFT-S-OFDM and CP-OFDM for 5G Uplink in mmWave band

Both conventional Cyclic Prefix Orthogonal Frequency Division Multiplexing (CP-OFDM) and Discrete Fourier Transform Spread OFDM (DFT-S-OFDM) have been adopted for their use in the Physical Uplink Shared Channel (PUSCH) in the 5G New Radio (NR) standard. While CP-OFDM can better exploit the frequency characteristics of the channel, DFTS-OFDM has the advantage of a lower peak-to-average power ratio (PAPR). Due to the interactions between PAPR and power amplifier (PA) non-linearity, users adopting DFT-S-OFDM waveform may benefit from a potentially higher PA efficiency and extend their coverage by increasing their transmit power. In this paper we study the uplink performance of both waveforms and their interaction with non-linear PA and uplink power control in the millimeter-wave (mmWave) band to determine their optimal operational range

A systematic review of clinicians' views and experiences of direct-acting oral anticoagulants in the management of non-valvular atrial fibrillation.

Introduction: While a plethora of systematic reviews have provided evidence of efficacy, effectiveness and safety of direct-acting oral anticoagulants (DOACs) in the management of non-valvular atrial fibrillation (AF), there has been little emphasis on clinicians' perspectives. This systematic review aimed to critically appraise, synthesise and present the available evidence of clinicians' views and experiences. Methods: Studies published in English from January 2006 to July 2017 reporting the views and/or experiences of doctors, nurses or pharmacists on any individual DOAC or as a pharmacological group were included. Studies were assessed for quality by two researchers, data extracted and findings synthesised using a narrative approach. Results: Following exclusion of duplicates, 777 titles, 394 abstracts and 196 studies were screened. Ten studies were included in the review, nine of which were quantitative (cross-sectional surveys) and one qualitative (semi-structured interviews), with marked heterogeneity in outcomes reported. Studies were conducted exclusively in Europe and the United States. In those studies reporting clinician preference, DOACs were first choice over warfarin in na{uml}ive patients, based on perceptions of evidence of effectiveness equivalent or superior to warfarin and superior safety. Other advantageous factors were in those with an unstable INR and likely to miss appointments. There were, however, concerns relating to management of over-anticoagulation and experiences of observed bleeding rates. Conclusion: There is a limited evidence base of clinicians' perspectives of DOACs, necessitating further research, particularly given the trajectory of increased use worldwide

Gestión de la activación de celdas secundarias en un escenario Dual Connectivity entre 4G y 5G

A major roll-out of 5G networks is currently underway around the world. In the first instance, users will connect to the 5G network in a non stand-alone mode. This paper presents a study on the optimization of the event B1 threshold for the inter Radio Access Technologies (inter-RAT) connection between LTE and NR technologies in a E-UTRAN New Radio Dual Connectivity (ENDC) scenario. For this purpose, a systemlevel simulator has been used to show the impact of changing the threshold value on the global user throughput and retainability using an File Transfer Protocol (FTP) service in a heterogeneous rural setting.Este trabajo ha sido financiado parcialmente por la Universidad a través del I Plan Propio de Investigación y Transferencia de la Universidad de Málaga y por Ericsson, que a su vez ha remitido la solicitud de financiación núm. 702C2000043 de la Línea de Programa de Apoyo I+D+i Empresarial convocada por la Junta de Andalucía. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

HISTORIAS DE DESLIZAMIENTOS Y ERUPCIONES: TSUNAMIS EN EL LAGO NAHUEL HUAPI

El 22 de mayo de 1960 un tsunami golpeó las costas de San Carlos de Bariloche. El antiguo muelle del Puerto San Carlos, que se hallaba en reconstrucción luego del incendio de 1958, colapsó durante dicho evento. ¿Cuáles fueron los mecanismos que generaron esta ola? ¿Se puede relacionar su origen con el gran sismo de Valdivia ocurrido simultáneamente? ¿Puede volver a ocurrir un evento como éste en el lago Nahuel Huapi, o en otro lago de la región? El Grupo de Estudios Ambientales del Instituto de Investigaciones en Biodiversidad y Medioambiente e investigadores del Instituto Argentino de Oceanografía estudian los sedimentos y la topografía del lecho del lago Nahuel Huapi con el objeto de comprender cómo se generan estos eventos lacustres y evaluar la peligrosidad que representan para las poblaciones costeras