iOS “versus” Android en aplicaciones de lectura infantil: diferencias y similitudes entre ambos sistemas operativos

Trabajo de Fin de Máster en Sistemas de Información Digital, curso 2015-2016[ES] Este trabajo, se centra en el análisis de las diferencias existentes en diferentes aplicaciones de lectura infantil disponibles en los sistemas operativos iOS y Android. El objetivo fundamental es estudiar, comprobar y señalar estas diferencias, estableciendo parámetros para la evaluación de las aplicaciones en dichos entornos, para lo que se han establecido una serie de indicadores referentes a la forma y contenido. Tras el análisis de 25 aplicaciones, se concluye que salvo en determinadas variables que predominan en las aplicaciones de iOS, en el resto de las variables analizadas apenas existen diferencias en los desarrollos creados para iOS y para Android. [EN] This work focuses on the analysis of the differences that exist in diverse reading applications for children available in iOS and Android operating systems. The main aim is to study, test and point out those differences, establishing parameters for the evaluation of the applications in such environments; for which there has been established a series of indicators for shape and content. After the analysis of 25 applications, it is concluded that apart from some variables that predominate in iOS applications, in the rest of them there is hardly any difference in the development created for iOS and Android

Archival research in translation and censorship: Digging into the “true museum of Francoism”

[FR] L’étude systématique de la censure appliquée à la traduction dans l’Espagne franquiste a commencé une dizaine d’années après le démantèlement définitif de l’appareil de censure du régime en 1985, avec l’ouverture au public des archives de censure Archivo General de la Administración (AGA) d’Alcalá de Henares. Depuis, de nombreuses études approfondies ont été menées sur la traduction de différents genres, utilisant comme source principale les fichiers de censure produits et archivés par le régime. Mais aucune réflexion rigoureuse sur la structure, l’utilisation et la fiabilité de ces données n’a encore vu le jour. Cet article examine les sources archivistiques utilisées dans l’étude de la censure en traduction, en examinant à cette fin l’histoire de l’AGA et la structure même des archives, et décrit les fonds documentaires et les possibilités qu’ils offrent pour étudier la censure appliquée à divers genres de textes. Si les données de l’AGA sont devenues un élément crucial dans l’enquête sur la censure en Espagne, il semble essentiel d’utiliser des informations complémentaires pour reconstruire le fonctionnement de l’activité de traduction pendant cette période, et pour comprendre comment ont été effectués les changements textuels observés dans les traductions censurées.[EN] Systematic research on translation and censorship in Francoist Spain started roughly ten years after the dismantling of the regime’s censorship apparatus in 1985, following the opening of the censorship archives at the Archivo General de la Administración (AGA) in Alcalá de Henares. Since then, numerous comprehensive studies on the translation of various genres have been produced, all of them making extensive use of the censorship files issued and archived by the regime as their main source of information. However, little to no reflection has been done on the structure, usefulness and reliability of those data. This paper examines archival sources in translation and censorship, delving into the AGA’s history and structure, as well as its unique position as a censorship repository. It describes the AGA’s document collections on censored cultural artefacts and the possibilities they afford to study the impact of censorship on the translation of various text types. Ultimately, it argues that while AGA data have proved to be a key component in censorship research in Spain, complementary information is essential in reconstructing translation activity at the time and to ascertain how textual changes observed in censored translations came about.[ES] El estudio sistemático de la censura en traducción durante la España franquista arrancó unos diez años después de que se desmantelara el aparato censorio del régimen de forma definitiva en 1985, con la apertura al público de los archivos de censura en el Archivo General de la Administración (AGA) de Alcalá de Henares. Desde entonces se han llevado a cabo numerosos estudios sobre la traducción de diversos géneros, los cuales utilizan como fuente primaria los expedientes de censura generados y archivados por el régimen. A pesar de haberse usado con asiduidad, no ha habido una reflexión rigurosa sobre la estructura, utilidad y fiabilidad de esos datos. Este artículo analiza las fuentes archivísticas empleadas en el estudio de la censura en traducción, examinando a tales efectos la historia del AGA, la estructura del archivo y su posición única como repositorio sobre censura. Asimismo, describe los fondos documentales sobre censura y las posibilidades que ofrecen para el estudio de la censura en varios géneros textuales traducidos. En última instancia, proponemos que, aunque los datos del AGA han resultado ser un elemento crucial en la investigación de la censura en España, es imprescindible utilizar información complementaria para reconstruir el funcionamiento de la actividad traductora de este período y determinar cómo se produjeron los cambios textuales que se observan en las traducciones censurada

Late-life depression accelerates cognitive impairment and tau-associated pathology in an Alzheimer´s disease model.

Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life depression and AD. The age of AD onset has been shown to be accelerated in patients with mild cognitive impairment (MCI) with a history of depression, and women appear to be particularly more vulnerable to this condition. In addition, individuals with MCI who present depressive symptoms have an elevated burden of amyloid-beta (Aβ), the main toxic protein associated with Alzheimer's pathology, and a higher risk of developing AD compared to non-depressed MCI patients. Although it has been described that some transgenic models of AD can develop signs similar to depression in advanced stages, the induction of Alzheimer's pathology due to a depressive process has not been studied under experimental conditions to emulate late-life depression as a risk factor for AD. In this study, we induced chronic unpredictable mild stress (CUMS) in P301S tau transgenic mice to determine whether depression is a cause, rather than a consequence, of the development of AD pathology. Our results suggest that transgenic tau mice subjected to CUMS seem to develop a depressive state. This animals display enhanced cognitive impairment compared to controls. In addition, histological studies show increased tau deposition, suggesting that late-life depression could worse AD progression by accelerating tau aggregation and worsening clinical signs. The findings generated in this project could provide evidence of depression as a risk factor for AD, providing new insights on molecular mechanisms involved in AD onset and progression.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Using Bayesian networks to estimate strategic indicators in the context of rapid software development

Background: During Rapid Software Development, a large amount of project and development data can be collected from different and heterogeneous data sources. Aims: Design a methodology to process these data and turn it into relevant strategic indicators to help companies make meaningful decisions. Method: We adapt an existing methodology to create and estimate strategic indicators using Bayesian Networks in the context of Rapid Software Development, and applied it to a use case. Results: Applying the methodology in the use case, we create a model to predict product quality based on software factors and metrics, using companies’ business knowledge and collected data. Conclusions: We proved the methodology’s feasibility and obtained positive feedback from the company’s use case.Postprint (author's final draft

Architectural decisions in AI-based systems: an ontological view

Architecting AI-based systems entails making some decisions that are particular to this type of systems. Therefore, it becomes necessary to gather all necessary knowledge to inform such decisions, and to articulate this knowledge in a form that facilitates knowledge transfer among different AI projects. In this exploratory paper, we first present the main results of a literature survey in the area, and then we propose a preliminary ontology for architectural decision making, which we exemplify using a subset of the papers selected in the literature review. In the discussion, we remark on the variety of decision types and system contexts, highlighting the need to further investigate the current state of research and practice in this area. Besides, we summarize our plans to move along this research area by widening the literature review and incorporating more AI-related concepts to this first version of the ontology.This paper has been funded by the Spanish Ministerio de Ciencia e Innovación under project / funding scheme PID2020-117191RB-I00 / AEI/10.13039/501100011033.Peer ReviewedPostprint (author's final draft

Actividad antioxidante de flavonoides de las hojas de Chromolaena tacotana (Klatt) R. M. King & H. Rob

Las plantas contienen metabolitos primarios y secundarios que dan características importantes a cada una de las especies y les permiten su supervivencia; En estudios del género Chromolaena se han encontrado metabolitos activos como sesquiterpenos, triterpenos, flavonoides y ácidos grasos (Domínguez, 2002). La Chromolaena tacotana, contiene diferentes metabolitos secundarios, dentro de los cuáles están los flavonoides, compuestos de interés en este estudio, ya que éstos se caracterizan por ser captadores de radicales libres (Brochet, 2009). A las hojas de la Chromolaena tacotana, se le hizo una extracción en Soxhlet con diclorometano (CH2Cl2) posteriormente los compuestos fueron aislados por cromatografías en columna y eluidas con solventes de diferente polaridad (CHCl3; CHCl3:MeOH, MeOH), para su identificación se hicieron cromatografías en capa fina y pruebas cualitativas como shinoda y cloruro férrico, se elucidaron estructuralmente por 1HRMN, 13CRMN y UV, donde se encontraron los siguientes flavonoides: (Ct1) 3, 5, 4´-trihidroxi-7-metoxiflavona, (Ct2) 3,5,8-trihidroxi-7,4´dimetoxiflavona o 3,5,7-trihidroxi-8,4´ dimetoxiflavona, (Ct3) 4´,5-trihidroxi-7-metoxiflavanonol y (Ct4) 5 ,7 ,3´,4´-tetrahidroxi-3-metoxiflavona. A cada flavonoide se le determinó la actividad antioxidante por los métodos DPPH● y ABTS●+, se utilizó como control positivo quercetina y trolox respectivamente y se obtuvo como resultados para el método de decoloración del radical ABTS●+, que el flavonoide con mayor actividad antioxidante fue el (Ct4) 5,7, 3´,4´-tetrahidroxi-3-metoxiflavona con un IC50 de 2,13 mg/L en comparación con el control trolox que arrojó un IC50 de 3,05 mg/L ,seguido por(Ct2) 3, 5, 8-trihidroxi-7,4´-dimetoxiflavona o 3,5,7-trihidroxi-8,4´dimetoxiflavona,con 3,51 mg/L , el (Ct1)3,5,4´trihidroxi-7-metoxiflavona con un valor de 6,26 mg/L y (Ct3)4´,5 dihidroxi-7 metoxi-flavanonol con valore de IC50 de 33,94 mg/L con el ensayo DPPH● el que mayor inhibición del radical presentó fue el flavonoide(Ct4), seguido por (Ct2) y (Ct1) con valores de IC50 de 2,51, 4,85 y 6,46 mg/L respectivamentePregradoQuímico(a

Self-Triggered Formation Control of Nonholonomic Robots

In this paper, we report the design of an aperiodic remote formation controller applied to nonholonomic robots tracking nonlinear, trajectories using an external positioning sensor network. Our main objective is to reduce wireless communication with external sensors and robots while guaranteeing formation stability. Unlike most previous work in the field of aperiodic control, we design a self-triggered controller that only updates the control signal according to the variation of a Lyapunov function, without taking the measurement error into account. The controller is responsible for scheduling measurement requests to the sensor network and for computing and sending control signals to the robots. We design two triggering mechanisms: centralized, taking into account the formation state and decentralized, considering the individual state of each unit. We present a statistical analysis of simulation results, showing that our control solution significantly reduces the need for communication in comparison with periodic implementations, while preserving the desired tracking performance. To validate the proposal, we also perform experimental tests with robots remotely controlled by a mini PC through an IEEE 802.11g wireless network, in which robots pose is detected by a set of camera sensors connected to the same wireless network

Hepatic disease as the first manifestation of progressive myoclonus epilepsy of Lafora

5 páginas, 2 figuras -- PAGS nros. 1369-1373Background: Lafora disease (LD; progressive myoclonus epilepsy type 2; EPM2) is an autosomal recessive disorder caused by mutations in the EPM2A and EPM2B genes. LD is characterized by the presence of strongly PAS-positive intracellular inclusions (Lafora bodies) in several tissues. Glycogen storage disease type IV (GSD-IV; Andersen disease) is an autosomal recessive disorder characterized by cirrhosis leading to severe liver failure. GSD-IV has been associated with mutations in the glycogen branching enzyme gene (GBE). Histopathologic changes of the liver in both diseases show an identical appearance, although cirrhosis has never been described in patients with LD. We report a LD family in which the proband presented severe liver failure at onset of the disease. Methods: Clinical histories, physical and neurologic examination, laboratory tests, EEGs, MRI of the brain, and liver or axillary skin biopsies were performed in the two affected siblings. The diagnosis was confirmed by molecular genetic analysis of the EPM2A, EPM2B, and GBE genes and loci. Results: During the first decade of life, abnormalities in liver function tests were detected in the two affected siblings. The proband's liver dysfunction was severe enough to require liver transplantation. Subsequently, both sibs developed LD. Mutation analysis of EPM2A revealed a homozygous Arg241stop mutation in both patients. Conclusions: This is the first description of severe hepatic dysfunction as the initial clinical manifestation of LD. The phenotypic differences between the two affected siblings suggest that modifier genes must condition clinical expression of the disease outside the CNSPeer reviewe