Improving the performance of biomass-derived carbons in rechargable lithium batteries

III Encuentro sobre Nanociencia y Nanotecnología de Investigadores y Tecnólogos Andaluce

Clinical practice in prevention of migraine with calcitonin-gene related peptide monoclonal antibodies: real-world evidence

Introducción: Los anticuerpos monoclonales (mAbs) del péptido relacionado con el gen de la calcitonina (CGRP) son un novedoso tratamiento para prevenir la migraña crónica y la episódica de alta frecuencia. Método: Se realizó un estudio observacional, retrospectivo, multicéntrico para analizar la efectividad y seguridad de los mAbs anti-CGRP (erenumab, galcanezumab, fremanezumab). La variable de efectividad fue la reducción en los días de migraña al mes (MMDs). La seguridad se midió con los efectos adversos descritos. Resultados: Los resultados de 127 pacientes muestran efectividad similar entre erenumab y galcanezumab en la reducción de los MMDs. Una proporción importante de pacientes cambió de mAb por pérdida de respuesta o fallo primario tras una media de 7 meses: 15,11% erenumab; 24% galcanezumab. Algunos pacientes se trataron concomitantemente con toxina botulínica A: 8,13% erenumab; 12% galcanezumab; 6,25% fremanezumab. Más del 60% de pacientes habían sido tratados previamente con toxina botulínica A con falta de respuesta tras varias dosis. Se describieron efectos adversos cardiovasculares (dolor en el pecho, taquicardia) exclusivamente en pacientes con erenumab. Conclusiones: La práctica clínica actual se basa en el intercambio de mABs anti-CGRP en casos de falta de respuesta o migraña refractaria, aunque su evidencia es limitada y se ha demostrado que la efectividad entre los tres fármacos es equivalente. Las Agencias Reguladoras recomiendan un período de 12 semanas para evaluar la efectividad del mAb. La mitad de los pacientes refirieron falta de seguimiento por Neurología. Los farmacéuticos clínicos son necesarios en la atención integrada de la migraña.Introduction: Calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) are novel therapeutic option for prevention of chronic migraine (CM) and high-frequency episodic migraine (HFEM). Method: An observational, retrospective, multicentre, real-world evidence study was developed to analyse the effectiveness and safety of anti-CGRP mAbs (erenumab, galcanezumab, fremanezumab). Effectiveness was measured by monthly migraine days (MMDs) reduction. Adverse events were recorded for safety outcome. Results: Results from 127 patients showed similar effectiveness between erenumab and galcanezumab in MMDs reduction. A notable proportion of patients switched of mAb because of loss of response or primary no-response after seven months: 15.11% erenumab; 24% galcanezumab. Some patients were concomitant treated with Onabotulinumtoxin A (Onabot A): 8.13% erenumab; 12% galcanezumab; 6.25% fremanezumab. More than 60% of the total were previously treated with Onabot A with loss of response. Cardiovascular adverse events are exclusively reported by erenumab group (chest pain, tachycardia). Conclusions: Current clinical practice is based on switching of CGRP mAbs after loss of response or refractory migraine, even though evidence for this practice is limited and effectiveness between the drugs has been demonstrated to be equivalent. The period of 12 weeks since the first dose of the CGRP mAb, recommended by Regulatory Agencies, should be respected to determine if the mAb selected is being ineffective. At least, half of the patients complained about lack of follow-up by reference neurologist. Clinical pharmacists are important to help these patients manage the burden of migraine

Physicochemical and microbiological characterization of the sensory deviation responsible for the origin of the special sherry wines "palo cortado" type

The aim of this study was to characterize the biochemical changes and microbiological processes involved in the sensory deviation of “sobretablas” wines during biological aging, which leads to the origin of special or rare “palo cortado” wines. Industrial trials of biological aging of “sobretablas” wines with the potential for the development of lactic acid bacteria (LAB) were performed to study this phenomenon. The results showed that sensory deviation was due to the development of malolactic fermentation (MLF) together with an attenuated aerobic metabolism of “flor” yeast. Malolactic fermentation (MLF) was promoted by the presence of malic acid concentrations that were higher than 1 g/L and the coexistence of LAB and “flor” velum yeast. Ethyl lactate, acetoin and 2,3-butanediol are some of the volatile compounds that are responsible for this sensory deviation. Wines with high levels of gluconic and malic acids (> 1 g/L) can cause, with very low probability, the sensory deviation of “palo cortado”. A lysozyme dose of 12 g/hL is an effective treatment to avoid malolactic fermentation (MFL) and sensory deviation. Understanding the biochemical and microbiological changes involved in sensory deviation can be useful to wineries as markers to identify the origin of the special sherry wines "palo cortado" type

Viabilidad comercial de un emprendimiento artesanal: Chocolatera ubicada en Cuenca – Ecuador.

This research paper examines the commercial viability of an artisanal chocolate enterprise located in Cuenca, Ecuador. The study focuses on the analysis of the theoretical framework of commercial viability and uses the empirical-analytical method to collect and analyze data. It was calculated that the per capita consumption of chocolate in the country is 64 units, which indicates an unsatisfied demand. The results of the research indicate that there is a commercial opportunity for artisanal chocolate in Cuenca, since the local market demand is not being fully satisfied. It is concluded that the commercial opportunity for an artisanal chocolate company is high, and that there is room for growth in the local market. This study is useful for entrepreneurs interested in establishing an artisanal chocolate business in the region and for researchers interested in analyzing the commercial viability of artisanal enterprises in general.Este trabajo investigativo examina la viabilidad comercial de un emprendimiento artesanal de chocolatería ubicado en Cuenca, Ecuador. El estudio se enfoca en realizar un amplio marco teórico sobre la viabilidad comercial y utiliza el método empírico-analítico para recolectar y analizar datos. Se calculó que el consumo per cápita de chocolate es de 64 unidades, lo que indica una demanda insatisfecha. De los resultados encontrados, se encontró la existencia de una alta probabilidad de viabilidad comercial para la chocolatería artesanal en Cuenca, porque se determinó que la demanda local no está completamente satisfecha. Se concluye que la oportunidad comercial para una empresa de chocolatería artesanal es alta, y que existe un espacio para crecer en el mercado local. Este estudio es útil para emprendedores interesados en establecer un negocio de chocolatería artesanal en la región y para investigadores interesados en el análisis de la viabilidad comercial de empresas artesanales en general

Baterías Li-ion de alta energía combinando silicio nanométrico y espinelas de alto potencial

II Encuentro sobre nanociencia y nanotecnología de investigadores y tecnólogos de la Universidad de Córdoba. NANOUC

Planteamiento de una metodología de mejora continua en la Tutorización y elaboración de Trabajos Fin de Grado

Fac. de Comercio y TurismoFALSEsubmitte

Evaluation of the use of multiflora bee pollen on the volatile compounds and sensorial profile of Palomino fino and Riesling white young wines

This study investigates the impact of bee pollen on volatile compounds, odour activity values and sensory profiles in Palomino fino and Riesling young white wines. Commercial bee pollen was added to grape must using six different doses (0 (control), 0.1, 0.25, 1, 5, 10 and 20 g/L) and fermented under controlled conditions. Volatile compounds were determined with GC and GC–MS chromatography and sensorial analysis using a qualified panel of tasters. Bee pollen produces an increase in volatile compounds depending on the grape variety and the dose applied. It also increases the synthesis of higher alcohols, methanol, esters, acetaldehyde and terpenes, reducing alcohols and fatty acids. Wines with low doses (0.1 and 0.25 g/L) showed the higher OAV values (fruity and floral) and scores in overall judgment for the sensory evaluation. High pollen doses decrease fruity character and could result in deviations affecting the sensorial quality.12 página

El Trabajo Fin de Grado y su tutorización: un enfoque integrador entre áreas y participantes implicados

Fac. de Comercio y TurismoFALSEsubmitte

Broadband modified-circle-shape patch antenna with H-aperture feeding for a passive radar array

In this paper, the design of a broadband modified-circle-shape patch antenna with H-aperture feeding is presented, to be used as single radiating element in the array of the surveillance channel of an UHF passive radar. Different techniques are proposed to achieve a relative bandwidth of more than 30%, and challenging radiation pattern characteristics for the defined application. The achievement of these requirements is proved through measurements in anechoic chamber. A NULA is designed using optimization techniques and considering coupling effects between elements. The NULA was integrated in IDEPAR, the passive radar demonstrator developed in the University of Alcalá, and validated through measurement campaigns. Results prove a significant improvement of the passive radar target detection and bearing estimation capabilities

DVB-T Receiver Independent of Channel Allocation, with Frequency Offset Compensation for Improving Resolution in Low Cost Passive Radar.

In this article, a commercial low cost solution for increasing DVB-T based passive radar (also referred to as passive coherentlocation)robustnesswith respectto channel allocation and range resolution, is designed. IDEPAR demonstrator is updated to include a new recording system in charge of DVB-T channels reallocation. The use of commercial hardware introduces frequency mismatching between acquired channels that compromises system operation. To face channel frequency alignment, fulfilling the requirements imposed by the high Doppler resolution typical of passive radars, a novel compensation algorithm is proposed, based on the minimization of signal dispersion in the Cross-Ambiguity Function domain. The well-known cyclic prefix van de Beek method is used as reference. Results show an increase in target signal to interference ratio and detection performances, as well as a reduction of clutter dispersion when the novel proposed algorithm is applied. The low cost solution is also compared to a high performance one capable of acquiring a wide bandwidth of sparse DVB-T channels, and performing channel reallocation by digital signal processing. Results show that both systems reached similar performances in terms of range resolution and SNR improvement